All Stories

  1. Targeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy

    Article • Signal Transduction and Targeted Therapy, September 2020, Springer Science + Business Media

    Professor Bostjan Kobe

  2. Evolutionary model of protein secondary structure capable of revealing new biological relationships

    Article • Proteins Structure Function and Bioinformatics, June 2020, Wiley

    Professor Bostjan Kobe

  3. Structure and Metal Binding Properties of Chlamydia trachomatis YtgA

    Article • Journal of Bacteriology, October 2019, ASM Journals

    Professor Bostjan Kobe

  4. Evolutionary model of protein secondary structure capable of revealing new biological relationships

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Professor Bostjan Kobe

  5. The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses

    Article • The Journal of Immunology, February 2019, The American Association of Immunologists

    Professor Bostjan Kobe

  6. Handling of nutrient copper in the bacterial envelope

    Article • Metallomics, January 2019, Oxford University Press (OUP)

    Professor Bostjan Kobe

  7. Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling

    Article • Journal of Leukocyte Biology, December 2018, Wiley

    Professor Bostjan Kobe

  8. Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

    Article • BMC Biology, December 2018, Springer Science + Business Media

    Professor Bostjan Kobe

  9. Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor

    Article • New Phytologist, November 2018, Wiley

    Professor Bostjan Kobe

  10. Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A

    Article • Molecular Plant Pathology, November 2018, Wiley

    Professor Bostjan Kobe

  11. Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles

    Article • Bioorganic & Medicinal Chemistry, November 2018, Elsevier

    Professor Bostjan Kobe, Ulrike Kappler

  12. Megahertz serial crystallography

    Article • Nature Communications, October 2018, Springer Science + Business Media

    Dr Kartik Ayyer, Professor Bostjan Kobe, Prof. Dr. Martin Trebbin

  13. Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae

    Article • FEBS Letters, June 2018, Wiley

    Professor Bostjan Kobe

  14. Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics

    Article • Seminars in Cell and Developmental Biology, May 2018, Elsevier

    Professor Bostjan Kobe

  15. Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane

    Article • PLoS ONE, March 2018, PLOS

    Professor Bostjan Kobe

  16. DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway

    Article • Biochimie, March 2018, Elsevier

    Professor Bostjan Kobe

  17. An optimized SEC-SAXS system enabling high X-ray dose for rapid SAXS assessment with correlated UV measurements for biomolecular structure analysis

    Article • Journal of Applied Crystallography, February 2018, International Union of Crystallography

    Professor Bostjan Kobe

  18. Structural and Functional Characterization of a Cross-Reactive Dengue Virus Neutralizing Antibody that Recognizes a Cryptic Epitope

    Article • Structure, January 2018, Elsevier

    Professor Bostjan Kobe

  19. Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P

    Article • Molecular Plant Pathology, November 2017, Wiley

    Professor Bostjan Kobe

  20. Emerging Insights into the Functions of Pathogenesis-Related Protein 1

    Article • Trends in Plant Science, October 2017, Elsevier

    Professor Bostjan Kobe

  21. Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

    Article • Nature Structural & Molecular Biology, July 2017, Springer Science + Business Media

    Tristan Croll, Professor Bostjan Kobe

  22. Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

    Article • Proceedings of the National Academy of Sciences, July 2017, Proceedings of the National Academy of Sciences

    Professor Bostjan Kobe

  23. The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways

    Article • Molecular Immunology, June 2017, Elsevier

    Professor Bostjan Kobe

  24. Cryptococcus neoformansADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design

    Article • Journal of Biological Chemistry, May 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe, Ulrike Kappler

  25. Towards the structure of the TIR-domain signalosome

    Article • Current Opinion in Structural Biology, April 2017, Elsevier

    Professor Bostjan Kobe

  26. A non-uniform sampling approach enables studies of dilute and unstable proteins

    Article • Journal of Biomolecular NMR, February 2017, Springer Science + Business Media

    Professor Bostjan Kobe

  27. PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylation

    Article • Bioinformatics, February 2017, Oxford University Press (OUP)

    Professor Bostjan Kobe

  28. Multiple functional self-association interfaces in plant TIR domains

    Article • Proceedings of the National Academy of Sciences, February 2017, Proceedings of the National Academy of Sciences

    Tristan Croll, Professor Bostjan Kobe

  29. Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization

    Article • mBio, January 2017, ASM Journals

    Dr Martina Sanderson-Smith, Professor Bostjan Kobe

  30. GMP Synthase Is Required for Virulence Factor Production and Infection byCryptococcus neoformans

    Article • Journal of Biological Chemistry, January 2017, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe, Ulrike Kappler, Elizabeth C Corfield

  31. The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

    Article • Proceedings of the National Academy of Sciences, October 2016, Proceedings of the National Academy of Sciences

