All Stories

  1. Myths and Verities in Protein Folding Theories. By Arieh Ben-Naim. World Scientific, 2015. Pp. 448. Hardback. Price GBP 45.00. ISBN 978-981-4725-98-9.
  2. Crystal structure of C117S mutant of human acidic fibroblast growth factor
  3. Crystal structure of C117A mutant of human acidic fibroblast growth factor
  4. Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium formate buffer
  5. Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
  6. Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium citrate buffer
  7. Crystal structure of C16T/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
  8. Crystal structure of K12V/C16S/C117V/P134V mutant of human acidic fibroblast growth factor
  9. Structure of a highly acidic β-lactamase from the moderate halophileChromohalobactersp. 560 and the discovery of a Cs+-selective binding site
  10. Mutation Choice to Eliminate Buried Free Cysteines in Protein Therapeutics
  11. Structural basis for acceptor-substrate recognition of UDP-glucose: anthocyanidin 3-O-glucosyltransferase fromClitoria ternatea
  12. Crystal Structure of 6xTyr/PV2: de novo designed beta-trefoil architecture with symmetric primary structure (L22Y/L44Y/L64Y/L85Y/L108Y/L132Y, Primitive Version 2)
  13. Crystal Structure of 6xTrp/PV2: de novo designed beta-trefoil architecture with symmetric primary structure (L22W/L44W/L64W/L85W/L108W/L132W his Primitive Version 2)
  14. Specificity studies on Kallikrein-related peptidase 7 (KLK7) and effects of osmolytes and glycosaminoglycans on its peptidase activity
  15. Beta-trefoil designed by folding nucleus symmetric expansion (""Phifoil"")
  16. A single aromatic core mutation converts a designed “primitive” protein from halophile to mesophile folding
  17. Evolution and Design of Protein Structure by Folding Nucleus Symmetric Expansion
  18. Structural characteristics of alkaline phosphatase from the moderately halophilic bacterium Halomonas sp. 593
  19. Isomannide-Based Peptidomimetics as Inhibitors for Human Tissue Kallikreins 5 and 7
  20. Symmetric Protein Architecture in Protein Design: Top-Down Symmetric Deconstruction
  21. Prebiotic protein design supports a halophile origin of foldable proteins
  22. Kallikrein-related peptidase 6: A biomarker for traumatic brain injury in the rat
  23. Kallikrein Cascades in Traumatic Spinal Cord Injury: In Vitro Evidence for Roles in Axonopathy and Neuron Degeneration
  24. Creation and structure determination of an artificial protein with three complete sequence repeats
  25. Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity
  26. Symfoil-4V synthetic protein with T30E/T72E/T116E mutations, and delta His tag
  27. Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
  28. Simplified protein design biased for prebiotic amino acids yields a foldable, halophilic protein
  29. Crystal structure of Symfoil-4P/PV2: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 2 (6xLeu / PV1)
  30. Clinical significance and novel mechanism of action of kallikrein 6 in glioblastoma
  31. Activation profiles of human kallikrein-related peptidases by matrix metalloproteinases
  32. Kallikrein-related Peptidase 6
  33. Experimental support for the foldability-function tradeoff hypothesis: Segregation of the folding nucleus and functional regions in fibroblast growth factor-1
  34. Pharmacokinetic Properties of 2nd-Generation Fibroblast Growth Factor-1 Mutants for Therapeutic Application
  35. Structure and Function of ∆1-Tetrahydrocannabinolic Acid (THCA) Synthase, the Enzyme Controlling the Psychoactivity of Cannabis sativa
  36. Protein design at the interface of the pre-biotic and biotic worlds
  37. Isomannide derivatives as new class of inhibitors for human kallikrein 7
  38. Designing proteins from simple motifs: opportunities in Top-Down Symmetric Deconstruction
  39. Crystal structure of tetrahydrocannabinolic acid synthase from Cannabis sativa
  40. Emergence of symmetric protein architecture from a simple peptide motif: evolutionary models
  41. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis
  42. Kallikrein 6 Regulates Early CNS Demyelination in a Viral Model of Multiple Sclerosis
