Professor William D Picking
Current affiliation: University of Kansas
Subject: Medicine And Medical Sciences
Primary location: United States
Characterization of a Novel Fusion Protein from IpaB and IpaD of Shigella spp. and Its Potential as a Pan-Shigella Vaccine
Published in:Infection and Immunity
Publication date:2013-09-23
Impact of Detergent on Biophysical Properties and Immune Response of the IpaDB Fusion Protein, a Candidate Subunit Vaccine against Shigella Species
Published in:Infection and Immunity
Publication date:2014-11-03
Helical Packing of Needles from Functionally Altered Shigella Type III Secretion Systems
Published in:Journal of Molecular Biology
Publication date:2005-11-01
Solution Structure of Monomeric BsaL, the Type III Secretion Needle Protein of Burkholderia pseudomallei
Published in:Journal of Molecular Biology
Publication date:2006-06-01
Structural dissection of the extracellular moieties of the type III secretion apparatus
Published in:Molecular BioSystems
Publication date:2008-01-01
IpaD Localizes to the Tip of the Type III Secretion System Needle of Shigella flexneri
Published in:Infection and Immunity
Publication date:2006-07-21
Bile Salts Stimulate Recruitment of IpaB to the Shigella flexneri Surface, Where It Colocalizes with IpaD at the Tip of the Type III Secretion Needle
Published in:Infection and Immunity
Publication date:2007-02-12
Shigella flexneri 2a Strain CVD 1207, with Specific Deletions in virG, sen, set, and guaBA, Is Highly Attenuated in Humans
Published in:Infection and Immunity
Publication date:2000-03-01
IpaD of Shigella flexneri Is Independently Required for Regulation of Ipa Protein Secretion and Efficient Insertion of IpaB and IpaC into Host Memb...
Published in:Infection and Immunity
Publication date:2005-02-23
The Structures of Coiled-Coil Domains from Type III Secretion System Translocators Reveal Homology to Pore-Forming Toxins
Published in:Journal of Molecular Biology
Publication date:2012-04-01
Structural Characterization of the N Terminus of IpaC from Shigella flexneri
Published in:Infection and Immunity
Publication date:2003-03-01
Interaction of Shigella flexneri IpaC with Model Membranes Correlates with Effects on Cultured Cells
Published in:Infection and Immunity
Publication date:2000-06-01
Liposomes Recruit IpaC to the Shigella flexneri Type III Secretion Apparatus Needle as a Final Step in Secretion Induction
Published in:Infection and Immunity
Publication date:2009-05-11
Biophysical Characterization of the Type III Secretion Tip Proteins and the Tip Proteins Attached to Bacterium-Like Particles
Published in:Journal of Pharmaceutical Sciences
Publication date:2015-02-01
Expression, limited proteolysis and preliminary crystallographic analysis of IpaD, a component of theShigella flexneritype III secretion system
Published in:Acta Crystallographica Section F Structural Biology and Crystallization Communications
Publication date:2006-08-11
Expression, purification, crystallization and preliminary crystallographic analysis of MxiH, a subunit of theShigella flexneritype III secretion sy...
Published in:Acta Crystallographica Section F Structural Biology and Crystallization Communications
Publication date:2006-02-28
Influence of oligomerization state on the structural properties of invasion plasmid antigen B fromShigella flexneriin the presence and absence of p...