    Tristan Croll, Professor Bostjan Kobe

  32. Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence inCryptococcus neoformans

    Article • ACS Infectious Diseases, September 2016, American Chemical Society (ACS)

    Dr Mark S Butler, Professor Bostjan Kobe, Ulrike Kappler

  33. Animal NLRs provide structural insights into plant NLR function

    Article • Annals of Botany, August 2016, Oxford University Press (OUP)

    Professor Bostjan Kobe

  34. Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins

    Article • The Plant Journal, August 2016, Wiley

    Professor Bostjan Kobe

  35. Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death

    Article • PLoS Pathogens, July 2016, PLOS

    Professor Bostjan Kobe

  36. Structural basis of thiol-based regulation of formaldehyde detoxification inH. influenzaeby a MerR regulator with no sensor region

    Article • Nucleic Acids Research, June 2016, Oxford University Press (OUP)

    Professor Bostjan Kobe

  37. Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-α

    Article • Traffic, May 2016, Wiley

    Professor Bostjan Kobe

  38. TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

    Article • Journal of Leukocyte Biology, May 2016, Wiley

    Professor Bostjan Kobe

  39. Protein crystal screening and characterization for serial femtosecond nanocrystallography

    Article • Scientific Reports, May 2016, Springer Science + Business Media

    Professor Bostjan Kobe

  40. Structural and Calorimetric Studies Demonstrate that Xeroderma Pigmentosum Type G (XPG) Can Be Imported to the Nucleus by a Classical Nuclear Import Pathway via a Monopartite NLS Sequence

    Article • Journal of Molecular Biology, May 2016, Elsevier

    Professor Bostjan Kobe

  41. Production of small cysteine-rich effector proteins inEscherichia colifor structural and functional studies

    Article • Molecular Plant Pathology, April 2016, Wiley

    Professor Bostjan Kobe

  42. Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence

    Article • March 2016, Cold Spring Harbor Laboratory Press

    Professor Bostjan Kobe

  43. Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery

    Article • FEBS Journal, February 2016, Wiley

    Professor Bostjan Kobe

  44. Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model

    Article • The Plant Cell, January 2016, American Society of Plant Biologists (ASPB)

    Professor Bostjan Kobe

  45. Characterizing the conformational dynamics of metal-free PsaA using molecular dynamics simulations and electron paramagnetic resonance spectroscopy

    Article • Biophysical Chemistry, December 2015, Elsevier

    Professor Bostjan Kobe

  46. Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA

    Article • Acta Crystallographica Section F Structural Biology Communications, November 2015, International Union of Crystallography

    Professor Bostjan Kobe

  47. Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production

    Article • Human Vaccines & Immunotherapeutics, October 2015, Taylor & Francis

    Professor Bostjan Kobe

  48. Structural Biology and Regulation of Protein Import into the Nucleus

    Article • Journal of Molecular Biology, October 2015, Elsevier

    Professor Bostjan Kobe

  49. Structural and Biochemical Analysis of a Single Amino-Acid Mutant of WzzBSF That Alters Lipopolysaccharide O-Antigen Chain Length in Shigella flexneri

    Article • PLoS ONE, September 2015, PLOS

    Professor Bostjan Kobe

  50. Computer-aided design of T-cell epitope-based vaccines: addressing population coverage

    Article • International Journal of Immunogenetics, July 2015, Wiley

    Professor Bostjan Kobe

  51. Fusion-protein-assisted protein crystallization

    Article • Acta Crystallographica Section F Structural Biology Communications, June 2015, International Union of Crystallography

    Professor Bostjan Kobe

  52. Discovery of Novel Pneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based Drug Design Approach

    Article • ACS Chemical Biology, March 2015, American Chemical Society (ACS)

    Professor Bostjan Kobe

  53. Stability of the Octameric Structure Affects Plasminogen-Binding Capacity of Streptococcal Enolase

    Article • PLoS ONE, March 2015, PLOS

    Professor Bostjan Kobe

  54. A linker strategy for the production and crystallization of Toll/interleukin-1 receptor/resistance protein domain complexes

    Article • Protein Engineering Design and Selection, March 2015, Oxford University Press (OUP)

    Professor Bostjan Kobe

  55. Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae

    Article • Nature Communications, March 2015, Springer Science + Business Media

    Professor Bostjan Kobe

  56. A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: Application to emerging infectious diseases

    Article • Vaccine, March 2015, Elsevier

    Professor Bostjan Kobe

  57. TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation

    Article • Molecular Biology of the Cell, March 2015, American Society for Cell Biology (ASCB)

