All Stories

  1. Unlocking P(V): Reagents for chiral phosphorothioate synthesis

    Article • Science, August 2018, American Association for the Advancement of Science

    Dr Martin D Eastgate

  2. On the design of complex drug candidate syntheses in the pharmaceutical industry

    Article • Nature Reviews Chemistry, February 2017, Nature

    Dr Martin D Eastgate

  3. A data-driven strategy for predicting greenness scores, rationally comparing synthetic routes and benchmarking PMI outcomes for the synthesis of molecules in the pharmaceutical industry

    Article • Green Chemistry, January 2017, Royal Society of Chemistry

    Dr Martin D Eastgate

  4. Decarboxylative Peptide Macrocyclization through Photoredox Catalysis

    Article • Angewandte Chemie International Edition, November 2016, Wiley

    Dr Martin D Eastgate

  5. Decarboxylative Peptide Macrocyclization through Photoredox Catalysis

    Article • Angewandte Chemie, November 2016, Wiley

    Dr Martin D Eastgate

  6. Pd-Catalyzed γ-C(sp3)–H Arylation of Free Amines Using a Transient Directing Group

    Article • Journal of the American Chemical Society, November 2016, American Chemical Society (ACS)

    Dr Martin D Eastgate

  7. Stereoselective Bulk Synthesis of CCR2 Antagonist BMS-741672: Assembly of an All-cis (S,R,R)-1,2,4-Triaminocyclohexane (TACH) Core via Sequential Heterogeneous Asymmetric Hydrogenations

    Article • Organic Process Research & Development, October 2016, American Chemical Society (ACS)

    Dr Martin D Eastgate

  8. Ligand-Promoted Meta -C–H Arylation of Anilines, Phenols, and Heterocycles

    Article • Journal of the American Chemical Society, July 2016, American Chemical Society (ACS)

    Dr Martin D Eastgate

  9. Development of a Safe and Robust Process for the Large-Scale Preparation of a Vinyl Bromide from a Ketone Using a (PhO) 3 P/Br 2 -Derived Reagent

    Article • Organic Process Research & Development, May 2016, American Chemical Society (ACS)

    Dr Martin D Eastgate

  10. Scalable and sustainable electrochemical allylic C–H oxidation

    Article • Nature, April 2016, Nature

    Dr Martin D Eastgate

  11. Synergistic Catalysis: Pd(II) Catalyzed Oxidation of 1,4-Dihydroquinones in the Pd(II) Catalyzed 1,4-Oxidation of Cyclic 1,3-Dienes

    Article • The Journal of Organic Chemistry, April 2016, American Chemical Society (ACS)

    Dr Martin D Eastgate

  12. Practical Ni-Catalyzed Aryl–Alkyl Cross-Coupling of Secondary Redox-Active Esters

    Article • Journal of the American Chemical Society, February 2016, American Chemical Society (ACS)

    Dr Martin D Eastgate

  13. Mono-Oxidation of Bidentate Bis-phosphines in Catalyst Activation: Kinetic and Mechanistic Studies of a Pd/Xantphos-Catalyzed C–H Functionalization

    Article • Journal of the American Chemical Society, October 2015, American Chemical Society (ACS)

    Dr Martin D Eastgate

  14. Ni-Catalyzed C–H Functionalization in the Formation of a Complex Heterocycle: Synthesis of the Potent JAK2 Inhibitor BMS-911543

    Article • The Journal of Organic Chemistry, June 2015, American Chemical Society (ACS)

    Dr Martin D Eastgate

  15. Development of a Diastereoselective Phosphorylation of a Complex Nucleoside via Dynamic Kinetic Resolution

    Article • The Journal of Organic Chemistry, May 2015, American Chemical Society (ACS)

    Dr Martin D Eastgate

  16. Mechanistic Insights into the Vanadium-Catalyzed Achmatowicz Rearrangement of Furfurol

    Article • The Journal of Organic Chemistry, February 2015, American Chemical Society (ACS)

    Dr Martin D Eastgate

  17. Ligand-Promotedortho-CH Amination with Pd Catalysts

    Article • Angewandte Chemie, January 2015, Wiley

    Dr Martin D Eastgate

  18. Ligand-Promotedortho-CH Amination with Pd Catalysts

    Article • Angewandte Chemie International Edition, January 2015, Wiley

    Dr Martin D Eastgate

  19. Current complexity: a tool for assessing the complexity of organic molecules

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Dr Martin D Eastgate

  20. Overcoming Electronics with Strategy

    Article • January 2015, Elsevier

    Dr Martin D Eastgate

  21. A Method for Heteroaromatic Nitration Demonstrating Remarkable Thermal Stability

    Article • Organic Process Research & Development, December 2014, American Chemical Society (ACS)

