All Stories

  1. Precise genomic mapping of 5-hydroxymethylcytosine via covalent tether-directed sequencing
  2. An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing
  3. Repurposing enzymatic transferase reactions for targeted labeling and analysis of DNA and RNA
  4. Editorial overview: Current advances in analytical biotechnology: from single molecules to whole organisms
  5. Animal Hen1 2′-O-methyltransferases as tools for 3′-terminal functionalization and labelling of single-stranded RNAs
  6. Excision of the doubly methylated base N 4 ,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
  7. Archaeal fibrillarin-Nop5 heterodimer 2’-O-methylates RNA independently of the C/D guide RNP particle
  8. Oligonucleotide-Addressed Covalent 3′-Terminal Derivatization of Small RNA Strands for Enrichment and Visualization
  9. Tethered Oligonucleotide-Primed Sequencing, TOP-Seq: A High-Resolution Economical Approach for DNA Epigenome Profiling
  10. Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation
  11. Synthesis of S ‐Adenosyl‐L‐Methionine Analogs with Extended Transferable Groups for Methyltransferase‐Directed Labeling of DNA and RNA
  12. Lineage-specific variations in the trigger loop modulate RNA proofreading by bacterial RNA polymerases
  13. Functional mapping of the plant small RNA methyltransferase: HEN1 physically interacts with HYL1 and DICER-LIKE 1 proteins
  14. Biosynthetic selenoproteins with genetically-encoded photocaged selenocysteines
  15. Selective Covalent Labeling of miRNA and siRNA Duplexes Using HEN1 Methyltransferase
  16. Direct Decarboxylation of 5-Carboxylcytosine by DNA C5- Methyltransferases
  17. Interplay between the trigger loop and the F loop during RNA polymerase catalysis
  18. DNA unmethylome profiling by covalent capture of CpG sites
  19. Mechanistic insights into small RNA recognition and modification by the HEN1 methyltransferase
  20. Enhanced Chemical Stability of AdoMet Analogues for Improved Methyltransferase-Directed Labeling of DNA
  21. Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA
  22. 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
  23. Recognition of guanosine by dissimilar tRNA methyltransferases
  24. Programmable sequence-specific click-labeling of RNA using archaeal box C/D RNP methyltransferases
  25. Usage of rRNA-methyltransferase for site-specific fluorescent labeling
  26. 5-Hydroxymethylcytosine – the elusive epigenetic mark in mammalian DNA
  27. Methyltransferase-Directed Derivatization of 5-Hydroxymethylcytosine in DNA
  28. Methyltransferase-Directed Derivatization of 5-Hydroxymethylcytosine in DNA
  29. Direct observation of cytosine flipping and covalent catalysis in a DNA methyltransferase
  30. Modulation of RNA polymerase activity through the trigger loop folding
  31. Kinetic and functional analysis of the small RNA methyltransferase HEN1: The catalytic domain is essential for preferential modification of duplex RNA
  32. DNA fluorocode: A single molecule, optical map of DNA with nanometre resolution
  33. Allosteric control of catalysis by the F loop of RNA polymerase
  34. A directed evolution design of a GCG-specific DNA hemimethylase
  35. Cytosine-5-methyltransferases add aldehydes to DNA
  36. Biophysical Approaches To Study Dna Base Flipping
  37. AdoMet-Dependent Methyltransferases, Chemistry of
  38. Chemical mapping of cytosines enzymatically flipped out of the DNA helix
  39. Specific Recognition of the -10 Promoter Element by the Free RNA Polymerase   Subunit
  40. The stereochemistry of benzo[a]pyrene-2′-deoxyguanosine adducts affects DNA methylation by SssI and HhaI DNA methyltransferases
  41. Targeted Labeling of DNA by Methyltransferase-Directed Transfer of Activated Groups (mTAG)
  42. A new tool for biotechnology: AdoMet-dependent methyltransferases
