All Stories

  1. Ask the experts: how to curb antibiotic resistance and plug the antibiotics gap?

    Article • Future Medicinal Chemistry, June 2016, Future Science

    Dr Sylvie Garneau-Tsodikova

  2. Arginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  3. A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides

    Article • MedChemComm, January 2016, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  4. Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria

    Article • ACS Infectious Diseases, June 2015, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  5. Biochemical and Structural Analysis of an Eis Family Aminoglycoside Acetyltransferase from Bacillus anthracis

    Article • Biochemistry, May 2015, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  6. Rapid Synthesis, RNA Binding, and Antibacterial Screening of a Peptidic-Aminosugar (PA) Library

    Article • ACS Chemical Biology, May 2015, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  7. Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts

    Article • Antimicrobial Agents and Chemotherapy, May 2015, ASM Journals

    Dr Sylvie Garneau-Tsodikova

  8. Influence of Linker Length and Composition on Enzymatic Activity and Ribosomal Binding of Neomycin Dimers

    Article • Antimicrobial Agents and Chemotherapy, April 2015, ASM Journals

    Dr Sylvie Garneau-Tsodikova

  9. The Biosynthesis of Capuramycin-type Antibiotics

    Article • Journal of Biological Chemistry, April 2015, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Sylvie Garneau-Tsodikova

  10. Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis

    Article • Natural Product Reports, January 2015, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  11. Concise synthesis of spergualin-inspired molecules with broad-spectrum antibiotic activity

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  12. Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  13. Adenylation and S -Methylation of Cysteine by the Bifunctional Enzyme TioN in Thiocoraline Biosynthesis

    Article • Journal of the American Chemical Society, December 2014, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  14. Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG

    Article • The Journal of Antibiotics, September 2014, Springer Science + Business Media

    Dr Sylvie Garneau-Tsodikova

  15. Inhibition of glioma progression by a newly discovered CD38 inhibitor

    Article • International Journal of Cancer, August 2014, Wiley

    Dr Sylvie Garneau-Tsodikova

  16. A Random Sequential Mechanism of Aminoglycoside Acetylation by Mycobacterium tuberculosis Eis Protein

    Article • PLoS ONE, April 2014, PLOS

    Dr Sylvie Garneau-Tsodikova

  17. New trends in the use of aminoglycosides

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  18. Carbohydrates themed issue

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  19. Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay

    Article • Bioorganic & Medicinal Chemistry Letters, December 2013, Elsevier

    Dr Sylvie Garneau-Tsodikova

  20. Cover Picture: Chemical and Structural Insights into the Regioversatility of the Aminoglycoside Acetyltransferase Eis (ChemBioChem 16/2013)

    Article • ChemBioChem, October 2013, Wiley

    Dr Sylvie Garneau-Tsodikova

  21. Crystal structure of Mycobacterium tuberculosis Eis in complex with coenzyme A and tobramycin

    Article • October 2013, Protein Data Bank, Rutgers University

    Dr Sylvie Garneau-Tsodikova

  22. KtzJ-dependent serine activation and O-methylation by KtzH for kutznerides biosynthesis

    Article • The Journal of Antibiotics, October 2013, Springer Science + Business Media

    Dr Sylvie Garneau-Tsodikova

  23. Discovery of Inhibitors of Bacillus anthracis Primase DnaG

    Article • Biochemistry, October 2013, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  24. Chemical and Structural Insights into the Regioversatility of the Aminoglycoside Acetyltransferase Eis

    Article • ChemBioChem, September 2013, Wiley

    Dr Sylvie Garneau-Tsodikova

  25. Redesign of Substrate Specificity and Identification of the Aminoglycoside Binding Residues of Eis from Mycobacterium tuberculosis

    Article • Biochemistry, July 2013, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  26. Synthesis and Evaluation of Hetero- and Homodimers of Ribosome-Targeting Antibiotics: Antimicrobial Activity, in Vitro Inhibition of Translation, and Drug Resistance

    Article • Journal of Medicinal Chemistry, July 2013, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  27. Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections

    Article • Future Medicinal Chemistry, July 2013, Future Science

    Dr Sylvie Garneau-Tsodikova

  28. Investigation of the role of linker moieties in bifunctional tacrine hybrids

    Article • Bioorganic & Medicinal Chemistry, June 2013, Elsevier

    Dr Sylvie Garneau-Tsodikova

  29. Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6′)-IId from Serratia marcescens

    Article • Biochimie, June 2013, Elsevier

    Dr Sylvie Garneau-Tsodikova

  30. Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

    Article • Beilstein Journal of Organic Chemistry, May 2013, Beilstein Institut

    Dr Sylvie Garneau-Tsodikova

  31. A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

    Article • Chemical Science, January 2013, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  32. Resistance in tuberculosis: what do we know and where can we go?

