All Stories

  1. The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity

    Article • Diabetes, June 2021, American Diabetes Association

    Makoto Fukuda

  2. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition

    Article • Journal of Clinical Investigation, August 2019, American Society for Clinical Investigation

    Makoto Fukuda

  3. Luciferase Reporter Mice for In Vivo Monitoring and Ex Vivo Assessment of Hypothalamic Signaling of Socs3 Expression

    Article • Journal of the Endocrine Society, April 2019, Endocrine Society

    Makoto Fukuda

  4. Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions

    Article • Cell Reports, September 2016, Elsevier

    Makoto Fukuda

  5. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice

    Article • Scientific Reports, March 2016, Nature

    Makoto Fukuda

  6. The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice

    Article • Endocrinology, December 2015, Endocrine Society

    Makoto Fukuda

  7. Estrogens Prevent Metabolic Dysfunctions Induced by Circadian Disruptions in Female Mice

    Article • Endocrinology, June 2015, Endocrine Society

    Makoto Fukuda

  8. Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice

    Article • British Journal of Pharmacology, May 2015, Wiley

    Makoto Fukuda

  9. Neuroanatomy and transgenic technologies

    Article • Frontiers in Neuroanatomy, January 2015, Frontiers

    Makoto Fukuda, Michael Lazarus

  10. Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

    Article • Cell Metabolism, September 2014, Elsevier

    Makoto Fukuda

  11. Galanin-Like Peptide (GALP) Neurone-Specific Phosphoinositide 3-Kinase Signalling Regulates GALP mRNA Levels in the Hypothalamus of Males and Luteinising Hormone Levels in Both Sexes

    Article • Journal of Neuroendocrinology, June 2014, Wiley

    Makoto Fukuda, Maricedes Acosta

  12. Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

    Article • Nature Communications, May 2014, Nature

    Makoto Fukuda

  13. Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice

    Article • Diabetologia, March 2014, Springer Science + Business Media

    Makoto Fukuda

  14. Central GLP-2 Enhances Hepatic Insulin Sensitivity via Activating PI3K Signaling in POMC Neurons

    Article • Cell Metabolism, July 2013, Elsevier

    Makoto Fukuda

  15. Central nervous control of energy and glucose balance: focus on the central melanocortin system

    Article • Annals of the New York Academy of Sciences, December 2011, Wiley

    Makoto Fukuda

  16. Induction of Leptin Resistance by Activation of cAMP-Epac Signaling

    Article • Cell Metabolism, March 2011, Elsevier

    Makoto Fukuda

  17. Leptin Induces Phosphorylation of Neuronal Nitric Oxide Synthase in Defined Hypothalamic Neurons

    Article • Endocrinology, November 2010, Endocrine Society

    Makoto Fukuda

  18. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver

    Article • Nature Neuroscience, October 2010, Nature

    Makoto Fukuda

  19. PI3K Signaling in the Ventromedial Hypothalamic Nucleus Is Required for Normal Energy Homeostasis

    Article • Cell Metabolism, July 2010, Elsevier

    Makoto Fukuda

  20. SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

    Article • Cell Metabolism, July 2010, Elsevier

    Makoto Fukuda

  21. Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

    Article • Cell Metabolism, April 2010, Elsevier

    Makoto Fukuda

  22. Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

    Article • Endocrinology, November 2009, Endocrine Society

    Makoto Fukuda

  23. Monitoring FoxO1 Localization in Chemically Identified Neurons

    Article • Journal of Neuroscience, December 2008, Society for Neuroscience

    Makoto Fukuda

  24. Identification of a DAF-16 Transcriptional Target Gene, scl-1, that Regulates Longevity and Stress Resistance in Caenorhabditis elegans

    Article • Current Biology, March 2003, Elsevier

    Makoto Fukuda

  25. The GTPase Ran Regulates Chromosome Positioning and Nuclear Envelope Assembly In Vivo

    Article • Current Biology, March 2002, Elsevier

    Makoto Fukuda

  26. Evidence for Existence of a Nuclear Pore Complex-mediated, Cytosol-independent Pathway of Nuclear Translocation of ERK MAP Kinase in Permeabilized Cells

    Article • Journal of Biological Chemistry, September 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Makoto Fukuda

  27. Identification of a nuclear export signal in MKK6, an activator of the carp p38 mitogen-activated protein kinases

    Article • European Journal of Biochemistry, July 2000, Wiley

    Makoto Fukuda

  28. Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism

    Article • The Journal of Cell Biology, March 2000, Rockefeller University Press

    Makoto Fukuda

  29. Two co-existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer

    Article • The EMBO Journal, October 1999, Wiley

    Makoto Fukuda

  30. Phosphorylation of WAVE Downstream of Mitogen-activated Protein Kinase Signaling

    Article • Journal of Biological Chemistry, September 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Makoto Fukuda

  31. Involvement of CRM1, a nuclear export receptor, in mRNA export in mammalian cells and fission yeast

    Article • Genes to Cells, May 1999, Wiley

    Makoto Fukuda

  32. Control of the Cell Morphology and the S Phase Entry by Mitogen-activated Protein Kinase Kinase: A REGULATORY ROLE OF ITS N-TERMINAL REGION

    Article • Journal of Biological Chemistry, April 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Makoto Fukuda

  33. Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

    Article • The EMBO Journal, May 1998, Wiley

    Makoto Fukuda

  34. Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

    Article • The EMBO Journal, March 1998, Wiley

    Makoto Fukuda

  35. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

    Article • The EMBO Journal, February 1998, Wiley

    Makoto Fukuda

  36. A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade: ROLE OF NUCLEAR EXPORT SIGNAL OF MAP KINASE KINASE

    Article • Journal of Biological Chemistry, December 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Makoto Fukuda

  37. Article • Nature, November 1997, Nature

    Makoto Fukuda

  38. Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase

    Article • The EMBO Journal, April 1997, Wiley

    Makoto Fukuda

  39. Cytoplasmic Localization of Mitogen-activated Protein Kinase Kinase Directed by Its NH2-terminal, Leucine-rich Short Amino Acid Sequence, Which Acts as a Nuclear Export Signal

    Article • Journal of Biological Chemistry, August 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Makoto Fukuda