All Stories

  1. The Protective Effect of Edaravone on TDP-43 Plus Oxidative Stress-Induced Neurotoxicity in Neuronal Cells: Analysis of Its Neuroprotective Mechanisms Using RNA Sequencing

    Article • Pharmaceuticals, July 2022, MDPI AG

    Professor Kazuhiko Watabe

  2. Praja1 RING‐finger E3 ubiquitin ligase is a common suppressor of neurodegenerative disease‐associated protein aggregation

    Article • Neuropathology, June 2022, Wiley

    Professor Kazuhiko Watabe

  3. Praja1 RING ‐finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP ‐43 aggregate formation

    Article • Neuropathology, July 2020, Wiley

    Professor Kazuhiko Watabe

  4. A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism

    Article • Journal of Neurochemistry, January 2018, Wiley

    Professor Soroku Yagihashi, Professor Kazuhiko Watabe

  5. Myelinating cocultures of rodent stem cell line-derived neurons and immortalized Schwann cells

    Article • Neuropathology, July 2017, Wiley

    Professor Kazuhiko Watabe

  6. Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging

    Article • PLoS ONE, June 2017, PLOS

    Professor Kazuhiko Watabe

  7. Quantitative analysis of the features of fasciculation potentials and their relation with muscle strength in amyotrophic lateral sclerosis

    Article • Neurological Sciences, August 2016, Springer Science + Business Media

    Professor Kazuhiko Watabe

  8. Predictive factors for prognosis following unsedated percutaneous endoscopic gastrostomy in ALS patients

    Article • Muscle & Nerve, July 2016, Wiley

    Professor Kazuhiko Watabe, Kota Bokuda

  9. Involvement of oxidative stress and impaired lysosomal degradation in amiodarone-induced schwannopathy

    Article • European Journal of Neuroscience, June 2016, Wiley

    Professor Kazuhiko Watabe

  10. Predictors of impaired communication in amyotrophic lateral sclerosis patients with tracheostomy-invasive ventilation

    Article • Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, June 2015, Informa Healthcare

    Professor Kazuhiko Watabe

  11. Schwann cells contribute to neurodegeneration in transthyretin amyloidosis

    Article • Journal of Neurochemistry, March 2015, Wiley

    Professor Kazuhiko Watabe

  12. Upregulation of galectin-3 in immortalized Schwann cells IFRS1 under diabetic conditions

    Article • Neuroscience Research, March 2015, Elsevier

    Professor Kazuhiko Watabe

  13. A Japanese patient with familial ALS and a p.K510M mutation in the gene for FUS (FUS) resulting in the totally locked-in state

    Article • Neuropathology, May 2014, Wiley

    Professor Kazuhiko Watabe, Hideshi Kawakami

  14. Complex fasciculation potentials and survival in amyotrophic lateral sclerosis

    Article • Clinical Neurophysiology, May 2014, Elsevier

    Professor Kazuhiko Watabe

  15. Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils

    Article • Neuropathology, March 2014, Wiley

    Professor Kazuhiko Watabe, Umeo Ito Umeo

  16. Spontaneously Immortalized Adult Rodent Schwann Cells as Valuable Tools for the Study of Peripheral Nerve Degeneration and Regeneration

    Article • January 2014, Springer Science + Business Media

    Professor Kazuhiko Watabe

  17. Adenoviral expression of TDP-43 and FUS genes and shRNAs for protein degradation pathways in rodent motoneurons in vitro and in vivo

    Article • Neuropathology, August 2013, Wiley

    Professor Kazuhiko Watabe

  18. Axon Guidance of Sympathetic Neurons to Cardiomyocytes by Glial Cell Line-Derived Neurotrophic Factor (GDNF)

    Article • PLoS ONE, July 2013, PLOS

    Professor Kazuhiko Watabe

  19. GDNF promotes neurite outgrowth and upregulates galectin-1 through the RET/PI3K signaling in cultured adult rat dorsal root ganglion neurons

    Article • Neurochemistry International, February 2013, Elsevier

    Professor Kazuhiko Watabe

  20. Astrocytic Involvement in the Maturation Phenomenon After Temporary Cerebral Ischemia

    Article • January 2013, Springer Science + Business Media

    Professor Kazuhiko Watabe

  21. Sympathetic Innervation Induced in Engrafted Engineered Cardiomyocyte Sheets by Glial Cell Line Derived Neurotrophic FactorIn Vivo

