All Stories

  1. Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma
  2. PNA-encoded chemical libraries
  3. Identifizierung von niedermolekularen kovalenten Bromodomäne-Bindern aus einer DNA-kodierten Bibliothek
  4. Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules
  5. DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
  6. In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis
  7. PNA-Encoded Synthesis (PES) of a 10 000-Member Hetero-Glycoconjugate Library and Microarray Analysis of Diverse Lectins
  8. A LecA Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion byPseudomonas aeruginosa
  9. A LecA Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion byPseudomonas aeruginosa
  10. Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway
  11. Nucleic Acid-tagged Peptides: Encoding Libraries and Controlling Dimerization and Conformation
  12. Rapid miRNA Imaging in Cells Using Fluorogenic Templated Staudinger Reaction Between PNA-Based Probes
  13. Assembly of PNA-Tagged Small Molecules, Peptides, and Carbohydrates onto DNA Templates: Programming the Combinatorial Pairing and Inter-ligand Distance
  14. Picture Perfect: DNA-Templated Photoaffinity Labeling
  15. Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis (Eur. J. Org. Chem. 20/2013)
  16. Reactions Templated by Nucleic Acids: More Ways to Translate Oligonucleotide-Based Instructions into Emerging Function
  17. Corrigendum: Expanding the Scope of PNA-Encoded Synthesis (PES): Mtt-Protected PNA Fully Orthogonal to Fmoc Chemistry and a Broad Array of Robust Diversity-Generating Reactions
  18. Nucleic Acid-programmed Assemblies: Translating Instruction into Function in Chemical Biology
  19. Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis
  20. Detection of miRNA in Live Cells by Using Templated RuII-Catalyzed Unmasking of a Fluorophore
  21. DNA as a Platform to Program Assemblies with Emerging Functions in Chemical Biology
  22. Self-Assembled Antibody Multimers through Peptide Nucleic Acid Conjugation
  23. Selective affinity-based probe for oncogenic kinases suitable for live cell imaging
  24. Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates
  25. Photoreductive Uncaging of Fluorophore in Response to Protein Oligomers by Templated Reaction in Vitro and in Cellulo
  26. Expanding the Scope of PNA-Encoded Synthesis (PES): Mtt-Protected PNA Fully Orthogonal to Fmoc Chemistry and a Broad Array of Robust Diversity-Generating Reactions
  27. DNA display of PNA-tagged ligands
  28. Asymmetric Synthesis of Pochonin E and F, Revision of Their Proposed Structure, and Their Conversion to Potent Hsp90 Inhibitors
  29. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis
  30. Diversity-Oriented Synthesis of Diverse Polycyclic Scaffolds Inspired by the Logic of Sesquiterpene Lactones Biosynthesis
  31. Nucleic Acid Templated Uncaging of Fluorophores Using Ru-Catalyzed Photoreduction with Visible Light
  32. Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries
  33. Synthesis of deguelin–biotin conjugates and investigation into deguelin’s interactions
  34. Nucleic Acid-Templated Energy Transfer Leading to a Photorelease Reaction and its Application to a System Displaying a Nonlinear Response
  35. Polyubiquitination of Transforming Growth Factor   (TGF )-associated Kinase 1 Mediates Nuclear Factor- B Activation in Response to Different Inflammatory Stimuli
  36. Cysteine Mapping in Conformationally Distinct Kinase Nucleotide Binding Sites: Application to the Design of Selective Covalent Inhibitors
  37. Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells
  38. DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker
  39. Rapid fluorescence imaging of miRNAs in human cells using templated Staudinger reaction
  40. DNA-templated combinatorial assembly of small molecule fragments amenable to selection/amplification cycles
  41. The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse
  42. Combinatorial Self-Assembly of Glycan Fragments into Microarrays
  43. Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation
  44. Concise Modular Asymmetric Synthesis of Deguelin, Tephrosin and Investigation into Their Mode of Action
  45. ChemInform Abstract: A Versatile Method for Parallel Synthesis
  46. ChemInform Abstract: Synthesis of Epothilones A and B in Solid and Solution Phase.
  47. The Novel Hsp90 Inhibitor NXD30001 Induces Tumor Regression in a Genetically Engineered Mouse Model of Glioblastoma Multiforme
  48. ChemInform Abstract: Synthesis of the Macrocyclic Core of Sanglifehrin A.
  49. ChemInform Abstract: Total Synthesis and Chemical Biology of the Sarcodictyins
  50. Autoactivation of Transforming Growth Factor  -activated Kinase 1 Is a Sequential Bimolecular Process
  51. ChemInform Abstract: The Art and Science of Total Synthesis and the Dawn of the Twenty-First Century
  52. Metathesis Reactions in Solid-Phase Organic Synthesis
  53. ChemInform Abstract: Synthesis and Biological Evaluation of Vancomycin Dimers with Potent Activity Against Vancomycin-Resistant Bacteria: Target-Accelerated Combinatorial Synthesis.
  54. ChemInform Abstract: Solid- and Solution-Phase Synthesis of Vancomycin and Vancomycin Analogues with Activity Against Vancomycin-Resistant Bacteria.
  55. Cover Picture: Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL (ChemMedChem 5/2010)
  56. Molecular Editing of Kinase-Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL
  57. Ligand dimerization programmed by hybridization to study multimeric ligand–receptor interactions
  58. Clickable peptide nucleic acids (cPNA) with tunable affinity
  59. Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation
  60. ChemInform Abstract: High-Throughput Synthesis of Natural Products
  61. Selection of bead-displayed, PNA-encoded chemicals
  62. Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights
  63. Cover Picture: Divergent Syntheses of Resorcylic Acid Lactones: L-783277, LL-Z1640-2, and Hypothemycin / Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases (Chem.
