All Stories

  1. Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis

    Article • Cell Calcium, May 2018, Elsevier

    Professor Marc Freichel

  2. TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation

    Article • Molecular Metabolism, March 2018, Elsevier

    Professor Marc Freichel

  3. Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory

    Article • The EMBO Journal, August 2017, EMBO

    Professor Marc Freichel

  4. Functional Characterization of Transient Receptor Potential (TRP) Channel C5 in Female Murine Gonadotropes

    Article • Endocrinology, January 2017, Endocrine Society

    Professor Marc Freichel

  5. Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells

    Article • Journal of Biological Chemistry, December 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Marc Freichel

  6. TRPM4-mediated control of FcεRI-evoked Ca2+ elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells

    Article • Scientific Reports, September 2016, Nature

    Professor Marc Freichel

  7. A background Ca2+entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling

    Article • European Heart Journal, June 2015, European Society of Cardiology

    Professor Marc Freichel

  8. Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice

    Article • Journal of Molecular and Cellular Cardiology, September 2014, Elsevier

    Professor Marc Freichel

  9. Increase in cytosolic Ca2+ produced by hypoxia and other depolarizing stimuli activates a non‐selective cation channel in chemoreceptor cells of rat carotid body

    Article • The Journal of Physiology, March 2014, Wiley

    Professor Marc Freichel, Professor Rudi Vennekens

  10. TRPC4- and TRPC4-Containing Channels

    Article • January 2014, Springer Science + Business Media

    Professor Marc Freichel

  11. TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

    Article • Nature Reports Stem Cells, November 2012, Nature

    Professor Marc Freichel

  12. Excision ofTrpv6Gene Leads to Severe Defects in Epididymal Ca2+Absorption and Male Fertility Much Like Single D541A Pore Mutation

    Article • Journal of Biological Chemistry, March 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Marc Freichel

  13. The Role of TRP Proteins in Mast Cells

    Article • Frontiers in Immunology, January 2012, Frontiers

    Professor Marc Freichel

  14. Melanopsin signalling in mammalian iris and retina

    Article • Nature, November 2011, Nature

    Professor Marc Freichel

  15. Male Fertility Depends on Ca2+ Absorption by TRPV6 in Epididymal Epithelia

    Article • Science Signaling, May 2011, American Association for the Advancement of Science

    Professor Marc Freichel

  16. Moderate Calcium Channel Dysfunction in Adult Mice with Inducible Cardiomyocyte-specific Excision of thecacnb2Gene

    Article • Journal of Biological Chemistry, February 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Marc Freichel

  17. Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice

    Article • Journal of Clinical Investigation, September 2010, American Society for Clinical Investigation

    Professor Marc Freichel

  18. Defective survival of naive CD8+ T lymphocytes in the absence of the β3 regulatory subunit of voltage-gated calcium channels

    Article • Nature Immunology, October 2009, Nature

    Professor Marc Freichel

  19. Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo

    Article • Gastroenterology, October 2009, Elsevier

    Professor Marc Freichel

  20. De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury

    Article • Nature Reports Stem Cells, January 2009, Nature

    Professor Marc Freichel

  21. TRPC4 and TRPC4-Deficient Mice

    Article • October 2008, Wiley

    Professor Marc Freichel

  22. Murine ORAI2 Splice Variants Form Functional Ca2+Release-activated Ca2+(CRAC) Channels

    Article • Journal of Biological Chemistry, April 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Marc Freichel

  23. Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4

    Article • Nature Immunology, February 2007, Nature

    Professor Marc Freichel

  24. Functional role of TRPC proteins in native systems: implications from knockout and knock-down studies

    Article • The Journal of Physiology, August 2005, Wiley

    Professor Marc Freichel

  25. The TRPV6 gene, cDNA and protein

    Article • Cell Calcium, May 2003, Elsevier

    Professor Marc Freichel

  26. Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice

    Article • Nature Cell Biology, February 2001, Nature

    Professor Marc Freichel

  27. Trp12, a novel Trp related protein from kidney

    Article • FEBS Letters, November 2000, Wiley

    Professor Marc Freichel

  28. Alternative splicing and tissue specific expression of the 5′ truncated bCCE 1 variant bCCE 1Δ514

    Article • FEBS Letters, February 1998, Wiley

    Professor Marc Freichel

  29. Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion

    Article • Endocrinology, September 1996, Endocrine Society

    Professor Marc Freichel