All Stories

  1. Absence of diurnal variation in visceromotor response to colorectal distention in normal Long Evans rats

    Article • F1000Research, January 2016, Faculty of 1000, Ltd.

    Dr René M van den Wijngaard, Andries Kalsbeek

  2. Dietary Marine n–3 PUFAs Do Not Affect Stress-Induced Visceral Hypersensitivity in a Rat Maternal Separation Model1–3

    Article • Journal of Nutrition, February 2015, Oxford University Press (OUP)

    Dr René M van den Wijngaard

  3. Proton Pump Inhibitors Partially Restore Mucosal Integrity in Patients With Proton Pump Inhibitor–Responsive Esophageal Eosinophilia but Not Eosinophilic Esophagitis

    Article • Clinical Gastroenterology and Hepatology, November 2014, Elsevier

    Dr René M van den Wijngaard

  4. Susceptibility to stress induced visceral hypersensitivity in maternally separated rats is transferred across generations

    Article • Neurogastroenterology & Motility, August 2013, Wiley

    Dr René M van den Wijngaard

  5. Stress-Induced Visceral Hypersensitivity in Maternally Separated Rats Can Be Reversed by Peripherally Restricted Histamine-1-Receptor Antagonists

    Article • PLoS ONE, June 2013, PLOS

    Dr René M van den Wijngaard

  6. Altered brain activation to colorectal distention in visceral hypersensitive maternal-separated rats

    Article • Neurogastroenterology & Motility, April 2012, Wiley

    Dr René M van den Wijngaard

  7. Mucosal Immune Cell Numbers and Visceral Sensitivity in Patients With Irritable Bowel Syndrome: Is There Any Relationship?

    Article • The American Journal of Gastroenterology, April 2012, Wolters Kluwer Health

    Dr René M van den Wijngaard

  8. Special issue on mast cells in inflammation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, January 2012, Elsevier

    Dr René M van den Wijngaard

  9. Nicotinic Acetylcholine Receptor Expression and Susceptibility to Cholinergic Immunomodulation in Human Monocytes of Smoking Individuals

    Article • NeuroImmunoModulation, January 2012, Karger Publishers

    Dr René M van den Wijngaard

  10. Intestinal mast cells in gut inflammation and motility disturbances

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, January 2012, Elsevier

    Dr René M van den Wijngaard

  11. Relevance of mast cell–nerve interactions in intestinal nociception

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, January 2012, Elsevier

    Dr René M van den Wijngaard

  12. Peripheral α-helical CRF (9-41) does not reverse stress-induced mast cell dependent visceral hypersensitivity in maternally separated rats

    Article • Neurogastroenterology & Motility, November 2011, Wiley

    Dr René M van den Wijngaard

  13. Mast cells trigger epithelial barrier dysfunction, bacterial translocation and postoperative ileus in a mouse model

    Article • Neurogastroenterology & Motility, November 2011, Wiley

    Dr René M van den Wijngaard

  14. The role of rectal chloride secretion in childhood constipation

    Article • Neurogastroenterology & Motility, August 2011, Wiley

    Dr René M van den Wijngaard

  15. Reply

    Article • Gastroenterology, June 2011, Elsevier

    Dr René M van den Wijngaard

  16. The enteric nervous system as a regulator of intestinal epithelial barrier function in health and disease

    Article • Expert Review of Gastroenterology & Hepatology, October 2010, Taylor & Francis

    Dr René M van den Wijngaard

  17. The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients

    Article • Neurogastroenterology & Motility, August 2010, Wiley

    Dr René M van den Wijngaard

  18. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome

    Article • Gut, July 2010, BMJ

    Dr René M van den Wijngaard

  19. 7 The Peripheral Histamine 1-Receptor Antagonist Fexofenadine Effectively Reverses Stress-Induced Visceral Hypersensitivity in a Rat Model of Maternal Separation

    Article • Gastroenterology, May 2010, Elsevier

    Dr René M van den Wijngaard

  20. 195 Free Immunoglobulin Light Chains May Be Involved in Stress-Induced Visceral Hypersensitivity in Maternal Separated Rats

    Article • Gastroenterology, May 2010, Elsevier

    Dr René M van den Wijngaard

  21. S1782 Acetylcholine Protects Against Cytokine Induced Epithelial Barrier Dysfunction

    Article • Gastroenterology, May 2010, Elsevier

    Dr René M van den Wijngaard

  22. T2045 Neuroanatomical Evidence for Activation of Vagal Motor Neurons by Intestinal Inflammation in a Model of Postoperative Ileus

    Article • Gastroenterology, May 2010, Elsevier

    Dr René M van den Wijngaard

  23. 139 The Mechanism of Intestinal Barrier Dysfunction Induced by Bowel Manipulation in a Model for Postoperative Ileus