  64. Divergent Syntheses of Resorcylic Acid Lactones: L-783277, LL-Z1640-2, and Hypothemycin
  65. Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases
  66. DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV
  67. DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV
  68. The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts
  69. Synthesis of pochoxime prodrugs as potent HSP90 inhibitors
  70. Imaging of mRNA in Live Cells Using Nucleic Acid-Templated Reduction of Azidorhodamine Probes
  71. Self-Assembly of PNA-Encoded Peptides into Microarrays
  72. Resorcylic acid lactones: A pluripotent scaffold with therapeutic potential
  73. Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor
  74. Divergent Synthesis of a Pochonin Library Targeting HSP90 and In Vivo Efficacy of an Identified Inhibitor
  75. Nucleic acid encoding to program self-assembly in chemical biology
  76. Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents
  77. A Highly Efficient Azide-Based Protecting Group for Amines and Alcohols.
  78. Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors
  79. Modular Synthesis of Radicicol A and Related Resorcylic Acid Lactones, Potent Kinase Inhibitors
  80. Azidomethyl Carbamate and Carbonate: Cleavage with Polymeric Phosphine
  81. IPy2BF4-Mediated Glycosylation and Glycosyl Fluoride Formation.
  82. Chemical Biology: From Small Molecules to Systems Biology and Drug Design. Edited by Stuart L. Schreiber, Tarun Kapoor, and Günther Wess.
  83. Expanding the scope of PNA-encoded libraries: divergent synthesis of libraries targeting cysteine, serine and metallo-proteases as well as tyrosine phosphatases
  84. A Highly Efficient Azide-Based Protecting Group for Amines and Alcohols
  85. Chemistry and Biology of Resorcylic Acid Lactones
  86. IPy2BF4-Mediated Glycosylation and Glycosyl Fluoride Formation
  87. Chemistry and biology of resorcylic acid lactones
  88. Fluorescence-based detection of single nucleotide permutation in DNA via catalytically templated reaction
  89. Diversity-Oriented Synthesis of Pochonins and Biological Evaluation against a Panel of Kinases
  90. Methods in Molecular Medicine 114: Microarrays in Clinical Diagnostics. Edited by Thomas O. Joos and Paolo Fortina.
  91. Self-Assembled Small-Molecule Microarrays for Protease Screening and Profiling
  92. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold
  93. Modular Asymmetric Synthesis of Aigialomycin D, a Kinase-Inhibitory Scaffold
  94. Concise Synthesis of Pochonin A, and HSP90 Inhibitor.
  95. Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries
  96. PNA Encoding (PNA=peptide nucleic acid): From Solution-Based Libraries to Organized Microarrays
  97. Concise Synthesis of Pochonin A, an HSP90 Inhibitor
  98. Solution- and Solid-Phase Synthesis of Radicicol (Monorden) and Pochonin C
  99. Design, Synthesis, and Biological Evaluation of HSP90 Inhibitors Based on Conformational Analysis of Radicicol and Its Analogues
  100. Modular Asymmetric Synthesis of Pochonin C (I).
  101. Development of a Functionalized Xenon Biosensor
  102. PNA-Encoded Protease Substrate Microarrays
  103. Activity Profile of Dust Mite Allergen Extract Using Substrate Libraries and Functional Proteomic Microarrays
  104. Synthesis of a PNA-encoded cysteine protease inhibitor library
  105. Modular Asymmetric Synthesis of Pochonin C
  106. Applications of laser-polarized 129xe to biomolecular assays
  107. Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis
  108. Profiling protein function with small molecule microarrays
  109. From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling
  110. Solid- and Solution-Phase Synthesis of Vancomycin and Vancomycin Analogues with Activity against Vancomycin-Resistant Bacteria
  111. Synthesis and Biological Evaluation of Vancomycin Dimers with Potent Activity against Vancomycin-Resistant Bacteria: Target-Accelerated Combinatorial Synthesis
  112. Cover Picture
  113. Cover Picture
  114. A New Photolabile Linker for the Photoactivation of Carboxyl Groups
  115. Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria
  116. Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria
  117. Total Synthesis of 16-Desmethylepothilone B, Epothilone B10, Epothilone F, and Related Side Chain Modified Epothilone B Analogues
  118. New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin
  119. New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin
  120. The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century
  121. The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century
  122. Total Synthesis of Vancomycin—Part 4: Attachment of the Sugar Moieties and Completion of the Synthesis
  123. Total Synthesis of Vancomycin
  124. Totalsynthese von Vancomycin
  125. Synthesis of the macrocyclic core of sanglifehrin A
  126. Total Synthesis and Chemical Biology of the Sarcodictyins.
  127. Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone
  128. The Art and Science of Organic and Natural Products Synthesis
  129. Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial Sarcodictyin Libraries
  130. Solid-Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide
  131. Solid-Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide
  132. Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Synthesis of a ( dl )-Muscone Library
  133. Polymer-supported selenium reagents for organic synthesis
  134. Gezielt entworfene Epothilone: kombinatorische Synthese, Induktion der Tubulin-Polymerisation und cytotoxische Wirkung gegen taxolresistente Tumorzellen
  135. Synthesis of epothilones A and B in solid and solution phase
  136. A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE)
  137. Multiple simultaneous synthesis of phenolic libraries
  138. Chemical Technologies: Probing Biology with Small Molecules