All Stories

  1. Antimicrobial and Structural Properties of Metal Ions Complexes with Thiosemicarbazide Motif and Related Heterocyclic Compounds

    Article • Current Medicinal Chemistry, April 2019, Bentham Science Publishers

    Piotr Guga, Ewelina Namiecinska

  2. Guanosine in a Single Stranded Region of Anticodon Stem-Loop tRNA Models is Prone to Oxidatively Generated Damage Resulting in Dehydroguanidinohydantoin and Spiroiminodihydantoin Lesions

    Article • Chemistry - A European Journal, March 2015, Wiley

    Piotr Guga

  3. LNA units present in the (2′-OMe)-RNA strand stabilize parallel duplexes (2′-OMe)-RNA/[All-RP-PS]-DNA and parallel triplexes (2′-OMe)-RNA/[All-RP-PS]-DNA/RNA. An improved tool for the inhibition of reverse transcription

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Piotr Guga

  4. Thermal stability and conformation of antiparallel duplexes formed by P-stereodefined phosphorothioate DNA/LNA chimeric oligomers with DNA and RNA matrices

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Piotr Guga

  5. Unexpected Loss of Stereoselectivity in Ring-Opening Reaction of 2-Alkoxy-2-Thio-1,3,2-Oxathiaphospholanes With a Pyrophosphate Anion

    Article • Chirality, November 2014, Wiley

    Piotr Guga

  6. Selenium and Tellurium Derivatives of Carbohydrates and Nucleotides

    Article • April 2014, Wiley

    Piotr Guga

  7. ChemInform Abstract: Phosphorothioate Nucleotides and Oligonucleotides-Recent Progress in Synthesis and Application

    Article • ChemInform, February 2013, Wiley

    Piotr Guga

  8. A Single Nuclease-Resistant Linkage in DNA as a Versatile Tool for the Characterization of DNA Lesions: Application to the Guanine Oxidative Lesion “G+34” Generated by Metalloporphyrin/KHSO 5 Reagent

    Article • Chemical Research in Toxicology, November 2012, American Chemical Society (ACS)

    Piotr Guga

  9. ChemInform Abstract: Phosphorothioate Nucleotides and Oligonucleotides - Recent Progress in Synthesis and Application

    Article • ChemInform, December 2011, Wiley

    Piotr Guga

  10. Phosphorothioate Nucleotides and Oligonucleotides - Recent Progress in Synthesis and Application

    Article • Chemistry & Biodiversity, September 2011, Wiley

    Piotr Guga

  11. Diastereomerically pure nucleoside-5′-O-(2-thio-4,4-pentamethylene-1,3,2-oxathiaphospholane)s-Substrates for synthesis of P-chiral derivatives of nucleoside-5′-O-phosphorothioates

    Article • Chirality, October 2010, Wiley

    Piotr Guga

  12. ChemInform Abstract: Oligo(nucleoside Phosphorothioate)s

    Article • ChemInform, June 2010, Wiley

    Piotr Guga

  13. ChemInform Abstract: Nucleoside 3′-O-(2-oxo-“spiro”-4.4-Pentamethylene-1.3.2-oxathiaphospholane)s: Monomers for Stereocontrolled Synthesis of Oligo(Nucleoside Phosphorothioate/Phosphate)s.

    Article • ChemInform, June 2010, Wiley

    Piotr Guga

  14. Restoration of catalytic functions in Cre recombinase mutants by electrostatic compensation between active site and DNA substrate

    Article • Nucleic Acids Research, May 2010, Oxford University Press (OUP)

    Piotr Guga

  15. ChemInform Abstract: Recent Advances in Stereocontrolled Synthesis of P-Chiral Analogues of Biophosphates.

    Article • ChemInform, May 2010, Wiley

    Piotr Guga

  16. Electrostatic Suppression Allows Tyrosine Site-specific Recombination in the Absence of a Conserved Catalytic Arginine

    Article • Journal of Biological Chemistry, May 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Piotr Guga

  17. Stereoselective formation of a P–P bond in the reaction of 2-alkoxy-2-thio-1,3,2-oxathiaphospholanes with O,O-dialkyl H-phosphonates and H-thiophosphonates

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Piotr Guga

  18. Reactions of Cre with Methylphosphonate DNA: Similarities and Contrasts with Flp and Vaccinia Topoisomerase

    Article • PLoS ONE, September 2009, PLOS

    Piotr Guga

  19. Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination

    Article • The EMBO Journal, May 2009, Wiley

    Piotr Guga

  20. ChemInform Abstract: 1,3,2-Oxathiaphospholane Approach to the Synthesis of P-Chiral Stereodefined Analogues of Oligonucleotides and Biologically Relevant Nucleoside Polyphosphates

    Article • ChemInform, January 2009, Wiley

    Piotr Guga

  21. Selenium-Derivatized Oligonucleotides

    Article • Phosphorus Sulfur and Silicon and the Related Elements, April 2008, Taylor & Francis

