All Stories

  1. Artificial RNA editing with ADAR for gene therapy

    Article • Current Gene Therapy, May 2020, Bentham Science Publishers

    Professor Toshifumi Tsukahara, Sonali Bhakta

  2. Comparative Activity of Adenosine Deaminase Acting on RNA (ADARs) Isoforms for Correction of Genetic Code in Gene Therapy

    Article • Current Gene Therapy, May 2019, Bentham Science Publishers

    Professor Toshifumi Tsukahara

  3. Chemical RNA Editing for Genetic Restoration: The Relationship between the Structure and Deamination Efficiency of Carboxyvinyldeoxyuridine Oligodeoxynucleotides

    Article • Chemical Biology & Drug Design, December 2015, Wiley

    Professor Toshifumi Tsukahara

  4. Changing Blue Fluorescent Protein to Green Fluorescent Protein Using Chemical RNA Editing as a Novel Strategy in Genetic Restoration

    Article • Chemical Biology & Drug Design, June 2015, Wiley

    Professor Toshifumi Tsukahara, Dr Takashi Sakamoto

  5. Alternative splicing regulation of APP exon 7 by RBFox proteins

    Article • Neurochemistry International, December 2014, Elsevier

    Professor Toshifumi Tsukahara

  6. A View of Pre-mRNA Splicing from RNase R Resistant RNAs

    Article • International Journal of Molecular Sciences, May 2014, MDPI AG

    Professor Toshifumi Tsukahara

  7. Computational extraction of a neural molecular network through alternative splicing

    Article • BMC Research Notes, January 2014, Springer Science + Business Media

    Professor Toshifumi Tsukahara

  8. Nested introns in an intron: Evidence of multi-step splicing in a large intron of the human dystrophin pre-mRNA

    Article • FEBS Letters, February 2013, Wiley

    Professor Toshifumi Tsukahara

  9. Alternative splicing produces structural and functional changes in CUGBP2

    Article • BMC Biochemistry, January 2012, Springer Science + Business Media

    Professor Toshifumi Tsukahara

  10. Functional Gene Expression Analysis of Tissue-Specific Isoforms of Mef2c

    Article • Cellular and Molecular Neurobiology, August 2011, Springer Science + Business Media

    Professor Toshifumi Tsukahara

  11. Possibility of genetic restoration for a disease treatment

    Article • April 2011, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Toshifumi Tsukahara

  12. Comprehensive Analysis of Alternative Splicing and Functionality in Neuronal Differentiation of P19 Cells

    Article • PLoS ONE, February 2011, PLOS

    Professor Toshifumi Tsukahara

  13. Retinoic acid treatment and cell aggregation independently regulate alternative splicing in P19 cells during neural differentiation

    Article • Cell Biology International, May 2010, Wiley

    Professor Toshifumi Tsukahara

  14. Alternative splicing ofMef2cpromoted by Fox-1 during neural differentiation in P19 cells

    Article • Genes to Cells, March 2010, Wiley

    Professor Toshifumi Tsukahara

  15. Multi-wall carbon nanotubes (MWCNTs)-doped polypyrrole DNA biosensor for label-free detection of genetically modified organisms by QCM and EIS

    Article • Talanta, January 2010, Elsevier

    Professor Toshifumi Tsukahara

  16. Expression analysis of Fgf8a & Fgf8b in early stage of P19 cells during neural differentiation

    Article • Cell Biology International, September 2009, Wiley

    Professor Toshifumi Tsukahara

  17. An effective method for the in situ synthesis of DNA–CPG conjugates using chemical ligation technology as tools for SNP analysis

    Article • Bioorganic & Medicinal Chemistry Letters, November 2007, Elsevier

    Professor Toshifumi Tsukahara

  18. A new hydrophobic linker effective for the in situ synthesis of DNA–CPG conjugates as tools for SNP analysis

    Article • July 2007, Elsevier

    Professor Toshifumi Tsukahara

  19. JAIST International Symposium on Nanotechnology 2006 (NT2006)

    Article • Science and Technology of Advanced Materials, January 2007, Taylor & Francis

