All Stories

  1. Cytochrome P450S and Alcoholic Liver Disease

    Article • Current Pharmaceutical Design, July 2018, Bentham Science Publishers

    Dr Yongke Lu

  2. Alcoholic Liver Disease: from CYP2E1 to CYP2A5

    Article • Current Molecular Pharmacology, May 2017, Bentham Science Publishers

    Dr Yongke Lu

  3. Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis

    Article • Toxicology, March 2017, Elsevier

    Dr Yongke Lu

  4. Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity

    Article • Biomolecules, October 2015, MDPI AG

    Dr Yongke Lu

  5. Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice

    Article • Digestive and Liver Disease, June 2015, Elsevier

    Dr Yongke Lu

  6. Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implications in Alcohol-Induced Liver Injury

    Article • November 2014, Springer Science + Business Media

    Dr Yongke Lu

  7. Osteopontin binding to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice

    Article • Hepatology, March 2014, Wolters Kluwer Health

    Dr Yongke Lu

  8. Ethanol Plus the Jo2 Fas Agonistic Antibody-Induced Liver Injury is Attenuated in Mice with Partial Ablation of Argininosuccinate Synthase

    Article • Alcoholism Clinical and Experimental Research, November 2013, Wiley

    Dr Yongke Lu

  9. Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver

    Article • Alcohol, August 2013, Elsevier

    Dr Yongke Lu

  10. Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis

    Article • August 2012, Springer Science + Business Media

    Dr Yongke Lu

  11. Ethanol Induction of CYP2A5: Role of CYP2E1-ROS-Nrf2 Pathway

    Article • Toxicological Sciences, May 2012, Oxford University Press (OUP)

    Dr Yongke Lu

  12. Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice

    Article • Hepatology, April 2012, Wolters Kluwer Health

    Dr Yongke Lu

  13. Fibromodulin, an Oxidative Stress-Sensitive Proteoglycan, Regulates the Fibrogenic Response to Liver Injury in Mice

    Article • Gastroenterology, March 2012, Elsevier

    Dr Yongke Lu

  14. Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin αVβ3 engagement and PI3K/pAkt/NFκB signaling

    Article • Hepatology, January 2012, Wiley

    Dr Yongke Lu

  15. Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress

    Article • AJP Gastrointestinal and Liver Physiology, November 2011, American Physiological Society

    Dr Yongke Lu

  16. Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice

    Article • Free Radical Biology and Medicine, November 2010, Elsevier

    Dr Yongke Lu

  17. Ethanol Induction of CYP2A5: Permissive Role for CYP2E1

    Article • Drug Metabolism and Disposition, November 2010, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Yongke Lu

  18. Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARα agonist AM580

    Article • Oncogene, May 2010, Springer Science + Business Media

    Dr Yongke Lu

  19. CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

    Article • Genes & Nutrition, October 2009, Springer Science + Business Media

    Dr Yongke Lu

  20. Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: Role of CYP2E1 and TNF-α and activation of JNK and P38 MAP kinase

    Article • Free Radical Biology and Medicine, September 2009, Elsevier

    Dr Yongke Lu

  21. Role of oxidative stress in alcohol-induced liver injury

    Article • Archives of Toxicology, May 2009, Springer Science + Business Media

    Dr Yongke Lu

  22. Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency

    Article • Toxicology, October 2008, Elsevier

    Dr Yongke Lu

  23. Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice

    Article • Hepatology, April 2008, Wiley

    Dr Yongke Lu

  24. CYP2E1 and oxidative liver injury by alcohol

    Article • Free Radical Biology and Medicine, March 2008, Elsevier

    Dr Yongke Lu

  25. The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: Modulation by ERK, ROS, glutathione, and thioredoxin

    Article • Free Radical Biology and Medicine, October 2007, Elsevier

    Dr Yongke Lu

  26. Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: Role of cytochrome P450 2E1 and 2A5

    Article • Hepatology, July 2006, Wiley

    Dr Yongke Lu

  27. Cisplatin-Induced Hepatotoxicity Is Enhanced by Elevated Expression of Cytochrome P450 2E1

    Article • Toxicological Sciences, February 2006, Oxford University Press (OUP)

    Dr Yongke Lu

  28. Alcohol Upregulation of CYP2A5: Role of Reactive Oxygen Species

    Article • Reactive Oxygen Species, January 2006, American Innovative Medical Sciences and Technologies (AIMSCI) Inc.

    Dr Yongke Lu

  29. Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole

    Article • AJP Gastrointestinal and Liver Physiology, August 2005, American Physiological Society

    Dr Yongke Lu

  30. Cisplatin-Induced Cytotoxicity in BSO-Exposed Renal Proximal Tubular Epithelial Cells: Sex, Age, and Species

    Article • Renal Failure, January 2005, Taylor & Francis

    Dr Yongke Lu

  31. Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice

    Article • Hepatology, January 2005, Wiley

    Dr Yongke Lu

  32. Effects of BSO and L‐Cysteine on Drug‐Induced Cytotoxicity in Primary Cell Cultures: Drug‐, Cell Type‐, and Species‐Specific Difference

    Article • Drug and Chemical Toxicology, January 2004, Taylor & Francis

    Dr Yongke Lu