All Stories

  1. New insights into the anticancer therapeutic potential of icaritin and its synthetic derivatives
  2. Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement
  3. Unveiling the Protective Role of Melatonin in Osteosarcoma: Current Knowledge and Limitations
  4. Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling
  5. B7-H3 at the crossroads between tumor plasticity and colorectal cancer progression: a potential target for therapeutic intervention
  6. Sweeteners and the Gut Microbiome: Effects on Gastrointestinal Cancers
  7. Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy
  8. Resveratrol as sensitizer in colorectal cancer plasticity
  9. Sweeteners and the Gut Microbiome: Effects on Gastrointestinal Cancers
  10. Could Metformin and Resveratrol Support Glioblastoma Treatment? A Mechanistic View at the Cellular Level
  11. The Influence of Gut Microbial Species on Diabetes Mellitus
  12. Curcumin, calebin A and chemosensitization: How are they linked to colorectal cancer?
  13. Potential Treatment Options for Neuroblastoma with Polyphenols through Anti-Proliferative and Apoptotic Mechanisms
  14. Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – a potential contribution to the predictive, preventive, and personalized medicine
  15. Flavonoids’ Dual Benefits in Gastrointestinal Cancer and Diabetes: A Potential Treatment on the Horizon?
  16. Tirzepatide—Friend or Foe in Diabetic Cancer Patients?
  17. The Juggernaut of Adaptive Metabolism in Cancers: Implications and Therapeutic Targets
  18. Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer
  19. COVID-19 Vaccines and Hyperglycemia—Is There a Need for Postvaccination Surveillance?
  20. Expression of 3-Methylcrotonyl-CoA Carboxylase in Brain Tumors and Capability to Catabolize Leucine by Human Neural Cancer Cells
  21. Flavonoids Synergistically Enhance the Anti-Glioblastoma Effects of Chemotherapeutic Drugs
  22. Treating Cancers Using Nature’s Medicine: Significance and Challenges
  23. Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review
  24. Caution, “normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021
  25. Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention
  26. Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer
  27. Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks
  28. Micro-RNA: The darkhorse of cancer
  29. Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposing
  30. Metabolic Anti-Cancer Effects of Melatonin: Clinically Relevant Prospects
  31. Flavonoids against the SARS-CoV-2 induced inflammatory storm
  32. The interplay between the vaginal microbiome and innate immunity in the focus of predictive, preventive, and personalized medical approach to combat HPV-induced cervical cancer
  33. Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles
  34. Natural Compounds in Glioblastoma Therapy: Preclinical Insights, Mechanistic Pathways, and Outlook
  35. Flavonoids Alleviate Peripheral Neuropathy Induced by Anticancer Drugs
  36. Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
  37. Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine
  38. Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
  39. Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
  40. Bacteriophage Treatment: Critical Evaluation of Its Application on World Health Organization Priority Pathogens
  41. Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
  42. Carotenoids in Cancer Metastasis—Status Quo and Outlook
  43. Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology
  44. Curcumin’s Beneficial Effects on Neuroblastoma: Mechanisms, Challenges, and Potential Solutions
  45. The role of plant-derived natural substances as immunomodulatory agents in carcinogenesis
  46. Implications of flavonoids as potential modulators of cancer neovascularity
  47. Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells
  48. Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
  49. Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer
  50. Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism
  51. Cisplatin's dual-effect on the circadian clock triggers proliferation and apoptosis
  52. Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications
