All Stories

  1. Physiologically Based Pharmacokinetic Modeling in Pediatric Oncology Drug Development

    Article • Drug Metabolism and Disposition, March 2016, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Nigel J Waters

  2. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound

    Article • ACS Medicinal Chemistry Letters, June 2015, American Chemical Society (ACS)

    Dr Nigel J Waters

  3. Evaluation of drug-drug interactions for oncology therapies:in vitro-in vivoextrapolation model-based risk assessment

    Article • British Journal of Clinical Pharmacology, May 2015, Wiley

    Dr Nigel J Waters

  4. EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

    Article • ACS Medicinal Chemistry Letters, May 2015, American Chemical Society (ACS)

    Dr Nigel J Waters

  5. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

    Article • Nature Chemical Biology, April 2015, Springer Science + Business Media

    Dr Nigel J Waters

  6. Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652

    Article • Drug Metabolism and Disposition, April 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Nigel J Waters

  7. Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension

    Article • Bioorganic & Medicinal Chemistry Letters, October 2014, Elsevier

    Dr Nigel J Waters

  8. Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

    Article • Biopharmaceutics & Drug Disposition, February 2014, Wiley

    Dr Nigel J Waters

  9. Computational Approaches in Drug Biotransformation Studies: Metabolite Prediction

    Article • January 2014, Wiley

    Dr Nigel J Waters

  10. Consideration of the Unbound Drug Concentration in Enzyme Kinetics

    Article • January 2014, Springer Science + Business Media

    Dr Nigel J Waters

  11. Structure–Efficiency Relationship of [1,2,4]Triazol-3-ylamines as Novel Nicotinamide Isosteres that Inhibit Tankyrases

    Article • Journal of Medicinal Chemistry, September 2013, American Chemical Society (ACS)

    Dr Nigel J Waters

  12. Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor

    Article • Journal of Medicinal Chemistry, August 2013, American Chemical Society (ACS)

    Dr Nigel J Waters

  13. Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance

    Article • The Journal of Clinical Pharmacology, January 2013, Wiley

    Dr Nigel J Waters

  14. Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 1: Volume of Distribution at Steady State

    Article • The Journal of Clinical Pharmacology, January 2013, Wiley

    Dr Nigel J Waters

  15. CHAPTER 3. High‐Resolution NMR‐Based Metabolic Profiling in Drug Discovery and Development

    Article • January 2013, Royal Society of Chemistry

    Dr Nigel J Waters

  16. In silico Prediction of Total Human Plasma Clearance

    Article • Journal of Chemical Information and Computer Sciences, August 2012, American Chemical Society (ACS)

    Dr Nigel J Waters

  17. Editorial [Hot topic: Drug Design from the ADME/PK Perspective: Does Chemical Intuition Suffice in Multifaceted Drug Discovery? (Guest Editors: Franco Lombardo & Nigel J. Waters)]

    Article • Current Topics in Medicinal Chemistry, February 2011, Bentham Science Publishers

    Dr Nigel J Waters

  18. The Role of Metabonomics at the Interface Between Drug Metabolism and Safety Assessment

    Article • Current Drug Metabolism, October 2010, Bentham Science Publishers

    Dr Nigel J Waters

  19. In Silico Prediction of Volume of Distribution in Human Using Linear and Nonlinear Models on a 669 Compound Data Set

    Article • Journal of Medicinal Chemistry, July 2009, American Chemical Society (ACS)

    Dr Nigel J Waters

  20. Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding

    Article • Journal of Pharmaceutical Sciences, October 2008, Elsevier

    Dr Nigel J Waters

  21. Advancements in Predictive In Silico Models for ADME

    Article • Current Chemical Biology, September 2008, Bentham Science Publishers

    Dr Nigel J Waters

  22. Advancements in Predictive In Silico Models for ADME

    Article • Current Chemical Biology, September 2008, Bentham Science Publishers

    Dr Nigel J Waters

  23. Quantitative Structure Activity Relationships in Drug Metabolism

    Article • Current Topics in Medicinal Chemistry, August 2006, Bentham Science Publishers

    Dr Nigel J Waters

  24. Integrated Metabonomic Analysis of Bromobenzene-Induced Hepatotoxicity:  Novel Induction of 5-Oxoprolinosis

    Article • Journal of Proteome Research, June 2006, American Chemical Society (ACS)

    Dr Nigel J Waters

  25. In Silico Human and Rat V ss Quantitative Structure−Activity Relationship Models

    Article • Journal of Medicinal Chemistry, March 2006, American Chemical Society (ACS)

    Dr Nigel J Waters

  26. Metabonomics

    Article • November 2005, Taylor & Francis

    Dr Nigel J Waters

  27. Metabonomic Deconvolution Of Embedded Toxicity:  Application To Thioacetamide Hepato- and Nephrotoxicity

    Article • Chemical Research in Toxicology, April 2005, American Chemical Society (ACS)

    Dr Nigel J Waters

  28. NMR and pattern recognition studies on liver extracts and intact livers from rats treated with α-naphthylisothiocyanate

    Article • Biochemical Pharmacology, July 2002, Elsevier

    Dr Nigel J Waters

  29. NMR and Pattern Recognition Studies on the Time-Related Metabolic Effects of α-Naphthylisothiocyanate on Liver, Urine, and Plasma in the Rat:  An Integrative Metabonomic Approach

    Article • Chemical Research in Toxicology, October 2001, American Chemical Society (ACS)

    Dr Nigel J Waters

  30. Plasma Protein Binding and Volume of Distribution: Determination, Prediction and Use in Early Drug Discovery

    Article • Wiley

    Dr Nigel J Waters