    Professor Bostjan Kobe

  58. Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling

    Article • Protein Expression and Purification, February 2015, Elsevier

    Professor Bostjan Kobe

  59. Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

    Article • APOPTOSIS, December 2014, Springer Science + Business Media

    Professor Bostjan Kobe

  60. Diversity and Variability of NOD-Like Receptors in Fungi

    Article • Genome Biology and Evolution, December 2014, Oxford University Press (OUP)

    Professor Bostjan Kobe

  61. Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation

    Article • Cell Cycle, October 2014, Taylor & Francis

    Professor Bostjan Kobe

  62. The Nuclear Immune Receptor RPS4 Is Required for RRS1SLH1-Dependent Constitutive Defense Activation in Arabidopsis thaliana

    Article • PLoS Genetics, October 2014, PLOS

    Professor Bostjan Kobe

  63. PhosphoPICK: modelling cellular context to map kinase-substrate phosphorylation events

    Article • Bioinformatics, October 2014, Oxford University Press (OUP)

    Professor Bostjan Kobe

  64. Factors influencing nucleo-cytoplasmic trafficking

    Article • Acta Crystallographica Section D Biological Crystallography, September 2014, International Union of Crystallography

    Gergely Rona, Professor Bostjan Kobe

  65. Structural Basis of Interaction of Bipartite Nuclear Localization Signal from Agrobacterium VirD2 with Rice Importin-α

    Article • Molecular Plant, June 2014, Elsevier

    Professor Bostjan Kobe

  66. The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4

    Article • Journal of Leukocyte Biology, May 2014, Wiley

    Professor Bostjan Kobe

  67. Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

    Article • Science, April 2014, American Association for the Advancement of Science

    Professor Bostjan Kobe

  68. AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis inStreptococcus pneumoniae

    Article • Molecular Microbiology, January 2014, Wiley

    Professor Bostjan Kobe

  69. International Year of Crystallography

    Article • Australian Journal of Chemistry, January 2014, CSIRO Publishing

    Professor Bostjan Kobe

  70. Small-Angle X-Ray Scattering for the Discerning Macromolecular Crystallographer

    Article • Australian Journal of Chemistry, January 2014, CSIRO Publishing

    Professor Bostjan Kobe

  71. Mechanism of Bacterial Interference with TLR4 Signaling by Brucella Toll/Interleukin-1 Receptor Domain-containing Protein TcpB

    Article • Journal of Biological Chemistry, November 2013, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  72. The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins

    Article • Acta Crystallographica Section D Biological Crystallography, November 2013, International Union of Crystallography

    Professor Bostjan Kobe

  73. Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights

    Article • Acta Crystallographica Section D Biological Crystallography, November 2013, International Union of Crystallography

    Professor Bostjan Kobe

  74. Crystallization and preliminary X-ray diffraction analyses of the TIR domains of three TIR–NB–LRR proteins that are involved in disease resistance inArabidopsis thaliana

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, October 2013, International Union of Crystallography

    Professor Bostjan Kobe

  75. Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity

    Article • Proceedings of the National Academy of Sciences, October 2013, Proceedings of the National Academy of Sciences

    Professor Bostjan Kobe

  76. The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site inplantnuclear import factor importin-α

    Article • Plant Signaling & Behavior, October 2013, Taylor & Francis

    Professor Bostjan Kobe

  77. Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from theBrucella melitensisTIR-domain-containing protein TcpB

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, September 2013, International Union of Crystallography

    Professor Mark A Schembri, Professor Bostjan Kobe

  78. Crystallization and preliminary X-ray diffraction analysis of the flax cytokinin oxidase LuCKX1.1

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, September 2013, International Union of Crystallography

    Professor Bostjan Kobe

  79. Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogenCryptococcus neoformans

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, August 2013, International Union of Crystallography

    Professor Bostjan Kobe

  80. Structure-Informed Design of an Enzymatically Inactive Vaccine Component for Group A Streptococcus

    Article • mBio, August 2013, ASM Journals

    Professor Bostjan Kobe, Mark Walker

  81. Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-α

    Article • Traffic, August 2013, Wiley

    Professor Bostjan Kobe

  82. Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, June 2013, International Union of Crystallography

    Professor Bostjan Kobe

  83. The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

    Article • Acta Crystallographica Section D Biological Crystallography, April 2013, International Union of Crystallography

    Professor Bostjan Kobe

  84. A Glutathione-Dependent Detoxification System Is Required for Formaldehyde Resistance and Optimal Survival of Neisseria meningitidis in Biofilms

    Article • Antioxidants & Redox Signaling, March 2013, Mary Ann Liebert Inc

    Professor Michael P Jennings, Professor Bostjan Kobe

  85. PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity

    Article • BMC Bioinformatics, February 2013, Springer Science + Business Media

    Professor Bostjan Kobe

  86. Protein Phosphorylation

    Article • January 2013, Springer Science + Business Media

    Professor Bostjan Kobe

  87. Crystal Structure of Rice Importin-  and Structural Basis of Its Interaction with Plant-Specific Nuclear Localization Signals

