All Stories

  1. Role of allosteric switches and adaptor domains in long-distance cross-talk and transient tunnel formation

    Article • Science Advances, April 2020, American Association for the Advancement of Science

    Professor Erick Strauss

  2. Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

    Article • MedChemComm, January 2019, Royal Society of Chemistry

    Professor Erick Strauss

  3. Probing the ligand preferences of the three types of bacterial pantothenate kinase

    Article • Bioorganic & Medicinal Chemistry, December 2018, Elsevier

    Professor Erick Strauss

  4. Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives

    Article • Chemistry - A European Journal, October 2018, Wiley

    Professor Erick Strauss

  5. Mutations at the hydrophobic core affect Hal3 trimer stability, reducing its Ppz1 inhibitory capacity but not its PPCDC moonlighting function

    Article • Scientific Reports, October 2018, Springer Science + Business Media

    Professor Joaquin Arino, Professor Erick Strauss

  6. Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity

    Article • Life Science Alliance, July 2018, Life Science Alliance, LLC

    Professor Erick Strauss

  7. Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

    Article • PLoS Pathogens, April 2018, PLOS

    Professor Erick Strauss

  8. Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action

    Article • ACS Infectious Diseases, January 2018, American Chemical Society (ACS)

    Professor Erick Strauss

  9. Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target

    Article • ACS Infectious Diseases, May 2017, American Chemical Society (ACS)

    Professor Erick Strauss

  10. The α-Thioglycoligase Derived from a GH89 α-N-Acetylglucosaminidase Synthesises α-N-Acetylglucosamine-Based Glycosides of Biomedical Interest

    Article • Advanced Synthesis & Catalysis, January 2017, Wiley

    Professor Erick Strauss

  11. Simultaneous quantification of coenzyme A and its salvage pathway intermediates in in vitro and whole cell-sourced samples

    Article • RSC Advances, January 2017, Royal Society of Chemistry

    Professor Erick Strauss

  12. Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product

    Article • ACS Infectious Diseases, September 2016, American Chemical Society (ACS)

    Professor Erick Strauss

  13. Coenzyme A: to make it or uptake it?

    Article • Nature Reviews Molecular Cell Biology, August 2016, Springer Science + Business Media

    Professor Erick Strauss

  14. Complex stability and dynamic subunit interchange modulates the disparate activities of the yeast moonlighting proteins Hal3 and Vhs3

    Article • Scientific Reports, October 2015, Springer Science + Business Media

    Professor Erick Strauss, Professor Joaquin Arino

  15. Jump-starting CoA biosynthesis

    Article • Nature Methods, October 2015, Springer Science + Business Media

    Professor Erick Strauss

  16. Antiplasmodial pantetheinase-resistant pantothenamide

    Article • Antimicrobial Agents and Chemotherapy, April 2015, ASM Journals

    Professor Erick Strauss

  17. Variation in pantothenate kinase type determines the pantothenamide mode of action and impacts on coenzyme A salvage biosynthesis

    Article • FEBS Journal, October 2014, Wiley

    Professor Erick Strauss

  18. Recent advances in targeting coenzyme A biosynthesis and utilization for antimicrobial drug development

    Article • Biochemical Society Transactions, August 2014, Portland Press Ltd.

    Professor Erick Strauss

  19. A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices

    Article • Analytical Biochemistry, April 2014, Elsevier

    Professor Erick Strauss

  20. The Schizosaccharomyces pombe fusion gene hal3 encodes three distinct activities

    Article • Molecular Microbiology, September 2013, Wiley

    Professor Joaquin Arino, Professor Erick Strauss

  21. Structural Modification of Pantothenamides Counteracts Degradation by Pantetheinase and Improves Antiplasmodial Activity

    Article • ACS Medicinal Chemistry Letters, August 2013, American Chemical Society (ACS)

    Professor Erick Strauss

  22. Pantothenamides Are Potent, On-Target Inhibitors of Plasmodium falciparum Growth When Serum Pantetheinase Is Inactivated

    Article • PLoS ONE, February 2013, PLOS

    Professor Erick Strauss

  23. Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights

    Article • Biochemistry, October 2012, American Chemical Society (ACS)

    Professor Erick Strauss

  24. The Antibiotic CJ-15,801 Is an Antimetabolite that Hijacks and Then Inhibits CoA Biosynthesis

    Article • Chemistry & Biology, May 2012, Elsevier

    Professor Erick Strauss

  25. Functional mapping of the disparate activities of the yeast moonlighting protein Hal3

    Article • Biochemical Journal, March 2012, Portland Press Ltd.

