All Stories

  1. Histidine–Lysine Axial Ligand Switching in a Hemoglobin: A Role for Heme Propionates

    Article • Biochemistry, January 2018, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  2. Dynamics of Lysine as a Heme Axial Ligand: NMR Analysis of the Chlamydomonas reinhardtii Hemoglobin THB1

    Article • Biochemistry, January 2017, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  3. Structure ofChlamydomonas reinhardtiiTHB1, a group 1 truncated hemoglobin with a rare histidine–lysine heme ligation

    Article • Acta Crystallographica Section F Structural Biology Communications, May 2015, International Union of Crystallography

    Dr Juliette T.J. Lecomte

  4. Direct NMR Detection of Bifurcated Hydrogen Bonding in the α-Helix N-Caps of Ankyrin Repeat Proteins

    Article • Journal of the American Chemical Society, January 2015, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  5. Heme Coordination Versatility in a Truncated Hemoglobin

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Juliette T.J. Lecomte

  6. NMR Evidence for Unusual Bifurcated Hydrogen Bonding in the TXXH Alpha-Helix N-capping Motif

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Juliette T.J. Lecomte

  7. Intact Protein Analysis by Mass Spectrometry to Characterize the Truncated Hemoglobin THB1 from Chlamydomonas Reinhardtii

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Juliette T.J. Lecomte

  8. The Unusual Heme Coordination of THB1, a Hemoglobin from Chlamydomonas Reinhardtii

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Juliette T.J. Lecomte

  9. Characterization of the truncated hemoglobin THB1 from protein extracts of Chlamydomonas reinhardtii

    Article • F1000Research, December 2014, Faculty of 1000, Ltd.

    Dr Juliette T.J. Lecomte

  10. Introduction of a covalent histidine–heme linkage in a hemoglobin: A promising tool for heme protein engineering

    Article • Journal of Inorganic Biochemistry, December 2014, Elsevier

    Dr Juliette T.J. Lecomte

  11. Characterization of THB1, a Chlamydomonas reinhardtii Truncated Hemoglobin: Linkage to Nitrogen Metabolism and Identification of Lysine as the Distal Heme Ligand

    Article • Biochemistry, July 2014, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  12. The Globin Family

    Article • November 2013, Wiley

    Dr Juliette T.J. Lecomte

  13. The 2/2 hemoglobin from the cyanobacterium Synechococcus sp. PCC 7002 with covalently attached heme: Comparison of X-ray and NMR structures

    Article • Proteins Structure Function and Bioinformatics, October 2013, Wiley

    Dr Juliette T.J. Lecomte

  14. Volumetric properties underlying ligand binding in a monomeric hemoglobin: A high-pressure NMR study

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, September 2013, Elsevier

    Dr Juliette T.J. Lecomte

  15. Facile Heme Vinyl Posttranslational Modification in a Hemoglobin

    Article • Biochemistry, May 2013, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  16. Protein Structure: Unusual Covalent Bonds

    Article • February 2013, Wiley

    Dr Juliette T.J. Lecomte

  17. The Globins of Cyanobacteria and Algae

    Article • January 2013, Elsevier

    Dr Juliette T.J. Lecomte

  18. Engineering a Heme-Protein Crosslink in 2/2 Hemoglobins

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Juliette T.J. Lecomte

  19. Modulation of Nitric Oxide Reactivity by Heme Posttranslational Modification in the Cyanobacterial Hemoglobin, GlbN

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Juliette T.J. Lecomte

  20. Comparison of the Crystal and Solution Structures of a Cyanobacterial Hemoglobin

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Juliette T.J. Lecomte

  21. 3-Fluorotyrosine as a Complementary Probe of Hemoglobin Structure and Dynamics: A 19F-NMR Study of Synechococcus sp. PCC 7002 GlbN

    Article • Chemistry & Biodiversity, September 2012, Wiley

    Dr Juliette T.J. Lecomte

  22. Influence of Heme Post-Translational Modification and Distal Ligation on the Backbone Dynamics of a Monomeric Hemoglobin

    Article • Biochemistry, July 2012, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  23. Electron self-exchange and self-amplified posttranslational modification in the hemoglobins from Synechocystis sp. PCC 6803 and Synechococcus sp. PCC 7002

    Article • JBIC Journal of Biological Inorganic Chemistry, February 2012, Springer Science + Business Media

    Dr Juliette T.J. Lecomte

  24. Structural properties of 2/2 hemoglobins: The group III protein from Helicobacter hepaticus

    Article • IUBMB Life, March 2011, Wiley

    Dr Juliette T.J. Lecomte

  25. The Influence of the Heme Sixth Ligand on the Backbone Dynamics of an Endogenously Hexacoordinate Hemoglobin

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Juliette T.J. Lecomte

  26. Proposed Mechanism for Reductively Driven Hybrid b/c Heme Formation in Synechocystis and Synechococcus Hemoglobins

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Juliette T.J. Lecomte

  27. Chemical reactivity of Synechococcus sp. PCC 7002 and Synechocystis sp. PCC 6803 hemoglobins: covalent heme attachment and bishistidine coordination