    Article • The Plant Cell, December 2012, American Society of Plant Biologists (ASPB)

    Professor Bostjan Kobe

  88. Intramolecular Interaction Influences Binding of the Flax L5 and L6 Resistance Proteins to their AvrL567 Ligands

    Article • PLoS Pathogens, November 2012, PLOS

    Professor Bostjan Kobe

  89. DLocalMotif: a discriminative approach for discovering local motifs in protein sequences

    Article • Bioinformatics, November 2012, Oxford University Press (OUP)

    Professor Bostjan Kobe

  90. De novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformans

    Article • PLoS Pathogens, October 2012, PLOS

    Professor Bostjan Kobe, Ulrike Kappler

  91. Wzy-Dependent Bacterial Capsules as Potential Drug Targets

    Article • Current Drug Targets, August 2012, Bentham Science Publishers

    Alistair Standish, Dr Renato Morona, Professor Bostjan Kobe

  92. Computational Modelling of Linear Motif-Mediated Protein Interactions

    Article • Current Topics in Medicinal Chemistry, August 2012, Bentham Science Publishers

    Professor Bostjan Kobe

  93. Adaptors in Toll-Like Receptor Signaling and their Potential as Therapeutic Targets

    Article • Current Drug Targets, August 2012, Bentham Science Publishers

    Professor Bostjan Kobe

  94. Prokaryotic Substrate-Binding Proteins as Targets for Antimicrobial Therapies

    Article • Current Drug Targets, August 2012, Bentham Science Publishers

    Professor Bostjan Kobe

  95. Structural basis of nuclear import of flap endonuclease 1 (FEN1)

    Article • Acta Crystallographica Section D Biological Crystallography, June 2012, International Union of Crystallography

    Professor Bostjan Kobe

  96. The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer

    Article • Acta Crystallographica Section D Biological Crystallography, May 2012, International Union of Crystallography

    Professor Bostjan Kobe

  97. Conserved anchorless surface proteins as group A streptococcal vaccine candidates

    Article • Journal of Molecular Medicine, April 2012, Springer Science + Business Media

    Professor Bostjan Kobe, Professor Steven P Djordjevic

  98. Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-α

    Article • Traffic, February 2012, Wiley

    Professor Bostjan Kobe

  99. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

    Article • Nature Genetics, December 2011, Springer Science + Business Media

    Professor Bostjan Kobe, Dr Natalie Niemi

  100. Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, November 2011, International Union of Crystallography

    Professor Bostjan Kobe

  101. Structural mix-n-match reveals molecular secrets of platelets

    Article • Blood, November 2011, American Society of Hematology

    Professor Bostjan Kobe

  102. A Molecular Mechanism for Bacterial Susceptibility to Zinc

    Article • PLoS Pathogens, November 2011, PLOS

    Professor Bostjan Kobe

  103. Residues in domain III of the dengue virus envelope glycoprotein involved in cell-surface glycosaminoglycan binding

    Article • Journal of General Virology, September 2011, Society for General Microbiology

    Professor Bostjan Kobe

  104. Structural Basis of Importin-α-Mediated Nuclear Transport for Ku70 and Ku80

    Article • Journal of Molecular Biology, September 2011, Elsevier

    Professor Bostjan Kobe

  105. Molecular basis for specificity of nuclear import and prediction of nuclear localization

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, September 2011, Elsevier

    Professor Bostjan Kobe

  106. Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

    Article • Proceedings of the National Academy of Sciences, August 2011, Proceedings of the National Academy of Sciences

    Professor Bostjan Kobe

  107. Ligand-induced Conformational Changes within a Hexameric Acyl-CoA Thioesterase

    Article • Journal of Biological Chemistry, August 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  108. An Autoactive Mutant of the M Flax Rust Resistance Protein Has a Preference for Binding ATP, Whereas Wild-Type M Protein Binds ADP

    Article • Molecular Plant-Microbe Interactions, August 2011, Scientific Societies

    Professor Bostjan Kobe

  109. Predicting Protein Kinase Specificity: Predikin Update and Performance in the DREAM4 Challenge

    Article • PLoS ONE, July 2011, PLOS

    Professor Bostjan Kobe

  110. Crystal structure of importin-α bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4

    Article • FEBS Journal, March 2011, Wiley

    Professor Bostjan Kobe

  111. Proteomic and Electron Microscopy Survey of Large Assemblies in Macrophage Cytoplasm

    Article • Molecular & Cellular Proteomics, March 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  112. A probabilistic model of nuclear import of proteins

