All Stories

  1. Synthetic Kavalactone Analogues with Increased Potency and Selective Anthelmintic Activity against Larvae of Haemonchus contortus In Vitro

    Article • Molecules, April 2020, MDPI AG

    Dr Brad E Sleebs

  2. Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

    Article • International Journal for Parasitology, March 2020, Elsevier

    Dr Brad E Sleebs

  3. Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

    Article • September 2019, Cold Spring Harbor Laboratory Press

    Dr Brad E Sleebs

  4. The Development Process for Discovery and Clinical Advancement of Modern Antimalarials

    Article • Journal of Medicinal Chemistry, August 2019, American Chemical Society (ACS)

    Dr Brad E Sleebs

  5. An appraisal of natural products active against parasitic nematodes of animals

    Article • Parasites & Vectors, June 2019, Springer Science + Business Media

    Dr Brad E Sleebs

  6. Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

    Article • Journal of Medicinal Chemistry, April 2019, American Chemical Society (ACS)

    Dr Brad E Sleebs

  7. Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria

    Article • Antimicrobial Agents and Chemotherapy, December 2018, ASM Journals

    Dr Brad E Sleebs

  8. Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P 2 position of PEXEL peptidomimetics

    Article • European Journal of Medicinal Chemistry, June 2018, Elsevier

    Dr Brad E Sleebs

  9. Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

    Article • Molecular Cell, November 2017, Elsevier

    Dr Brad E Sleebs

  10. Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery

    Article • Antimicrobial Agents and Chemotherapy, July 2017, ASM Journals

    Dr Brad E Sleebs

  11. Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

    Article • Nature Microbiology, March 2017, Nature

    Dr Brad E Sleebs

  12. Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity

    Article • Journal of Medicinal Chemistry, January 2017, American Chemical Society (ACS)

    Dr Brad E Sleebs

  13. Analysis of Ca2 + mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules

    Article • Cellular Microbiology, January 2017, Wiley

    Dr Brad E Sleebs

  14. Exploration of the P 3 region of PEXEL peptidomimetics leads to a potent inhibitor of the Plasmodium protease, plasmepsin V

    Article • Bioorganic & Medicinal Chemistry, May 2016, Elsevier

    Dr Brad E Sleebs

  15. Synthesis of amino heterocycle aspartyl protease inhibitors

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Dr Brad E Sleebs

  16. Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Dr Brad E Sleebs

  17. Isolation and structural analysis of the covalent adduct formed between a bis-amino mitoxantrone analogue and DNA: a pathway to major–minor groove cross-linked adducts

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Dr Brad E Sleebs

  18. An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

    Article • eLife, November 2015, eLife

    Dr Brad E Sleebs

  19. HIV-1 and Human PEG10 Frameshift Elements Are Functionally Distinct and Distinguished by Novel Small Molecule Modulators

    Article • PLoS ONE, October 2015, PLOS

    Dr Brad E Sleebs

  20. Mitoxantrone, More than Just Another Topoisomerase II Poison

    Article • Medicinal Research Reviews, August 2015, Wiley

    Dr Brad E Sleebs

  21. Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

    Article • Nature Structural & Molecular Biology, July 2015, Springer Science + Business Media

    Dr Brad E Sleebs

  22. Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum

    Article • BMC Biology, July 2015, Springer Science + Business Media

    Dr Brad E Sleebs

  23. The effect of N-methylation on transition state mimetic inhibitors of the Plasmodium protease, plasmepsin V

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Dr Brad E Sleebs

  24. Macrocyclic N-Methylated Cyclic Peptides and Depsipeptides

    Article • January 2015, Elsevier

    Dr Brad E Sleebs

  25. Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity

    Article • ACS Medicinal Chemistry Letters, October 2014, American Chemical Society (ACS)

    Dr Brad E Sleebs

  26. Transition State Mimetics of the Plasmodium Export Element Are Potent Inhibitors of Plasmepsin V from P. falciparum and P. vivax

    Article • Journal of Medicinal Chemistry, September 2014, American Chemical Society (ACS)

    Dr Brad E Sleebs

  27. Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

    Article • PLoS Biology, July 2014, PLOS

    Dr Brad E Sleebs, Dr Lea K Barfod, Dr Philip J. Shaw

  28. Structure-Guided Rescaffolding of Selective Antagonists of BCL-X L

    Article • ACS Medicinal Chemistry Letters, June 2014, American Chemical Society (ACS)