    Article • JBIC Journal of Biological Inorganic Chemistry, January 2011, Springer Science + Business Media

    Dr Juliette T.J. Lecomte

  28. Functional and Structural Characterization of the 2/2 Hemoglobin from Synechococcus sp. PCC 7002,

    Article • Biochemistry, August 2010, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  29. 1H, 15N, and 13C resonance assignments of the 2/2 hemoglobin from the cyanobacterium Synechococcus sp. PCC 7002 in the ferric bis-histidine state

    Article • Biomolecular NMR Assignments, June 2009, Springer Science + Business Media

    Dr Juliette T.J. Lecomte

  30. A de novo redesign of the WW domain

    Article • Protein Science, January 2009, Wiley

    Dr Juliette T.J. Lecomte

  31. Cloning, expression, purification, and preliminary characterization of a putative hemoglobin from the cyanobacterium synechocystis sp. PCC 6803

    Article • Protein Science, December 2008, Wiley

    Dr Juliette T.J. Lecomte

  32. Insertion of the cytochrome b5 heme-binding loop into an SH3 domain. Effects on structure and stability, and clues about the cytochrome's architecture

    Article • Protein Science, December 2008, Wiley

    Dr Juliette T.J. Lecomte

  33. Synechoxanthin, an Aromatic C 40 Xanthophyll that Is a Major Carotenoid in the Cyanobacterium Synechococcus sp. PCC 7002

    Article • Journal of Natural Products, September 2008, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  34. Structural and thermodynamic encoding in the sequence of rat microsomal cytochromeb5

    Article • Biopolymers, May 2008, Wiley

    Dr Juliette T.J. Lecomte

  35. Structural propensities in the heme binding region of apocytochrome b5. I. Free peptides

    Article • Biopolymers, January 2008, Wiley

    Dr Juliette T.J. Lecomte

  36. Structural propensities in the heme binding region of apocytochrome b5. II. Heme conjugates

    Article • Biopolymers, January 2008, Wiley

    Dr Juliette T.J. Lecomte

  37. The Phylogeny and Structural Properties of 2/2 Haemoglobins

    Article • January 2008, Springer Science + Business Media

    Dr Juliette T.J. Lecomte

  38. Structural and thermodynamic consequences of b heme binding for monomeric apoglobins and other apoproteins

    Article • Gene, August 2007, Elsevier

    Dr Juliette T.J. Lecomte

  39. Loop anchor modification causes the population of an alternative native state in an SH3-like domain

    Article • Protein Science, May 2007, Wiley

    Dr Juliette T.J. Lecomte

  40. Structural and Dynamic Repercussions of Heme Binding and Heme−Protein Cross-linking in Synechococcus sp. PCC 7002 Hemoglobin †

    Article • Biochemistry, November 2006, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  41. Proximal Influences in Two-on-Two Globins:  Effect of the Ala69Ser Replacement on Synechocystis sp. PCC 6803 Hemoglobin †

    Article • Biochemistry, September 2006, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  42. A Phylogenetic and Structural Analysis of Truncated Hemoglobins

    Article • Journal of Molecular Evolution, February 2006, Springer Science + Business Media

    Dr Juliette T.J. Lecomte

  43. A dynamic N-capping motif in cytochrome b5: Evidence for a pH-controlled conformational switch

    Article • Proteins Structure Function and Bioinformatics, December 2005, Wiley

    Dr Juliette T.J. Lecomte

  44. Structural and dynamic properties of Synechocystis sp. PCC 6803 Hb revealed by reconstitution with Zn-protoporphyrin IX

    Article • Journal of Inorganic Biochemistry, August 2005, Elsevier

    Dr Juliette T.J. Lecomte

  45. Protein Dynamics in Living Cells †

    Article • Biochemistry, July 2005, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  46. Structural divergence and distant relationships in proteins: evolution of the globins

    Article • Current Opinion in Structural Biology, June 2005, Elsevier

    Dr Juliette T.J. Lecomte

  47. Protein Structure: Unusual Covalent Bonds

    Article • May 2005, Wiley

    Dr Juliette T.J. Lecomte

  48. Cyanide Binding to Hexacoordinate Cyanobacterial Hemoglobins:  Hydrogen-Bonding Network and Heme Pocket Rearrangement in Ferric H117A Synechocystis Hemoglobin †

    Article • Biochemistry, October 2004, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  49. A Relationship between Heme Binding and Protein Stability in Cytochrome b 5 †