    Article • Bioinformatics, March 2011, Oxford University Press (OUP)

    Professor Bostjan Kobe

  113. Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

    Article • Cell Host & Microbe, March 2011, Elsevier

    Professor Bostjan Kobe

  114. Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, January 2011, International Union of Crystallography

    Professor Bostjan Kobe

  115. Functional and structural properties of mammalian acyl-coenzyme A thioesterases

    Article • Progress in Lipid Research, October 2010, Elsevier

    Professor Bostjan Kobe

  116. Hybrid Methods for Protein Structure Prediction

    Article • September 2010, Wiley

    Professor Bostjan Kobe

  117. Quantitative Structural Analysis of Importin-β Flexibility: Paradigm for Solenoid Protein Structures

    Article • Structure, September 2010, Elsevier

    Dr Murray Stewart, Professor Bostjan Kobe

  118. Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogenCryptococcus

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, August 2010, International Union of Crystallography

    Professor Bostjan Kobe

  119. Probing the Specificity of Binding to the Major Nuclear Localization Sequence-binding Site of Importin-  Using Oriented Peptide Library Screening

    Article • Journal of Biological Chemistry, April 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  120. UpaH Is a Newly Identified Autotransporter Protein That Contributes to Biofilm Formation and Bladder Colonization by Uropathogenic Escherichia coli CFT073

    Article • Infection and Immunity, February 2010, ASM Journals

    Professor Bostjan Kobe, A/Prof Scott A Beatson

  121. Principles of Kinase Regulation

    Article • January 2010, Elsevier

    Professor Bostjan Kobe

  122. Substrates of Cyclic Nucleotide-Dependent Protein Kinases

    Article • January 2010, Elsevier

    Professor Bostjan Kobe

  123. The AvrM Effector from Flax Rust Has a Structured C-Terminal Domain and Interacts Directly with the M Resistance Protein

    Article • Molecular Plant-Microbe Interactions, January 2010, Scientific Societies

    Professor Bostjan Kobe

  124. The Many Faces of Platelet Glycoprotein Ibα - Thrombin Interaction

    Article • Current Protein and Peptide Science, December 2009, Bentham Science Publishers

    Professor Bostjan Kobe, Rebecca Buchholz

  125. In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses

    Article • Antiviral Research, December 2009, Elsevier

    Professor Bostjan Kobe

  126. Comparing METS and OAI-ORE for Encapsulating Scientific Data Products: A Protein Crystallography Case Study

    Article • December 2009, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Bostjan Kobe

  127. Interaction between Plate Make and Protein in Protein Crystallisation Screening

    Article • PLoS ONE, November 2009, PLOS

    Professor Bostjan Kobe

  128. Biochemical characterization of arabidopsis developmentally regulated G-proteins (DRGs)

    Article • Protein Expression and Purification, October 2009, Elsevier

    Professor Bostjan Kobe

  129. Importin-  Is a GDP-to-GTP Exchange Factor of Ran: IMPLICATIONS FOR THE MECHANISM OF NUCLEAR IMPORT

    Article • Journal of Biological Chemistry, June 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  130. Crystallization of the flexible nuclear import receptor importin-β in the unliganded state

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, May 2009, International Union of Crystallography

    Professor Bostjan Kobe

  131. Defining the Structural Basis of Human Plasminogen Binding by Streptococcal Surface Enolase

    Article • Journal of Biological Chemistry, April 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  132. Identification of novel target sites and an inhibitor of the dengue virus E protein

    Article • Journal of Computer-Aided Molecular Design, February 2009, Springer Science + Business Media

    Professor Bostjan Kobe

  133. Crystallography and protein–protein interactions: biological interfaces and crystal contacts

    Article • Biochemical Society Transactions, December 2008, Portland Press Ltd.

    Professor Bostjan Kobe, Rebecca Buchholz

  134. Kap95p Binding Induces the Switch Loops of RanGDP to Adopt the GTP-Bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics

    Article • Journal of Molecular Biology, November 2008, Elsevier

    Dr Murray Stewart, Professor Bostjan Kobe

  135. United we stand: combining structural methods

    Article • Current Opinion in Structural Biology, October 2008, Elsevier

    Professor Bostjan Kobe

  136. Soybean Nodule Autoregulation Receptor Kinase Phosphorylates Two Kinase-associated Protein Phosphatases in Vitro

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  137. Identification of Disulfide-Containing Chemical Cross-Links in Proteins Using MALDI-TOF/TOF-Mass Spectrometry

    Article • Analytical Chemistry, July 2008, American Chemical Society (ACS)

    Professor Bostjan Kobe

  138. Federated repositories of X-ray diffraction images

    Article • Acta Crystallographica Section D Biological Crystallography, June 2008, International Union of Crystallography