    Professor Toshifumi Tsukahara

  20. Upregulations ofGata4 and oxytocin receptor are important in cardiomyocyte differentiation processes of P19CL6 cells

    Article • Journal of Cellular Biochemistry, January 2007, Wiley

    Professor Toshifumi Tsukahara

  21. Hesr1knockout mice exhibit behavioral alterations through the dopaminergic nervous system

    Article • Journal of Neuroscience Research, November 2006, Wiley

    Professor Toshifumi Tsukahara

  22. Expression profiling of muscles from Fukuyama-type congenital muscular dystrophy and laminin-α2 deficient congenital muscular dystrophy; is congenital muscular dystrophy a primary fibrotic disease?

    Article • Biochemical and Biophysical Research Communications, April 2006, Elsevier

    Professor Toshifumi Tsukahara

  23. NSSRs/TASRs/SRp38s function as splicing modulators via binding to pre-mRNAs

    Article • Genes to Cells, April 2005, Wiley

    Professor Toshifumi Tsukahara

  24. Prediction of tertiary structure of NSSRs’ RNA recognition motif and the RNA binding activity

    Article • Science and Technology of Advanced Materials, January 2005, Taylor & Francis

    Professor Toshifumi Tsukahara

  25. Probe-on-carriers for oligonucleotide microarrays (DNA chips)

    Article • Science and Technology of Advanced Materials, January 2004, Taylor & Francis

    Professor Toshifumi Tsukahara

  26. Increased expression level of the splicing variant of SIP1 in motor neuron diseases

    Article • The International Journal of Biochemistry & Cell Biology, June 2002, Elsevier

    Professor Toshifumi Tsukahara

  27. CDNA microarray analysis of gene expression in fibroblasts of patients with x-linked Emery-Dreifuss muscular dystrophy

    Article • Muscle & Nerve, May 2002, Wiley

    Professor Toshifumi Tsukahara

  28. Nuclear accumulation of expandedPABP2 gene product in oculopharyngeal muscular dystrophy

    Article • Muscle & Nerve, January 2000, Wiley

    Professor Toshifumi Tsukahara

  29. Changes in pre-mRNA splicing factors during neural differentiation in P19 embryonal carcinoma cells

    Article • The International Journal of Biochemistry & Cell Biology, November 1999, Elsevier

    Professor Toshifumi Tsukahara

  30. Apoptosis in favourable neuroblastomas is not dependent on Fas (CD95/APO‐1) expression but on activated caspase 3 (CPP32)

    Article • The Journal of Pathology, November 1999, Wiley

    Professor Toshifumi Tsukahara

  31. Apoptosis in favourable neuroblastomas is not dependent on Fas (CD95/APO-1) expression but on activated caspase 3 (CPP32)

    Article • The Journal of Pathology, November 1999, Wiley

    Professor Toshifumi Tsukahara

  32. Cloning and characterization of two neural-salient serine/arginine-rich (NSSR) proteins involved in the regulation of alternative splicing in neurones

    Article • Genes to Cells, October 1999, Wiley

    Professor Toshifumi Tsukahara

  33. RA70 Is a Src Kinase-Associated Protein Expressed Ubiquitously

    Article • Biochemical and Biophysical Research Communications, November 1998, Elsevier

    Professor Toshifumi Tsukahara

  34. Presence of emerinopathy in cases of rigid spine syndrome

    Article • Neuromuscular Disorders, October 1998, Elsevier

    Professor Toshifumi Tsukahara

  35. Mutations in the integrin α7 gene cause congenital myopathy

    Article • Nature Genetics, May 1998, Springer Science + Business Media

    Professor Toshifumi Tsukahara

  36. Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas

    Article • Cell Death and Differentiation, April 1998, Springer Science + Business Media

    Professor Toshifumi Tsukahara

  37. Clinical and genetic analyses of Emery-Dreifuss muscular dystrophy and rigid spine syndrome

    Article • Neuromuscular Disorders, September 1997, Elsevier

    Professor Toshifumi Tsukahara

  38. Involvement ofSonic hedgehogin the Cell Growth of LK-2 Cells, Human Lung Squamous Carcinoma Cells

    Article • Biochemical and Biophysical Research Communications, September 1997, Elsevier