    Article • Frontiers in Microbiology, January 2013, Frontiers

    Dr Sylvie Garneau-Tsodikova

  33. Aminoglycoside Multiacetylating Activity of the Enhanced Intracellular Survival Protein from Mycobacterium smegmatis and Its Inhibition

    Article • Biochemistry, June 2012, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  34. Innentitelbild: 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes (Angew. Chem. 23/2012)

    Article • Angewandte Chemie, May 2012, Wiley

    Dr Sylvie Garneau-Tsodikova

  35. Inside Cover: 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes (Angew. Chem. Int. Ed. 23/2012)

    Article • Angewandte Chemie International Edition, May 2012, Wiley

    Dr Sylvie Garneau-Tsodikova

  36. 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes

    Article • Angewandte Chemie, April 2012, Wiley

    Dr Sylvie Garneau-Tsodikova

  37. 6′′-Thioether Tobramycin Analogues: Towards Selective Targeting of Bacterial Membranes

    Article • Angewandte Chemie International Edition, April 2012, Wiley

    Dr Sylvie Garneau-Tsodikova

  38. The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI

    Article • Protein Science, March 2012, Wiley

    Dr Sylvie Garneau-Tsodikova

  39. Importance of the MbtH-like protein TioT for production and activation of the thiocoraline adenylation domain of TioK

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  40. Editorial: natural products themed issue

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  41. Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis

    Article • Molecular BioSystems, January 2012, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  42. Back Cover: Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis (ChemMedChem 1/2012)

    Article • ChemMedChem, December 2011, Wiley

    Dr Sylvie Garneau-Tsodikova

  43. Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis

    Article • ChemMedChem, September 2011, Wiley

    Dr Sylvie Garneau-Tsodikova

  44. Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  45. Assessment of 6′- and 6′′′-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  46. Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster

    Article • Molecular BioSystems, January 2011, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  47. Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4′)

    Article • Biochemical and Biophysical Research Communications, December 2010, Elsevier

    Dr Sylvie Garneau-Tsodikova

  48. Redesign of Cosubstrate Specificity and Identification of Important Residues for Substrate Binding to hChAT

    Article • Biochemistry, July 2010, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  49. ChemInform Abstract: The Future of Aminoglycosides: The End or Renaissance?

    Article • ChemInform, June 2010, Wiley

    Dr Sylvie Garneau-Tsodikova

  50. Special Series: Natural products at the core of drug discovery

    Article • Biopolymers, June 2010, Wiley

    Dr Sylvie Garneau-Tsodikova

  51. Recent developments in bisintercalator natural products

    Article • Biopolymers, June 2010, Wiley

    Dr Sylvie Garneau-Tsodikova

  52. The Future of Aminoglycosides: The End or Renaissance?

    Article • ChemBioChem, April 2010, Wiley

    Dr Sylvie Garneau-Tsodikova

  53. A New Scaffold of an Old Protein Fold Ensures Binding to the Bisintercalator Thiocoraline

    Article • Journal of Molecular Biology, March 2010, Elsevier

    Dr Sylvie Garneau-Tsodikova

  54. Cover Picture: Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides (ChemBioChem 1/2010)

    Article • ChemBioChem, December 2009, Wiley

    Dr Sylvie Garneau-Tsodikova

  55. Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides

    Article • ChemBioChem, November 2009, Wiley

    Dr Sylvie Garneau-Tsodikova

  56. hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors

    Article • ChemBioChem, September 2009, Wiley

    Dr Sylvie Garneau-Tsodikova

  57. Exact and user-friendly kinetic analysis of the two-step rapid equilibrium Michaelis–Menten mechanism

    Article • Analytical Biochemistry, April 2009, Elsevier

    Dr Sylvie Garneau-Tsodikova

  58. A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis

    Article • Analytical Biochemistry, March 2009, Elsevier

    Dr Sylvie Garneau-Tsodikova

  59. Automated genome mining for natural products

    Article • BMC Bioinformatics, January 2009, Springer Science + Business Media

    Dr Sylvie Garneau-Tsodikova

  60. Protein Kinase Inhibitors in the Treatment of Pulmonary Fibrosis

    Article • Current Medicinal Chemistry, October 2008, Bentham Science Publishers

    Dr Sylvie Garneau-Tsodikova

  61. Book Review of Asymmetric Organic Synthesis with Enzymes Asymmetric Organic Synthesis with Enzymes . Edited by Vicente Gotor (Universidad de Oviedo, Spain), Ignacio Alfonso (Universidad Jaume I, Castellón, Spain), and Eduardo García-Urdiales (EMBL-Bi...

