All Stories

  1. Mitochondria-targeted esculetin inhibits PAI-1 levels by modulating STAT3 activation and miR-19b via SIRT3: Role in acute coronary artery syndrome

    Article • Journal of Cellular Physiology, May 2017, Wiley

    Dr Srigiridhar Kotamraju

  2. AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation

    Article • FEBS Journal, August 2015, Wiley

    Dr Srigiridhar Kotamraju

  3. Synthesis of novel 1-substituted triazole linked 1,2-benzothiazine 1,1-dioxido propenone derivatives as potent anti-inflammatory agents and inhibitors of monocyte-to-macrophage differentiation

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Dr Srigiridhar Kotamraju

  4. Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis

    Article • Diabetes, December 2014, American Diabetes Association

    Dr Srigiridhar Kotamraju

  5. Synthesis and anticancer evaluation of 3-aryl-6-phenylimidazo[2,1-b]thiazoles

    Article • Bioorganic & Medicinal Chemistry Letters, December 2014, Elsevier

    Dr Srigiridhar Kotamraju

  6. Fluvastatin Mediated Breast Cancer Cell Death: A Proteomic Approach to Identify Differentially Regulated Proteins in MDA-MB-231 Cells

    Article • PLoS ONE, September 2014, PLOS

    Dr Srigiridhar Kotamraju

  7. Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms

    Article • FEBS Journal, July 2014, Wiley

    Dr Srigiridhar Kotamraju

  8. Antibacterial effect of an extract of the endophytic fungus Alternaria alternata and its cytotoxic activity on MCF-7 and MDA MB-231 tumour cell lines

    Article • June 2014, De Gruyter

    Dr Srigiridhar Kotamraju

  9. Synthesis of novel 1,2,3-triazole substituted-N-alkyl/aryl nitrone derivatives, their anti-inflammatory and anticancer activity

    Article • European Journal of Medicinal Chemistry, June 2014, Elsevier

    Dr Srigiridhar Kotamraju

  10. Synthesis of Novel Pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine Derivatives and Their Cytotoxic Activity

    Article • Journal of Heterocyclic Chemistry, March 2014, Wiley

    Dr Srigiridhar Kotamraju

  11. Studies on Synthesis of Novel Triazole Tagged Pyrazole Fused Naphthalene 5-Thiazine-5,5-dioxide Derivatives, Their Antimicrobial, and Antioxidant Activity

    Article • Journal of Heterocyclic Chemistry, March 2014, Wiley

    Dr Srigiridhar Kotamraju

  12. Mitochondrial-Targeted Curcuminoids: A Strategy to Enhance Bioavailability and Anticancer Efficacy of Curcumin

    Article • PLoS ONE, March 2014, PLOS

    Dr Srigiridhar Kotamraju

  13. Synthesis of novel 1,2-benzothiazine 1,1-dioxide-3-ethanone oxime N-aryl acetamide ether derivatives as potent anti-inflammatory agents and inhibitors of monocyte-to-macrophage transformation

    Article • European Journal of Medicinal Chemistry, March 2014, Elsevier

    Dr Srigiridhar Kotamraju

  14. Synthesis, Characterization and Antitumor Activity of Novel Triazole/ Isoxazole Tagged Pyridine Hybrids

    Article • Letters in Organic Chemistry, February 2014, Bentham Science Publishers

    Dr Srigiridhar Kotamraju

  15. Synthesis of imidazo[2,1-b][1,3,4]thiadiazole–chalcones as apoptosis inducing anticancer agents

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Dr Srigiridhar Kotamraju

  16. Back Cover: Synthesis and Biological Evaluation of Imidazopyridine-Oxindole Conjugates as Microtubule-Targeting Agents (ChemMedChem 12/2013)

    Article • ChemMedChem, November 2013, Wiley

    Dr Srigiridhar Kotamraju

  17. Synthesis and Biological Evaluation of Imidazopyridine-Oxindole Conjugates as Microtubule-Targeting Agents

    Article • ChemMedChem, September 2013, Wiley

    Dr Srigiridhar Kotamraju

  18. Impact of Hyperhomocysteinemia on Breast Cancer Initiation and Progression: Epigenetic Perspective

    Article • Cell Biochemistry and Biophysics, August 2013, Springer Science + Business Media

    Dr Srigiridhar Kotamraju

  19. Novel 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamides as antioxidant and/or anti-inflammatory compounds

    Article • European Journal of Medicinal Chemistry, August 2013, Elsevier

    Dr Srigiridhar Kotamraju

  20. Nanomaterial-based electrochemical biosensors for cytochrome c using cytochrome c reductase

    Article • Bioelectrochemistry, June 2013, Elsevier

    Dr Srigiridhar Kotamraju

  21. Gold Nanoparticles with Self-Assembled Cysteine Monolayer Coupled to Nitrate Reductase in Polypyrrole Matrix Enhanced Nitrate Biosensor