    Piotr Guga

  22. 1,3,2-Oxathiaphospholane approach to the synthesis of P-chiral stereodefined analogs of oligonucleotides and biologically relevant nucleoside polyphosphates

    Article • Pure and Applied Chemistry, January 2008, De Gruyter

    Piotr Guga

  23. Hoogsteen-Paired Homopurine [RP-PS]-DNA and Homopyrimidine RNA Strands Form a Thermally Stable Parallel Duplex

    Article • Biophysical Journal, November 2007, Elsevier

    Piotr Guga

  24. P-Chiral Oligonucleotides in Biological Recognition Processes

    Article • Current Topics in Medicinal Chemistry, April 2007, Bentham Science Publishers

    Piotr Guga

  25. Unusual Thermal Stability of RNA/[RP-PS]-DNA/RNA Triplexes Containing a Homopurine DNA Strand

    Article • Biophysical Journal, April 2007, Elsevier

    Piotr Guga

  26. Cyclization versus oligomerization of SP- and RP-5′-OH-N4-benzoyl-2′-deoxycytidine-3′-O-(2-thio-4,4-pentamethylene-1,3,2-oxathiaphospholane)s

    Article • Tetrahedron, March 2006, Elsevier

    Piotr Guga

  27. Enhanced P-stereodependent stability of complexes formed by phosphorothioate oligonucleotides due to involvement of sulfur as strong hydrogen bond acceptor

    Article • Pure and Applied Chemistry, January 2006, De Gruyter

    Piotr Guga

  28. Oxathiaphospholane Approach to the Synthesis of Oligodeoxyribonucleotides Containing Stereodefined Internucleotide Phosphoroselenoate Function †

    Article • Organic Letters, September 2005, American Chemical Society (ACS)

    Piotr Guga

  29. Effect of Phosphorothioate Chirality on i-Motif Structure and Stability †

    Article • Biochemistry, May 2004, American Chemical Society (ACS)

    Piotr Guga

  30. Comparison of the cleavage profiles of oligonucleotide duplexes with or without phosphorothioate linkages by using a chemical nuclease probe

    Article • JBIC Journal of Biological Inorganic Chemistry, March 2004, Springer Science + Business Media

    Dr Arkadiusz Chworos, Piotr Guga

  31. P-Chirality-Dependent Immune Activation by Phosphorothioate CpG Oligodeoxynucleotides

    Article • Oligonucleotides, December 2003, Mary Ann Liebert Inc

    Piotr Guga

  32. Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition?

    Article • Biophysical Journal, October 2003, Elsevier

    Piotr Guga

  33. Synthesis of Phosphorothioate Oligonucleotides with Stereodefined Phosphorothioate Linkages

    Article • Current Protocols in Nucleic Acid Chemistry, September 2003, Wiley

    Piotr Guga

  34. Stereodefined Phosphorothioate Analogues of DNA:  Relative Thermodynamic Stability of the Model PS-DNA/DNA and PS-DNA/RNA Complexes †

    Article • Biochemistry, October 2002, American Chemical Society (ACS)

    Piotr Guga

  35. Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model

    Article • FEBS Letters, August 2002, Wiley

    Piotr Guga

  36. Synthesis of P-Chiral [ 18 O]-Labeled Isotopomeric Oligo(deoxyribonucleoside Phosphorothioate)s and Phosphates

    Article • Phosphorus Sulfur and Silicon and the Related Elements, June 2002, Taylor & Francis

    Piotr Guga

  37. Retention of Configuration in the Action of Human Plasma 3‘-Exonuclease on Oligo(deoxynucleoside phosphorothioate). A New Method for Assignment of Absolute Configuration at Phosphorus in Isotopomeric Deoxyadenosine 5‘- O -[ 18 O]Phosphorothioate

    Article • Journal of the American Chemical Society, May 2002, American Chemical Society (ACS)

    Piotr Guga

  38. Recent Advances in Stereocontrolled Synthesis of P-Chiral Analogues of Biophosphates

    Article • January 2002, Springer Science + Business Media

    Piotr Guga

  39. Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope

    Article • Angewandte Chemie, February 2001, Wiley

    Piotr Guga

  40. Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope

    Article • Angewandte Chemie International Edition, February 2001, Wiley

    Piotr Guga

  41. Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope

    Article • Angewandte Chemie International Edition, January 2001, Wiley

    Piotr Guga

  42. Effect of P-Chirality of Internucleotide Bonds on B−Z Conversion of Stereodefined Self-Complementary Phosphorothioate Oligonucleotides of the [PS]-d(CG) 4 and [PS]-d(GC) 4 Series †

    Article • Biochemistry, September 2000, American Chemical Society (ACS)

    Piotr Guga

  43. Nucleoside 3′-O-(2-Oxo-“Spiro”-4.4-Pentamethylene-1.3.2-Oxathiaphospholane)S: Monomers For Stereocontrolled Synthesis Of Oligo(Nucleoside Phosphorothioate/Phosphate)S