    Article • Gastroenterology, May 2010, Elsevier

    Dr René M van den Wijngaard

  24. M1220 The Role of Colorectal Chloride Secretion in Childhood Constipation

    Article • Gastroenterology, May 2010, Elsevier

    Dr René M van den Wijngaard

  25. 198 Role of IL-1R-MyD88 Signaling in the Pathogenesis of Postoperative Ileus

    Article • Gastroenterology, May 2010, Elsevier

    Dr René M van den Wijngaard

  26. Neuropeptide Receptors in Intestinal Disease: Physiology and Therapeutic Potential

    Article • Current Pharmaceutical Design, March 2010, Bentham Science Publishers

    Dr René M van den Wijngaard

  27. Neuropeptide Receptors in Intestinal Disease: Physiology and Therapeutic Potential

    Article • Current Pharmaceutical Design, March 2010, Bentham Science Publishers

    Dr René M van den Wijngaard

  28. Peripheral relays in stress-induced activation of visceral afferents in the gut

    Article • Autonomic Neuroscience, February 2010, Elsevier

    Dr René M van den Wijngaard

  29. Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats

    Article • Neurogastroenterology & Motility, October 2009, Wiley

    Dr René M van den Wijngaard

  30. Possible role for TRPV1 in neomycin-induced inhibition of visceral hypersensitivity in rat

    Article • Neurogastroenterology & Motility, August 2009, Wiley

    Dr René M van den Wijngaard

  31. The Role of Mast Cell Stabilization in Treatment of Postoperative Ileus: A Pilot Study

    Article • The American Journal of Gastroenterology, June 2009, Wolters Kluwer Health

    Dr René M van den Wijngaard

  32. 908 CRH-Receptor Antagonism Prevents the Development of Stress-Induced Visceral Hypersensitivity But Fails to Affect Established Hypersensitivity

    Article • Gastroenterology, May 2009, Elsevier

    Dr René M van den Wijngaard

  33. 683 Mast Cell Induced Bacterial Translocation in the Pathogenesis of Postoperative Ileus

    Article • Gastroenterology, May 2009, Elsevier

    Dr René M van den Wijngaard

  34. 684 Vagus Nerve Efferent Activity Enhances Bacterial Uptake and Potentiates TGF-Beta Signaling in Intestinal Lamina Propria Macrophages

    Article • Gastroenterology, May 2009, Elsevier

    Dr René M van den Wijngaard

  35. Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMP

    Article • In Vitro Cellular & Developmental Biology - Animal, July 2008, Springer Science + Business Media

    Dr René M van den Wijngaard

  36. 290 Stress Induced Visceral Hypersensitivity After Maternal Separation in Rats Is Transferred Across Generations in a Behavioral and Mast Cell Dependent Fashion

    Article • Gastroenterology, April 2008, Elsevier

    Dr René M van den Wijngaard

  37. S1715 Mast Cell Induced Bacterial Translocation in the Pathogenesis of Post-Operative Ileus Studied in a Mouse Model

    Article • Gastroenterology, April 2008, Elsevier

    Dr René M van den Wijngaard

  38. Activation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Postoperative Ileus in Mice

    Article • Gastroenterology, October 2007, Elsevier

    Dr René M van den Wijngaard

  39. Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus

    Article • Gut, May 2007, BMJ

    Dr René M van den Wijngaard

  40. Delayed visceral hypersensitivity in maternal separation depends on mast cell degranulation and is mediated by NGF and the nociceptor TRPV-1

    Article • European Journal of Gastroenterology & Hepatology, January 2006, Wolters Kluwer Health

    Dr René M van den Wijngaard

  41. Assessment of visceral sensitivity using radio telemetry in a rat model of maternal separation

    Article • Neurogastroenterology & Motility, December 2005, Wiley

    Dr René M van den Wijngaard

  42. Parental Care, Mast Cells and Visceral Hypersensitivity

    Article • Journal of Pediatric Gastroenterology and Nutrition, September 2005, Wolters Kluwer Health

    Dr René M van den Wijngaard

  43. Achalasia: From New Insights in Pathophysiology to Treatment

    Article • Journal of Pediatric Gastroenterology and Nutrition, September 2005, Wolters Kluwer Health

    Dr René M van den Wijngaard

  44. The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice

    Article • British Journal of Pharmacology, September 2005, Wiley

    Dr René M van den Wijngaard

  45. Inflammation and Gut Motility; Neural Control of Intestinal Immune Cell Activation

    Article • Journal of Pediatric Gastroenterology and Nutrition, September 2005, Wolters Kluwer Health

    Dr René M van den Wijngaard

  46. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

    Article • Nature Immunology, July 2005, Springer Science + Business Media

    Dr René M van den Wijngaard

  47. Non-lesional vitiliginous melanocytes are not characterized by an increased proneness to nitric oxide-induced apoptosis

    Article • Experimental Dermatology, June 2005, Wiley

    Dr René M van den Wijngaard

  48. Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice

    Article • Gastroenterology, August 2004, Elsevier

    Dr René M van den Wijngaard

  49. Autoimmune Aspects of Depigmentation in Vitiligo

    Article • Journal of Investigative Dermatology Symposium Proceedings, January 2004, Elsevier

    Dr René M van den Wijngaard

  50. PP-33 Nitric-Oxide-Induced Detachment of Human Melanocytes from Extracellular Matrix Components is Dependent on Cyclic GMP: Significance in Vitiligo Pathology

    Article • Pigment Cell Research, October 2003, Wiley

    Dr René M van den Wijngaard

  51. Postoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in mice1 1The authors thank Prof. Yvette van Kooyk, Department of Molecular Cell Biology, Free University, Amsterdam, for her gift of blocking a...

