All Stories

  1. Therapeutic targeting of transcriptional cyclin-dependent kinases

    Article • Transcription, November 2018, Taylor & Francis

    Dr Joaquin M Espinosa

  2. ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels

    Article • Cell Cycle, October 2014, Taylor & Francis

    Dr Joaquin M Espinosa, Dr. Kelly D Sullivan

  3. Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

    Article • eLife, May 2014, eLife

    Kelly Sullivan, Veronica L. Dengler, Dr Zdenek Andrysik, Dr Joaquin M Espinosa, Dr. Kelly D Sullivan

  4. Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels

    Article • Cell Reports, April 2014, Elsevier

    Dr Zdenek Andrysik, Dr Joaquin M Espinosa, Paola Maycotte

  5. Back to Bases: How a Nucleotide Biosynthetic Enzyme Controls p53 Activation

    Article • Molecular Cell, February 2014, Elsevier

    Dr Joaquin M Espinosa

  6. Transcriptional regulation by hypoxia inducible factors

    Article • Critical Reviews in Biochemistry and Molecular Biology, October 2013, Taylor & Francis

    Veronica L. Dengler, Dr Joaquin M Espinosa

  7. HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

    Article • Cell, June 2013, Elsevier

    Dr Joaquin M Espinosa

  8. A Genetic Screen Identifies TCF3/E2A and TRIAP1 as Pathway-Specific Regulators of the Cellular Response to p53 Activation

    Article • Cell Reports, May 2013, Elsevier

    Dr Zdenek Andrysik, Dr Joaquin M Espinosa

  9. Tumor Suppression by p53: Is Apoptosis Important or Not?

    Article • Cell Reports, May 2013, Elsevier

    Dr Joaquin M Espinosa

  10. How does ΔNp63α drive cancer?

    Article • Epigenomics, February 2013, Future Medicine

    Dr Joaquin M Espinosa

  11. ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells

    Article • Cell Cycle, February 2013, Taylor & Francis

    Dr Joaquin M Espinosa

  12. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53

    Article • Nature Chemical Biology, June 2012, Springer Science + Business Media

    Kelly Sullivan, Dr Joaquin M Espinosa, Dr. Kelly D Sullivan

  13. The p53 circuit board

    Article • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, April 2012, Elsevier

    Kelly Sullivan, Dr Joaquin M Espinosa, Dr. Kelly D Sullivan

  14. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX

    Article • The EMBO Journal, January 2012, Wiley

    Dr Zdenek Andrysik, Dr Joaquin M Espinosa

  15. Get Back TFIIF, Don't Let Me Gdown1

    Article • Molecular Cell, January 2012, Elsevier

    Dr Joaquin M Espinosa

  16. Lessons on transcriptional control from the serum response network

    Article • Current Opinion in Genetics & Development, April 2011, Elsevier

    Dr Joaquin M Espinosa

  17. The Meaning of Pausing

    Article • Molecular Cell, November 2010, Elsevier

    Dr Joaquin M Espinosa

  18. Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes

    Article • Cell Cycle, September 2010, Taylor & Francis

    Dr Joaquin M Espinosa

  19. CDK8

    Article • Transcription, July 2010, Taylor & Francis

    Dr Joaquin M Espinosa

  20. CDK8 is a positive regulator of transcriptional elongation within the serum response network

    Article • Nature Structural & Molecular Biology, January 2010, Springer Science + Business Media

    Dr Joaquin M Espinosa

  21. The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

    Article • Cell, January 2010, Elsevier

    Dr Joaquin M Espinosa

  22. Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation

    Article • Cell Cycle, August 2008, Taylor & Francis

    Dr Joaquin M Espinosa

  23. BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

    Article • Cell Cycle, July 2008, Taylor & Francis

    Dr Joaquin M Espinosa

  24. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3

    Article • The EMBO Journal, April 2008, Wiley

    Dr Joaquin M Espinosa

  25. RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes

    Article • Nature Structural & Molecular Biology, December 2007, Springer Science + Business Media

    Dr Joaquin M Espinosa

  26. Stimulus-Specific Transcriptional Regulation Within the p53 Network

    Article • Cell Cycle, November 2007, Taylor & Francis

    Dr Joaquin M Espinosa

  27. Doxazolidine Induction of Apoptosis by a Topoisomerase II Independent Mechanism

    Article • Journal of Medicinal Chemistry, September 2007, American Chemical Society (ACS)

    Dr Joaquin M Espinosa

  28. CDK8 Is a Stimulus-Specific Positive Coregulator of p53 Target Genes

    Article • Molecular Cell, July 2007, Elsevier

    Dr Joaquin M Espinosa

  29. SESSION 1: CHROMATIN REMODELING Chromatin Remodeling 2003

    Article • Toxicologic Pathology, January 2004, SAGE Publications

    Dr Joaquin M Espinosa

  30. Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

    Article • Molecular Cell, July 2001, Elsevier

    Dr Joaquin M Espinosa

  31. mRNA Encoding a Putative RNA Helicase of the DEAD-Box Gene Family is Up-Regulated in Trypomastigotes of Trypanosoma cruzi

    Article • Journal of Eukaryotic Microbiology, November 2000, Wiley

    Dr Joaquin M Espinosa

  32. Factors from Trypanosoma cruzi Interacting with AP-1 Sequences

    Article • Journal of Eukaryotic Microbiology, September 1999, Wiley

    Dr Joaquin M Espinosa

  33. Control of Trypanosoma cruzi Epimastigote Motility through the Nitric Oxide Pathway

    Article • Journal of Eukaryotic Microbiology, March 1997, Wiley

    Dr Joaquin M Espinosa