    Professor Toshifumi Tsukahara

  39. Wortmannin Enhances CPP32-like Activity during Neuronal Differentiation of P19 Embryonal Carcinoma Cells Induced by Retinoic Acid

    Article • Biochemical and Biophysical Research Communications, March 1997, Elsevier

    Professor Toshifumi Tsukahara

  40. Emerin deficiency at the nuclear membrane in patients with Emery-Dreif uss muscular dystrophy

    Article • Nature Genetics, March 1996, Springer Science + Business Media

    Professor Toshifumi Tsukahara

  41. WS-14-1 Deficiency of laminin α2 chain in muscle and nerve tissues and muscular dystrophy

    Article • Electroencephalography and Clinical Neurophysiology/Electromyography and Motor Control, September 1995, Elsevier

    Professor Toshifumi Tsukahara

  42. Deficiency of laminin ?2-Chain mRNA in muscle in a patient with merosin-negative congenital muscular dystrophy

    Article • Muscle & Nerve, September 1995, Wiley

    Professor Toshifumi Tsukahara

  43. Regulation of alternative splicing in the amyloid precursor protein (APP) mRNA during neuronal and glial differentiation of P19 embryonal carcinoma cells

    Article • Brain Research, May 1995, Elsevier

    Professor Toshifumi Tsukahara

  44. Identification of a third ubiquitous calpain species — chicken muscle expresses four distinct calpains

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, April 1995, Elsevier

    Professor Toshifumi Tsukahara

  45. Alternative splicing of β-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5′- and 3′-splice sites of the nonmuscle/smooth muscle exon 6

    Article • Nucleic Acids Research, January 1994, Oxford University Press (OUP)

    Professor Toshifumi Tsukahara

  46. Laminin in Animal Models for Muscular Dystrophy Defect of Laminin M in Skeletal and Cardiac Muscles and Peripheral Nerve of the Homozygous Dystrophic dy/dy Mice.

    Article • Proceedings of the Japan Academy Series B, January 1993, Japan Academy

    Professor Toshifumi Tsukahara

  47. Changes of lysosomal proteinase activities and their expression in rat cultured keratinocytes during differentiation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 1991, Elsevier

    Professor Toshifumi Tsukahara

  48. 26S multicatalytic proteinase complexes decrease during the differentiation of murine erythroleukemia cells

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, September 1991, Elsevier

    Professor Toshifumi Tsukahara

  49. Aminopeptidase A in human placenta and pregnant serum

    Article • Clinica Chimica Acta, February 1991, Elsevier

    Professor Toshifumi Tsukahara

  50. Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy

    Article • Journal of the Neurological Sciences, February 1991, Elsevier

    Professor Toshifumi Tsukahara

  51. Identification of an elastase-like activity, that decreased during the differentiation of mel cells, as a prolyl endopeptidase

    Article • International Journal of Biochemistry, January 1991, Elsevier

    Professor Toshifumi Tsukahara

  52. Molecular cloning of cDNAs for two subunits of rat multicatalytic proteinase. Existence of N-terminal conserved and C-terminal diverged sequences among subunits

    Article • European Journal of Biochemistry, November 1990, Wiley

    Professor Toshifumi Tsukahara

  53. Calcium is essential for both the membrane binding and lytic activity of pore-forming protein (perforin) from cytotoxic T-lymphocyte

    Article • Molecular Immunology, August 1990, Elsevier

    Professor Toshifumi Tsukahara

  54. Distribution of Alzheimer's disease amyloid A4-generating enzymes in rat brain tissue

    Article • Neuroscience Letters, July 1990, Elsevier

    Professor Toshifumi Tsukahara

  55. Changes in proteinase activities during the differentiation of murine erythroleukemia cells

    Article • Experimental Cell Research, May 1990, Elsevier

    Professor Toshifumi Tsukahara

  56. Detection of a fast isoform of C-protein with an antiserum directed against the N-terminal portion of dystrophin

    Article • Biochemical and Biophysical Research Communications, May 1990, Elsevier

