All Stories

  1. Influence of Polymer Molecular Weight on Drug–polymer Solubility: A Comparison between Experimentally Determined Solubility in PVP and Prediction Derived from Solubility in Monomer

    Article • Journal of Pharmaceutical Sciences, September 2015, Elsevier

    Dr Rene Holm

  2. Investigation of enzyme-sensitive lipid nanoparticles for delivery of siRNA to blood–brain barrier and glioma cells

    Article • International Journal of Nanomedicine, September 2015, Dove Medical Press

    Dr Rene Holm, Dr Rasmus Irming Jølck

  3. Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats – A comparative study

    Article • International Journal of Pharmaceutics, May 2015, Elsevier

    Dr Rene Holm

  4. Kolliphor Surfactants Affect Solubilization and Bioavailability of Fenofibrate. Studies of in Vitro Digestion and Absorption in Rats

    Article • Molecular Pharmaceutics, April 2015, American Chemical Society (ACS)

    Dr Rene Holm

  5. Evaluation of Drug–Polymer Solubility Curves Through Formal Statistical Analysis: Comparison of Preparation Techniques

    Article • Journal of Pharmaceutical Sciences, January 2015, Elsevier

    Dr Rene Holm

  6. Evaluation of the Use of Göttingen Minipigs to Predict Food Effects on the Oral Absorption of Drugs in Humans

    Article • Journal of Pharmaceutical Sciences, January 2015, Elsevier

    Dr Rene Holm

  7. Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media

    Article • European Journal of Pharmaceutics and Biopharmaceutics, January 2015, Elsevier

    Dr Rene Holm

  8. Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs—a fenofibrate case example

    Article • International Journal of Pharmaceutics, October 2014, Elsevier

    Dr Rene Holm

  9. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models

    Article • International Journal of Pharmaceutics, October 2014, Elsevier

    Dr Rene Holm

  10. Computational Investigation of Enthalpy–Entropy Compensation in Complexation of Glycoconjugated Bile Salts with β-Cyclodextrin and Analogs

    Article • The Journal of Physical Chemistry, September 2014, American Chemical Society (ACS)

    Dr Rene Holm

  11. In vivo and In vitro Evaluations of Intestinal Gabapentin Absorption: Effect of Dose and Inhibitors on Carrier-Mediated Transport

    Article • Pharmaceutical Research, September 2014, Springer Science + Business Media

    Dr Rene Holm

  12. Complexation Thermodynamics of Modified Cyclodextrins: Extended Cavities and Distorted Structures

    Article • The Journal of Physical Chemistry, August 2014, American Chemical Society (ACS)

    Dr Rene Holm

  13. The solid-state continuum: a perspective on the interrelationships between different solid-state forms in drug substance and drug product

    Article • Journal of Pharmacy and Pharmacology, August 2014, Oxford University Press (OUP)

    Dr Rene Holm, Dr David Philip/P Elder

  14. Pharmacokinetic aspects of the anti-epileptic drug substance vigabatrin: focus on transporter interactions

    Article • Therapeutic Delivery, August 2014, Future Science

    Dr Rene Holm

  15. Ex Vivo Correlation of the Permeability of Metoprolol Across Human and Porcine Buccal Mucosa

    Article • Journal of Pharmaceutical Sciences, July 2014, Elsevier

    Dr Jette Jacobsen, Dr Rene Holm

  16. Determination of the aggregation number for micelles by isothermal titration calorimetry

    Article • Thermochimica Acta, July 2014, Elsevier

    Dr Rene Holm

  17. Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

    Article • European Journal of Pharmaceutical Sciences, June 2014, Elsevier

    Dr Rene Holm

  18. Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS)

    Article • European Journal of Pharmaceutical Sciences, June 2014, Elsevier

    Dr Rene Holm

  19. In vitro models for the prediction of in vivo performance of oral dosage forms

    Article • European Journal of Pharmaceutical Sciences, June 2014, Elsevier

    Dr Rene Holm

  20. Early pharmaceutical profiling to predict oral drug absorption: Current status and unmet needs

    Article • European Journal of Pharmaceutical Sciences, June 2014, Elsevier

    Dr Rene Holm

  21. In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

    Article • European Journal of Pharmaceutical Sciences, June 2014, Elsevier

    Dr Rene Holm

  22. Intestinal absorption of the antiepileptic drug substance vigabatrin in Göttingen mini-pigs is unaffected by co-administration of amino acids

    Article • International Journal of Pharmaceutics, May 2014, Elsevier

    Dr Rene Holm

  23. In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

    Article • The AAPS Journal, April 2014, American Association of Pharmaceutical Scientists (AAPS)

    Dr Rene Holm

  24. Azone® Decreases the Buccal Mucosal Permeation of Diazepam in a Concentration-Dependent Manner via a Reservoir Effect

    Article • Journal of Pharmaceutical Sciences, April 2014, Elsevier

    Dr Rene Holm

  25. Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo.