  53. Calcium Entry through TRPV1: A Potential Target for the Regulation of Proliferation and Apoptosis in Cancerous and Healthy Cells
  54. Flavonoids in Cancer Metastasis
  55. Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine
  56. Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses
  57. Dietary phytochemicals as the potential protectors against carcinogenesis and their role in cancer chemoprevention
  58. Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer
  59. Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression
  60. The Plant-Derived Compound Resveratrol in Brain Cancer: A Review
  61. Phytochemicals and Gastrointestinal Cancer: Cellular Mechanisms and Effects to Change Cancer Progression
  62. Anticancer Potential of Lichens’ Secondary Metabolites
  63. Combination Therapy with Vitamin C Could Eradicate Cancer Stem Cells
  64. Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer
  65. Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium
  66. Paclitaxel’s Mechanistic and Clinical Effects on Breast Cancer
  67. Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy
  68. Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels
  69. DNA Methylation Status in Cancer Disease: Modulations by Plant-Derived Natural Compounds and Dietary Interventions
  70. Health implication of vitamin D on the cardiovascular and the renal system
  71. Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection
  72. Why the Gold Standard Approach by Mammography Demands Extension by Multiomics? Application of Liquid Biopsy miRNA Profiles to Breast Cancer Disease Management
  73. The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression
  74. Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro
  75. Controlling metastatic cancer: the role of phytochemicals in cell signaling
  76. Dietary Phytochemicals Targeting Cancer Stem Cells
  77. Droplet digital PCR revealed high concordance between primary tumors and lymph node metastases in multiplex screening of KRAS mutations in colorectal cancer
  78. High Glucose Represses the Anti-Proliferative and Pro-Apoptotic Effect of Metformin in Triple Negative Breast Cancer Cells
  79. Flavonoids in Cancer and Apoptosis
  80. Triptolide Decreases Cell Proliferation and Induces Cell Death in Triple Negative MDA-MB-231 Breast Cancer Cells
  81. Experiencing Tanzania: Reflections of a Medical Service Learning Trip Through the Eyes of Aspiring Physicians
  82. Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach
  83. Challenges and perspectives in the treatment of diabetes associated breast cancer
  84. The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers
  85. Differential Expression and Pathway Analysis in Drug-Resistant Triple-Negative Breast Cancer Cell Lines Using RNASeq Analysis
  86. Chemotherapeutic agents for the treatment of metastatic breast cancer: An update
  87. MicroRNA-15a expression measured in urine samples as a potential biomarker of renal cell carcinoma
  88. Adipokines in neurovascular diseases
  89. Melatonin and breast cancer: Evidences from preclinical and human studies
  90. Open Reading Frame Filtering Methods for Identification of Genic Sequences
  91. Are plant-based functional foods better choice against cancer than single phytochemicals? A critical review of current breast cancer research
  92. Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plant extracts
  93. Alamandine reverses hyperhomocysteinemia-induced vascular dysfunction via PKA-dependent mechanisms
  94. Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders
  95. Antineoplastic effects of clove buds (Syzygium aromaticumL.) in the model of breast carcinoma
  96. Targeting Intracellular Calcium Signaling ([Ca2+]i) to Overcome Acquired Multidrug Resistance of Cancer Cells: A Mini-Overview
  97. Angiomodulators in cancer therapy: New perspectives
  98. Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
  99. Nitric oxide in the pathophysiology of retinopathy: evidences from preclinical and clinical researches
  100. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma
  101. Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect
  102. Chili pepper as a body weight-loss food
  103. Creatine and creatine pyruvate reduce hypoxia-induced effects on phrenic nerve activity in the juvenile mouse respiratory system