    Article • Gastroenterology, October 2003, Elsevier

    Dr René M van den Wijngaard

  52. Melanocyte-Specific Immune Response in Melanoma and Vitiligo: Two Faces of the Same Coin?

    Article • Pigment Cell Research, June 2003, Wiley

    Dr René M van den Wijngaard

  53. Immunopolarization of CD4+ and CD8+ T Cells to Type-1–Like is Associated with Melanocyte Loss in Human Vitiligo

    Article • Laboratory Investigation, May 2003, Springer Science + Business Media

    Dr René M van den Wijngaard

  54. Mast cell degranulation in manipulated intestine mediates prolonged postoperative ileus in mice

    Article • Gastroenterology, April 2003, Elsevier

    Dr René M van den Wijngaard

  55. Aberrant expression of complement regulatory proteins, membrane cofactor protein and decay accelerating factor, in the involved epidermis of patients with vitiligo

    Article • British Journal of Dermatology, January 2002, Wiley

    Dr René M van den Wijngaard

  56. Autoimmune Melanocyte Destruction in Vitiligo

    Article • Laboratory Investigation, August 2001, Springer Science + Business Media

    Dr René M van den Wijngaard

  57. Relationship between manipulation-induced intestinal inflammation and delayed gastric emptying following abdominal surgery

    Article • Gastroenterology, April 2001, Elsevier

    Dr René M van den Wijngaard

  58. A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo

    Article • Trends in Immunology, March 2001, Elsevier

    Dr René M van den Wijngaard

  59. Differential Expression of Functional Guanylyl Cyclases in Melanocytes: Absence of Nitric-Oxide-Sensitive Isoform in Metastatic Cells

    Article • Journal of Investigative Dermatology, March 2001, Elsevier

    Dr René M van den Wijngaard

  60. Evidence for VIP1 /PACAP receptors in the afferent pathway mediating surgery-induced fundic relaxation in the rat

    Article • British Journal of Pharmacology, October 2000, Wiley

    Dr René M van den Wijngaard

  61. Expression and modulation of apoptosis regulatory molecules in human melanocytes: significance in vitiligo

    Article • British Journal of Dermatology, September 2000, Wiley

    Dr René M van den Wijngaard

  62. Expression and modulation of apoptosis regulatory molecules in human melanocytes: significance in vitiligo

    Article • British Journal of Dermatology, September 2000, Wiley

    Dr René M van den Wijngaard

  63. Local Immune Response in Skin of Generalized Vitiligo Patients

    Article • Laboratory Investigation, August 2000, Springer Science + Business Media

    Dr René M van den Wijngaard

  64. Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesion

    Article • British Journal of Dermatology, August 1997, Wiley

    Dr René M van den Wijngaard

  65. In contrast to their murine counterparts, normal human keratinocytes and human epidermoid cell lines A431 and HaCaT fail to express IL‐10 mRNA and protein

    Article • Clinical & Experimental Immunology, January 1997, Wiley

    Dr René M van den Wijngaard

  66. Generation of a human melanocyte cell line by introduction of HPV16 E6 and E7 genes

    Article • In Vitro Cellular & Developmental Biology - Animal, January 1997, Springer Science + Business Media

    Dr René M van den Wijngaard

  67. Foetal Human Melanocytes: In Situ Detection, In Vitro Culture and Differentiation Characteristics at 6–11 Weeks EGA

    Article • Pigment Cell Research, June 1996, Wiley

    Dr René M van den Wijngaard

  68. Human melanocytes in regional skin immunity and pathology

    Article • Melanoma Research, September 1995, Wolters Kluwer Health

    Dr René M van den Wijngaard

  69. Expression of apoptosis-related antigens in cultured melanocytes

    Article • Melanoma Research, September 1995, Wolters Kluwer Health

    Dr René M van den Wijngaard

  70. Normal human melanocytes immortalized by HPV16E6E7 genes

    Article • Melanoma Research, September 1995, Wolters Kluwer Health

    Dr René M van den Wijngaard

  71. Catechol-O-methyltransferase in vitiligo

    Article • Archives of Dermatological Research, February 1994, Springer Science + Business Media

    Dr René M van den Wijngaard

  72. Organotypic Culture of Human Skin to Study Melanocyte Migration

    Article • Pigment Cell Research, February 1994, Wiley

    Dr René M van den Wijngaard

  73. Review of the etiopathomechanism of vitiligo: A convergence theory

    Article • Experimental Dermatology, August 1993, Wiley

    Dr René M van den Wijngaard

  74. Expression of different immunological markers by cultured human melanocytes

    Article • Archives of Dermatological Research, August 1993, Springer Science + Business Media

    Dr René M van den Wijngaard

  75. Presence or Absence of Melanocytes in Vitiligo Lesions: An Immunohistochemical Investigation

    Article • Journal of Investigative Dermatology, June 1993, Elsevier

    Dr René M van den Wijngaard