    Professor Bostjan Kobe, Mr Neil A Dickson, Mr David Groenewegen

  139. Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites

    Article • BMC Bioinformatics, May 2008, Springer Science + Business Media

    Professor Bostjan Kobe

  140. The Predikin webserver: improved prediction of protein kinase peptide specificity using structural information

    Article • Nucleic Acids Research, May 2008, Oxford University Press (OUP)

    Professor Bostjan Kobe

  141. Discovering Sequence Motifs with Arbitrary Insertions and Deletions

    Article • PLoS Computational Biology, May 2008, PLOS

    Professor Bostjan Kobe

  142. Cortactin Adopts a Globular Conformation and Bundles Actin into Sheets

    Article • Journal of Biological Chemistry, March 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  143. Fibroblast Growth Factor Receptor 2 Phosphorylation on Serine 779 Couples to 14-3-3 and Regulates Cell Survival and Proliferation

    Article • Molecular and Cellular Biology, March 2008, ASM Journals

    Professor Bostjan Kobe

  144. Histidine protonation and the activation of viral fusion proteins

    Article • Biochemical Society Transactions, February 2008, Portland Press Ltd.

    Professor Bostjan Kobe

  145. Structural Proteomics

    Article • January 2008, Springer Science + Business Media

    Professor Jules Mitchell Guss, Professor Bostjan Kobe

  146. Increasing Protein Crystallization Screening Success with Heterogeneous Nucleating Agents

    Article • January 2008, Springer Science + Business Media

    Professor Bostjan Kobe

  147. A General Target Selection Method for Crystallographic Proteomics

    Article • January 2008, Springer Science + Business Media

    Professor Bostjan Kobe

  148. A Medium or High Throughput Protein Refolding Assay

    Article • January 2008, Springer Science + Business Media

    Professor Bostjan Kobe

  149. Improved Success of Sparse Matrix Protein Crystallization Screening with Heterogeneous Nucleating Agents

    Article • PLoS ONE, October 2007, PLOS

    Professor Bostjan Kobe

  150. Evaluating protein:protein complex formation using synchrotron radiation circular dichroism spectroscopy

    Article • Proteins Structure Function and Bioinformatics, September 2007, Wiley

    Professor Bostjan Kobe

  151. Crystal Structures of Flax Rust Avirulence Proteins AvrL567-A and -D Reveal Details of the Structural Basis for Flax Disease Resistance Specificity

    Article • The Plant Cell, September 2007, American Society of Plant Biologists (ASPB)

    Professor Bostjan Kobe

  152. Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation

    Article • Proceedings of the National Academy of Sciences, June 2007, Proceedings of the National Academy of Sciences

    Professor Bostjan Kobe

  153. Purification of the M flax-rust resistance protein expressed in Pichia pastoris

    Article • The Plant Journal, April 2007, Wiley

    Professor Bostjan Kobe

  154. The use of Co2+for crystallization and structure determination, using a conventional monochromatic X-ray source, of flax rust avirulence protein

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, February 2007, International Union of Crystallography

    Professor Bostjan Kobe

  155. Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases

    Article • Microbiology and Molecular Biology Reviews, December 2006, ASM Journals

    Professor Bostjan Kobe

  156. Focusing in on structural genomics: The University of Queensland structural biology pipeline

    Article • Biomolecular Engineering, December 2006, Elsevier

    Professor Bostjan Kobe

  157. Incorporating a TEV cleavage site reduces the solubility of nine recombinant mouse proteins

    Article • Protein Expression and Purification, November 2006, Elsevier

    Professor Bostjan Kobe

  158. The Role of Histidine Residues in Low-pH-Mediated Viral Membrane Fusion

    Article • Structure, October 2006, Elsevier

    Professor Bostjan Kobe

  159. Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes

    Article • Proceedings of the National Academy of Sciences, June 2006, Proceedings of the National Academy of Sciences

    Professor Bostjan Kobe

  160. An automatable screen for the rapid identification of proteins amenable to refolding

    Article • PROTEOMICS, March 2006, Wiley

    Professor Bostjan Kobe

  161. Article • BMC Bioinformatics, January 2006, Springer Science + Business Media

    Professor Bostjan Kobe

  162. Substrate specificity of protein kinases and computational prediction of substrates

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, December 2005, Elsevier

    Professor Bostjan Kobe

  163. Modelling the structure of latexin-carboxypeptidase A complex based on chemical cross-linking and molecular docking

    Article • Protein Engineering Design and Selection, November 2005, Oxford University Press (OUP)

