All Stories

  1. Unconjugated bilirubin inhibits proteolytic cleavage of von Willebrand factor by ADAMTS13 protease

    Article • Journal of Thrombosis and Haemostasis, April 2015, Wiley

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  2. Platelet-delivered ADAMTS13 inhibits arterial thrombosis and prevents thrombotic thrombocytopenic purpura in murine models

    Article • Blood, March 2015, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  3. ADAMTS13, lucky to have a hydrophobic pocket

    Article • Blood, March 2015, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  4. ADAMTS13 and its variants promote angiogenesis via upregulation of VEGF and VEGFR2

    Article • Cellular and Molecular Life Sciences, June 2014, Springer Science + Business Media

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  5. Anti-ADAMTS13 IgG autoantibodies present in healthy individuals share linear epitopes with those in patients with thrombotic thrombocytopenic purpura

    Article • Haematologica, February 2014, Ferrata Storti Foundation (Haematologica)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  6. DNase, ADAMTS13, and iPAD4: good for the heart

    Article • Blood, January 2014, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  7. Carboxyl Terminus of ADAMTS13 Directly Inhibits Platelet Aggregation and Ultra Large von Willebrand Factor String Formation Under Flow in a Free-Thiol-Dependent Manner

    Article • Arteriosclerosis Thrombosis and Vascular Biology, December 2013, Wolters Kluwer Health

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  8. Compromised shear-dependent cleavage of type 2N von Willebrand factor variants by ADAMTS13 in the presence of factor VIII

    Article • Thrombosis and Haemostasis, May 2013, Schattauer GmbH

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  9. AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura

    Article • Blood, March 2013, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  10. ADAMTS13, TTP and Beyond

    Article • Hereditary Genetics, January 2013, OMICS Publishing Group

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  11. Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice

    Article • Annals of Neurology, December 2012, Wiley

    Dr X. Long Zheng

  12. Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease

    Article • Journal of Biological Chemistry, August 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  13. Genetic Ablation of Adamts13 Gene Dramatically Accelerates the Formation of Early Atherosclerosis in a Murine Model

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2012, Wolters Kluwer Health

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  14. ADAMTS13 meets MR, then what?

    Article • Blood, April 2012, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  15. Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

    Article • Blood, January 2012, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  16. A shear-based assay for assessing plasma ADAMTS13 activity and inhibitors in patients with thrombotic thrombocytopenic purpura

    Article • Transfusion, January 2011, Wiley

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  17. Novel recombinant glycosylphosphatidylinositol (GPI)-anchored ADAMTS13 and variants for assessment of anti-ADAMTS13 autoantibodies in patients with thrombotic thrombocytopenic purpura

    Article • Thrombosis and Haemostasis, January 2011, Schattauer GmbH

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  18. Factor VIII and Platelets Synergistically Accelerate Cleavage of von Willebrand Factor by ADAMTS13 under Fluid Shear Stress

    Article • Journal of Biological Chemistry, July 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  19. Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura

    Article • Haematologica, April 2010, Ferrata Storti Foundation (Haematologica)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  20. ADAMTS13 testing: why bother?

    Article • Blood, February 2010, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  21. Amino acid residues Arg659, Arg660, and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor

    Article • Blood, January 2010, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  22. A novel association of acquired ADAMTS13 inhibitor and acute dengue virus infection

    Article • Transfusion, January 2010, Wiley

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  23. von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size

    Article • Journal of Thrombosis and Haemostasis, October 2009, Wiley

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  24. Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site

    Article • Blood, June 2009, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  25. A team player: the disintegrin domain of ADAMTS13

    Article • Blood, May 2009, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  26. Correction of murine ADAMTS13 deficiency by hematopoietic progenitor cell-mediated gene therapy

    Article • Blood, January 2009, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  27. Correction of ADAMTS13 Deficiency by In Utero Gene Transfer of Lentiviral Vector encoding ADAMTS13 Genes

    Article • Molecular Therapy, January 2009, Elsevier

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  28. Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells

    Article • Journal of Thrombosis and Haemostasis, July 2008, Wiley

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  29. Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13

    Article • Proceedings of the National Academy of Sciences, May 2008, Proceedings of the National Academy of Sciences

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  30. The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow

    Article • Blood, May 2007, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  31. The Proximal Carboxyl-terminal Domains of ADAMTS13 Determine Substrate Specificity and Are All Required for Cleavage of von Willebrand Factor

    Article • Journal of Biological Chemistry, June 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  32. Molecular Biology of ADAMTS13 and Diagnostic Utility of ADAMTS13 Proteolytic Activity and Inhibitor Assays

    Article • Seminars in Thrombosis and Hemostasis, January 2005, Thieme Publishing Group

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  33. Binding of platelet glycoprotein Ibα to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13

    Article • Proceedings of the National Academy of Sciences, July 2004, Proceedings of the National Academy of Sciences

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  34. Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura

    Article • Blood, June 2004, American Society of Hematology

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  35. Cleavage of the ADAMTS13 Propeptide Is Not Required for Protease Activity

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  36. Cleavage of von Willebrand Factor Requires the Spacer Domain of the Metalloprotease ADAMTS13

    Article • Journal of Biological Chemistry, June 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  37. Remission of Chronic Thrombotic Thrombocytopenic Purpura after Treatment with Cyclophosphamide and Rituximab

    Article • Annals of Internal Medicine, January 2003, American College of Physicians

    Dr X. Long Zheng

  38. ADAMTS13 and TTP

    Article • Current Opinion in Hematology, September 2002, Wolters Kluwer Health

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  39. Mucin-like Domain of Enteropeptidase Directs Apical Targeting in Madin-Darby Canine Kidney Cells

    Article • Journal of Biological Chemistry, November 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  40. Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura

    Article • Journal of Biological Chemistry, September 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  41. Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide 1 1Edited by R. Huber

    Article • Journal of Molecular Biology, September 1999, Elsevier

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  42. Apical Sorting of Bovine Enteropeptidase Does Not Involve Detergent-resistant Association with Sphingolipid-Cholesterol Rafts

    Article • Journal of Biological Chemistry, January 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  43. Bovine Proenteropeptidase Is Activated by Trypsin, and the Specificity of Enteropeptidase Depends on the Heavy Chain

    Article • Journal of Biological Chemistry, December 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  44. Synthetic Estrogen-Mediated Alterations in Uterine Cell Fate

    Article • January 1997, Springer Science + Business Media

    Dr X. Long Zheng

  45. Effect of protein C inhibitor (PCI) on in vitro fertilization

    Article • Immunopharmacology, June 1996, Elsevier

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  46. Protein C inhibitor (PCI)

    Article • Immunopharmacology, May 1996, Elsevier

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  47. Serine protease inhibitors (serpins) in human seminal plasma: Concentrations and inhibition of acrosin

    Article • Fibrinolysis and Proteolysis, November 1994, Elsevier

    Dr X. Long Zheng, Professor and chair X. Long Zheng

  48. Effect of protein C inhibitor (PCI) on in vitro fertilization

    Article • Fibrinolysis and Proteolysis, January 1994, Elsevier

    Dr X. Long Zheng, Professor and chair X. Long Zheng