All Stories

  1. Preclinical target validation using patient-derived cells

    Article • Nature Reviews Drug Discovery, February 2015, Springer Science + Business Media

    Dr Rab K Prinjha

  2. Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation

    Article • The Journal of Experimental Medicine, February 2015, Rockefeller University Press

    Dr Rab K Prinjha

  3. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

    Article • Nature Chemical Biology, January 2015, Springer Science + Business Media

    Dr Rab K Prinjha, Dr. Daniel J Slade

  4. The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

    Article • Annals of the Rheumatic Diseases, December 2014, BMJ

    Dr Rab K Prinjha

  5. BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes

    Article • European Journal of Immunology, December 2014, Wiley

    Dr Rab K Prinjha

  6. Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

    Article • eLife, November 2014, eLife

    Dr Wenxian Fu, Dr Rab K Prinjha

  7. Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation

    Article • Nature Communications, November 2014, Springer Science + Business Media

    Dr Rab K Prinjha

  8. 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

    Article • ACS Medicinal Chemistry Letters, November 2014, American Chemical Society (ACS)

    Dr Rab K Prinjha

  9. The Epigenetic Regulator I-BET151 Induces BIM-Dependent Apoptosis and Cell Cycle Arrest of Human Melanoma Cells

    Article • Journal of Investigative Dermatology, November 2014, Elsevier

    Dr Rab K Prinjha

  10. Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11

    Article • British Journal of Pharmacology, October 2014, Wiley

    Dr Rab K Prinjha

  11. The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor

    Article • Journal of Medicinal Chemistry, October 2014, American Chemical Society (ACS)

    Dr Rab K Prinjha

  12. Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

    Article • Nature, August 2014, Springer Science + Business Media

    Dr Rab K Prinjha

  13. Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

    Article • Cell, August 2014, Elsevier

    Dr Rab K Prinjha

  14. AB0059 Chromatin Modifying Mechanisms in Macrophages Differ between Healthy Controls and Patients Wih Rheumatoid Arthritis

    Article • Annals of the Rheumatic Diseases, June 2014, BMJ

    Dr Rab K Prinjha

  15. Treatment with an antibody directed against Nogo-A delays disease progression in the SOD1G93A mouse model of Amyotrophic lateral sclerosis

    Article • Human Molecular Genetics, March 2014, Oxford University Press (OUP)

    Dr Rab K Prinjha

  16. The Commonly Used PI3-Kinase Probe LY294002 Is an Inhibitor of BET Bromodomains

    Article • ACS Chemical Biology, February 2014, American Chemical Society (ACS)

    Dr Rab K Prinjha

  17. A1.68 An Acetyl-Histone MiMetic blocks inflammatory activation of rheumatoid arthritis fibroblast-like synoviocytes

    Article • Annals of the Rheumatic Diseases, January 2014, BMJ

    Dr Rab K Prinjha

  18. The structure based design of dual HDAC/BET inhibitors as novel epigenetic probes

    Article • MedChemComm, January 2014, Royal Society of Chemistry

    Dr Rab K Prinjha

  19. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762

    Article • Blood, December 2013, American Society of Hematology

    Dr Rab K Prinjha

  20. BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane

    Article • PLoS ONE, November 2013, PLOS

    Dr Rab K Prinjha

  21. Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

    Article • Leukemia, November 2013, Springer Science + Business Media

    Dr Rab K Prinjha

  22. Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

    Article • Journal of Medicinal Chemistry, October 2013, American Chemical Society (ACS)

    Dr Rab K Prinjha

  23. BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

    Article • PLoS ONE, August 2013, PLOS

    Dr Rab K Prinjha

  24. Chromatin targeting drugs in cancer and immunity

    Article • Genes & Development, August 2013, Cold Spring Harbor Laboratory Press

    Dr Rab K Prinjha

  25. BET protein inhibition shows efficacy against JAK2V617F-driven neoplasms

    Article • Leukemia, August 2013, Springer Science + Business Media

    Dr Rab K Prinjha

  26. Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription

    Article • Molecular Cell, August 2013, Elsevier

    Dr Rab K Prinjha

  27. FRI0039 An acetyl-histone mimetic blocks inflammatory activation of rheumatoid arthritis fibroblast-like synoviocytes

    Article • Annals of the Rheumatic Diseases, June 2013, BMJ

    Dr Rab K Prinjha

  28. The "Histone Mimicry" by Pathogens

    Article • Cold Spring Harbor Symposia on Quantitative Biology, January 2013, Cold Spring Harbor Laboratory Press

    Dr Rab K Prinjha

  29. Selective inhibition of CD4 + T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

    Article • Proceedings of the National Academy of Sciences, August 2012, Proceedings of the National Academy of Sciences