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Professor Kazuhiko Watabe

  22. Immortalized adult rodent Schwann cells as useful tools for the study of peripheral nerve regeneration

    Article • Rinsho Shinkeigaku, January 2013, Societas Neurologica Japonica

    Professor Kazuhiko Watabe

  23. Galectin-1 as a Multifunctional Molecule in the Peripheral Nervous System After Injury

    Article • March 2012, IntechOpen

    Professor Kazuhiko Watabe

  24. Myelination in coculture of established neuronal and Schwann cell lines

    Article • Histochemistry and Cell Biology, February 2012, Springer Science + Business Media

    Professor Kazuhiko Watabe

  25. Myelination in cocultures of established neuronal and Schwann cell lines

    Article • Neuroscience Research, September 2011, Elsevier

    Professor Kazuhiko Watabe

  26. Reevaluation of transthyretin gene expression in the peripheral nervous system

    Article • Neuroscience Research, September 2011, Elsevier

    Professor Kazuhiko Watabe

  27. Metallothionein-III prevents neuronal death and prolongs life span in amyotrophic lateral sclerosis model mice

    Article • Neuroscience, August 2011, Elsevier

    Professor Kazuhiko Watabe

  28. A morphometric study of the vagus nerve in amyotropic lateral sclerosis with circulatory collapse

    Article • Amyotrophic Lateral Sclerosis, March 2011, Taylor & Francis

    Professor Kazuhiko Watabe

  29. Spontaneously immortalized Schwann cells from adult Fischer rat as a valuable tool for exploring neuron-Schwann cell interactions

    Article • Journal of Neuroscience Research, March 2011, Wiley

    Professor Kazuhiko Watabe

  30. Morphological changes of Golgi apparatus in adult rats after facial nerve injuries

    Article • Neuropathology, January 2011, Wiley

    Professor Kazuhiko Watabe

  31. Immortalized Adult Rodent Schwann Cells as In Vitro Models to Study Diabetic Neuropathy

    Article • Experimental Diabetes Research, January 2011, Hindawi Publishing Corporation

    Professor Kazuhiko Watabe

  32. Hyperosmolar hyperglycemic state in advanced amyotrophic lateral sclerosis

    Article • Amyotrophic Lateral Sclerosis, December 2010, Taylor & Francis

    Professor Kazuhiko Watabe

  33. Presenilin-1 holoprotein is an interacting partner of sarco endoplasmic reticulum calcium-ATPase and confers resistance to endoplasmic reticulum stress

    Article • Alzheimer s & Dementia, July 2010, Elsevier

    Professor Kazuhiko Watabe

  34. Presenilin-1 Holoprotein is an Interacting Partner of Sarco Endoplasmic Reticulum Calcium-ATPase and Confers Resistance to Endoplasmic Reticulum Stress

    Article • Journal of Alzheimer s Disease, March 2010, IOS Press

    Professor Kazuhiko Watabe

  35. Adenoviral expression of TDP-43 and FUS genes in adult rat motoneurons in vivo

    Article • Neuroscience Research, January 2010, Elsevier

    Professor Kazuhiko Watabe

  36. Spontaneously immortalized adult Fischer rat Schwann cells IFRS1 as a valuable tool for exploring neuron–Schwann cell interactions

    Article • Neuroscience Research, January 2010, Elsevier

    Professor Kazuhiko Watabe

  37. Effects of Schwann cell alignment along the oriented electrospun chitosan nanofibers on nerve regeneration

    Article • Journal of Biomedical Materials Research Part A, December 2009, Wiley

    Professor Kazuhiko Watabe

  38. Establishment of an Improved Mouse Model for Infantile Neuroaxonal Dystrophy That Shows Early Disease Onset and Bears a Point Mutation in Pla2g6

    Article • American Journal Of Pathology, December 2009, Elsevier

    Professor Kazuhiko Watabe

  39. Mice deficient in alivin1/amigo2 show enhanced locomotor activity

    Article • Neuroscience Research, January 2009, Elsevier

    Professor Kazuhiko Watabe

  40. Differential Effects of High Glucose and Methylglyoxal on Viability and Polyol Metabolism in Immortalized Adult Mouse Schwann Cells

    Article • The Open Diabetes Journal, December 2008, Bentham Science Publishers

    Professor Kazuhiko Watabe

  41. Spinal anterior horn cells in sporadic amyotrophic lateral sclerosis show ribosomal detachment from, and cisternal distention of the rough endoplasmic reticulum