    Dr Martin D Eastgate

  22. Synthesis of the 6-Azaindole Containing HIV-1 Attachment Inhibitor Pro-Drug, BMS-663068

    Article • The Journal of Organic Chemistry, September 2014, American Chemical Society (ACS)

    Dr Martin D Eastgate

  23. Development of Efficient Processes for the Preparation of Di- tert -butyl Potassium Phosphate and Di- tert -butyl (Chloromethyl) Phosphate

    Article • Organic Process Research & Development, May 2014, American Chemical Society (ACS)

    Dr Martin D Eastgate

  24. Palau’chlor: A Practical and Reactive Chlorinating Reagent

    Article • Journal of the American Chemical Society, May 2014, American Chemical Society (ACS)

    Dr Martin D Eastgate

  25. Development of a Robust Process for the Preparation of High-Quality Dicyclopropylamine Hydrochloride

    Article • Organic Process Research & Development, April 2014, American Chemical Society (ACS)

    Dr Martin D Eastgate

  26. A Mild, Ferrocene-Catalyzed C–H Imidation of (Hetero)Arenes

    Article • Journal of the American Chemical Society, April 2014, American Chemical Society (ACS)

    Dr Martin D Eastgate

  27. Natural product synthesis in the age of scalability

    Article • Natural Product Reports, January 2014, Royal Society of Chemistry

    Dr Martin D Eastgate

  28. The Impact of Palladium(II) Reduction Pathways on the Structure and Activity of Palladium(0) Catalysts

    Article • Angewandte Chemie, April 2013, Wiley

    Dr Martin D Eastgate

  29. The Impact of Palladium(II) Reduction Pathways on the Structure and Activity of Palladium(0) Catalysts

    Article • Angewandte Chemie International Edition, April 2013, Wiley

    Dr Martin D Eastgate

  30. Bis(dibenzylideneacetone)palladium(0)

    Article • April 2013, Wiley

    Dr Martin D Eastgate

  31. Regioselective Bromination of Fused HeterocyclicN-Oxides

    Article • Organic Letters, February 2013, American Chemical Society (ACS)

    Dr Martin D Eastgate

  32. Development of a Process for the Preparation of Chloromethyl Chlorosulfate

    Article • Organic Process Research & Development, November 2012, American Chemical Society (ACS)

    Dr Martin D Eastgate

  33. Regioselective synthesis of 1,4-disubstituted imidazoles

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Dr Martin D Eastgate

  34. The Development of Scalable and Efficient Methods for the Preparation of Dicyclopropylamine HCl Salt

    Article • Organic Process Research & Development, July 2011, American Chemical Society (ACS)

    Dr Martin D Eastgate

  35. On the Mechanism of Lewis Base Catalyzed Aldol Addition Reactions: Kinetic and Spectroscopic Investigations Using Rapid-Injection NMR

    Article • Journal of the American Chemical Society, August 2009, American Chemical Society (ACS)

    Dr Martin D Eastgate

  36. Mechanistic Insight into the Palladium-Catalyzed 1,4-Oxidation of 1,3-Dienes to 1,4-Dicarboxy-alk-2-enes

    Article • Angewandte Chemie International Edition, July 2009, Wiley

    Dr Martin D Eastgate

  37. Mechanistic Insight into the Palladium-Catalyzed 1,4-Oxidation of 1,3-Dienes to 1,4-Dicarboxy-alk-2-enes

    Article • Angewandte Chemie, June 2009, Wiley

    Dr Martin D Eastgate

  38. Lewis Base Catalyzed, Enantioselective Aldol Addition of Methyl Trichlorosilyl Ketene Acetal to Ketones

    Article • The Journal of Organic Chemistry, June 2005, American Chemical Society (ACS)

    Dr Martin D Eastgate

  39. Lewis Base Activation of Lewis Acids:  Catalytic, Enantioselective Addition of Silyl Ketene Acetals to Aldehydes

    Article • Journal of the American Chemical Society, March 2005, American Chemical Society (ACS)

    Dr Martin D Eastgate

  40. Synthesis of Enantiomerically Pure 2,2,3,4,5-Pentasubstituted Pyrrolidines by Phenylsulfanyl Migration†

    Article • Organic Letters, December 2002, American Chemical Society (ACS)

    Dr Martin D Eastgate

  41. The chemistry of lithiated phosphine oxides: the stereoselective synthesis of alkene-4,5-diols

    Article • Journal of the Chemical Society Perkin Transactions 1, January 2001, Royal Society of Chemistry

    Dr Martin D Eastgate