    Article • Pharmacology Research & Perspectives, March 2014, Wiley

    Dr Rene Holm

  26. Conscious and anaesthetised Göttingen mini-pigs as anin-vivomodel for buccal absorption – pH-dependent absorption of metoprolol from bioadhesive tablets

    Article • Drug Development and Industrial Pharmacy, February 2014, Taylor & Francis

    Dr Rene Holm

  27. A study of salt effects on the complexation between β-cyclodextrins and bile salts based on the Hofmeister series

    Article • Journal of Inclusion Phenomena and Macrocyclic Chemistry, January 2014, Springer Science + Business Media

    Dr Rene Holm

  28. Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

    Article • European Journal of Pharmaceutical Sciences, January 2014, Elsevier

    Dr Rene Holm

  29. The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

    Article • European Journal of Pharmaceutical Sciences, January 2014, Elsevier

    Dr Rene Holm

  30. Biological conversion of aripiprazole lauroxil − An N-acyloxymethyl aripiprazole prodrug

    Article • Results in Pharma Sciences, January 2014, Elsevier

    Dr Rene Holm

  31. Buccal absorption of propofol when dosed in 1-perfluorobutylpentane to anaesthetised and conscious Wistar rats and Göttingen mini-pigs

    Article • European Journal of Pharmaceutics and Biopharmaceutics, November 2013, Elsevier

    Dr Rene Holm

  32. Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

    Article • European Journal of Pharmaceutics and Biopharmaceutics, November 2013, Elsevier

    Dr Rene Holm

  33. Bile salts and their importance for drug absorption

    Article • International Journal of Pharmaceutics, August 2013, Elsevier

    Dr Rene Holm

  34. Aqueous solubility: Simple predictive methods (in silico, in vitro and bio-relevant approaches)

    Article • International Journal of Pharmaceutics, August 2013, Elsevier

    Dr Rene Holm

  35. Use of pharmaceutical salts and cocrystals to address the issue of poor solubility

    Article • International Journal of Pharmaceutics, August 2013, Elsevier

    Dr Rene Holm

  36. Lipid-based formulations for oral administration of poorly water-soluble drugs

    Article • International Journal of Pharmaceutics, August 2013, Elsevier

    Dr Rene Holm

  37. In vitro, ex vivo and in vivo examination of buccal absorption of metoprolol with varying pH in TR146 cell culture, porcine buccal mucosa and Göttingen minipigs

    Article • European Journal of Pharmaceutical Sciences, May 2013, Elsevier

    Dr Rene Holm

  38. Extending the hydrophobic cavity of β-cyclodextrin results in more negative heat capacity changes but reduced binding affinities

    Article • Journal of Inclusion Phenomena and Macrocyclic Chemistry, March 2013, Springer Science + Business Media

    Dr Rene Holm

  39. Determination of stability constants of tauro- and glyco-conjugated bile salts with the negatively charged sulfobutylether-β-cyclodextrin: comparison of affinity capillary electrophoresis and isothermal titration calorimetry and thermodynamic analysis ...

    Article • Journal of Inclusion Phenomena and Macrocyclic Chemistry, January 2013, Springer Science + Business Media

    Dr Rene Holm

  40. Supersaturated Self-Nanoemulsifying Drug Delivery Systems (Super-SNEDDS) Enhance the Bioavailability of the Poorly Water-Soluble Drug Simvastatin in Dogs

    Article • The AAPS Journal, November 2012, American Association of Pharmaceutical Scientists (AAPS)

    Dr Rene Holm

  41. In vitro investigations of α-amylase mediated hydrolysis of cyclodextrins in the presence of ibuprofen, flurbiprofen, or benzo[a]pyrene

    Article • Carbohydrate Research, November 2012, Elsevier

    Dr Rene Holm

  42. Affinity capillary electrophoresis method for investigation of bile salts complexation with sulfobutyl ether-β-cyclodextrin

    Article • Journal of Separation Science, September 2012, Wiley

    Dr Rene Holm

  43. Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development

    Article • The AAPS Journal, September 2012, American Association of Pharmaceutical Scientists (AAPS)

    Dr Rene Holm

  44. Intestinal Drug Transport via the Proton-Coupled Amino Acid Transporter PAT1 (SLC36A1) Is Inhibited by Gly-X aa Dipeptides

    Article • Molecular Pharmaceutics, September 2012, American Chemical Society (ACS)

    Dr Rene Holm

  45. Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

    Article • European Journal of Pharmaceutical Sciences, September 2012, Elsevier

    Dr Rene Holm

  46. Thermodynamics of the interaction of γ-cyclodextrin and tauro- and glyco-conjugated bile salts

    Article • Journal of Inclusion Phenomena and Macrocyclic Chemistry, June 2012, Springer Science + Business Media

    Dr Rene Holm

  47. Influence of bile on the absorption of halofantrine from lipid-based formulations

    Article • European Journal of Pharmaceutics and Biopharmaceutics, June 2012, Elsevier

    Dr Rene Holm

  48. Higher Order Inclusion Complexes and Secondary Interactions Studied by Global Analysis of Calorimetric Titrations

    Article • Analytical Chemistry, March 2012, American Chemical Society (ACS)