  43. A structural mechanism for dimeric to tetrameric oligomer conversion inHalomonassp. nucleoside diphosphate kinase
  44. Substrate recognition mechanism of a glycosyltrehalose trehalohydrolase fromSulfolobus solfataricusKM1
  45. Crystal structure of Symfoil-4P/PV1: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 1
  46. Crystal structure of Symfoil-4P/PV1: de novo designed beta-trefoil architecture with symmetric primary structure, primitive version 1
  47. Crystal structure of K15R/E18D/Y22W/H41G/F44W/E51D/E53P/K57R/E60D/Y64W/H82G/F85W/E90D/E94P/K98R/E101D/Y108W/H129G/F132W/E137D Symfoil-4P: de novo designed beta-trefoil architecture with symmetric primary structure
  48. Development of “second-generation” forms of FGF-1 for therapeutic application
  49. Expression and Function of the Kallikrein-Related Peptidase 6 in the Human Melanoma Microenvironment
  50. Substrate specificity of kallikrein-related peptidase 13 activated by salts or glycosaminoglycans and a search for natural substrate candidates
  51. Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7
  52. A Polypeptide “Building Block” for the β-Trefoil Fold Identified by “Top-Down Symmetric Deconstruction”
  53. Functional Role of Kallikrein 6 in Regulating Immune Cell Survival
  54. North American Brain Injury Societyʼs Ninth Annual Conference on Brain Injury
  55. Experimental support for the evolution of symmetric protein architecture from a simple peptide motif
  56. Substrate specificity and inhibition of human kallikrein-related peptidase 3 (KLK3 or PSA) activated with sodium citrate and glycosaminoglycans
  57. Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis
  58. T4 Lysozyme S44E/WT*
  59. Analysis of the Dynamics of Assembly and Structural Impact for a Histidine Tagged FGF1−1.5 nm Au Nanoparticle Bioconjugate
  60. X-ray structure and biophysical properties of rabbit fibroblast growth factor 1
  61. Engineering an improved crystal contact across a solvent-mediated interface of human fibroblast growth factor 1
  62. Structural Basis of Conserved Cysteine in the Fibroblast Growth Factor Family: Evidence for a Vestigial Half-Cystine
  63. The Interaction between Thermodynamic Stability and Buried Free Cysteines in Regulating the Functional Half-Life of Fibroblast Growth Factor-1
  64. Alternative type I and I′ turn conformations in the β8/β9 β-hairpin of human acidic fibroblast growth factor
  65. Structure and stability effects of mutations designed to increase the primary sequence symmetry within the core region of a β-trefoil
  66. A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15
  67. S1′ and S2′ subsite specificities of human plasma kallikrein and tissue kallikrein 1 for the hydrolysis of peptides derived from the bradykinin domain of human kininogen
  68. Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis
  69. Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines
  70. Development of Hydrogen and Hydration Database for Biomolecules (HHDB)
  71. Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration
  72. Mutagenesis of the crystal contact of acidic fibroblast growth factor
  73. A Logical OR Redundancy within the Asx-Pro-Asx-Gly Type I β-Turn Motif
  74. Substrate specificity of human kallikreins 1 and 6 determined by phage display
  75. Activation Profiles and Regulatory Cascades of the Human Kallikrein-related Peptidases
  76. Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and C terminus β-Strand Interactions
  77. The Autolytic Regulation of Human Kallikrein-Related Peptidase 6†
  78. Proteinase-activated Receptors, Targets for Kallikrein Signaling
  79. Potential scope of action of tissue kallikreins in CNS immune-mediated disease
  80. Dynamic role of kallikrein 6 in traumatic spinal cord injury
  81. Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs)
  82. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins
  83. Substrate Specificity of Human Kallikrein 6: SALT AND GLYCOSAMINOGLYCAN ACTIVATION EFFECTS
  84. Redesigning symmetry-related “mini-core” regions of FGF-1 to increase primary structure symmetry: Thermodynamic and functional consequences of structural symmetry
  85. Hydrogen and hydration database for bio-macromolecules (HHDB)
  86. Structural and Energetic Consequences of Mutations in a Solvated Hydrophobic Cavity