    Professor Bostjan Kobe

  164. Modification of recombinatorial cloning for small affinity tag fusion protein construct generation

    Article • Analytical Biochemistry, November 2005, Elsevier

    Professor Bostjan Kobe

  165. Crystallization and preliminary X-ray diffraction analysis of importin-α complexed with NLS peptidomimetics

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, June 2005, Elsevier

    Professor Bostjan Kobe

  166. Verprolin Cytokinesis Function Mediated by the Hof One Trap Domain

    Article • Traffic, May 2005, Wiley

    Professor Bostjan Kobe

  167. An Inflammatory Role for the Mammalian Carboxypeptidase Inhibitor Latexin: Relationship to Cystatins and the Tumor Suppressor TIG1

    Article • Structure, February 2005, Elsevier

    Professor Bostjan Kobe

  168. Expression and biochemical analysis of the entire HIV-2 gp41 ectodomain: determinants of stability map to N- and C-terminal sequences outside the 6-helix bundle core

    Article • FEBS Letters, May 2004, Wiley

    Professor Bostjan Kobe, Dr Heidi E Drummer

  169. Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-α

    Article • Biochemical Journal, October 2003, Portland Press Ltd.

    Professor Bostjan Kobe

  170. Crystal structures of fusion proteins with large-affinity tags

    Article • Protein Science, July 2003, Wiley

    Professor Bostjan Kobe

  171. Structural Basis for the Specificity of Bipartite Nuclear Localization Sequence Binding by Importin- 

    Article • Journal of Biological Chemistry, April 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  172. Comparison of three commercial sparse-matrix crystallization screens

    Article • Acta Crystallographica Section D Biological Crystallography, March 2003, International Union of Crystallography

    Professor Bostjan Kobe

  173. Principles of Kinase Regulation

    Article • January 2003, Elsevier

    Professor Bostjan Kobe

  174. Peptide Substrates of Cyclic Nucleotide-Dependent Protein Kinases

    Article • January 2003, Elsevier

    Professor Bostjan Kobe

  175. Structural basis and prediction of substrate specificity in protein serine/threonine kinases

    Article • Proceedings of the National Academy of Sciences, December 2002, Proceedings of the National Academy of Sciences

    Professor Bostjan Kobe

  176. Structural characterization of the N‐terminal autoregulatory sequence of phenylalanine hydroxylase

    Article • Protein Science, August 2002, Wiley

    Associate Professor Paul R Gooley, Professor Bostjan Kobe

  177. Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information

    Article • Protein Science, May 2002, Wiley

    Professor Bostjan Kobe

  178. A computational analysis of substrate binding strength by phosphorylase kinase and protein kinase A

    Article • Journal of Molecular Recognition, January 2002, Wiley

    Professor Bostjan Kobe

  179. Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes

    Article • January 2002, Springer Science + Business Media

    Professor Bostjan Kobe

  180. The leucine-rich repeat as a protein recognition motif

    Article • Current Opinion in Structural Biology, December 2001, Elsevier

    Professor Bostjan Kobe

  181. Biophysical Characterization of Interactions Involving Importin-  during Nuclear Import

    Article • Journal of Biological Chemistry, July 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Bostjan Kobe

  182. Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases

    Article • Acta Crystallographica Section D Biological Crystallography, March 2001, International Union of Crystallography

    Professor Bostjan Kobe

  183. Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase

    Article • FEBS Letters, January 2001, Wiley

    Professor Bostjan Kobe

  184. Functional Analysis, Using in Vitro Mutagenesis, of Amino Acids Located in the Phenylalanine Hydroxylase Active Site

    Article • Archives of Biochemistry and Biophysics, December 2000, Elsevier

    Professor Bostjan Kobe

  185. When protein folding is simplified to protein coiling: the continuum of solenoid protein structures

    Article • Trends in Biochemical Sciences, October 2000, Elsevier

    Professor Bostjan Kobe

  186. Structural interpretation of mutations in phenylalanine hydroxylase protein aids in identifying genotype–phenotype correlations in phenylketonuria

    Article • European Journal of Human Genetics, August 2000, Springer Science + Business Media

    Professor Bostjan Kobe

  187. Functional Implications of the Human T-Lymphotropic Virus Type 1 Transmembrane Glycoprotein Helical Hairpin Structure

    Article • Journal of Virology, July 2000, ASM Journals

    Professor Bostjan Kobe

  188. Identification and predicted structure of a leucine-rich repeat motif shared by Leishmania major proteophosphoglycan and Parasite Surface Antigen 2

