All Stories

  1. D242N, a K V 7.1 LQTS mutation uncovers a key residue for I Ks voltage dependence

    Article • Journal of Molecular and Cellular Cardiology, September 2017, Elsevier

    Dr Carmen Valenzuela

  2. Fludarabine Inhibits KV1.3 Currents in Human B Lymphocytes

    Article • Frontiers in Pharmacology, March 2017, Frontiers

    Dr Carmen Valenzuela

  3. In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K+ Channels; Interaction and New Targets

    Article • Frontiers in Physiology, November 2016, Frontiers

    Dr Carmen Valenzuela

  4. M-channels and n-3 polyunsaturated fatty acids: role in pain and epilepsy

    Article • Acta Physiologica, June 2016, Wiley

    Dr Carmen Valenzuela

  5. Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease

    Article • Journal of Clinical Investigation, January 2016, American Society for Clinical Investigation

    Dr Carmen Valenzuela, Jose Naranjo

  6. Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death

    Article • PLoS ONE, October 2015, PLOS

    Dr Carmen Valenzuela

  7. A newKCNQ1mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome

    Article • Cardiovascular Research, July 2015, European Society of Cardiology

    Dr Carmen Valenzuela

  8. Pharmacological Consequences of PKC Inhibition on Kv1.5+Kvbeta1.3 Channels

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Carmen Valenzuela

  9. Marine n-3 PUFAs modulate IKs gating, channel expression, and location in membrane microdomains

    Article • Cardiovascular Research, December 2014, European Society of Cardiology

    Dr Carmen Valenzuela

  10. PKC inhibition results in a Kv1.5 + Kvβ1.3 pharmacology closer to Kv1.5 channels

    Article • British Journal of Pharmacology, September 2014, Wiley

    Dr Carmen Valenzuela

  11. Functional Assembly of Kv7.1/Kv7.5 Channels With Emerging Properties on Vascular Muscle Physiology

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2014, Wolters Kluwer Health

    Dr Carmen Valenzuela

  12. Modulation of Voltage-Dependent and Inward Rectifier Potassium Channels by 15-Epi-Lipoxin-A4 in Activated Murine Macrophages: Implications in Innate Immunity

    Article • The Journal of Immunology, November 2013, The American Association of Immunologists

    Dr Carmen Valenzuela, Lisardo Bosca

  13. Modulation of Kv and Kir Currents by 15-Epi-Lipoxin-A4 in activated Macrophages. Implications for the Regulation of the Innate Immune Response

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Carmen Valenzuela

  14. Female gender: risk factor for congenital long QT-related arrhythmias

    Article • Cardiovascular Research, June 2012, European Society of Cardiology

    Dr Carmen Valenzuela

  15. Stereoselective Interactions between Local Anesthetics and Ion Channels

    Article • Chirality, June 2012, Wiley

    Dr Carmen Valenzuela

  16. Protein Kinase C (PKC) Activity Regulates Functional Effects of Kv 1.3 Subunit on KV1.5 Channels: IDENTIFICATION OF A CARDIAC Kv1.5 CHANNELOSOME

    Article • Journal of Biological Chemistry, April 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Carmen Valenzuela

  17. Polyunsaturated Fatty Acids Modify the Gating of Kv Channels

    Article • Frontiers in Pharmacology, January 2012, Frontiers

    Dr Carmen Valenzuela

  18. Effects of n−3 Polyunsaturated Fatty Acids on Cardiac Ion Channels

    Article • Frontiers in Physiology, January 2012, Frontiers

    Dr Carmen Valenzuela

  19. Irvalec Inserts Into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Carmen Valenzuela

  20. Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries

    Article • AJP Cell Physiology, July 2011, American Physiological Society

    Dr Carmen Valenzuela

  21. Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

    Article • PLoS ONE, April 2011, PLOS

    Dr Carmen Valenzuela

  22. Celecoxib Blocks Cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) Channels. Effects on Cardiac Action Potentials

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Carmen Valenzuela

  23. Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels

    Article • Journal of Molecular and Cellular Cardiology, December 2010, Elsevier

    Dr Carmen Valenzuela

  24. 439 Rapid effects of Irvalec on tumor cell integrity associated with changes in the ionic membrane conductance

