Dr Nigel J Waters
Subject: Medicine And Medical Sciences
Primary location: United States
Advancements in Predictive In Silico Models for ADME
Published in:Current Chemical Biology
Publication date:2008-09-01
Computational Approaches in Drug Biotransformation Studies: Metabolite Prediction
Published in:Handbook of Metabolic Pathways of Xenobiotics
Publication date:2014-01-15
The Role of Metabonomics at the Interface Between Drug Metabolism and Safety Assessment
Published in:Current Drug Metabolism
Publication date:2010-10-01
Quantitative Structure Activity Relationships in Drug Metabolism
Published in:Current Topics in Medicinal Chemistry
Publication date:2006-08-01
Editorial [Hot topic: Drug Design from the ADME/PK Perspective: Does Chemical Intuition Suffice in Multifaceted Drug Discovery? (Guest Editors: Fra...
Published in:Current Topics in Medicinal Chemistry
Publication date:2011-02-01
Advancements in Predictive In Silico Models for ADME
Published in:Current Chemical Biology
Publication date:2008-09-01
Plasma Protein Binding and Volume of Distribution: Determination, Prediction and Use in Early Drug Discovery
Published in:Hit and Lead Profiling
Publication date:Not available
Metabonomics
Published in:Surrogate Tissue Analysis
Publication date:2005-11-10Metabolic Profiling and Pattern Recognition Analysis of Body Fluids and Tissues for Characterization of Drug Toxicity and Disease Diagnosis
In Silico Human and Rat V ss Quantitative Structure−Activity Relationship Models
Published in:Journal of Medicinal Chemistry
Publication date:2006-03-01
Metabonomic Deconvolution Of Embedded Toxicity: Application To Thioacetamide Hepato- and Nephrotoxicity
Published in:Chemical Research in Toxicology
Publication date:2005-04-01
Integrated Metabonomic Analysis of Bromobenzene-Induced Hepatotoxicity: Novel Induction of 5-Oxoprolinosis
Published in:Journal of Proteome Research
Publication date:2006-06-01
NMR and pattern recognition studies on liver extracts and intact livers from rats treated with α-naphthylisothiocyanate
Published in:Biochemical Pharmacology
Publication date:2002-07-01
In silico Prediction of Total Human Plasma Clearance
Published in:Journal of Chemical Information and Modeling
Publication date:2012-08-27
CHAPTER 3. High‐Resolution NMR‐Based Metabolic Profiling in Drug Discovery and Development
Published in:New Applications of NMR in Drug Discovery and Development
Publication date:Not available
Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding
Published in:Journal of Pharmaceutical Sciences
Publication date:2008-10-01
Consideration of the Unbound Drug Concentration in Enzyme Kinetics
Published in:Methods in Molecular Biology
Publication date:2014-01-01
In Silico Prediction of Volume of Distribution in Human Using Linear and Nonlinear Models on a 669 Compound Data Set
Published in:Journal of Medicinal Chemistry
Publication date:2009-07-23
NMR and Pattern Recognition Studies on the Time-Related Metabolic Effects of α-Naphthylisothiocyanate on Liver, Urine, and Plasma in the Rat: An I...
Published in:Chemical Research in Toxicology
Publication date:2001-10-01
Evaluation of drug-drug interactions for oncology therapies:in vitro-in vivoextrapolation model-based risk assessment
Published in:British Journal of Clinical Pharmacology
Publication date:2015-05-22In vitro-in vivomodel-based risk assessment of DDI in oncology
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension
Published in:Bioorganic & Medicinal Chemistry Letters
Publication date:2014-10-01
Structure–Efficiency Relationship of [1,2,4]Triazol-3-ylamines as Novel Nicotinamide Isosteres that Inhibit Tankyrases
Published in:Journal of Medicinal Chemistry
Publication date:2013-09-12
Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance
Published in:The Journal of Clinical Pharmacology
Publication date:2013-01-24The Journal of Clinical Pharmacology
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound
Published in:ACS Medicinal Chemistry Letters
Publication date:2015-06-11
Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 1: Volume of Distribution at Steady...
Published in:The Journal of Clinical Pharmacology
Publication date:2013-01-24The Journal of Clinical Pharmacology
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
Published in:ACS Medicinal Chemistry Letters
Publication date:2015-05-14
Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase In...
Published in:Journal of Medicinal Chemistry
Publication date:2013-08-22
Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor
Published in:Biopharmaceutics & Drug Disposition
Publication date:2014-02-14NONCLINICAL PK AND METABOLISM OF EPZ-5676, A DOT1L INHIBITOR
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models
Published in:Nature Chemical Biology
Publication date:2015-04-27
Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652
Published in:Drug Metabolism and Disposition
Publication date:2015-04-17
Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development
Published in:Drug Metabolism and Disposition
Publication date:2016-03-02