  104. TRPV currents and their role in the nociception and neuroplasticity
  105. The known and missing links between Toxoplasma gondii and schizophrenia
  106. A few things everybody should know about osteoporosis. Keep you bones healthy and strong!
  107. Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model
  108. Histone Deacetylase Inhibitor Trichostatin A (TSA) and DNA Methyltransferase Inhibitor 5-aza-2′-deoxycitidine (5-AZA) Enhanced the Cisplatin (CDDP) Induced Cytotoxicity of Neuroblastoma Cells, in Vitro
  109. Intracellular Calcium in Development and Treatment of Neuroblastoma
  110. The Role of Intracellular Calcium for the Development and Treatment of Neuroblastoma
  111. Recent updates on metal compounds in our environment and their implications on human health
  112. Auranofin, an Anti-Rheumatic Gold Compound, Modulates Apoptosis by Elevating the Intracellular Calcium Concentration ([Ca2+]i) in MCF-7 Breast Cancer Cells
  113. Effects of Glycinergic Inhibition Failure on Respiratory Rhythm and Pattern Generation
  114. Cisplatin (CDDP) triggers cell death of MCF-7 cells following disruption of intracellular calcium ([Ca2+]i) homeostasis
  115. Involvement Of Intracellular Calcium [ca2+]i In The Treatment Of Human Neuroblastoma With Cisplatin (cddp) And Topotecan (topo)
  116. Lead impairs synaptic transmission by interfering with calcium
  117. The two opposite facets of arsenic: toxic and anticancer drug
  118. Breast cancer and possible mechanisms of therapy resistance
  119. Lead (Pb2+) neurotoxicity: Ion-mimicry with calcium (Ca2+) impairs synaptic transmission. A review with animated illustrations of the pre- and post-synaptic effects of lead
  120. Editors' page: Introduction
  121. Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease
  122. Analgesic ineffectiveness of lacosamide after spinal nerve ligation and its sodium channel activity in injured neurons
  123. Metals and Disease
  124. Metal Toxicity at the Synapse: Presynaptic, Postsynaptic, and Long-Term Effects
  125. Changing Patterns of Fertility and Family Formation in the Islamic World: Dimensions, Causes and Implications
  126. Additive inhibitory effects of calcitonin and capsaicin on voltage activated calcium channel currents in nociceptive neurones of rat
  127. Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
  128. Metals and Breast Cancer: Risk Factors or Healing Agents?
  129. Metal toxicity at the synapse: presynaptic, postsynaptic and long-term effects
  130. Anti-allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38 and protein kinase C mediated modulation of Ca2+ channels
  131. Myricetin reduces voltage activated potassium channel currents in DRG neurons by a p38 dependent mechanism
  132. Website Resources versus Text Resources: Which do Millenneal Medical Students Utilize Most?
  133. Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor-necrosis-factor-α
  134. Modulation spannungsabhängiger Kalcium- und Kaliumkanäle in sensorischen Neuronen durch Flavonoide: Neue Substanzklasse in der experimentellen Schmerzforschung?
  135. Anti-cancer drugs interfere with intracellular calcium signaling
  136. Heat-Induced Action Potential Discharges in Nociceptive Primary Sensory Neurons of Rats
  137. Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity
  138. Metallic compounds (arsenic trioxide and trimethyltin chloride) interact with calcium homeostasis and trigger cell death in “in vitro” systems
  139. SnCl2 reduces voltage-activated calcium channel currents of dorsal root ganglion neurons of rats
  140. Arsenic trioxide in environmentally and clinically relevant concentrations interacts with calcium homeostasis and induces cell type specific cell death in tumor and non-tumor cells
  141. TNF-α differentially modulates ion channels of nociceptive neurons
  142. Feedback mechanisms in the regulation of intracellular calcium ([Ca2+]i) in the peripheral nociceptive system: Role of TRPV-1 and pain related receptors
  143. Modulation of intracellular calcium influences capsaicin-induced currents of TRPV-1and voltage-activated channel currents in nociceptive neurones
  144. IP3 receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+ -influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis
  145. Medullary pacemaker neurons are essential for both eupnea and gasping in mammals vs. medullary pacemaker neurons are essential for gasping, but not eupnea, in mammals
  146. Arsenic trioxide (As2O3) induced calcium signals and cytotoxicity in two human cell lines: SY-5Y neuroblastoma and 293 embryonic kidney (HEK)
