All Stories

  1. Combining label-free cell phenotypic profiling with computational approaches for novel drug discovery

    Article • Expert Opinion on Drug Discovery, March 2015, Informa Healthcare

    Dr Ye Fang

  2. Label-Free Cell Phenotypic Drug Discovery

    Article • Combinatorial Chemistry & High Throughput Screening, July 2014, Bentham Science Publishers

    Dr Ye Fang

  3. Label-free cell phenotypic profiling identifies pharmacologically active compounds in two traditional Chinese medicinal plants

    Article • RSC Advances, January 2014, Royal Society of Chemistry

    Dr Ye Fang

  4. Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery

    Article • Journal of Pharmacological and Toxicological Methods, March 2013, Elsevier

    Dr Ye Fang

  5. A label-free optical biosensor with microfluidics identifies an intracellular signalling wave mediated through the β2-adrenergic receptor

    Article • Integrative Biology, January 2013, Oxford University Press (OUP)

    Dr Ye Fang

  6. Probing Biochemical Mechanisms of Action of Muscarinic M3 Receptor Antagonists with Label-Free Whole Cell Assays

    Article • Analytical Chemistry, October 2012, American Chemical Society (ACS)

    Dr Ye Fang

  7. Dynamic Mass Redistribution Assay Decodes Differentiation of a Neural Progenitor Stem Cell

    Article • October 2012, SAGE Publications

    Dr Ye Fang

  8. Ligand–receptor interaction platforms and their applications for drug discovery

    Article • Expert Opinion on Drug Discovery, August 2012, Informa Healthcare

    Dr Ye Fang

  9. Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues

    Article • ACS Medicinal Chemistry Letters, July 2012, American Chemical Society (ACS)

    Dr Ye Fang

  10. Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists

    Article • Bioorganic & Medicinal Chemistry Letters, June 2012, Elsevier

    Dr Ye Fang

  11. High resolution resonant waveguide grating imager for cell cluster analysis under physiological condition

    Article • Applied Physics Letters, May 2012, American Institute of Physics

    Dr Ye Fang

  12. Multiple tyrosine metabolites are GPR35 agonists

    Article • Scientific Reports, April 2012, Springer Science + Business Media

    Dr Ye Fang

  13. Aspirin metabolites are GPR35 agonists

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, April 2012, Springer Science + Business Media

    Dr Ye Fang

  14. Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

    Article • ACS Medicinal Chemistry Letters, February 2012, American Chemical Society (ACS)

    Dr Ye Fang

  15. Dynamic Mass Redistribution Assays Decode Surface Influence on Signaling of Endogenous Purinergic P2Y Receptors

    Article • Assay and Drug Development Technologies, February 2012, Mary Ann Liebert Inc

    Dr Ye Fang

  16. Discovery of nitrophenols as GPR35 agonists

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Dr Ye Fang

  17. Anti-Inflammatory Gallic Acid and Wedelolactone Are G Protein-Coupled Receptor-35 Agonists

    Article • Pharmacology, January 2012, Karger Publishers

    Dr Ye Fang

  18. The development of label-free cellular assays for drug discovery

    Article • Expert Opinion on Drug Discovery, December 2011, Informa Healthcare

    Dr Ye Fang

  19. Discovery of 2-(4-Methylfuran-2(5 H )-ylidene)malononitrile and Thieno[3,2- b ]thiophene-2-carboxylic Acid Derivatives as G Protein-Coupled Receptor 35 (GPR35) Agonists

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Dr Ye Fang

  20. GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

    Article • Nature Chemical Biology, October 2011, Springer Science + Business Media

    Dr Ye Fang

  21. Ligand-Directed Functional Selectivity at the Mu Opioid Receptor Revealed by Label-Free Integrative Pharmacology On-Target

    Article • PLoS ONE, October 2011, PLOS

    Dr Ye Fang

  22. Air stability of supported lipid membrane spots

    Article • Chemical Physics Letters, August 2011, Elsevier

    Dr Ye Fang

  23. Label-free integrative pharmacology on-target of drugs at the β2-adrenergic receptor

    Article • Scientific Reports, July 2011, Springer Science + Business Media

    Dr Ye Fang

  24. Tyrphostin analogs are GPR35 agonists

    Article • FEBS Letters, May 2011, Wiley

    Dr Ye Fang

  25. Agonist-Directed Desensitization of the β2-Adrenergic Receptor

    Article • PLoS ONE, April 2011, PLOS

    Dr Ye Fang

  26. Microfluidic resonant waveguide grating biosensor system for whole cell sensing

    Article • Applied Physics Letters, April 2011, American Institute of Physics

    Dr Ye Fang

  27. Label-free optical biosensor with microfluidics for sensing ligand-directed functional selectivity on trafficking of thrombin receptor