Published in:Proteins Structure Function and Bioinformatics
Publication date:2014-08-21Interaction of IpaB with Liposomes
Conformational Changes in IpaD from Shigella flexneri upon Binding Bile Salts Provide Insight into the Second Step of Type III Secretion
Published in:Biochemistry
Publication date:2011-01-18
Identification of functional regions within invasion plasmid antigen C (IpaC) of Shigella flexneri
Published in:Molecular Microbiology
Publication date:2001-01-01
Oligomeric states of theShigellatranslocator protein IpaB provide structural insights into formation of the type III secretion translocon
Published in:Protein Science
Publication date:2013-03-18
Studies of the conformational stability of invasion plasmid antigen B fromShigella
Published in:Protein Science
Publication date:2013-03-26
Spectroscopic and Calorimetric Analyses of Invasion Plasmid Antigen D (IpaD) from Shigella flexneri Reveal the Presence of Two Structural Domains †
Published in:Biochemistry
Publication date:2006-08-01
Preparation and Characterization of Translocator/Chaperone Complexes and Their Component Proteins from Shigella flexneri †
Published in:Biochemistry
Publication date:2007-07-01
Identification of the bile salt binding site on ipad from Shigella flexneri and the influence of ligand binding on IpaD structure
Published in:Proteins Structure Function and Bioinformatics
Publication date:2011-12-23
Binding Affects the Tertiary and Quaternary Structures of the Shigella Translocator Protein IpaB and Its Chaperone IpgC
Published in:Biochemistry
Publication date:2012-05-15
IpaC from Shigella and SipC from Salmonella possess similar biochemical properties but are functionally distinct
Published in:Molecular Microbiology
Publication date:2001-10-01
The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells
Published in:Microbial Pathogenesis
Publication date:2008-10-01
N-Terminus of IpaB Provides a Potential Anchor to the Shigella Type III Secretion System Tip Complex Protein IpaD
Published in:Biochemistry
Publication date:2013-12-10
Characterization of the Interaction of Single Tryptophan Containing Mutants of IpaC from Shigella flexneri with Phospholipid Membranes †
Published in:Biochemistry
Publication date:2006-01-01
Deletion in the Shigella Enterotoxin Genes Further Attenuates Shigella flexneri 2a Bearing Guanine Auxotrophy in a Phase 1 Trial of CVD 1204 and C...
Published in:The Journal of Infectious Diseases
Publication date:2004-11-15
Visualization of the type III secretion sorting platform of Shigella flexneri
Published in:Proceedings of the National Academy of Sciences
Publication date:2015-01-12
Protein-protein interactions in the assembly of Shigella flexneri invasion plasmid antigens IpaB and IpaC into protein complexes
Published in:Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
Publication date:1998-12-01
Förster Resonance Energy Transfer (FRET) as a Tool for Dissecting the Molecular Mechanisms for Maturation of the Shigella Type III Secretion Needle...
Published in:International Journal of Molecular Sciences
Publication date:2012-11-16
Structural Analysis of Invasion Plasmid Antigen D (Ipad) from Shigella flexneri
Published in:Biochemical and Biophysical Research Communications
Publication date:1995-09-01
SeMet substituted Shigella Flexneri Ipad
Published in:Not available
Publication date:2006-11-30
Cholera Toxin
Published in:Wiley Encyclopedia of Molecular Medicine
Publication date:2002-01-15
Experimental salmonellosis challenge model in older calves
Published in:Veterinary Microbiology
Publication date:2014-05-01
Deoxycholate Interacts with IpaD of Shigella flexneri in Inducing the Recruitment of IpaB to the Type III Secretion Apparatus Needle Tip
Published in:Journal of Biological Chemistry
Publication date:2008-05-01
The Needle Component of the Type III Secreton of Shigella Regulates the Activity of the Secretion Apparatus
Published in:Journal of Biological Chemistry
Publication date:2005-10-14
Structure-Function Analysis of Invasion Plasmid Antigen C (IpaC) from Shigella flexneri
Published in:Journal of Biological Chemistry
Publication date:2002-11-08
Production of IFN- and IL-10 to Shigella Invasins by Mononuclear Cells from Volunteers Orally Inoculated with a Shiga Toxin-Deleted Shigella dysen...
Published in:The Journal of Immunology
Publication date:2000-02-15
pH sensitivity of type III secretion system tip proteins
Published in:Proteins Structure Function and Bioinformatics
Publication date:2008-01-03
The response of type three secretion system needle proteins MxiHΔ5, BsaLΔ5, and PrgIΔ5 to temperature and pH
Published in:Proteins Structure Function and Bioinformatics
Publication date:2008-05-19
Cloning, Expression, and Affinity Purification of RecombinantShigella flexneriInvasion Plasmid Antigens IpaB and IpaC
Published in:Protein Expression and Purification
Publication date:1996-12-01
The Effect of Fiber Truncations on the Stability of Adenovirus Type 5
Published in:Molecular Biotechnology
Publication date:2014-07-01
Fluorescence characterization of the environment encountered by nascent polyalanine and polyserine as they exit Escherichia coli ribosomes during t...