  147. Cisplatin modulates voltage gated channel currents of dorsal root ganglion neurons of rats
  148. New pharmaceutic interventions in the therapy of chronic pain
  149. Anti-cancer drugs elevate intracellular calcium by different mechanisms
  150. Various „drugs“ influence the respiratory rhythm
  151. Occurrence, use and potential toxic effects of metals and metal compounds
  152. Toxic effects of metals: modulation of intracellular calcium homeostasis
  153. Modulation of intracellular calcium homeostasis by trimethyltin chloride in human tumour cells: Neuroblastoma SY5Y and cervix adenocarcinoma HeLa S3
  154. Capsaicin differentially modulates voltage-activated calcium channel currents in dorsal root ganglion neurones of rats
  155. Elevated Ca2+i transients induced by trimethyltin chloride in HeLa cells: types and levels of response
  156. Modulation of voltage-gated channel currents by harmaline and harmane
  157. Actions of metals on membrane channels, calcium homeostasis and synaptic plasticity
  158. A combined blockade of glycine and calcium-dependent potassium channels abolishes the respiratory rhythm
  159. The Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on membrane currents and intrasynaptosomal calcium
  160. The respiratory rhythm in mutant oscillator mice
  161. Reorganisation of respiratory network activity after loss of glycinergic inhibition
  162. Inactivation and tachyphylaxis of heat‐evoked inward currents in nociceptive primary sensory neurones of rats
  163. Respiratory Rhythm Generation: Plasticity of a Neuronal Network
  164. 1-Methyl-4-Phenyl-l,2,3,6-Tetrahydropyridine and 1-Methyl-4-Phenylpyridinium Ions have Opposite Effects on Membrane Currents of Cultured Dorsal Root Ganglia Neurons
  165. Interference of Lead with the Calcium Release Activated Calcium Flux of Osteoblast-Like Cells
  166. Effects of (±)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats
  167. Effects of Lead, Mercury, and Methyl Mercury on Gap Junctions and [Ca2+]i in Bone Cells
  168. A Calcium Release Activated Calcium Influx in Primary Cultures of Rat Osteoblast-like Cells
  169. Lead interferes with calcium entry through membrane pores
  170. Histaminergic System in Co-cultures of Hippocampus and Posterior Hypothalamus: A Morphological and Electrophysiological Study in the Rat
  171. Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons
  172. Voltage-activated calcium channel currents of rat dorsal root ganglion cells are reduced by trimethyl lead
  173. Neurotoxikologie in vitro mit Hilfe der Elektrophysiologie
  174. Methyl mercury reduces voltage-activated currents of rat dorsal root ganglion neurons
  175. Calcium channels as target sites of heavy metals
  176. Aluminum Impairs Hippocampal Long-Term Potentiation in Rats in Vitro and in Vivo
  177. Pb2+ reduces voltage- andN-methyl-d-aspartate (NMDA)-activated calcium channel currents
  178. Mercury (Hg2+) and zinc (Zn2+): Two divalent cations with different actions on voltage-activated calcium channel currents
  179. Combined actions of Pb2+, Zn2+, and Al3+ on voltage-activated calcium channel currents
  180. Actions of aluminum on voltage-activated calcium channel currents
  181. Aluminium reduces glutamate-activated currents of rat hippocampal neurones
  182. Mammalian voltage-activated calcium channel currents are blocked by Pb2+, Zn2+, and Al3+
  183. Mercury (Hg2+) decreases voltage-gated calcium channel currents in rat DRG and Aplysia neurons
  184. Voltage gated calcium channel currents of rat dorsal root ganglion (DRG) cells are blocked by Al3+
  185. Extracellular pH modulates aluminium-blockade of mammalian voltage-activated calcium channel currents
  186. Pb2+ modulates the NMDA-receptor-channel complex
  187. Lead Blocks LTP by an Action Not at NMDA Receptors
  188. Zinc (Zn2+) blocks voltage gated calcium channels in cultured rat dorsal root ganglion cells
  189. Pb2+ blocks calcium currents of cultured dorsal root ganglion cells
  190. Properties of tuberomammillary histamine neurones and their response to galanin
  191. Lead and zinc block a voltage-activated calcium channel of Aplysia neurons
  192. Zn2+ blocks the voltage activated calcium current of Aplysia neurons
  193. Lead inhibits the voltage-activated calcium current of aplysia neurons
  194. EFFECTS OF EXOGENOUS LIPID APPLICATION ON EXCITABILITY OF APLYSIA NEURONS
  195. Effects of Exogenous Ganglioside and Cholesterol Application on Excitability ofAplysiaNeurons