    Article • Neuropathology and Applied Neurobiology, December 2008, Wiley

    Professor Kazuhiko Watabe

  42. Neuroprotective effect of sonic hedgehog up-regulated in Schwann cells following sciatic nerve injury

    Article • Journal of Neurochemistry, October 2008, Wiley

    Professor Kazuhiko Watabe

  43. Establishment and characterization of immortalized Schwann cells from murine model of Niemann-Pick disease type C (spm/spm)

    Article • Journal of the Peripheral Nervous System, July 2008, Wiley

    Professor Kazuhiko Watabe

  44. Relationship between ribosomal RNA gene transcription activity and motoneuron death: Observations of avulsion and axotomy of the facial nerve in rats

    Article • Journal of Neuroscience Research, January 2008, Wiley

    Professor Kazuhiko Watabe

  45. Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant α-galactosidase

    Article • Journal of Human Genetics, October 2007, Springer Science + Business Media

    Professor Kazuhiko Watabe

  46. Enhanced Lysosomal Pathology Caused by β-Synuclein Mutants Linked to Dementia with Lewy Bodies

    Article • Journal of Biological Chemistry, July 2007, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Kazuhiko Watabe

  47. A Novel Drug Therapy for Recurrent Laryngeal Nerve Injury Using T-588

    Article • The Laryngoscope, July 2007, Wiley

    Professor Kazuhiko Watabe

  48. Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells

    Article • Biochemical and Biophysical Research Communications, May 2007, Elsevier

    Professor Kazuhiko Watabe

  49. Hepatoma-derived growth factor, a new trophic factor for motor neurons, is up-regulated in the spinal cord of PQBP-1 transgenic mice before onset of degeneration

    Article • Journal of Neurochemistry, October 2006, Wiley

    Professor Kazuhiko Watabe

  50. Adenoviral gene transfer of hepatocyte growth factor prevents death of injured adult motoneurons after peripheral nerve avulsion

    Article • Brain Research, September 2006, Elsevier

    Professor Kazuhiko Watabe

  51. High glucose-induced activation of the polyol pathway and changes of gene expression profiles in immortalized adult mouse Schwann cells IMS32

    Article • Journal of Neurochemistry, July 2006, Wiley

    Professor Kazuhiko Watabe

  52. Sox10 regulates ciliary neurotrophic factor gene expression in Schwann cells

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Professor Kazuhiko Watabe

  53. Corrective effect on Fabry mice of yeast recombinant human α-galactosidase with N-linked sugar chains suitable for lysosomal delivery

    Article • Journal of Human Genetics, March 2006, Springer Science + Business Media

    Professor Kazuhiko Watabe

  54. Adenoviral gene transfer of BDNF and GDNF synergistically prevent motoneuron loss in the nucleus ambiguus

    Article • Brain Research, March 2006, Elsevier

    Professor Kazuhiko Watabe

  55. Growth inhibitory factor (GIF) can protect from brain damage due to stab wounds in rat brain

    Article • Neuroscience Letters, March 2006, Elsevier

    Professor Kazuhiko Watabe

  56. Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population

    Article • Amyotrophic Lateral Sclerosis, January 2006, Taylor & Francis

    Professor Kazuhiko Watabe

  57. Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration

    Article • Neuropathology, December 2005, Wiley

    Professor Kazuhiko Watabe

  58. Adenoviral GDNF gene transfer enhances neurofunctional recovery after recurrent laryngeal nerve injury

    Article • Gene Therapy, October 2005, Nature

    Professor Kazuhiko Watabe

  59. Establishment of immortalized Schwann cells from Sandhoff mice and corrective effect of recombinant human β-hexosaminidase A on the accumulated GM2 ganglioside

    Article • Journal of Human Genetics, September 2005, Springer Science + Business Media

    Professor Kazuhiko Watabe

  60. GALC transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo

    Article • Molecular Genetics and Metabolism, April 2005, Elsevier

    Professor Kazuhiko Watabe

  61. Widespread and highly persistent gene transfer to the CNS by retrovirus vectorin utero: implication for gene therapy to Krabbe disease

    Article • The Journal of Gene Medicine, January 2005, Wiley

    Professor Kazuhiko Watabe

  62. Motoneuron degeneration after facial nerve avulsion is exacerbated in presymptomatic transgenic rats expressing human mutant Cu/Zn superoxide dismutase

    Article • Journal of Neuroscience Research, January 2005, Wiley

    Professor Kazuhiko Watabe

  63. Distinctive expression of midkine in the repair period of rat brain during neurogenesis: Immunohistochemical and immunoelectron microscopic observations

    Article • Journal of Neuroscience Research, March 2004, Wiley

    Professor Kazuhiko Watabe

  64. Postischemic administration of Sendai virus vector carrying neurotrophic factor genes prevents delayed neuronal death in gerbils

