Current affiliation: University of SussexSubject speciality: Life SciencesPrimary location: United Kingdom
Published in:Molecular and Cellular BiologyPublication date:2004-12-15
This paper describes the components of the Smc5/6 complex: these are two large coiled coil protein - Smc5 and Smc6, as well as some smaller non-Smc...
This paper describes the biochemical role of a protein Nse2. The protein is required for the attachment of a small protein modifier (SUMO) to Smc5,...
Published in:PLoS ONEPublication date:2014-05-12
eIF4G has a key role in the initiation of proein synthesis. It acts as a scaffold protein and interacts with a number of other key initiation facto...
Published in:Biochemical JournalPublication date:2005-07-15
Nedd8 is a small protein modifier that can be covalently attached to proteins in a manner similar to that of ubiquitin and SUMO. We identified this...
Published in:GenePublication date:1990-10-01
Published in:Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisPublication date:1997-09-01
Published in:PLoS ONEPublication date:2009-08-25
Published in:PLoS ONEPublication date:2010-09-27
This protein has two SUMO-like domains and interacts with the Smc5/6 complex. It is required or theDNA damage response. This paper describes a char...
Published in:Journal of Biological ChemistryPublication date:1996-07-19
Published in:Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisPublication date:1991-09-01
Published in:Cell Motility and the CytoskeletonPublication date:1997-01-01
Published in:Biochemical Society TransactionsPublication date:2007-12-01
Published in:YeastPublication date:1992-11-01
Published in:Biochemical JournalPublication date:2003-05-15
Published in:Nucleic Acids ResearchPublication date:1998-12-01
Published in:Nucleic Acids ResearchPublication date:1991-01-01
Published in:Nucleic Acids ResearchPublication date:1990-08-11
Published in:Nucleic Acids ResearchPublication date:1995-01-01
Published in:Not availablePublication date:1991-01-01
Published in:ChromosomaPublication date:2009-09-12
S. pombe rad4 is an essential gene required for response to DNA damage. It has a number of roles, including in DNA replication, for which it is ess...
Published in:Nucleic Acids ResearchPublication date:1993-01-01
The S. pombe Rad8 gene encodes a large protein, that has subsequently been demonstrated to be a ubiquitin E3 ligase. One of it key roles is in poly...
Published in:Nucleic Acids ResearchPublication date:1999-07-01
Published in:NaturePublication date:1985-07-04
This is the first identification of myosin in a single celled organism.
Published in:Molecular and Cell Biology of the Plant Cell CyclePublication date:1993-01-01
Published in:Genes & DevelopmentPublication date:2008-08-01
Crb2 is part of the signalling process in the DNA damage checkpoint. It is required to arrest the cell cycle to allow repair of DNA damage. Crb2 co...
Published in:Acta Crystallographica Section D Biological CrystallographyPublication date:2003-06-27
Published in:ChromosomaPublication date:2006-10-10
Published in:BioEssaysPublication date:2011-05-17
SUMO chains and sumoylated proteins suggest that heterogeneous and complex interactions lie at the centre of the synaptonemal complex
Published in:EMBO ReportsPublication date:2014-06-12
Published in:Biochemical GeneticsPublication date:2005-04-01
Published in:Seminars in Cell and Developmental BiologyPublication date:2004-04-01
Published in:ChromosomaPublication date:2013-06-28
What regulates the regulator?
SUMO is a small ubiquitin-like protein modifier that is covalently attached to other proteins. It can alter protein localisation, protein-protein i...
Published in:DNA RepairPublication date:2010-02-04
This review summarises what is known about the functions of interactions involving inter-BRCT linker regions.
Published in:DNA RepairPublication date:2006-03-01
PCNA is a key protein required for many aspects of DNA metabolism, includingDNA replication and repair. It acts as a molecular tool belt for the re...
Published in:Molecular Biology of the CellPublication date:2006-04-26
PCNA is a key protein in the nucleus. It acts as a molecular tool belt and as such interacts with a range of different proteins to facilitate a gai...
Published in:Molecular CellPublication date:2005-09-01
Published in:Nucleic Acids ResearchPublication date:2001-10-15
Published in:Nucleic Acids ResearchPublication date:1990-01-01
Published in:Nucleic Acids ResearchPublication date:1989-01-01
Published in:Plant Molecular BiologyPublication date:1992-01-01
Published in:Nucleic Acids ResearchPublication date:1997-03-15
Published in:Nucleic Acids ResearchPublication date:1997-06-01
The rhp9 gene (now called Crb2) is required for the G2/M DNA damage checkpoint. It is a signal transduction molecule required to signal the presenc...
Published in:Nucleic Acids ResearchPublication date:1992-01-01
Published in:Neuroscience LettersPublication date:1993-09-01
Published in:Plant Molecular BiologyPublication date:1994-10-01
Published in:TranslationPublication date:2014-01-01
Protein synthesis is a key process in all living cells. It is essential that it is regulated effectively, as unregulated protein synthesis can seri...
Published in:Cell ReportsPublication date:2015-12-01
Failure to correctly repair DNA damage has important consequences for cells, and can lead to the inheritance of mutations, cancer or cell death. 53...
Published in:Journal of Cell SciencePublication date:2016-05-09
Published in:Nature Structural & Molecular BiologyPublication date:2016-05-30
Published in:BiomoleculesPublication date:2016-12-16