    Dr Rene Holm

  49. Rectal Absorption of Vigabatrin, a Substrate of the Proton Coupled Amino Acid Transporter (PAT1, Slc36a1), in Rats

    Article • Pharmaceutical Research, January 2012, Springer Science + Business Media

    Dr Rene Holm

  50. Complexation of tauro- and glyco-conjugated bile salts with α-cyclodextrin and hydroxypropyl-α-cyclodextrin studied by affinity capillary electrophoresis and molecular modelling

    Article • Journal of Separation Science, October 2011, Wiley

    Dr Rene Holm

  51. Solid state compatibility studies with tablet excipients using non thermal methods

    Article • Journal of Pharmaceutical and Biomedical Analysis, June 2011, Elsevier

    Dr Rene Holm

  52. Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats

    Article • Journal of Pharmacy and Pharmacology, May 2011, Oxford University Press (OUP)

    Dr Rene Holm

  53. Oral bioavailability of a poorly aqueous drug from three different SBE7-β-cyclodextrin based formulations in beagle dogs

    Article • Results in Pharma Sciences, May 2011, Elsevier

    Dr Rene Holm

  54. A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs

    Article • European Journal of Pharmaceutical Sciences, March 2011, Elsevier

    Dr Rene Holm

  55. Thermodynamics of complexation of tauro- and glyco-conjugated bile salts with two modified β-cyclodextrins

    Article • Journal of Inclusion Phenomena and Macrocyclic Chemistry, July 2010, Springer Science + Business Media

    Dr Rene Holm

  56. 5-Hydroxy-l-tryptophan alters gaboxadol pharmacokinetics in rats: Involvement of PAT1 and rOat1 in gaboxadol absorption and elimination

    Article • European Journal of Pharmaceutical Sciences, January 2010, Elsevier

    Dr Rene Holm

  57. Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats

    Article • Journal of Pharmacy and Pharmacology, January 2010, Oxford University Press (OUP)

    Dr Rene Holm

  58. Use of correction factors in mobility shift affinity capillary electrophoresis for weak analyte - ligand interactions

    Article • Journal of Separation Science, May 2009, Wiley

    Dr Rene Holm

  59. Thermodynamics and structure of inclusion compounds of tauro- and glyco-conjugated bile salts and β-cyclodextrin

    Article • Physical Chemistry Chemical Physics, January 2009, Royal Society of Chemistry

    Dr Rene Holm

  60. Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: The influence of polysorbate 60 and 80

    Article • European Journal of Pharmaceutical Sciences, October 2008, Elsevier

    Dr Rene Holm

  61. Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats

    Article • Psychopharmacology, July 2008, Springer Science + Business Media

    Dr Rene Holm

  62. Lipid-based Formulations for Danazol Containing a Digestible Surfactant, Labrafil M2125CS: In Vivo Bioavailability and Dynamic In Vitro Lipolysis

    Article • Pharmaceutical Research, July 2008, Springer Science + Business Media

    Dr Rene Holm

  63. Characterization of the complexation of tauro- and glyco-conjugated bile salts with γ-cyclodextrin and 2-hydroxypropyl-γ-cyclodextrin using affinity capillary electrophoresis

    Article • Journal of Inclusion Phenomena and Macrocyclic Chemistry, January 2008, Springer Science + Business Media

    Dr Rene Holm

  64. Characterization and Physical Stability of Spray Dried Solid Dispersions of Probucol and PVP-K30

    Article • Pharmaceutical Development and Technology, January 2008, Taylor & Francis

    Dr Rene Holm

  65. Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: Assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms

    Article • European Journal of Pharmaceutical Sciences, December 2007, Elsevier

    Dr Rene Holm

  66. Complexation of tauro- and glyco-conjugated bile salts with three neutral β-CDs studied by ACE

    Article • Electrophoresis, October 2007, Wiley

    Dr Rene Holm

  67. Food matrices affect the bioavailability of (n−3) polyunsaturated fatty acids in a single meal study in humans

    Article • Food Research International, October 2007, Elsevier

    Dr Rene Holm

  68. Lymphatic fatty acids in canines dosed with pharmaceutical formulations containing structured triacylglycerols

    Article • European Journal of Lipid Science and Technology, September 2006, Wiley

    Dr Rene Holm, Christopher Porter

  69. Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture

    Article • Journal of Pharmaceutical Sciences, January 2006, Elsevier

    Dr Rene Holm

  70. Influence of the Type of Surfactant and the Degree of Dispersion on the Lymphatic Transport of Halofantrine in Conscious Rats

    Article • Pharmaceutical Research, August 2004, Springer Science + Business Media

    Dr Rene Holm

  71. Successful in silico predicting of intestinal lymphatic transfer

    Article • International Journal of Pharmaceutics, March 2004, Elsevier

    Dr Rene Holm

  72. Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats

    Article • European Journal of Pharmaceutical Sciences, December 2001, Elsevier

    Dr Rene Holm