All Stories

  1. Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells

    Article • BioMedicine, August 2018, EDP Sciences

    Dr Chi-Cheng Lu

  2. Late onset of biliopleural fistula following percutaneous transhepatic biliary drainage: a case report

    Article • BioMedicine, February 2018, EDP Sciences

    Dr Chi-Cheng Lu, Dr Jai-Sing Yang

  3. Epigallocatechin gallate sensitizes cisplatin-resistant oral cancer CAR cell apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multidrug resistance 1 signaling

    Article • Environmental Toxicology, May 2016, Wiley

    Dr Chi-Cheng Lu, Dr Jai-Sing Yang

  4. Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation

    Article • Journal of Agricultural and Food Chemistry, August 2015, American Chemical Society (ACS)

    Dr Chi-Cheng Lu

  5. Antioxidative and anti-inflammatory activity of functional foods

    Article • Current Opinion in Food Science, April 2015, Elsevier

    Dr Chi-Cheng Lu

  6. AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-κB pathway

    Article • Environmental Toxicology, December 2014, Wiley

    Dr Chi-Cheng Lu, Dr Jai-Sing Yang

  7. DJ-1 plays an important role in caffeic acid-mediated protection of the gastrointestinal mucosa against ketoprofen-induced oxidative damage

    Article • The Journal of Nutritional Biochemistry, October 2014, Elsevier

    Dr Chi-Cheng Lu

  8. Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells

    Article • Environmental Toxicology, September 2014, Wiley

    Dr Chi-Cheng Lu, Dr Jai-Sing Yang

  9. Ursolic acid triggers nonprogrammed death (necrosis) in human glioblastoma multiforme DBTRG-05MG cells through MPT pore opening and ATP decline

    Article • Molecular Nutrition & Food Research, September 2014, Wiley

    Dr Chi-Cheng Lu, Professor GC YEN

  10. Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, July 2014, Elsevier

    Dr Chi-Cheng Lu

  11. Quinazoline analog HMJ-30 inhibits angiogenesis: Involvement of endothelial cell apoptosis through ROS-JNK-mediated death receptor 5 signaling

    Article • Oncology Reports, June 2014, Spandidos Publications

    Dr Chi-Cheng Lu

  12. The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells

    Article • International Journal of Oncology, June 2014, Spandidos Publications

    Dr Chi-Cheng Lu

  13. Ethanol extract ofHedyotis diffusawilld upregulates G0/G1 phase arrest and induces apoptosis in human leukemia cells by modulating caspase cascade signaling and altering associated genes expression was assayed by cDNA microarray

    Article • Environmental Toxicology, March 2014, Wiley

    Dr Chi-Cheng Lu

  14. Antitumor effects with apoptotic death in human promyelocytic leukemia HL-60 cells and suppression of leukemia xenograft tumor growth by irinotecan HCl

    Article • Environmental Toxicology, January 2014, Wiley

    Dr Chi-Cheng Lu

  15. Allyl isothiocyanate inhibits cell metastasis through suppression of the MAPK pathways in epidermal growth factor‑stimulated HT29 human colorectal adenocarcinoma cells

    Article • Oncology Reports, November 2013, Spandidos Publications

    Dr Chi-Cheng Lu

  16. Effect of DNA damage response by quinazolinone analogue HMJ-38 on human umbilical vein endothelial cells

    Article • Human & Experimental Toxicology, September 2013, SAGE Publications

    Dr Chi-Cheng Lu

  17. Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells

    Article • International Journal of Oncology, August 2013, Spandidos Publications

    Dr Chi-Cheng Lu

  18. Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling

    Article • Toxicology and Applied Pharmacology, June 2013, Elsevier

    Dr Chi-Cheng Lu

  19. The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells

    Article • Molecular Medicine Reports, March 2013, Spandidos Publications

    Dr Chi-Cheng Lu

  20. Suppressions of Migration and Invasion by Cantharidin in TSGH-8301 Human Bladder Carcinoma Cells through the Inhibitions of Matrix Metalloproteinase-2/-9 Signaling

    Article • Evidence-based Complementary and Alternative Medicine, January 2013, Hindawi Publishing Corporation