  87. 1.70 Å X-ray structure of human apo kallikrein 1: Structural changes upon peptide inhibitor/substrate binding
  88. Symmetric Primary and Tertiary Structure Mutations within a Symmetric Superfold: A Solution, not a Constraint, to Achieve a Foldable Polypeptide
  89. Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease
  90. An atomic resolution structure for human fibroblast growth factor 1
  91. Targeting kallikrein 6‐proteolysis attenuates CNS inflammatory disease
  92. Nano-dynamics: engineering allostery via tandem duplication and turn energetics
  93. Accommodation of a highly symmetric core within a symmetric protein superfold
  94. Identification of a Key Structural Element for Protein Folding Within β-Hairpin Turns
  95. Structural Biology of the Aldo-Keto Reductase Family of Enzymes: Catalysis and Cofactor Binding
  96. Crystal Structure and Biochemical Characterization of Human Kallikrein 6 Reveals That a Trypsin-like Kallikrein Is Expressed in the Central Nervous System
  97. Enzymatic Properties of Rat Myelencephalon-Specific Protease †
  98. Structural assembly of the active site in an aldo-keto reductase by NADPH cofactor
  99. Thermodynamic Characterization of Mutants of Human Fibroblast Growth Factor 1 with an Increased Physiological Half-Life†
  100. Preferential expression of myelencephalon-specific protease by oligodendrocytes of the adult rat spinal cord white matter
  101. Molecular modeling of substrate binding in wild-type and mutantCorynebacteria 2,5-diketo-D-gluconate reductases
  102. Reversible Thermal Denaturation of Human FGF-1 Induced by Low Concentrations of Guanidine Hydrochloride
  103. Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography
  104. Crystal structure of 2,5-diketo- d -gluconic acid reductase A complexed with NADPH at 2.1-Å resolution
  105. Biophysical and structural analysis of human acidic fibroblast growth factor
  106. X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor † , ‡
  107. Alanine Scanning Mutagenesis of the α-Helix 115-123 of Phage T4 Lysozyme: Effects on Structure, Stability and the Binding of Solvent
  108. 2.0 ANGSTROM STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR
  109. Accommodation of Amino Acid Insertions in an α-Helix of T4 Lysozyme
  110. Determination of α-Helix Propensity within the Context of a Folded Protein
  111. Response
  112. STRUCTURAL BASIS OF ALPHA-HELIX PROPENSITY AT TWO SITES IN T4 LYSOZYME
  113. Energetic cost and structural consequences of burying a hydroxyl group within the core of a protein determined from Ala .fwdarw. Ser and Val .fwdarw. Thr substitutions in T4 lysozyme
  114. Synthetic chimeras of mouse growth factor-associated glandular kallikreins. II. Growth factor binding properties
  115. Synthetic chimeras of mouse growth factor-associated glandular kallikreins. I. Kinetic properties
  116. Prediction of the three-dimensional structures of the nerve growth factor and epidermal growth factor binding proteins (kallikreins) and an hypothetical structure of the high molecular weight complex of epidermal growth factor with its binding protein
  117. Structural basis of amino acid alpha helix propensity
  118. Response
  119. Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect
  120. Dissection of protein structure and folding by directed mutagenesis
  121. The characterization of recombinant mouse glandular kallikreins fromE. coli
  122. Chapter 13 Neurotrophic factors in the CNS: biosynthetic processing and functional responses
  123. Substrate specificities of growth factor associated kallikreins of the mouse submandibular gland
  124. A complete cDNA sequence for the major epidermal growth factor binding protein in the male mouse submandibular gland
  125. Epidermal growth factor binding protein: identification of a different protein
  126. Complete nucleotide sequence of the Escherichia coli gene encoding malate dehydrogenase
  127. Purification and characterization of recombinant single-chain urokinase produced in Escherichia coli
  128. Purification and Characterization of Recombinant Urokinase from Escherichia coli
  129. Cloning and Expression of the Gene for Pro-urokinase in Escherichia coli