    Professor Toshifumi Tsukahara

  57. Identification of a putative amyloid A4-generating enzyme as a prolyl endopeptidase

    Article • FEBS Letters, January 1990, Wiley

    Professor Toshifumi Tsukahara

  58. Molecular and biochemical properties of the ATP-stimulated multicatalytic proteinase, ingensin, from rat liver

    Article • International Journal of Biochemistry, January 1990, Elsevier

    Professor Toshifumi Tsukahara

  59. Antiserum against the synthetic polypeptide fragment of dystrophin cross-reacts with Myofibrillar C-protein.

    Article • Proceedings of the Japan Academy Series B, January 1990, Japan Academy

    Professor Toshifumi Tsukahara

  60. Putative N -terminal splitting enzyme of amyloid A4 peptides is the multicatalytic proteinase, ingensin, which is widely distributed in mammalian cells

    Article • FEBS Letters, November 1989, Wiley

    Professor Toshifumi Tsukahara

  61. Addition of ATP increases the apparent molecular mass of the multicatalytic proteinase, ingensin

    Article • FEBS Letters, October 1989, Wiley

    Professor Toshifumi Tsukahara

  62. RNA degrading activity is tightly associated with the multicatalytic proteinase, ingensin

    Article • FEBS Letters, September 1989, Wiley

    Professor Toshifumi Tsukahara

  63. Mature 98,000-dalton acid ?-glucosidase is deficient in Japanese quails with acid maltase deficiency

    Article • Muscle & Nerve, August 1989, Wiley

    Professor Toshifumi Tsukahara

  64. Dystrophin digest

    Article • Nature, February 1989, Springer Science + Business Media

    Professor Toshifumi Tsukahara

  65. Mosaic Expression of Dystrophin in Symptomatic Carriers of Duchenne's Muscular Dystrophy

    Article • New England Journal of Medicine, January 1989, New England Journal of Medicine (NEJM/MMS)

    Professor Toshifumi Tsukahara

  66. An ATP-dependent protease and ingensin, the multicatalytic proteinase, in K562 cells

    Article • European Journal of Biochemistry, November 1988, Wiley

    Professor Toshifumi Tsukahara

  67. Immunostaining of skeletal and cardiac muscle surface membrane with antibody against Duchenne muscular dystrophy peptide

    Article • Nature, June 1988, Springer Science + Business Media

    Professor Toshifumi Tsukahara

  68. Biosyntheses and processing of lysosomal cysteine proteinases in rat macrophages

    Article • FEBS Letters, April 1988, Wiley

    Professor Toshifumi Tsukahara

  69. The "ATP-dependent protease" in human erythroleukemia (K562) cells is identical to a high-molecular-mass protease, ingensin.

    Article • Proceedings of the Japan Academy Series B, January 1988, Japan Academy

    Professor Toshifumi Tsukahara

  70. Localization of BLT serine esterase is distinct from that of perforin in cytotoxic T lymphocyte.

    Article • Proceedings of the Japan Academy Series B, January 1988, Japan Academy

    Professor Toshifumi Tsukahara

  71. Negative immunostaining of Duchenne muscular dystrophy(DMD) and mdx muscle surface membrane with antibody against synthetic peptide fragment predicted from DMD cDNA.

    Article • Proceedings of the Japan Academy Series B, January 1988, Japan Academy

    Professor Toshifumi Tsukahara

  72. Autodegradation of lysosomal cysteine proteinases

    Article • Biochemical and Biophysical Research Communications, April 1987, Elsevier

    Professor Toshifumi Tsukahara

  73. Studies on thiol proteinase inhibitors in rat peripheral blood cells

    Article • Biochemical and Biophysical Research Communications, September 1984, Elsevier

    Professor Toshifumi Tsukahara

  74. A Comparative Gene Expression Analysis of Emery-Dreifuss Muscular Dystrophy Using a cDNA Microarray

    Article • Springer Science + Business Media

    Professor Toshifumi Tsukahara