    Article • Biochemistry, September 2004, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  50. Characterization of the heme–histidine cross-link in cyanobacterial hemoglobins from Synechocystis sp. PCC 6803 and Synechococcus sp. PCC 7002

    Article • JBIC Journal of Biological Inorganic Chemistry, January 2004, Springer Science + Business Media

    Dr Juliette T.J. Lecomte

  51. Structural properties of cyanobacterial hemoglobins: the unusual heme-protein cross-link of Synechocystis sp. PCC 6803 Hb and Synechococcus sp. PCC 7002 Hb

    Article • Micron, January 2004, Elsevier

    Dr Juliette T.J. Lecomte

  52. The Solution Structure of the Recombinant Hemoglobin from the Cyanobacterium Synechocystis sp. PCC 6803 in its Hemichrome State

    Article • Journal of Molecular Biology, December 2002, Elsevier

    Dr Juliette T.J. Lecomte

  53. Novel Histidine−Heme Covalent Linkage in a Hemoglobin

    Article • Journal of the American Chemical Society, July 2002, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  54. Truncated Hemoglobin from the Cyanobacterium Synechococcus sp. PCC 7002:  Evidence for Hexacoordination and Covalent Adduct Formation in the Ferric Recombinant Protein † , ‡

    Article • Biochemistry, June 2002, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  55. Electrostatic Effects in Highly Charged Proteins:  Salt Sensitivity of p K a Values of Histidines in Staphylococcal Nuclease †

    Article • Biochemistry, April 2002, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  56. Binding of Ferric Heme by the Recombinant Globin from the CyanobacteriumSynechocystissp. PCC 6803†

    Article • Biochemistry, May 2001, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  57. Structural and Dynamic Perturbations Induced by Heme Binding in Cytochrome b 5 † , ‡

    Article • Biochemistry, April 2001, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  58. Salt Effects on Ionization Equilibria of Histidines in Myoglobin

    Article • Biophysical Journal, September 2000, Elsevier

    Dr Juliette T.J. Lecomte

  59. The Solution Structure of Photosystem I Accessory Protein E from the Cyanobacterium Nostoc sp. Strain PCC 8009 † , ‡

    Article • Biochemistry, October 1999, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  60. Backbone Dynamics of Apocytochrome b 5 in Its Native, Partially Folded State

    Article • Biochemistry, July 1999, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  61. Backbone Dynamics of Apocytochrome b 5 in Its Native, Partially Folded State †

    Article • Biochemistry, February 1999, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  62. Conformational properties of native sperm whale apomyoglobin in solution

    Article • Protein Science, January 1999, Wiley

    Dr Juliette T.J. Lecomte

  63. A test of the relationship between sequence and structure in proteins: Excision of the heme binding site in apocytochrome b5

    Article • Protein Science, September 1998, Wiley

    Dr Juliette T.J. Lecomte

  64. The native state of apomyoglobin described by proton NMR spectroscopy: The A‐B‐G‐H interface of wild‐type sperm whale apomyoglobin

    Article • Proteins Structure Function and Bioinformatics, July 1996, Wiley

    Dr Juliette T.J. Lecomte

  65. Design Challenges for Hemoproteins:  The Solution Structure of Apocytochrome b 5 † , ‡

    Article • Biochemistry, January 1996, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  66. 1H and 15N NMR assignments of PsaE, a photosystem I subunit from the cyanobacterium Synechococcus sp. strain PCC 7002

    Article • Biochemistry, May 1994, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  67. Three-Dimensional Solution Structure of PsaE from the Cyanobacterium Synechococcus sp. Strain PCC 7002, a Photosystem I Protein That Shows Structural Homology with SH3 Domains

    Article • Biochemistry, May 1994, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  68. The native state of apomyoglobin described by proton NMR spectroscopy: Interaction with the paramagnetic probe HyTEMPO and the fluorescent dye ANS

    Article • Protein Science, February 1994, Wiley

    Dr Juliette T.J. Lecomte

  69. Determination of the zero-field splitting constant for proton NMR chemical shift analysis in metaquomyoglobin. The dipolar shift as a structural probe

    Article • Journal of the American Chemical Society, October 1993, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  70. Characterization of an independent structural unit in apocytochrome b5

    Article • Biochemistry, January 1993, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  71. Unraveling the mechanism of protein folding: new tricks for an old problem

    Article • Protein Engineering Design and Selection, January 1993, Oxford University Press (OUP)

    Dr Juliette T.J. Lecomte

  72. Histidine 82 influences heme orientational isomerism in sperm whale myoglobin. Long-range effect due to mutation of a conserved residue

    Article • Journal of the American Chemical Society, December 1992, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  73. Structural comparison of apomyoglobin and metaquomyoglobin: pH titration of histidines by NMR spectroscopy