    Professor Joaquin Arino, Professor Erick Strauss

  26. An enzyme-initiated Smiles rearrangement enables the development of an assay of MshB, the GlcNAc-Ins deacetylase of mycothiol biosynthesis

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Professor Erick Strauss

  27. Grand Challenge Commentary: Exploiting single-cell variation for new antibiotics

    Article • Nature Chemical Biology, December 2010, Springer Science + Business Media

    Professor Erick Strauss

  28. Michael Acceptor-Containing Coenzyme A Analogues As Inhibitors of the Atypical Coenzyme A Disulfide Reductase from Staphylococcus aureus

    Article • Journal of the American Chemical Society, September 2010, American Chemical Society (ACS)

    Professor Erick Strauss

  29. Creating Cellulose-Binding Domain Fusions of the Coenzyme A Biosynthetic Enzymes to Enable Reactor-Based Biotransformations

    Article • ChemCatChem, September 2010, Wiley

    Professor Erick Strauss

  30. Biocatalytic Production of Coenzyme A Analogues

    Article • ChemCatChem, July 2010, Wiley

    Professor Erick Strauss

  31. 3-Fluoroaspartate and Pyruvoyl-Dependant Aspartate Decarboxylase: Exploiting the Unique Characteristics of Fluorine To Probe Reactivity and Binding

    Article • Chemistry - A European Journal, July 2010, Wiley

    Professor Erick Strauss

  32. Coenzyme A Biosynthesis and Enzymology

    Article • January 2010, Elsevier

    Professor Erick Strauss

  33. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis

    Article • November 2009, Nature

    Professor Joaquin Arino, Professor Erick Strauss

  34. Structural Basis for Substrate Binding and the Catalytic Mechanism of Type III Pantothenate Kinase†

    Article • Biochemistry, February 2008, American Chemical Society (ACS)

    Professor Erick Strauss

  35. Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization

    Article • Organic & Biomolecular Chemistry, January 2008, Royal Society of Chemistry

    Professor Erick Strauss

  36. One-pot preparation of coenzyme A analogues via an improved chemo-enzymatic synthesis of pre-CoA thioester synthons

    Article • Chemical Communications, January 2007, Royal Society of Chemistry

    Professor Erick Strauss

  37. Crystal Structure of a Type III Pantothenate Kinase: Insight into the Mechanism of an Essential Coenzyme A Biosynthetic Enzyme Universally Distributed in Bacteria

    Article • Journal of Bacteriology, August 2006, ASM Journals

    Professor Diana R. Tomchick, Professor Erick Strauss

  38. Characterization of a New Pantothenate Kinase Isoform fromHelicobacter pylori

    Article • Journal of Biological Chemistry, March 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Erick Strauss

  39. The Selectivity for Cysteine over Serine in Coenzyme A Biosynthesis

    Article • ChemBioChem, March 2005, Wiley

    Professor Erick Strauss

  40. The Selectivity for Cysteine over Serine in Coenzyme A Biosynthesis

    Article • ChemBioChem, December 2004, Wiley

    Professor Erick Strauss

  41. Mechanistic Studies on Phosphopantothenoylcysteine Decarboxylase:  Trapping of an Enethiolate Intermediate with a Mechanism-Based Inactivating Agent †

    Article • Biochemistry, December 2004, American Chemical Society (ACS)

    Professor Erick Strauss

  42. Structure of Human Phosphopantothenoylcysteine Synthetase at 2.3 Å Resolution

    Article • Structure, August 2003, Elsevier

    Professor Erick Strauss

  43. Functional copper at the acetyl-CoA synthase active site

    Article • Proceedings of the National Academy of Sciences, February 2003, Proceedings of the National Academy of Sciences

    Professor Erick Strauss

  44. Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli

    Article • Bioorganic & Medicinal Chemistry Letters, February 2003, Elsevier

    Professor Erick Strauss

  45. The Antibiotic Activity ofN-Pentylpantothenamide Results from Its Conversion to Ethyldethia-Coenzyme A, a Coenzyme A Antimetabolite

    Article • Journal of Biological Chemistry, October 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Erick Strauss

  46. Top Down Characterization of Larger Proteins (45 kDa) by Electron Capture Dissociation Mass Spectrometry

    Article • Journal of the American Chemical Society, January 2002, American Chemical Society (ACS)

    Professor Erick Strauss

  47. Mechanistic Studies on Phosphopantothenoylcysteine Decarboxylase

    Article • Journal of the American Chemical Society, July 2001, American Chemical Society (ACS)

    Professor Erick Strauss

  48. The biosynthesis of coenzyme a in bacteria

    Article • January 2001, Elsevier

    Professor Erick Strauss

  49. Thermal fragmentation of 2-chloropentylphosphonic salts in the solid state. Counter-ion effects on reactivity and selectivity

    Article • Heteroatom Chemistry, January 1997, Wiley

    Professor Erick Strauss