    Dr Chi-Cheng Lu

  21. Apigenin Induces Apoptosis through Mitochondrial Dysfunction in U-2 OS Human Osteosarcoma Cells and Inhibits Osteosarcoma Xenograft Tumor Growth in Vivo

    Article • Journal of Agricultural and Food Chemistry, November 2012, American Chemical Society (ACS)

    Dr Chi-Cheng Lu

  22. ERK-modulated intrinsic signaling and G2/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells

    Article • International Journal of Oncology, September 2012, Spandidos Publications

    Dr Chi-Cheng Lu

  23. Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway

    Article • Oncology Reports, August 2012, Spandidos Publications

    Dr Chi-Cheng Lu

  24. Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2

    Article • Oncology Reports, August 2012, Spandidos Publications

    Dr Chi-Cheng Lu

  25. AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells

    Article • International Journal of Oncology, August 2012, Spandidos Publications

    Dr Chi-Cheng Lu

  26. Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells

    Article • International Journal of Oncology, July 2012, Spandidos Publications

    Dr Chi-Cheng Lu

  27. The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells

    Article • Oncology Reports, July 2012, Spandidos Publications

    Dr Chi-Cheng Lu

  28. Novel Quinazolinone MJ-29 Triggers Endoplasmic Reticulum Stress and Intrinsic Apoptosis in Murine Leukemia WEHI-3 Cells and Inhibits Leukemic Mice

    Article • PLoS ONE, May 2012, PLOS

    Dr Chi-Cheng Lu

  29. Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model

    Article • Food and Chemical Toxicology, May 2012, Elsevier

    Dr Chi-Cheng Lu

  30. Activations of Both Extrinsic and Intrinsic Pathways in HCT 116 Human Colorectal Cancer Cells Contribute to Apoptosis through p53-Mediated ATM/Fas Signaling byEmilia sonchifoliaExtract, a Folklore Medicinal Plant

    Article • Evidence-based Complementary and Alternative Medicine, January 2012, Hindawi Publishing Corporation

    Dr Chi-Cheng Lu

  31. Triggering Apoptotic Death of Human Malignant Melanoma A375.S2 Cells by Bufalin: Involvement of Caspase Cascade-Dependent and Independent Mitochondrial Signaling Pathways

    Article • Evidence-based Complementary and Alternative Medicine, January 2012, Hindawi Publishing Corporation

    Dr Chi-Cheng Lu

  32. Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells

    Article • Environmental Toxicology, September 2011, Wiley

    Dr Chi-Cheng Lu

  33. Safrole suppresses murine myelomonocytic leukemia WEHI-3 cellsin vivo, and stimulates macrophage phagocytosis and natural killer cell cytotoxicity in leukemic mice

    Article • Environmental Toxicology, August 2011, Wiley

    Dr Chi-Cheng Lu

  34. Proteomic approaches to study epigallocatechin gallate-provoked apoptosis of TSGH-8301 human urinary bladder carcinoma cells: Roles of AKT and heat shock protein 27-modulated intrinsic apoptotic pathways

    Article • Oncology Reports, July 2011, Spandidos Publications

    Dr Chi-Cheng Lu

  35. The synthesized novel fluorinated compound (LJJ-10) induces death receptor- and mitochondria-dependent apoptotic cell death in the human osteogenic sarcoma U-2 OS cells

    Article • European Journal of Medicinal Chemistry, July 2011, Elsevier

    Dr Chi-Cheng Lu

  36. The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor

    Article • International Journal of Oncology, June 2011, Spandidos Publications

    Dr Chi-Cheng Lu

  37. Phenethyl isothiocyanate promotes immune responses in normal BALB/c mice, inhibits murine leukemia WEHI-3 cells, and stimulates immunomodulationsin vivo