    Article • Journal of the American Chemical Society, August 2008, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  62. Characterization of TioF, a tryptophan 2,3-dioxygenase involved in 3-hydroxyquinaldic acid formation during thiocoraline biosynthesis

    Article • Molecular BioSystems, January 2008, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  63. Chemoenzymatic Formation of Novel Aminocoumarin Antibiotics by the Enzymes CouN1 and CouN7 †

    Article • Biochemistry, July 2007, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  64. Covalent CouN7 Enzyme Intermediate for Acyl Group Shuttling in Aminocoumarin Biosynthesis

    Article • Chemistry & Biology, June 2007, Elsevier

    Dr Sylvie Garneau-Tsodikova

  65. Nature′s Inventory of Halogenation Catalysts: Oxidative Strategies Predominate

    Article • ChemInform, November 2006, Wiley

    Dr Sylvie Garneau-Tsodikova

  66. Enzymatic Generation of the Antimetabolite γ,γ-Dichloroaminobutyrate by NRPS and Mononuclear Iron Halogenase Action in a Streptomycete

    Article • Chemistry & Biology, November 2006, Elsevier

    Dr Sylvie Garneau-Tsodikova

  67. Biological Formation of Pyrroles: Nature′s Logic and Enzymatic Machinery

    Article • ChemInform, October 2006, Wiley

    Dr Sylvie Garneau-Tsodikova

  68. Protein Assembly Line Components in Prodigiosin Biosynthesis:  Characterization of PigA,G,H,I,J

    Article • Journal of the American Chemical Society, October 2006, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  69. Facile Detection of Acyl and Peptidyl Intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions during Tandem Mass Spectrometry †

    Article • Biochemistry, October 2006, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  70. Nature's Inventory of Halogenation Catalysts:  Oxidative Strategies Predominate

    Article • Chemical Reviews, August 2006, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  71. Installation of the Pyrrolyl-2-carboxyl Pharmacophore by CouN1 and CouN7 in the Late Biosynthetic Steps of the Aminocoumarin Antibiotics Clorobiocin and Coumermycin A 1 †

    Article • Biochemistry, July 2006, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  72. Protein Posttranslational Modifications: The Chemistry of Proteome Diversifications

    Article • ChemInform, February 2006, Wiley

    Dr Sylvie Garneau-Tsodikova

  73. Activity Screening of Carrier Domains within Nonribosomal Peptide Synthetases Using Complex Substrate Mixtures and Large Molecule Mass Spectrometry †

    Article • Biochemistry, February 2006, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  74. Biological formation of pyrroles: Nature's logic and enzymatic machinery

    Article • Natural Product Reports, January 2006, Royal Society of Chemistry

    Dr Sylvie Garneau-Tsodikova

  75. Posttranslationale Proteinmodifikation: die Chemie der Proteomdiversifizierung

    Article • Angewandte Chemie, November 2005, Wiley

    Dr Sylvie Garneau-Tsodikova

  76. Protein Posttranslational Modifications: The Chemistry of Proteome Diversifications

    Article • Angewandte Chemie International Edition, November 2005, Wiley

    Dr Sylvie Garneau-Tsodikova

  77. Characterization of the Formation of the Pyrrole Moiety during Clorobiocin and Coumermycin A 1 Biosynthesis †

    Article • Biochemistry, March 2005, American Chemical Society (ACS)

    Dr Sylvie Garneau-Tsodikova

  78. Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b

    Article • Bioorganic & Medicinal Chemistry, December 2004, Elsevier

    Dr Sylvie Garneau-Tsodikova

  79. Hybrid Nonribosomal Peptide-Polyketide Interfaces in Epothilone Biosynthesis

    Article • Chemistry & Biology, November 2004, Elsevier

    Dr Sylvie Garneau-Tsodikova

  80. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase

    Article • European Journal of Biochemistry, September 2003, Wiley

    Dr Sylvie Garneau-Tsodikova

  81. Two-peptide bacteriocins produced by lactic acid bacteria

    Article • Biochimie, May 2002, Elsevier

    Dr Sylvie Garneau-Tsodikova

  82. Stabilisation of spread monolayers of an amine-functionalised biphenyl mesogen by association with a carboxymethyl cellulose salt

    Article • Macromolecular Chemistry and Physics, November 2000, Wiley

    Dr Sylvie Garneau-Tsodikova

  83. Stabilisation of spread monolayers of an amine-functionalised biphenyl mesogen by association with a carboxymethyl cellulose salt

    Article • Macromolecular Chemistry and Physics, November 2000, Wiley

    Dr Sylvie Garneau-Tsodikova

  84. Glutamyl Adenylate Analogues Are Inhibitors of Glutamyl-tRNA Synthetase

    Article • Bioorganic Chemistry, June 1998, Elsevier

    Dr Sylvie Garneau-Tsodikova