    Article • European Journal of Cancer Supplements, November 2010, Elsevier

    Dr Carmen Valenzuela

  25. Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels

    Article • Biochemical Pharmacology, September 2010, Elsevier

    Dr Carmen Valenzuela

  26. Kv1.5-Kvβ Interactions: Molecular Determinants and Pharmacological Consequences

    Article • Mini-Reviews in Medicinal Chemistry, June 2010, Bentham Science Publishers

    Dr Carmen Valenzuela

  27. Immunomodulation of voltage-dependent K + channels in macrophages: molecular and biophysical consequences

    Article • The Journal of General Physiology, January 2010, Rockefeller University Press

    Dr Carmen Valenzuela

  28. Immunomodulation of Voltage-Dependent K+ Channels in Macrophages: Molecular and Biophysical Consequences

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Carmen Valenzuela

  29. Differential Regulation Of Navß Subunits During Myogenesis

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Carmen Valenzuela

  30. Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts

    Article • AJP Heart and Circulatory Physiology, July 2008, American Physiological Society

    Dr Carmen Valenzuela

  31. Cell cycle-dependent expression of Kv1.5 is involved in myoblast proliferation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, May 2008, Elsevier

    Dr Carmen Valenzuela

  32. Differential regulation of Navβ subunits during myogenesis

    Article • Biochemical and Biophysical Research Communications, April 2008, Elsevier

    Dr Carmen Valenzuela

  33. Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, α-linolenic acid

    Article • Journal of Molecular and Cellular Cardiology, February 2008, Elsevier

    Dr Carmen Valenzuela

  34. Voltage-dependent Na+ channel phenotype changes in myoblasts. Consequences for cardiac repair☆

    Article • Cardiovascular Research, December 2007, European Society of Cardiology

    Dr Carmen Valenzuela

  35. Kvβ1.3 Reduces the Degree of Stereoselective Bupivacaine Block of Kv1.5 Channels

    Article • Anesthesiology, October 2007, Wolters Kluwer Health

    Dr Carmen Valenzuela

  36. The induction of NOS2 expression by the hybrid cecropin A–melittin antibiotic peptide CA(1–8)M(1–18) in the monocytic line RAW 264.7 is triggered by a temporary and reversible plasma membrane permeation

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, January 2006, Elsevier

    Dr Carmen Valenzuela

  37.  -3 and  -6 polyunsaturated fatty acids block HERG channels

    Article • AJP Cell Physiology, November 2005, American Physiological Society

    Dr Carmen Valenzuela

  38. Stereoselective Interactions Between Local Anesthetics and Cardiac K+ Channels

    Article • Drug Design Reviews - Online, August 2005, Bentham Science Publishers

    Dr Carmen Valenzuela

  39. Pharmacology of cardiac potassium channels

    Article • Cardiovascular Research, April 2004, European Society of Cardiology

    Dr Carmen Valenzuela

  40. Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current

    Article • Cardiovascular Research, April 2004, European Society of Cardiology

    Dr Carmen Valenzuela

  41. Pharmacological electrical remodelling in human atria induced by chronic β-blockade

    Article • Cardiovascular Research, June 2003, European Society of Cardiology

    Dr Carmen Valenzuela

  42. Effects of propafenone and its main metabolite, 5-hydroxypropafenone, on HERG channels

    Article • Cardiovascular Research, March 2003, European Society of Cardiology

    Dr Carmen Valenzuela

  43. Spironolactone and Its Main Metabolite, Canrenoic Acid, Block Human Ether-a-Go-Go-Related Gene Channels

    Article • Circulation, February 2003, Wolters Kluwer Health

    Dr Carmen Valenzuela

  44. Effects of Irbesartan on Cloned Potassium Channels Involved in Human Cardiac Repolarization

    Article • Journal of Pharmacology and Experimental Therapeutics, February 2003, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Carmen Valenzuela