    Article • FEBS Letters, March 2011, Wiley

    Dr Ye Fang

  28. Resonant waveguide grating imager for live cell sensing

    Article • Applied Physics Letters, November 2010, American Institute of Physics

    Dr Ye Fang

  29. Probing cancer signaling with resonant waveguide grating biosensors

    Article • Expert Opinion on Drug Discovery, November 2010, Informa Healthcare

    Dr Ye Fang

  30. Label-free receptor assays

    Article • Drug Discovery Today Technologies, March 2010, Elsevier

    Dr Ye Fang

  31. Label-Free and Non-invasive Biosensor Cellular Assays for Cell Adhesion

    Article • Journal of Adhesion Science and Technology, January 2010, Taylor & Francis

    Dr Ye Fang

  32. Interrogation of phosphor-specific interaction on a high-throughput label-free optical biosensor system–Epic®system

    Article • Journal of Receptors and Signal Transduction, July 2009, Taylor & Francis

    Dr Ye Fang

  33. Label-free optical biosensor for probing integrative role of adenylyl cyclase in G protein-coupled receptor signaling

    Article • Journal of Receptors and Signal Transduction, July 2009, Taylor & Francis

    Dr Ye Fang

  34. Guest Editor’s Introduction: Label-free optical biosensors to cell biology and drug discovery

    Article • Journal of Receptors and Signal Transduction, July 2009, Taylor & Francis

    Dr Ye Fang

  35. Live Cell Optical Sensing for High Throughput Applications

    Article • January 2009, Springer Science + Business Media

    Dr Ye Fang

  36. Resonant Waveguide Grating Biosensor for Whole-Cell GPCR Assays

    Article • January 2009, Springer Science + Business Media

    Dr Ye Fang

  37. GPCR Microspot Assays on Solid Substrates

    Article • January 2009, Springer Science + Business Media

    Dr Ye Fang

  38. Duplexed Label-Free G Protein—Coupled Receptor Assays for High-Throughput Screening

    Article • December 2008, SAGE Publications

    Dr Ye Fang

  39. The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains G i and Downstream Signaling Cascade Activation

    Article • Journal of Biological Chemistry, November 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Ye Fang

  40. Label-Free Cell-Based Assays for GPCR Screening

    Article • Combinatorial Chemistry & High Throughput Screening, June 2008, Bentham Science Publishers

    Dr Ye Fang

  41. Evaluation of Dynamic Mass Redistribution Technology for Pharmacological Studies of Recombinant and Endogenously Expressed G Protein-Coupled Receptors

    Article • Assay and Drug Development Technologies, February 2008, Mary Ann Liebert Inc

    Dr Ye Fang

  42. Label-free optical biosensor for ligand-directed functional selectivity acting on β2adrenoceptor in living cells

    Article • FEBS Letters, January 2008, Wiley

    Dr Ye Fang

  43. Non-invasive Optical Biosensor for Probing Cell Signaling

    Article • Sensors, October 2007, MDPI AG

    Dr Ye Fang

  44. Optical biosensor differentiates signaling of endogenous PAR1 and PAR2 in A431 cells

    Article • BMC Cell Biology, June 2007, Springer Science + Business Media

    Dr Ye Fang

  45. Multiplexing G protein-coupled receptors in microarrays: A radioligand-binding assay

    Article • Analytical Biochemistry, June 2007, Elsevier

    Dr Ye Fang

  46. Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells

    Article • Journal of Pharmacological and Toxicological Methods, May 2007, Elsevier

    Dr Ye Fang

  47. Label-Free Cell-Based Assays with Optical Biosensors in Drug Discovery

    Article • Assay and Drug Development Technologies, October 2006, Mary Ann Liebert Inc