    Article • Advanced Chemistry Letters, March 2013, American Scientific Publishers

    Dr Srigiridhar Kotamraju, Dr Niroj Kumar Sethy

  22. Synthesis and cytotoxicity of novel 6H-indolo[2,3-b]quinoxaline derivatives

    Article • Medicinal Chemistry Research, December 2012, Springer Science + Business Media

    Dr Srigiridhar Kotamraju

  23. Oxidative stress in coronary artery disease: epigenetic perspective

    Article • Molecular and Cellular Biochemistry, November 2012, Springer Science + Business Media

    Dr Srigiridhar Kotamraju

  24. Mitochondrial-Targeted Curcuminoids as an Effective Anti-Cancer Agent

    Article • Free Radical Biology and Medicine, November 2012, Elsevier

    Dr Srigiridhar Kotamraju

  25. Virtual electrochemical nitric oxide analyzer using copper, zinc superoxide dismutase immobilized on carbon nanotubes in polypyrrole matrix

    Article • Talanta, October 2012, Elsevier

    Dr Srigiridhar Kotamraju

  26. Synthesis, antimicrobial and cytotoxic activities of novel 4-trifluoromethyl-(1,2,3)-thiadiazolo-5-carboxylic acid hydrazide Schiff’s bases

    Article • Medicinal Chemistry Research, July 2012, Springer Science + Business Media

    Dr Srigiridhar Kotamraju

  27. Garlic provides protection to mice heart against isoproterenol-induced oxidative damage: Role of nitric oxide

    Article • Nitric Oxide, June 2012, Elsevier

    Dr Srigiridhar Kotamraju

  28. A facile and single pot strategy for the synthesis of novel naphthyridine derivatives under microwave irradiation conditions using ZnCl2 as catalyst, evaluation of AChE inhibitory activity, and molecular modeling studies

    Article • Medicinal Chemistry Research, June 2011, Springer Science + Business Media

    Dr Srigiridhar Kotamraju

  29. Simultaneous electrochemical determination of superoxide anion radical and nitrite using Cu,ZnSOD immobilized on carbon nanotube in polypyrrole matrix

    Article • Biosensors and Bioelectronics, October 2010, Elsevier

    Dr Srigiridhar Kotamraju

  30. Down-regulation of the global regulator SATB1 by statins in COLO205 colon cancer cells

    Article • Molecular Medicine Reports, August 2010, Spandidos Publications

    Dr Srigiridhar Kotamraju

  31. Superoxide Anion Radical Biosensor Using Self-Assembled Cysteine Monolayer on Gold Nanoparticles in Polypyrrole Matrix Facilitated Electron Transfer in Cu, ZnSOD

    Article • Sensor Letters, August 2010, American Scientific Publishers

    Dr Srigiridhar Kotamraju

  32. Novel synthetic route to the tricyclic core of (±)-galanthamine

    Article • Tetrahedron Letters, August 2009, Elsevier

    Dr Srigiridhar Kotamraju

  33. Statin-Induced Breast Cancer Cell Death: Role of Inducible Nitric Oxide and Arginase-Dependent Pathways

    Article • Cancer Research, August 2007, American Association for Cancer Research (AACR)

    Dr Srigiridhar Kotamraju

  34. Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: A bell-shaped signaling response

    Article • Free Radical Biology and Medicine, April 2007, Elsevier

    Dr Srigiridhar Kotamraju

  35. Expression of the hemochromatosis gene modulates the cytotoxicity of doxorubicin in breast cancer cells

    Article • International Journal of Cancer, July 2006, Wiley

    Dr Srigiridhar Kotamraju

  36. Upregulation of immunoproteasomes by nitric oxide: Potential antioxidative mechanism in endothelial cells

    Article • Free Radical Biology and Medicine, March 2006, Elsevier

    Dr Srigiridhar Kotamraju

  37. Sepiapterin attenuates 1-methyl-4-phenylpyridinium-induced apoptosis in neuroblastoma cells transfected with neuronal NOS: Role of tetrahydrobiopterin, nitric oxide, and proteasome activation

    Article • Free Radical Biology and Medicine, October 2005, Elsevier

    Dr Srigiridhar Kotamraju

  38. Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: Role of mitochondrial superoxide

    Article • Free Radical Biology and Medicine, September 2005, Elsevier

    Dr Srigiridhar Kotamraju

  39. Nitric Oxide, Proteasomal Function, and Iron Homeostasis—Implications in Aging and Neurodegenerative Diseases

    Article • January 2005, Elsevier

    Dr Srigiridhar Kotamraju

  40. Supplementation of Endothelial Cells with Mitochondria-targeted Antioxidants Inhibit Peroxide-induced Mitochondrial Iron Uptake, Oxidative Damage, and Apoptosis

    Article • Journal of Biological Chemistry, June 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  41. Ceramide-induced Intracellular Oxidant Formation, Iron Signaling, and Apoptosis in Endothelial Cells: PROTECTIVE ROLE OF ENDOGENOUS NITRIC OXIDE

    Article • Journal of Biological Chemistry, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  42. Doxorubicin Induces Apoptosis in Normal and Tumor Cells via Distinctly Different Mechanisms: INTERMEDIACY OF H2O2- AND p53-DEPENDENT PATHWAYS

    Article • Journal of Biological Chemistry, March 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  43. Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?