  45. Stereoselective Drug-Channel Interactions

    Article • January 2003, Springer Science + Business Media

    Dr Carmen Valenzuela

  46. Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block

    Article • British Journal of Pharmacology, December 2002, Wiley

    Dr Carmen Valenzuela

  47. Assembly with the Kvβ1.3 Subunit Modulates Drug Block of hKv1.5 Channels

    Article • Molecular Pharmacology, December 2002, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Carmen Valenzuela

  48. Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5)

    Article • Cardiovascular Research, October 2002, European Society of Cardiology

    Dr Carmen Valenzuela

  49. Bupivacaine effects on hKv1.5 channels are dependent on extracellular pH

    Article • British Journal of Pharmacology, September 2001, Wiley

    Dr Carmen Valenzuela

  50. Stereoselective effects of the enantiomers of a new local anaesthetic, IQB-9302, on a human cardiac potassium channel (Kv1.5)

    Article • British Journal of Pharmacology, January 2001, Wiley

    Dr Carmen Valenzuela

  51. Effects of a quaternary bupivacaine derivative on delayed rectifier K+ currents

    Article • British Journal of Pharmacology, May 2000, Wiley

    Dr Carmen Valenzuela

  52. Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac Kv1.5 channels

    Article • British Journal of Pharmacology, November 1999, Wiley

    Dr Carmen Valenzuela

  53. Benzocaine enhances and inhibits the K+ current through a human cardiac cloned channel (Kv1.5)

    Article • Cardiovascular Research, May 1999, European Society of Cardiology

    Dr Carmen Valenzuela

  54. Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line

    Article • Cardiovascular Research, January 1999, European Society of Cardiology

    Dr Carmen Valenzuela

  55. Blockade of Cardiac Potassium and Other Channels by Antihistamines

    Article • Drug Safety, January 1999, Springer Science + Business Media

    Dr Carmen Valenzuela

  56. Effects of propafenone and 5-hydroxy-propafenone on hKv1.5 channels

    Article • British Journal of Pharmacology, November 1998, Wiley

    Dr Carmen Valenzuela

  57. Effect of descarboethoxyloratadine, the major metabolite of loratadine, on the human cardiac potassium channel Kv1.5

    Article • British Journal of Pharmacology, November 1997, Wiley

    Dr Carmen Valenzuela

  58. Block of human cardiac Kv1.5 channels by loratadine: voltage-, time- and use-dependent block at concentrations above therapeutic levels

    Article • Cardiovascular Research, August 1997, European Society of Cardiology

    Dr Carmen Valenzuela

  59. Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels

    Article • European Journal of Pharmacology, May 1997, Elsevier

    Dr Carmen Valenzuela

  60. Effects of Ropivacaine on a Potassium Channel (hKv1.5) Cloned from Human Ventricle

    Article • Anesthesiology, March 1997, Wolters Kluwer Health

    Dr Carmen Valenzuela

  61. Electrophysiological effects of CI-980, a tubulin binding agent, on guinea-pig papillary muscles

    Article • British Journal of Pharmacology, January 1997, Wiley

    Dr Carmen Valenzuela

  62. Mechanisms of block of a human cloned potassium channel by the enantiomers of a new bradycardic agent: S-16257-2 and S-16260-2

    Article • British Journal of Pharmacology, March 1996, Wiley

    Dr Carmen Valenzuela

  63. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers

    Article • Biophysical Journal, August 1995, Elsevier

    Dr Carmen Valenzuela

  64. Electromechanical Effects of Zatebradine on Isolated Guinea Pig Cardiac Preparations

    Article • Journal of Cardiovascular Pharmacology, July 1995, Wolters Kluwer Health

    Dr Carmen Valenzuela

  65. Effects of the two enantiomers, S-16257-2 and S-16260-2, of a new bradycardic agent on guinea-pig isolated cardiac preparations