Published in:Biochemistry
Publication date:1992-03-01
In Vitro Assembly of Novel Cholera Toxin-like Complexes
Published in:Analytical Biochemistry
Publication date:2001-05-01
The Use of Fluorescence Resonance Energy Transfer to Detect Conformational Changes in Protein Toxins
Published in:Bacterial Toxins
Publication date:Not available
Cholera Toxin Conformational Changes Associated with Changes in Membrane Structure
Published in:Membrane Structure in Disease and Drug Therapy
Publication date:2000-05-10
Fluorescence analysis of the interaction between ganglioside GM1-containing phospholipid vesicles and the B subunit of cholera toxin
Published in:Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
Publication date:1995-02-01
Formulation and Immunogenicity Studies of Type III Secretion System Needle Antigens as Vaccine Candidates
Published in:Journal of Pharmaceutical Sciences
Publication date:2010-11-01
Formulation and Immunogenicity of a Potential Multivalent Type III Secretion System-Based Protein Vaccine
Published in:Journal of Pharmaceutical Sciences
Publication date:2010-11-01
Purification and Characterization of Two Active Derivatives of Recombinant YplA, a Secreted Phospholipase from Yersinia entercolitica
Published in:Biochemical and Biophysical Research Communications
Publication date:2002-03-01
A synthetic alanyl-initiator tRNA with initiator tRNA properties as determined by flourescence measurements: comparison to a synthetic alanyl-elong...
Published in:Nucleic Acids Research
Publication date:1991-01-01
Evidence for RNA in the peptidyl transferase center of Escherichia coli ribosomes as indicated by fluorescence
Published in:Biochemistry
Publication date:1992-12-01
Movement of tRNA but not the nascent peptide during peptide bond formation on ribosomes
Published in:Biochemistry
Publication date:1990-12-01
The synthesis of polyphenylalanine on ribosomes to which erythromycin is bound
Published in:European Journal of Biochemistry
Publication date:1991-06-01
Fluorescence Analysis of Galactose, Lactose, and Fucose Interaction with the Cholera Toxin B Subunit
Published in:Biochemical and Biophysical Research Communications
Publication date:1996-09-01
Localization of the Binding Site for Modified Gb 3 on Verotoxin 1 Using Fluorescence Analysis †
Published in:Biochemistry
Publication date:1999-06-01
Evaluating Burkholderia pseudomallei Bip proteins as vaccines and Bip antibodies as detection agents
Published in:FEMS Immunology & Medical Microbiology
Publication date:2008-01-01
Eukaryotic protein synthesis initiation factor 2. A target for inactivation by proanthocyanidin
Published in:European Journal of Biochemistry
Publication date:1991-05-01
The extension of polyphenylalanine and polylysine peptides on Escherichia coli ribosomes
Published in:Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Publication date:1990-08-01
Destabilization of phospholipid model membranes by YplA, a phospholipase A2 secreted by Yersinia enterocolitica
Published in:Chemistry and Physics of Lipids
Publication date:2004-09-01
Conformational Changes in Cholera Toxin B Subunit−Ganglioside GM1 Complexes Are Elicited by Environmental pH and Evoke Changes in Membrane Structu...
Published in:Biochemistry
Publication date:1997-07-01
A Systematic Approach Toward Stabilization of CagL, a Protein Antigen from Helicobacter Pylori That is a Candidate Subunit Vaccine
Published in:Journal of Pharmaceutical Sciences
Publication date:2013-08-01
Fluorescence studies on the interaction of inhibitor 2 and okadaic acid with the catalytic subunit of type 1 phosphoprotein phosphatases
Published in:Biochemistry
Publication date:1991-10-01
Biophysical Characterization of the Type III Secretion System Translocator Proteins and the Translocator Proteins Attached to Bacterium-Like Particles
Published in:Journal of Pharmaceutical Sciences
Publication date:2015-12-01