    Dr Rab K Prinjha

  30. Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)

    Article • Bioorganic & Medicinal Chemistry Letters, April 2012, Elsevier

    Dr Rab K Prinjha

  31. Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response

    Article • The Journal of Experimental Medicine, March 2012, Rockefeller University Press

    Dr Rab K Prinjha

  32. Suppression of the antiviral response by an influenza histone mimic

    Article • Nature, March 2012, Springer Science + Business Media

    Dr Randy A Albrecht, Dr Rab K Prinjha

  33. Place your BETs: the therapeutic potential of bromodomains

    Article • Trends in Pharmacological Sciences, March 2012, Elsevier

    Dr Rab K Prinjha

  34. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Article • Nature, October 2011, Springer Science + Business Media

    Dr Rab K Prinjha

  35. Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains

    Article • Journal of Medicinal Chemistry, June 2011, American Chemical Society (ACS)

    Dr Rab K Prinjha

  36. Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

    Article • Nature Immunology, December 2010, Springer Science + Business Media

    Dr Rab K Prinjha

  37. Suppression of inflammation by a synthetic histone mimic

    Article • Nature, November 2010, Springer Science + Business Media

    Dr Rab K Prinjha

  38. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

    Article • Human Molecular Genetics, November 2008, Oxford University Press (OUP)

    Dr Rab K Prinjha

  39. Aβ1–42 reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: A quantitative analysis

    Article • Journal of Neuroscience Methods, October 2008, Elsevier

    Dr Rab K Prinjha

  40. PINK1 mutations and parkinsonism

    Article • Neurology, August 2008, Wolters Kluwer Health

    Dr Rab K Prinjha

  41. O3-02-07: Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways

    Article • Alzheimer s & Dementia, July 2008, Elsevier

    Dr Rab K Prinjha

  42. LRRK2 Gly2019Ser penetrance in Arab–Berber patients from Tunisia: a case-control genetic study

    Article • The Lancet Neurology, July 2008, Elsevier

    Dr Rab K Prinjha

  43. Proteomic identification and early validation of complement 1 inhibitor and pigment epithelium-derived factor: Two novel biomarkers of Alzheimer's disease in human plasma

    Article • PROTEOMICS - CLINICAL APPLICATIONS, April 2008, Wiley

    Dr Rab K Prinjha

  44. Candidate Single-Nucleotide Polymorphisms From a Genomewide Association Study of Alzheimer Disease

    Article • Archives of Neurology, January 2008, American Medical Association (AMA)

    Dr Rab K Prinjha

  45. O2-03-07

    Article • Alzheimer s & Dementia, July 2006, Elsevier

    Dr Rab K Prinjha

  46. Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease

    Article • Muscle & Nerve, January 2006, Wiley

    Dr Rab K Prinjha

  47. A complementary peptide approach applied to the design of novel semaphorin/neuropilin antagonists

    Article • Journal of Neurochemistry, January 2005, Wiley

    Dr Rab K Prinjha

  48. Strategies for developing Nogo antagonists

    Article • Drug Discovery Today Therapeutic Strategies, September 2004, Elsevier

    Dr Rab K Prinjha

  49. Nogo A expression in the adult enteric nervous system

    Article • Neurogastroenterology & Motility, August 2004, Wiley

    Dr Rab K Prinjha

  50. Nogo-A expression in the intact and injured nervous system

    Article • Molecular and Cellular Neuroscience, December 2003, Elsevier

    Dr Rab K Prinjha

  51. Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons

    Article • Molecular and Cellular Neuroscience, March 2003, Elsevier

    Dr Rab K Prinjha

  52. Nogo

    Article • January 2002, Wiley

    Dr Rab K Prinjha

  53. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1

    Article • Pain, November 2000, Wolters Kluwer Health

    Dr Rab K Prinjha

  54. Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology

    Article • British Journal of Pharmacology, June 2000, Wiley

    Dr Rab K Prinjha

  55. Voltage‐ and time‐dependent properties of the recombinant rat vanilloid receptor (rVR1)

    Article • The Journal of Physiology, June 2000, Wiley

    Dr Rab K Prinjha

  56. Neuropilin-2 Is Required In Vivo for Selective Axon Guidance Responses to Secreted Semaphorins

    Article • Neuron, January 2000, Elsevier

    Dr Rab K Prinjha

  57. Cloning and sequencing of cDNAs encoding the actin cross-liking protein transgelin defines a new family of actin-associated proteins

    Article • Cell Motility and the Cytoskeleton, January 1994, Wiley

    Dr Rab K Prinjha