    Article • Nucleosides and Nucleotides, September 1998, Taylor & Francis

    Piotr Guga

  44. Deoxyribonucleoside 3‘- O -(2-Thio- and 2-Oxo-“spiro”-4,4-pentamethylene-1,3,2-oxathiaphospholane)s:  Monomers for Stereocontrolled Synthesis of Oligo(deoxyribonucleoside phosphorothioate)s and Chimeric PS/PO Oligonucleotides §

    Article • Journal of the American Chemical Society, July 1998, American Chemical Society (ACS)

    Piotr Guga

  45. Stability of Stereoregular Oligo(nucleoside Phosphorothioate)s in Human Plasma: Diastereoselectivity of Plasma 3‵-Exonuclease

    Article • Antisense and Nucleic Acid Drug Development, February 1997, Mary Ann Liebert Inc

    Piotr Guga

  46. Stereochemistry of Dbu-Assisted Reaction of Nucleoside 3'-O-(2-Thiono-1.3.2-Oxathiaphospholanes) with 5'-Hydroxynucleosides

    Article • Phosphorus Sulfur and Silicon and the Related Elements, February 1996, Taylor & Francis

    Piotr Guga

  47. Stereochemistry of Dbu-Assisted Reaction of Nucleoside 3'-O-(2-Thiono-1.3.2-Oxathiaphospholanes) with 5'-Hydroxynucleosides

    Article • Phosphorus Sulfur and Silicon and the Related Elements, January 1996, Taylor & Francis

    Piotr Guga

  48. Diastereomers of Nucleoside 3'-O-(2-Thio-1,3,2-oxathia(selena)phospholanes): Building Blocks for Stereocontrolled Synthesis of Oligo(nucleoside phosphorothioate)s

    Article • Journal of the American Chemical Society, December 1995, American Chemical Society (ACS)

    Piotr Guga

  49. Activation of the Carboxy Terminus of a Peptide for Carboxy-Terminal Sequencing

    Article • The Journal of Organic Chemistry, April 1995, American Chemical Society (ACS)

    Piotr Guga

  50. Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent

    Article • Nucleic Acids Research, January 1995, Oxford University Press (OUP)

    Piotr Guga

  51. The effects of tumor necrosis factor (TNF) derivatives on TNF receptors

    Article • Cytokine, March 1993, Elsevier

    Piotr Guga

  52. The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophilsin vitro

    Article • Mediators of Inflammation, January 1993, Hindawi Publishing Corporation

    Piotr Guga

  53. Synthesis of a gene encoding bovine substance P precursors and its expression in Escherichia coli

    Article • Gene, August 1992, Elsevier

    Piotr Guga

  54. Stereochemistry of the reaction of ribonucleoside cyclic 3?,5?-phosphorothioates with oxiranes

    Article • Heteroatom Chemistry, October 1991, Wiley

    Piotr Guga

  55. Mechanism of Formation of Ribonucleoside Cyclic 2′,3′-Phosphates in the Reaction of Appropriate 3′,5′-Phos-Phorothioates with Epoxides

    Article • Phosphorus Sulfur and Silicon and the Related Elements, September 1990, Taylor & Francis

    Piotr Guga

  56. Mechanism of Formation of Ribonucleoside Cyclic 2',3'-Phosphates in the Reaction of Appropriate 3',5'-Phosphorothioates with Epoxides

    Article • Phosphorus Sulfur and Silicon and the Related Elements, January 1990, Taylor & Francis

    Piotr Guga

  57. Novel approach to the synthesis of isotopomeric monoalkyl [16O,17O,18O]phosphates. The stereospecific one-pot conversion of (RP)-thymidine 3′-(4-nitrophenyl)phosphorothioate into (RP)-thymidine 3′-...

    Article • Journal of the Chemical Society Chemical Communications, January 1987, Royal Society of Chemistry

    Piotr Guga

  58. DNA-Triesters - The Synthesis and Absolute Configuration Assignments at P-Stereogenic Centres

    Article • Nucleosides and Nucleotides, January 1987, Taylor & Francis

    Piotr Guga

  59. Direct transformation of ribonucleoside cyclic 3′,5′-phosphorothioates into cyclic 2′,3′-phosphates

    Article • Journal of the Chemical Society Chemical Communications, January 1985, Royal Society of Chemistry

    Piotr Guga

  60. Stereoretentive conversion of dialkyl [18O]-phosphoranilidates into dialkyl hydrogen [18O]-phosphates

    Article • Tetrahedron Letters, January 1985, Elsevier

    Piotr Guga

  61. Synthesis and absolute configuration of P-chiral -isopropyl oligonucleotide triesters

    Article • Tetrahedron Letters, January 1985, Elsevier

    Piotr Guga

  62. Stereospecific conversion of P-chiral nucleoside phosphorothioates into [18O]phosphates

    Article • Tetrahedron Letters, January 1984, Elsevier

    Piotr Guga

  63. Stereoretentive conversion of dialkyl phosphorothioates into [18O]-phosphates

    Article • Tetrahedron Letters, January 1983, Elsevier

    Piotr Guga