    Article • Biochemistry, July 1992, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  74. Characterization of taxol in methylene chloride by nmr spectroscopy

    Article • Tetrahedron Letters, February 1992, Elsevier

    Dr Juliette T.J. Lecomte

  75. Helix formation in apocytochrome b5: the role of a neutral histidine at the N-cap position

    Article • Journal of the American Chemical Society, December 1991, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  76. Similarities in structure between holocytochrome b5 and apocytochrome b5: NMR studies of the histidine residues

    Article • Biochemistry, August 1991, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  77. Practical considerations for the measurement of the homonuclear overhauser effect on strongly relaxed protons in paramagnetic proteins

    Article • Journal of Magnetic Resonance (1969), August 1991, Elsevier

    Dr Juliette T.J. Lecomte

  78. Characterization of hydrophobic cores in apomyoglobin: a proton NMR spectroscopy study

    Article • Biochemistry, December 1990, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  79. Structural features of the protoporphyrin-apomyoglobin complex: a proton NMR spectroscopy study

    Article • Biochemistry, December 1990, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  80. Structural properties of apocytochrome b5: presence of a stable native core

    Article • Biochemistry, February 1990, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  81. Structural and electronic properties of the liver fluke heme cavity by nuclear magnetic resonance and optical spectroscopy

    Article • Journal of Molecular Biology, September 1989, Elsevier

    Dr Juliette T.J. Lecomte

  82. Proton NMR resonance assignment and dynamic analysis of phenylalanine CD1 in a low-spin ferric complex of sperm whale myoglobin

    Article • Journal of the American Chemical Society, June 1988, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  83. Proton NMR probe for hydrogen bonding of distal residues to bound ligands in heme proteins: isotope effect on heme electronic structure of myoglobin

    Article • Journal of the American Chemical Society, November 1987, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  84. Structural and electronic properties of the liver fluke hemoglobin heme cavity by nuclear magnetic resonance: Hemin isotope labeling

    Article • Journal of Molecular Biology, September 1987, Elsevier

    Dr Juliette T.J. Lecomte

  85. Proton magnetic resonance characterization of phoratoxins and homologous proteins related to crambin

    Article • Biochemistry, February 1987, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  86. Identification of the altered pyrrole in sulfmyoglobin and an extractable sulfhemin: participation of the 4-vinyl group in the saturation of the pyrrole in one form of sulfmyoglobin

    Article • Journal of the American Chemical Society, October 1986, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  87. NMR study of the molecular and electronic structure of the heme cavity of Aplysia metmyoglobin. Resonance assignments based on isotope labeling and proton nuclear Overhauser effect measurements

    Article • Biochemistry, September 1986, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  88. Influence of propionate side chains on the equilibrium heme orientation in sperm whale myoglobin. Heme resonance assignments and structure determination by nuclear Overhauser effect measurements

    Article • Journal of the American Chemical Society, September 1986, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  89. Multiple forms of sulfmyoglobin as detected by 1H nuclear magnetic resonance spectroscopy

    Article • Biochemical and Biophysical Research Communications, February 1986, Elsevier

    Dr Juliette T.J. Lecomte

  90. Proton NMR study of labile proton exchange in the heme cavity as a probe for the potential ligand entry channel in myoglobin

    Article • Biochemistry, December 1985, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  91. The utility of the nuclear overhauser effect for peak assignment and structure elucidation in paramagnetic proteins

    Article • Journal of Magnetic Resonance (1969), October 1985, Elsevier

    Dr Juliette T.J. Lecomte

  92. Characterization of heme orientational disorder in myoglobin by proton nuclear Overhauser effects

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, June 1985, Elsevier

    Dr Juliette T.J. Lecomte

  93. Proton nuclear magnetic resonance investigation of the heme cavity structure of liver fluke (Dirocoelium dendriticum) methemoglobin

    Article • Journal of Molecular Biology, December 1984, Elsevier

    Dr Juliette T.J. Lecomte

  94. Chemical characterization of the aromatic proton magnetic resonance spectrum of crambin

    Article • Biochemistry, September 1984, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  95. Proton NMR spectral patterns of rapidly flipping tyrosyl rings: a study of crambin in organic solvents

    Article • Journal of the American Chemical Society, May 1984, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  96. Proton NMR studies of barley and wheat thionins: structural homology with crambin

    Article • Biochemistry, September 1982, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte

  97. Solvent and Temperature Effects on Crambin, a Hydrophobic Protein, as Investigated by Proton Magnetic Resonance

    Article • European Journal of Biochemistry, October 1981, Wiley

    Dr Juliette T.J. Lecomte

  98. Proton magnetic resonance study of Crambin, a hyperstable hydrophobic protein, at 250 and 600 MHz

    Article • Biochemistry, March 1980, American Chemical Society (ACS)

    Dr Juliette T.J. Lecomte