  43. Approaches for Studying MicroRNA and Small Interfering RNA Methylation In Vitro and In Vivo
  44. Synthesis of S-adenosyl-L-methionine analogs and their use for sequence-specific transalkylation of DNA by methyltransferases
  45. A Basal Promoter Element Recognized by Free RNA Polymerase σ Subunit Determines Promoter Recognition by RNA Polymerase Holoenzyme
  46. HhaI DNA methyltransferase complex with oligonucleotide containing 2- aminopurine opposite to the target base (GCGC:GMPC) and SAH
  47. Time-resolved fluorescence of 2-aminopurine as a probe of base flipping in M.HhaI-DNA complexes
  48. Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases
  49. Probing a rate-limiting step by mutational perturbation of AdoMet binding in the HhaI methyltransferase
  50. Processive Methylation of Hemimethylated CpG Sites by Mouse Dnmt1 DNA Methyltransferase
  51. HhaI DNA Methyltransferase Uses the Protruding Gln237 for Active Flipping of Its Target Cytosine
  52. Solubility engineering of the HhaI methyltransferase
  53. N4,5-dimethylcytosine, a novel hypermodified base in DNA
  54. Circular permutation of DNA cytosine-N4 methyltransferases: in vivo coexistence in the BcnI system and in vitro probing by hybrid formation
  55. The Mechanism of DNA Cytosine-5 Methylation: KINETIC AND MUTATIONAL DISSECTION OF HhaI METHYLTRANSFERASE
  56. Affinity photo-crosslinking study of the DNA base flipping pathway by HhaI methyltransferase
  57. Bisulfite Sequencing Protocol Displays both 5-Methylcytosine and N4-Methylcytosine
  58. Chemical display of thymine residues flipped out by DNA methyltransferases
  59. 2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases
  60. Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution
  61. Enzymatic C5-Cytosine Methylation of DNA: Mechanistic Implications of New Crystal Structures forHhaI Methyltransferase-DNA-AdoHcy Complexes
  62. Sequence similarity among type-II restriction endonucleases, related by their recognized 6-bp target and tetranucleotide-overhang cleavage
  63. Disruption of the target G-C base-pair by the HhaI methyltransferase
  64. M Hha l binds tightly to substrates containing mismatches at the target base
  65. Hhal methyltransferase flips its target base out of the DNA helix
  66. The DNA (cytosine-5) methyltransferases
  67. Crystal Structure of the HhaI DNA Methyltransferase
  68. Purification and properties of the Eco57l restriction endonuclease and methylas—prototypes of a new class (type IV)
  69. Cloning and sequence analysis of the genes coding for Eco57l type IV restriction-modification enzymes
  70. Alw 26l, Eco 31l and Esp 3l-type Ils methyltransferases modifying cytosine and adenine in complementary strands of the target DNA
  71. The sequence specificity domain of cytosine-C5 methylases
  72. M. Sma l is an N4-methylcytosine specific DNA-methylase
  73. Sequence motifs characteristic of DNA[cytosine-N4]methyltransferases: similarity to adenine and cytosine-C5 DNA-methylases
  74. Restriction endonucleases of a new type
  75. Interaction of AluI, Cfr6I and PvuII restriction-modification enzymes with substrates containing either N4-methylcytosine or 5-methylcytosine
  76. Synthesis and physical characterization of DNA fragments containing N4-methylcytosine and 5-methylcytosine
  77. Cleavage of methylated CCCGGG sequences containing either N4-methylcytosine or 5-methytcytosine with Mspl, Hpall, Smal, Xmal and Cfr9I restriction endonudeases
  78. Analysis of products of DNA modification by methylases: A procedure for the determination of 5- and N4-methylcytosines in DNA
  79. Characterization of restriction-modification enzymes Cfr13 I fromCitrobacter freundiiRFL13
  80. Investigation of restriction-modification enzymes from M. varians RFL19 with a new type of specificity toward modification of substrate
  81. Cytosine modification in DNA by Bcn I methylase yields N 4 -methylcytosine