    Article • Molecular and Biochemical Parasitology, April 2000, Elsevier

    Professor Bostjan Kobe

  189. FHA domain boundaries of the Dun1p and Rad53p cell cycle checkpoint kinases

    Article • FEBS Letters, April 2000, Wiley

    Professor Bostjan Kobe

  190. Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-α11Edited by K. Nagai

    Article • Journal of Molecular Biology, April 2000, Elsevier

    Professor Bostjan Kobe

  191. Protein Serine/Threonine Kinases

    Article • January 2000, Springer Science + Business Media

    Professor Bostjan Kobe

  192. Active site-directed protein regulation

    Article • Nature, November 1999, Springer Science + Business Media

    Professor Bostjan Kobe

  193. Evolutionary Conservation of the Membrane Fusion Machine

    Article • IUBMB Life, August 1999, Wiley

    Professor Bostjan Kobe

  194. Evolutionary Conservation of the Membrane Fusion Machine

    Article • IUBMB Life, August 1999, Taylor & Francis

    Professor Bostjan Kobe

  195. Turn up the HEAT

    Article • Structure, May 1999, Elsevier

    Professor Bostjan Kobe

  196. Article • Nature Structural Biology, May 1999, Springer Science + Business Media

    Professor Bostjan Kobe

  197. Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins

    Article • Proceedings of the National Academy of Sciences, April 1999, Proceedings of the National Academy of Sciences

    Professor Bostjan Kobe

  198. Article • Nature Structural Biology, April 1999, Springer Science + Business Media

    Professor Bostjan Kobe

  199. Crystallization of importin α, the nuclear-import receptor

    Article • Acta Crystallographica Section D Biological Crystallography, February 1999, International Union of Crystallography

    Professor Bostjan Kobe

  200. Open up review system

    Article • Nature, December 1998, Springer Science + Business Media

    Professor Bostjan Kobe

  201. Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein

    Article • Protein Science, July 1998, Wiley

    Professor Bostjan Kobe

  202. Crystallization and preliminary X-ray analysis of ferric enterobactin receptor FepA, an integral membrane protein fromEscherichia coli

    Article • Acta Crystallographica Section D Biological Crystallography, July 1998, International Union of Crystallography

    Professor Bostjan Kobe

  203. Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase

    Article • Protein Science, June 1997, Wiley

    Professor Bostjan Kobe

  204. The myosin-I-binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins

    Article • Proceedings of the National Academy of Sciences, April 1997, Proceedings of the National Academy of Sciences

    Professor Bostjan Kobe

  205. 3 Intrasteric regulation of protein kinases

    Article • January 1997, Elsevier

    Professor Bostjan Kobe

  206. Mechanism of Ribonuclease Inhibition by Ribonuclease Inhibitor Protein Based on the Crystal Structure of its Complex with Ribonuclease A

    Article • Journal of Molecular Biology, December 1996, Elsevier

    Professor Bostjan Kobe

  207. Leucines on a roll

    Article • Nature Structural Biology, December 1996, Springer Science + Business Media

    Professor Bostjan Kobe

  208. Ca2+ /S100 regulation of giant protein kinases

    Article • Nature, April 1996, Springer Science + Business Media

    Professor Bostjan Kobe

  209. Proteins with leucine-rich repeats

    Article • Current Opinion in Structural Biology, June 1995, Elsevier

    Professor Bostjan Kobe

  210. A structural basis of the interactions between leucine-rich repeats and protein ligands

    Article • Nature, March 1995, Springer Science + Business Media

    Professor Bostjan Kobe

  211. The leucine-rich repeat: a versatile binding motif

    Article • Trends in Biochemical Sciences, October 1994, Elsevier

    Professor Bostjan Kobe

  212. Complex between Bovine Ribonuclease A and Porcine Ribonuclease Inhibitor Crystallizes in a Similar Unit Cell as Free Ribonuclease Inhibitor

    Article • Journal of Molecular Biology, August 1994, Elsevier

    Professor Bostjan Kobe

  213. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats

    Article • Nature, December 1993, Springer Science + Business Media

    Professor Bostjan Kobe

  214. Crystallization and Preliminary X-ray Analysis of Porcine Ribonuclease Inhibitor, a Protein with Leucine-rich Repeats

    Article • Journal of Molecular Biology, May 1993, Elsevier

    Professor Bostjan Kobe

  215. Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments

    Article • Biochemistry, May 1993, American Chemical Society (ACS)

    Professor Bostjan Kobe

  216. Use of distance geometry approach for the in vitro antiviral activity evaluation of N-bridgehead C-nucleosides

    Article • European Journal of Medicinal Chemistry, April 1992, Elsevier

    Professor Bostjan Kobe

  217. Conformations of wild-type and mutant OmpA signal sequences in membrane mimetic environments

    Article • January 1992, Springer Science + Business Media

    Professor Bostjan Kobe

  218. Crystallization and Crystal Structure Determination of Ribonuclease A-Ribonuclease Inhibitor Protein Complex

    Article • Springer Science + Business Media

    Professor Bostjan Kobe

  219. Protein Serine/Threonine Kinases

    Article • Springer Science + Business Media

    Professor Bostjan Kobe