    Article • Archives of Biochemistry and Biophysics, March 2004, Elsevier

    Dr Srigiridhar Kotamraju

  44. 1-Methyl-4-phenylpyridinium-induced Apoptosis in Cerebellar Granule Neurons Is Mediated by Transferrin Receptor Iron-dependent Depletion of Tetrahydrobiopterin and Neuronal Nitric-oxide Synthase-derived Superoxide

    Article • Journal of Biological Chemistry, January 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  45.  -Synuclein Up-regulation and Aggregation during MPP+-induced Apoptosis in Neuroblastoma Cells: INTERMEDIACY OF TRANSFERRIN RECEPTOR IRON AND HYDROGEN PEROXIDE

    Article • Journal of Biological Chemistry, January 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  46. Oxidant-Induced Iron Signaling in Doxorubicin-Mediated Apoptosis

    Article • January 2004, Elsevier

    Dr Srigiridhar Kotamraju

  47. Nitric oxide inhibits H 2 O 2 -induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway

    Article • Proceedings of the National Academy of Sciences, September 2003, Proceedings of the National Academy of Sciences

    Dr Srigiridhar Kotamraju

  48. Reactive oxygen species induce reversible PECAM-1 tyrosine phosphorylation and SHP-2 binding

    Article • AJP Heart and Circulatory Physiology, July 2003, American Physiological Society

    Dr Srigiridhar Kotamraju

  49. 1-Methyl-4-phenylpyridinium (MPP+)-induced apoptosis and mitochondrial oxidant generation: role of transferrin-receptor-dependent iron and hydrogen peroxide

    Article • Biochemical Journal, April 2003, Portland Press Ltd.

    Dr Srigiridhar Kotamraju

  50. Activation of nuclear factor-κB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide

    Article • Biochemical Journal, November 2002, Portland Press Ltd.

    Dr Srigiridhar Kotamraju

  51. Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: scavenging of reactive oxygen species versus induction of heme oxygenase-1

    Article • Free Radical Biology and Medicine, October 2002, Elsevier

    Dr Srigiridhar Kotamraju

  52. Nitration of PECAM-1 ITIM tyrosines abrogates phosphorylation and SHP-2 binding

    Article • Biochemical and Biophysical Research Communications, September 2002, Elsevier

    Dr Srigiridhar Kotamraju

  53. Transferrin Receptor-dependent Iron Uptake Is Responsible for Doxorubicin-mediated Apoptosis in Endothelial Cells: ROLE OF OXIDANT-INDUCED IRON SIGNALING IN APOPTOSIS

    Article • Journal of Biological Chemistry, May 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  54. Doxorubicin-induced apoptosis: Implications in cardiotoxicity

    Article • January 2002, Springer Science + Business Media

    Dr Srigiridhar Kotamraju

  55. Doxorubicin-induced Apoptosis Is Associated with Increased Transcription of Endothelial Nitric-oxide Synthase: EFFECT OF ANTIAPOPTOTIC ANTIOXIDANTS AND CALCIUM

    Article • Journal of Biological Chemistry, September 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  56. Inhibition of Oxidized Low-density Lipoprotein-induced Apoptosis in Endothelial Cells by Nitric Oxide: PEROXYL RADICAL SCAVENGING AS AN ANTIAPOPTOTIC MECHANISM

    Article • Journal of Biological Chemistry, February 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  57. Doxorubicin-induced Apoptosis in Endothelial Cells and Cardiomyocytes Is Ameliorated by Nitrone Spin Traps and Ebselen: ROLE OF REACTIVE OXYGEN AND NITROGEN SPECIES

    Article • Journal of Biological Chemistry, July 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Srigiridhar Kotamraju

  58. Doxorubicin-induced apoptosis is reversed by nitrone spin traps & ebselen

    Article • Free Radical Biology and Medicine, January 1999, Elsevier

    Dr Srigiridhar Kotamraju

  59. Iron-deficient intestine is more susceptible to peroxidative damage during iron supplementation in rats

    Article • Free Radical Biology and Medicine, October 1998, Elsevier

    Dr Srigiridhar Kotamraju