All Stories

  1. cGAS–STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control
  2. Effective drug discovery in Chagas disease
  3. Frequency Variation and Dose Modification of Benznidazole Administration for the Treatment of Trypanosoma cruzi Infection in Mice, Dogs, and Nonhuman Primates
  4. Validation of a multiplex microsphere immunoassay for detection ofTrypanosoma cruziantibodies in dogs
  5. Delayed Activation of T Cells at the Site of Infection Facilitates the Establishment of Trypanosoma cruzi in Both Naive and Immune Hosts
  6. Frequency variation and dose modification of benznidazole administration for the treatment ofTrypanosoma cruziinfection in mice, dogs and non-human primates
  7. Epitopes in the Glycosylphosphatidylinositol Attachment Signal Peptide of Trypanosoma cruzi Mucin Proteins Generate Robust but Delayed and Nonprotective CD8+ T Cell Responses
  8. Avoiding Clinical Trial Failures in Neglected Tropical Diseases: The Example of Chagas Disease
  9. Prophylactic low-dose, bi-weekly benznidazole treatment fails to prevent Trypanosoma cruzi infection in dogs under intense transmission pressure
  10. Quantitative 3D Imaging of <em>Trypanosoma cruzi</em>-Infected Cells, Dormant Amastigotes, and T Cells in Intact Clarified Organs
  11. High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA
  12. Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease
  13. High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA
  14. A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease
  15. Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion
  16. Strain-specific genome evolution inTrypanosoma cruzi, the agent of Chagas disease
  17. Chagas Disease Drug Discovery: Multiparametric Lead Optimization against Trypanosoma cruzi in Acylaminobenzothiazole Series
  18. Protozoan persister-like cells and drug treatment failure
  19. Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection
  20. Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure
  21. Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure
  22. Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins
  23. The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to Trypanosoma cruzi in Serodiscordant Subjects
  24. Correction for Ekanayake et al., “Epigenetic Regulation of Transcription and Virulence in Trypanosoma cruzi by O-Linked Thymine Glucosylation of DNA”
  25. Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection
  26. Chagas Disease: A Solvable Problem, Ignored
  27. Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi
  28. Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominanttrans-Sialidase-Specific CD8+T Cells
  29. Treatment Success in Trypanosoma cruzi Infection Is Predicted by Early Changes in Serially Monitored Parasite-Specific T and B Cell Responses
  30. A framework for ontology-based question answering with application to parasite immunology
  31. CD8+ T cells in Trypanosoma cruzi infection
  32. Reaching for the Holy Grail: insights from infection/cure models on the prospects for vaccines for Trypanosoma cruzi infection
  33. Perturbed T Cell IL-7 Receptor Signaling in Chronic Chagas Disease
  34. Chemokine receptor 7 (CCR7)-expression and IFNγ production define vaccine-specific canine T-cell subsets
  35. CRISPR-Cas9-Mediated Single-Gene and Gene Family Disruption in Trypanosoma cruzi
  36. Chagas Disease and the London Declaration on Neglected Tropical Diseases
  37. The Trypanosoma cruzi Flagellum Is Discarded via Asymmetric Cell Division following Invasion and Provides Early Targets for Protective CD8+ T Cells
  38. Potential new clinical therapies for Chagas disease
  39. Frequency of IFNγ-producing T cells correlates with seroreactivity and activated T cells during canine Trypanosoma cruzi infection
  40. Polyfunctional T Cell Responses in Children in Early Stages of Chronic Trypanosoma cruzi Infection Contrast with Monofunctional Responses of Long-term Infected Adults
  41. Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen
  42. Ask the Experts: Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease
  43. Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate inTrypanosoma cruzipersistence
  44. New, Combined, and Reduced Dosing Treatment Protocols Cure Trypanosoma cruzi Infection in Mice
  45. From Questions to Effective Answers: On the Utility of Knowledge-Driven Querying Systems for Life Sciences Data
  46. A Systematic Review of High Quality Diagnostic Tests for Chagas Disease
  47. Sequential combined treatment with allopurinol and benznidazole in the chronic phase of Trypanosoma cruzi infection: a pilot study