    Article • British Journal of Pharmacology, July 1995, Wiley

    Dr Carmen Valenzuela

  66. Effects of lisinopril on cardiac contractility and ionic currents

    Article • General Pharmacology The Vascular System, September 1994, Elsevier

    Dr Carmen Valenzuela

  67. Gating of cardiac Na+ channels in excised membrane patches after modification by alpha-chymotrypsin

    Article • Biophysical Journal, July 1994, Elsevier

    Dr Carmen Valenzuela

  68. Class I and III antiarrhythmic actions of prazosin in guinea-pig papillary muscles

    Article • British Journal of Pharmacology, March 1994, Wiley

    Dr Carmen Valenzuela

  69. Effects of lisinopril on electromechanical properties and membrane currents in guinea-pig cardiac preparations

    Article • British Journal of Pharmacology, July 1993, Wiley

    Dr Carmen Valenzuela

  70. Electrophysiological Effects of the Combination of Imipramine and Desipramine in Guinea Pig Papillary Muscles

    Article • Journal of Cardiovascular Pharmacology, January 1993, Wolters Kluwer Health

    Dr Carmen Valenzuela

  71. New insights into the pharmacology of sodium channel blockers

    Article • European Heart Journal, November 1992, European Society of Cardiology

    Dr Carmen Valenzuela

  72. Electrophysiological effects of CRE-1087 in guinea-pig ventricular muscles

    Article • British Journal of Pharmacology, October 1992, Wiley

    Dr Carmen Valenzuela

  73. Pharmacology of CRE-1087, A New Antiarrhythmic Drug

    Article • Cardiovascular Drug Reviews, September 1992, Wiley

    Dr Carmen Valenzuela

  74. Voltage- and Use-Dependent Modulation of Calcium Channel Current in Guinea Pig Ventricular Cells by Amiodarone and Des-Oxo-Amiodarone

    Article • Journal of Cardiovascular Pharmacology, June 1991, Wolters Kluwer Health

    Dr Carmen Valenzuela

  75. Electrophysiological effects of the combination of mexiletine and flecainide in guinea-pig ventricular fibres

    Article • British Journal of Pharmacology, June 1991, Wiley

    Dr Carmen Valenzuela

  76. Tonic and frequency-dependent $$\mathop {\text{V}}\limits^{\text{.}} _{{\text{max}}} $$ block induced by (S)-nafenodone, a new antidepressant drug, in guinea-pig papillary muscles

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, June 1991, Springer Science + Business Media

    Dr Carmen Valenzuela

  77. Tonic and Frequency-Dependent Vmax Block Induced by Imipramine in Guinea Pig Ventricular Muscle Fibers

    Article • Journal of Cardiovascular Pharmacology, March 1990, Wolters Kluwer Health

    Dr Carmen Valenzuela

  78. Electrophysiologic Interactions Between Mexiletine-Quinidine and Mexiletine-Ropitoin in Guinea Pig Papillary Muscle

    Article • Journal of Cardiovascular Pharmacology, November 1989, Wolters Kluwer Health

    Dr Carmen Valenzuela

  79. Electrophysiologic Interactions Between Mexiletine and Propafenone in Guinea Pig Papillary Muscles

    Article • Journal of Cardiovascular Pharmacology, September 1989, Wolters Kluwer Health

    Dr Carmen Valenzuela

  80. Electrophysiological effects of E-3753, a new antiarrhythmic drug, in guinea-pig ventricular muscle

    Article • British Journal of Pharmacology, April 1989, Wiley

    Dr Carmen Valenzuela

  81. Tonic and Phasic Vmax Block Induced by 5-Hydroxypropafenone in Guinea Pig Ventricular Muscles

    Article • Journal of Cardiovascular Pharmacology, October 1988, Wolters Kluwer Health

    Dr Carmen Valenzuela

  82. Electrophysiological Effects of 5-Hydroxypropafenone on Guinea Pig Ventricular Muscle Fibres

    Article • Journal of Cardiovascular Pharmacology, November 1987, Wolters Kluwer Health

    Dr Carmen Valenzuela

  83. Effects of 5-hydroxy-propafenone in guinea-pig atrial fibres

    Article • British Journal of Pharmacology, March 1987, Wiley

    Dr Carmen Valenzuela

  84. Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria

    Article • British Journal of Pharmacology, February 1986, Wiley

    Dr Carmen Valenzuela

  85. Negative inotropic effect of somatostatin in guinea-pig atrial fibres

    Article • British Journal of Pharmacology, November 1985, Wiley

    Dr Carmen Valenzuela