    Article • Environmental Toxicology, May 2011, Wiley

    Dr Chi-Cheng Lu

  38. Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways

    Article • Environmental Toxicology, May 2011, Wiley

    Dr Chi-Cheng Lu

  39. Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways

    Article • International Journal of Oncology, May 2011, Spandidos Publications

    Dr Chi-Cheng Lu

  40. Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways

    Article • Oncology Reports, April 2011, Spandidos Publications

    Dr Chi-Cheng Lu

  41. A comparative study of the interaction of Bartonella henselae strains with human endothelial cells

    Article • Veterinary Microbiology, April 2011, Elsevier

    Dr Chi-Cheng Lu

  42. Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway

    Article • Journal of Orthopaedic Research®, March 2011, Wiley

    Dr Chi-Cheng Lu

  43. Death receptor 5-mediated TNFR family signaling pathways modulate γ-humulene-induced apoptosis in human colorectal cancer HT29 cells

    Article • Oncology Reports, February 2011, Spandidos Publications

    Dr Chi-Cheng Lu

  44. Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 CellsIn Vitroand Enhances Phagocytosis in Leukemia MiceIn Vivo

    Article • Evidence-based Complementary and Alternative Medicine, January 2011, Hindawi Publishing Corporation

    Dr Chi-Cheng Lu

  45. Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells

    Article • Journal of Dental Research, December 2010, SAGE Publications

    Dr Chi-Cheng Lu

  46. Dietary Effect ofAntrodia CamphorateExtracts on Immune Responses in WEHI-3 Leukemia BALB/c Mice

    Article • Nutrition and Cancer, June 2010, Taylor & Francis

    Dr Chi-Cheng Lu

  47. Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway

    Article • Oncology Reports, June 2010, Spandidos Publications

    Dr Chi-Cheng Lu

  48. Danthron Induces DNA Damage and Inhibits DNA Repair Gene Expressions in GBM 8401 Human Brain Glioblastoma Multiforms Cells

    Article • Neurochemical Research, April 2010, Springer Science + Business Media

    Dr Chi-Cheng Lu

  49. Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells

    Article • Molecular Nutrition & Food Research, February 2010, Wiley

    Dr Chi-Cheng Lu

  50. Curcumin inhibits human lung large cell carcinoma cancer tumour growth in a murine xenograft model

    Article • Phytotherapy Research, January 2010, Wiley

    Dr Chi-Cheng Lu

  51. Benzyl isothiocyanate inhibits murine WEHI-3 leukemia cells in vitro and promotes phagocytosis in BALB/c mice in vivo

    Article • Leukemia Research, November 2009, Elsevier

    Dr Chi-Cheng Lu

  52. Danthron Induced Apoptosis Through Mitochondria- and Caspase-3-Dependent Pathways in Human Brain Glioblastoma Multiforms GBM 8401 Cells

    Article • Neurochemical Research, September 2009, Springer Science + Business Media

    Dr Chi-Cheng Lu

  53. Houttuynia cordata Thunb extract induces apoptosis through mitochondrial-dependent pathway in HT-29 human colon adenocarcinoma cells

    Article • Oncology Reports, September 2009, Spandidos Publications

    Dr Chi-Cheng Lu

  54. Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model

    Article • Phytomedicine, September 2009, Elsevier

    Dr Chi-Cheng Lu

  55. Gallic Acid Induces Apoptosis via Caspase-3 and Mitochondrion-Dependent Pathways in Vitro and Suppresses Lung Xenograft Tumor Growth in Vivo

    Article • Journal of Agricultural and Food Chemistry, August 2009, American Chemical Society (ACS)

    Dr Chi-Cheng Lu

  56. The synthesized 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one (CHM-1) promoted G2/M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells

    Article • Journal of Gastroenterology, August 2009, Springer Science + Business Media

    Dr Chi-Cheng Lu

  57. Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo

    Article • Leukemia Research, June 2009, Elsevier

    Dr Chi-Cheng Lu

  58. Quercetin inhibited murine leukemia WEHI-3 cells in vivo and promoted immune response

    Article • Phytotherapy Research, May 2009, Wiley

    Dr Chi-Cheng Lu

  59. Curcumin-Induced DNA Damage and Inhibited DNA Repair Genes Expressions in Mouse–Rat Hybrid Retina Ganglion Cells (N18)

    Article • Neurochemical Research, March 2009, Springer Science + Business Media

    Dr Chi-Cheng Lu