    Dr Ye Fang

  48. Resonant Waveguide Grating Biosensor for Living Cell Sensing

    Article • Biophysical Journal, September 2006, Elsevier

    Dr Ye Fang

  49. Label-Free Profiling of Ligands for Endogenous GPCRs Using a Cell-Based High-Throughput Screening Technology

    Article • JALA Journal of the Association for Laboratory Automation, August 2006, SAGE Publications

    Dr Ye Fang

  50. G-Protein-Coupled Receptor Microarrays for Multiplexed Compound Screening

    Article • June 2006, SAGE Publications

    Dr Ye Fang

  51. Spreading and Segregation of Lipids in Air-Stable Lipid Microarrays

    Article • Journal of the American Chemical Society, March 2006, American Chemical Society (ACS)

    Dr Ye Fang

  52. Cellular functions of cholesterol probed with optical biosensors

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, February 2006, Elsevier

    Dr Ye Fang

  53. Air-Stable G Protein-Coupled Receptor Microarrays and Ligand Binding Characteristics

    Article • Analytical Chemistry, January 2006, American Chemical Society (ACS)

    Dr Ye Fang

  54. Functional GPCR Microarrays

    Article • Journal of the American Chemical Society, November 2005, American Chemical Society (ACS)

    Dr Ye Fang

  55. Optical biosensor provides insights for bradykinin B2receptor signaling in A431 cells

    Article • FEBS Letters, October 2005, Wiley

    Dr Ye Fang

  56. Characteristics of Dynamic Mass Redistribution of Epidermal Growth Factor Receptor Signaling in Living Cells Measured with Label-Free Optical Biosensors

    Article • Analytical Chemistry, September 2005, American Chemical Society (ACS)

    Dr Ye Fang

  57. Probing cytoskeleton modulation by optical biosensors

    Article • FEBS Letters, July 2005, Wiley

    Dr Ye Fang

  58. G protein-coupled receptor microarrays for drug discovery

    Article • Drug Discovery Today, August 2003, Elsevier

    Dr Ye Fang

  59. Ganglioside Microarrays for Toxin Detection †

    Article • Langmuir, March 2003, American Chemical Society (ACS)

    Dr Ye Fang

  60. G-Protein-Coupled Receptor Microarrays

    Article • ChemBioChem, October 2002, Wiley

    Dr Ye Fang

  61. G protein-coupled receptor (GPCR) microarrays

    Article • June 2002, SPIE

    Dr Ye Fang

  62. Membrane Protein Microarrays

    Article • Journal of the American Chemical Society, February 2002, American Chemical Society (ACS)

    Dr Ye Fang

  63. Article • Biomedical Microdevices, January 2001, Springer Science + Business Media

    Dr Ye Fang

  64. Cationic silanes stabilize intermediates in DNA condensation

    Article • FEBS Letters, October 1999, Wiley

    Dr Ye Fang

  65. Ethanol-induced structural transitions of DNA on mica

    Article • Nucleic Acids Research, April 1999, Oxford University Press (OUP)

    Dr Ye Fang

  66. Heptameric structures of two ?-hemolysin mutants imaged with in situ atomic force microscopy

    Article • Microscopy Research and Technique, March 1999, Wiley

    Dr Ye Fang

  67. Early Intermediates in Spermidine-Induced DNA Condensation on the Surface of Mica

    Article • Journal of the American Chemical Society, September 1998, American Chemical Society (ACS)

    Dr Ye Fang

  68. Surface-directed DNA condensation in the absence of soluble multivalent cations

    Article • Nucleic Acids Research, January 1998, Oxford University Press (OUP)

    Dr Ye Fang

  69. The Heptameric Prepore of a Staphylococcal α-Hemolysin Mutant in Lipid Bilayers Imaged by Atomic Force Microscopy †

    Article • Biochemistry, August 1997, American Chemical Society (ACS)

    Dr Ye Fang

  70. The growth of bilayer defects and the induction of interdigitated domains in the lipid-loss process of supported phospholipid bilayers

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, March 1997, Elsevier

    Dr Ye Fang

  71. Characterization of triplex RNA poly[rU]· poly[rA]· poly[rU] adsorbed on silver colloids by Fourier transform surface enhanced Raman scattering and scanning tunneling microscopy

    Article • Applied Surface Science, August 1995, Elsevier

    Dr Ye Fang