    Article • Gene Therapy, February 2004, Nature

    Professor Kazuhiko Watabe

  65. Synthesis, localization and externalization of galectin-1 in mature dorsal root ganglion neurons and Schwann cells

    Article • European Journal of Neuroscience, January 2004, Wiley

    Professor Kazuhiko Watabe

  66. Growth inhibitory factor prevents degeneration of injured adult rat motoneurons

    Article • Neuroreport, December 2003, Wolters Kluwer Health

    Professor Kazuhiko Watabe

  67. Oral administration of a neuroprotective compound T‐588 prevents motoneuron degeneration after facial nerve avulsion in adult rats

    Article • Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, June 2003, Taylor & Francis

    Professor Kazuhiko Watabe

  68. Oral administration of a neuroprotective compound T-588 prevents motoneuron degeneration after facial nerve avulsion in adult rats

    Article • June 2003, Taylor & Francis

    Professor Kazuhiko Watabe

  69. Adenoviral gene transfer of GDNF, BDNF and TGF?2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion

    Article • Journal of Neuroscience Research, March 2003, Wiley

    Professor Kazuhiko Watabe

  70. Tissue culture methods to study neurological disorders: Establishment of immortalized Schwann cells from murine disease models

    Article • Neuropathology, March 2003, Wiley

    Professor Kazuhiko Watabe

  71. Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils

    Article • Gene Therapy, March 2003, Nature

    Professor Kazuhiko Watabe

  72. Adenoviral GDNF gene transfer prevents motoneuron loss in the nucleus ambiguus

    Article • Brain Research, February 2003, Elsevier

    Professor Kazuhiko Watabe

  73. Sendai Virus Vector-mediated Gene Transfer of Glial Cell Line-Derived Neurotrophic Factor Prevents Delayed Neuronal Death after Transient Global Ischemia in Gerbils.

    Article • Experimental Animals, January 2003, Japanese Association for Laboratory Animal Science

    Professor Kazuhiko Watabe

  74. Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients

    Article • Brain, January 2003, Oxford University Press (OUP)

    Dr Osamu Onodera, Professor Kazuhiko Watabe

  75. Establishment and characterization of spontaneously immortalized Schwann cells from murine model of globoid cell leukodystrophy (twitcher)

    Article • Journal of Neuroscience Research, May 2002, Wiley

    Professor Kazuhiko Watabe

  76. Lysosomal storage results in impaired survival but normal neurite outgrowth in dorsal root ganglion neurones from a mouse model of Sandhoff disease

    Article • Neuropathology and Applied Neurobiology, February 2002, Wiley

    Professor Kazuhiko Watabe

  77. 反回神経麻ひの遺伝子治療

    Article • Nihon Kikan Shokudoka Gakkai Kaiho, January 2002, Japan Broncho-Esophagological Society

    Professor Kazuhiko Watabe

  78. Inhibition of Ras extracellular-signal-regulated kinase (ERK) mediated signaling promotes ciliary neurotrophic factor (CNTF) expression in Schwann cells

    Article • Journal of Neurochemistry, December 2001, Wiley

    Professor Kazuhiko Watabe

  79. Intraventricular administration of recombinant adenovirus to neonatal twitcher mouse leads to clinicopathological improvements

    Article • Gene Therapy, July 2001, Nature

    Professor Kazuhiko Watabe

  80. Skeletal muscle regeneration after insulin-like growth factor I gene transfer by recombinant Sendai virus vector

    Article • Gene Therapy, July 2001, Nature

    Professor Kazuhiko Watabe

  81. Establishment and characterization of immortalized Schwann cells from murine model of Niemann-Pick disease type C (spm/spm)

    Article • Journal of the Peripheral Nervous System, June 2001, Wiley

    Professor Kazuhiko Watabe

  82. Rescue of ischemic brain injury by adenoviral gene transfer of glial cell line-derived neurotrophic factor after transient global ischemia in gerbils

    Article • Brain Research, December 2000, Elsevier

    Professor Kazuhiko Watabe

  83. Adenoviral vector-mediated GDNF gene transfer prevents death of adult facial motoneurons

    Article • Neuroreport, June 2000, Wolters Kluwer Health

    Professor Kazuhiko Watabe

  84. Immunohistochemical localization of substance P receptors in the midline glia of the developing rat medulla oblongata with special reference to the formation of raphe nuclei

    Article • Developmental Brain Research, June 2000, Elsevier

    Professor Kazuhiko Watabe

  85. Adenovirus-Mediated Transduction with Human Glial Cell Line-Derived Neurotrophic Factor Gene Prevents 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Dopamine Depletion in Striatum of Mouse Brain