    Dr Brad E Sleebs

  29. Stereoselective Synthesis and Application of β-Amino Ketones

    Article • Current Organic Chemistry, January 2014, Bentham Science Publishers

    Dr Brad E Sleebs

  30. Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X L

    Article • Journal of Medicinal Chemistry, July 2013, American Chemical Society (ACS)

    Dr Brad E Sleebs

  31. Diastereoselective synthesis of cyclic β2,3-amino acids utilizing 4-substituted-1,3-oxazinan-6-ones

    Article • Tetrahedron, July 2013, Elsevier

    Dr Brad E Sleebs

  32. Structure-guided design of a selective BCL-XL inhibitor

    Article • Nature Chemical Biology, April 2013, Springer Science + Business Media

    Dr Brad E Sleebs

  33. Synthesis of N-Cbz-Substituted β3-Amino Ketones Utilizing 4-Substituted 1,3-Oxazinan-6-ones

    Article • Synlett, March 2013, Thieme Publishing Group

    Dr Brad E Sleebs

  34. A Mild Multistep Conversion of N-Protected α-Amino Acids into N-Protected β3-Amino Acids Utilizing the Nef Reaction

    Article • Synlett, March 2013, Thieme Publishing Group

    Dr Brad E Sleebs

  35. Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome

    Article • Traffic, February 2013, Wiley

    Dr Brad E Sleebs

  36. Corrigendum to “Diastereoselective synthesis of highly functionalized β2,2,3-substituted amino acids from 4-substituted-1,3-oxazinan-6-ones” [Tetrahedron 68 (2012) 4745–4756]

    Article • Tetrahedron, September 2012, Elsevier

    Dr Brad E Sleebs

  37. Diastereoselective synthesis of highly functionalized β2,2,3-substituted amino acids from 4-substituted-1,3-oxazinan-6-ones

    Article • Tetrahedron, June 2012, Elsevier

    Professor Jonathan White, Dr Brad E Sleebs

  38. Corrigendum to “Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors” [Bioorg. Med. Chem. Lett. 21 (2011) 5992–5994]

    Article • Bioorganic & Medicinal Chemistry Letters, January 2012, Elsevier

    Dr Brad E Sleebs

  39. M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe

    Article • Biochemical Pharmacology, December 2011, Elsevier

    Dr Brad E Sleebs

  40. Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, October 2011, Elsevier

    Dr Brad E Sleebs

  41. Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

    Article • Journal of Medicinal Chemistry, March 2011, American Chemical Society (ACS)

    Dr Brad E Sleebs

  42. Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Dr Brad E Sleebs

  43. Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Dr Brad E Sleebs

  44. New Anthracenedione Derivatives with Improved Biological Activity by Virtue of Stable Drug−DNA Adduct Formation

    Article • Journal of Medicinal Chemistry, October 2010, American Chemical Society (ACS)

    Dr Brad E Sleebs

  45. De Novo Synthesis of a Potent LIMK1 Inhibitor

    Article • Synthesis, January 2010, Thieme Publishing Group

    Dr Brad E Sleebs

  46. Recent Advances in Stereoselective Synthesis and Application of β-Amino Acids

    Article • Organic Preparations and Procedures International, November 2009, Taylor & Francis

    Dr Brad E Sleebs

  47. Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

    Article • Journal of Biological Chemistry, September 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Brad E Sleebs

  48. Studies of 2-Substituted 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones as Precursors for the Synthesis ofN-Alkyl-β-Amino Acids

    Article • Synthetic Communications, December 2008, Taylor & Francis

    Dr Brad E Sleebs

  49. Exploitation of the Arndt-Eistert Homologation of N-Methyl-�-Amino Acids for Concomitant Ester and N-Methyl Peptide Formation

    Article • Australian Journal of Chemistry, January 2008, CSIRO Publishing

    Dr Brad E Sleebs

  50. Diastereoselective Synthesis of α-Methyl and α-Hydroxy-β-Amino Acids via 4-Substituted-1,3-Oxazinan-6-ones

    Article • The Journal of Organic Chemistry, April 2007, American Chemical Society (ACS)

    Dr Brad E Sleebs

  51. Effective Methods for the Synthesis ofN-Methylβ-Amino Acids from All Twenty Commonα-Amino Acids Using 1,3-Oxazolidin-5-ones and 1,3-Oxazinan-6-ones

    Article • Helvetica Chimica Acta, November 2006, Wiley

    Dr Brad E Sleebs

  52. Synthesis of New β-Amino Acids via 5-Oxazolidinones and the Arndt–Eistert Procedure

    Article • Australian Journal of Chemistry, January 2005, CSIRO Publishing

    Dr Brad E Sleebs