All Stories

  1. Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

    Article • Clinical Pharmacology & Therapeutics, September 2018, Wiley

    Mr Neil J Parrott

  2. Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib

    Article • The Journal of Clinical Pharmacology, July 2018, Wiley

    Mr Neil J Parrott

  3. Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development

    Article • Clinical Pharmacology & Therapeutics, December 2017, Wiley

    Mr Neil J Parrott, Dr Alex N Phipps

  4. The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

    Article • PROTEOMICS - CLINICAL APPLICATIONS, April 2015, Wiley

    Mr Neil J Parrott

  5. Evaluating a physiologically based pharmacokinetic model for prediction of omeprazole clearance and assessing ethnic sensitivity in CYP2C19 metabolic pathway

    Article • European Journal of Clinical Pharmacology, March 2015, Springer Science + Business Media

    Mr Neil J Parrott

  6. Role of Modeling and Simulation in Toxicology Prediction

    Article • September 2014, Wiley

    Mr Neil J Parrott

  7. Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

    Article • Pharmaceutical Research, July 2014, Springer Science + Business Media

    Mr Neil J Parrott

  8. Physiologically Based Absorption Modelling to Predict the Impact of Drug Properties on Pharmacokinetics of Bitopertin

    Article • The AAPS Journal, June 2014, American Association of Pharmaceutical Scientists (AAPS)

    Mr Neil J Parrott

  9. Applications of a 7-day Caco-2 cell model in drug discovery and development

    Article • European Journal of Pharmaceutical Sciences, June 2014, Elsevier

    Mr Neil J Parrott

  10. Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: Influence of time between substrate and inducer administration

    Article • European Journal of Pharmaceutical Sciences, June 2014, Elsevier

    Mr Neil J Parrott

  11. Pharmacokinetics of Paracetamol in Göttingen Minipigs: In Vivo Studies and Modeling to Elucidate Physiological Determinants of Absorption

    Article • Pharmaceutical Research, May 2014, Springer Science + Business Media

    Mr Neil J Parrott

  12. PBPK: IntegratingIn VitroandIn SilicoData in Physiologically Based Models

    Article • March 2014, Wiley

    Mr Neil J Parrott

  13. Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state

    Article • European Journal of Pharmaceutics and Biopharmaceutics, August 2013, Elsevier

    Mr Neil J Parrott

  14. In Vitro and Ex Vivo Investigation of the Impact of Luminal Lipid Phases on Passive Permeability of Lipophilic Small Molecules Using PAMPA

    Article • Pharmaceutical Research, July 2013, Springer Science + Business Media

    Mr Neil J Parrott

  15. Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin

    Article • Clinical Pharmacokinetics, April 2013, Springer Science + Business Media

    Mr Neil J Parrott

  16. In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

    Article • Molecular Pharmaceutics, April 2013, American Chemical Society (ACS)

    Mr Neil J Parrott

  17. A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation

    Article • Pharmaceutical Research, November 2012, Springer Science + Business Media

    Mr Neil J Parrott

  18. Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™

    Article • European Journal of Pharmaceutical Sciences, September 2012, Elsevier

    Mr Neil J Parrott

  19. Use of physiologically based pharmacokinetic modeling for assessment of drug–drug interactions

    Article • Future Medicinal Chemistry, April 2012, Future Science

    Mr Neil J Parrott

  20. Mass Spectrometry-Based Quantification of CYP Enzymes to Establish In Vitro/In Vivo Scaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

    Article • Pharmaceutical Research, February 2012, Springer Science + Business Media

    Mr Neil J Parrott

  21. Systems Toxicology Modeling for Prediction in Humans

    Article • September 2011, Wiley

    Mr Neil J Parrott

  22. Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

    Article • Clinical Pharmacokinetics, September 2011, Springer Science + Business Media

    Mr Neil J Parrott

  23. Applications of Physiologically Based Absorption Models in Drug Discovery and Development

    Article • Molecular Pharmaceutics, October 2008, American Chemical Society (ACS)

    Mr Neil J Parrott

  24. A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

    Article • Clinical Pharmacokinetics, January 2006, Springer Science + Business Media

    Mr Neil J Parrott

  25. Predicting Pharmacokinetic Food Effects Using Biorelevant Solubility Media and Physiologically Based Modelling

    Article • Clinical Pharmacokinetics, January 2006, Springer Science + Business Media

    Mr Neil J Parrott

  26. A strategy for preclinical formulation development using GastroPlus™ as pharmacokinetic simulation tool and a statistical screening design applied to a dog study

    Article • European Journal of Pharmaceutical Sciences, January 2006, Elsevier

    Mr Neil J Parrott

  27. An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery

    Article • Journal of Pharmaceutical Sciences, October 2005, Elsevier

    Mr Neil J Parrott

  28. Application of Full Physiological Models for Pharmaceutical Drug Candidate Selection and Extrapolation of Pharmacokinetics to Man

    Article • Basic & Clinical Pharmacology & Toxicology, March 2005, Wiley

    Mr Neil J Parrott

  29. Interspecies Scaling

    Article • January 2004, Springer Science + Business Media

    Mr Neil J Parrott

  30. Prediction of intestinal absorption: comparative assessment of gastroplus™ and idea™

    Article • European Journal of Pharmaceutical Sciences, October 2002, Elsevier

    Mr Neil J Parrott

  31. A fast virtual screening filter for cytochrome P450 3A4 inhibition liability of compound libraries

    Article • Quantitative Structure-Activity Relationships, August 2002, Wiley

    Mr Neil J Parrott

  32. Physiologically Based Pharmacokinetic Models

    Article • Wiley

    Mr Neil J Parrott

  33. Putting it All Together

    Article • Wiley

    Mr Neil J Parrott