    Article • Biochemical and Biophysical Research Communications, September 1997, Elsevier

    Professor Kazuhiko Watabe

  86. A Case of Renal Amyloidosis Associated with Hepatic Adenoma: The Pathogenetic Role of Tumor Necrosis Factor-α

    Article • Nephron, January 1997, Karger Publishers

    Professor Kazuhiko Watabe

  87. Effects of bromocriptine and/orl-DOPA on neurons in substantia nigra of MPTP-treated C57BL/6 mice

    Article • Brain Research, July 1996, Elsevier

    Professor Kazuhiko Watabe

  88. Effects of bromocriptine and/or ?-DOPA on neurons in substantia nigra of MPTP-treated C57BL/6 mice

    Article • Brain Research, July 1996, Elsevier

    Professor Kazuhiko Watabe

  89. Gene therapy for metachromatic leukodystrophy

    Article • Pediatrics International, April 1996, Wiley

    Professor Kazuhiko Watabe

  90. An autopsy case of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes(MELAS) undergoing long-term hemodialysis.

    Article • Nihon Toseki Igakkai Zasshi, January 1996, Japanese Society for Dialysis Therapy

    Professor Kazuhiko Watabe

  91. Spontaneously immortalized adult mouse Schwann cells secrete autocrine and paracrine growth-promoting activities

    Article • Journal of Neuroscience Research, June 1995, Wiley

    Professor Kazuhiko Watabe

  92. Mitogenic effects of platelet-derived growth factor, fibroblast growth factor, transforming growth factor-?, and heparin-binding serum factor for adult mouse Schwann cells

    Article • Journal of Neuroscience Research, December 1994, Wiley

    Professor Kazuhiko Watabe

  93. Pathological and biochemical studies of fetal Krabbe disease

    Article • Brain and Development, November 1994, Elsevier

    Professor Kazuhiko Watabe

  94. Immunohistochemistry of neuronal inclusions in the cerebral cortex and brain-stem in Lewy body disease

    Article • Pathology International, October 1993, Wiley

    Professor Kazuhiko Watabe

  95. Increased Susceptibility of Human Fetal Astrocytes to Human T-Lymphotropic Virus Type I in Culture

    Article • Journal of Neuropathology & Experimental Neurology, March 1991, Oxford University Press (OUP)

    Professor Kazuhiko Watabe

  96. Transfection and Stable Transformation of Adult Mouse Schwann Cells with SV-40 Large T Antigen Gene

    Article • Journal of Neuropathology & Experimental Neurology, September 1990, Oxford University Press (OUP)

    Professor Kazuhiko Watabe

  97. Transplantation of human sympathetic neurons and adrenal chromaffin cells into parkinsonian monkeys: no reversal of clinical symptoms

    Article • Journal of the Neurological Sciences, December 1989, Elsevier

    Professor Kazuhiko Watabe

  98. Human and Simian Glial Cells Infected by Human T-Lymphotropic Virus Type I in Culture

    Article • Journal of Neuropathology & Experimental Neurology, November 1989, Oxford University Press (OUP)

    Professor Kazuhiko Watabe

  99. Phagocytic Activity of Human Adult Astrocytes and Oligodendrocytes in Culture

    Article • Journal of Neuropathology & Experimental Neurology, September 1989, Oxford University Press (OUP)

    Professor Kazuhiko Watabe

  100. Developmental microvascular architecture of the rat cerebellar cortex

    Article • Referate und Beiträge zur Anatomie und Entwickelungsgeschichte, February 1985, Springer Science + Business Media

    Professor Kazuhiko Watabe

  101. Immunohistochemical study on neuroglia identified by the monoclonal antibody against a macrophage differentiation antigen (mac-1)

    Article • Journal of Neuroimmunology, January 1985, Elsevier

    Professor Kazuhiko Watabe

  102. An immunohistochemical study of aldolase C in normal and neoplastic nervous tissues

    Article • Acta Neuropathologica, January 1985, Springer Science + Business Media

    Professor Kazuhiko Watabe

  103. Glial fibrillary acidic protein in medulloblastomas

    Article • Acta Neuropathologica, January 1985, Springer Science + Business Media

    Professor Kazuhiko Watabe

  104. Tactile-like corpuscles in neurofibromas: Immunohistochemical demonstration of S-100 protein

    Article • Acta Neuropathologica, January 1983, Springer Science + Business Media

    Professor Kazuhiko Watabe