  48. Is Chagas Disease Really the “New HIV/AIDS of the Americas”?
  49. Kinetoplastids: Trypanosoma cruzi (Chagas disease)
  50. Inhibitory Receptors Are Expressed by Trypanosoma cruzi-Specific Effector T Cells and in Hearts of Subjects with Chronic Chagas Disease
  51. Transgenic parasites accelerate drug discovery
  52. A Semantic Problem Solving Environment for Integrative Parasite Research: Identification of Intervention Targets for Trypanosoma cruzi
  53. Knockout of the dhfr-ts Gene in Trypanosoma cruzi Generates Attenuated Parasites Able to Confer Protection against a Virulent Challenge
  54. Impact of Aetiological Treatment on Conventional and Multiplex Serology in Chronic Chagas Disease
  55. Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA
  56. Oral Exposure to Trypanosoma cruzi Elicits a Systemic CD8+T Cell Response and Protection against Heterotopic Challenge
  57. Methodological advances in drug discovery for Chagas disease
  58. Identification of Contractile Vacuole Proteins in Trypanosoma cruzi
  59. Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization
  60. Epigenetic Regulation of Transcription and Virulence in Trypanosoma cruzi by O-Linked Thymine Glucosylation of DNA
  61. In Vitro and In Vivo High-Throughput Assays for the Testing of Anti-Trypanosoma cruzi Compounds
  62. CD8+ T Cells Specific for ImmunodominantTrans-Sialidase Epitopes Contribute to Control ofTrypanosoma cruziInfection but Are Not Required for Resistance
  63. Generation of Trypanosoma cruzi-Specific CD8+ T-Cell Immunity Is Unaffected by the Absence of Type I Interferon Signaling
  64. Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina
  65. Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines
  66. Changes inTrypanosoma cruzi–Specific Immune Responses after Treatment: Surrogate Markers of Treatment Efficacy
  67. Chronic Human Infection with Trypanosoma cruzi Drives CD4+ T Cells to Immune Senescence
  68. The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi
  69. CD8+ T cells in Trypanosoma cruzi infection
  70. Insufficient TLR Activation Contributes to the Slow Development of CD8+ T Cell Responses in Trypanosoma cruzi Infection
  71. Chromosome level assembly of the hybrid Trypanosoma cruzi genome
  72. Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi
  73. Proteomic analysis of the Trypanosoma cruzi ribosomal proteins
  74. Ontology-Driven Provenance Management in eScience: An Application in Parasite Research
  75. High Throughput Selection of Effective Serodiagnostics for Trypanosoma cruzi infection
  76. Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease
  77. Kinetoplastids: related protozoan pathogens, different diseases
  78. The Challenges of Chagas Disease— Grim Outlook or Glimmer of Hope?
  79. Correction: TGF-β regulates pathology but not tissue CD8+ T cell dysfunction during experimentalTrypanosoma cruzi infection
  80. TGF-β regulates pathology but not tissue CD8+ T cell dysfunction during experimentalTrypanosoma cruzi infection
  81. Immune system recognition of Trypanosoma cruzi
  82. A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi
  83. Multidimensional analysis of the insoluble sub-proteome ofOceanobacillus iheyensis HTE831, an alkaliphilic and halotolerant deep-sea bacterium isolated from the Iheya ridge
  84. Glycoproteomics ofTrypanosoma cruziTrypomastigotes Using Subcellular Fractionation, Lectin Affinity, and Stable Isotope Labeling
  85. Endogenous CD4+ CD25+ Regulatory T Cells Have a Limited Role in the Control of Trypanosoma cruzi Infection in Mice
  86. Limited Role for CD4+ T-Cell Help in the Initial Priming of Trypanosoma cruzi-Specific CD8+ T Cells
  87. Multidimensional Proteomic Analysis of the Soluble Subproteome of the Emerging Nosocomial Pathogen Ochrobactrum anthropi
  88. CD8+ T-Cell Responses to Trypanosoma cruzi Are Highly Focused on Strain-Variant trans-Sialidase Epitopes
  89. A Combined Shotgun and Multidimensional Proteomic Analysis of the Insoluble Subproteome of the Obligate Thermophile, Geobacillus thermoleovorans T80
  90. Analysis of theTrypanosoma cruzicyclophilin gene family and identification of Cyclosporin A binding proteins
  91. Trypanosoma cruzi modulates the profile of memory CD8+ T cells in chronic Chagas' disease patients
  92. New approaches in vaccine development for parasitic infections
  93. The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease
  94. The Trypanosoma cruzi Proteome
  95. A Heuristic Method for Assigning a False-discovery Rate for Protein Identifications from Mascot Database Search Results
  96. Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection
  97. Inducible Nitric Oxide Synthase Is Not Essential for Control of Trypanosoma cruzi Infection in Mice
  98. Frequency of Interferon‐γ–Producing T Cells Specific forTrypanosoma cruziInversely Correlates with Disease Severity in Chronic Human Chagas Disease
  99. Chagas disease: a role for autoimmunity?
  100. Microarray profiling of gene expression during trypomastigote to amastigote transition in Trypanosoma cruzi
  101. Genetic immunization with LYT1 or a pool of trans-sialidase genes protects mice from lethal Trypanosoma cruzi infection
  102. Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR
  103. Genetic Immunization Elicits Antigen-Specific Protective Immune Responses and Decreases Disease Severity in Trypanosoma cruzi Infection
  104. Parasite genomics: current status and future prospects
  105. Parasite Persistence Correlates with Disease Severity and Localization in Chronic Chagas' Disease
  106. Chagas Disease Etiology: Autoimmunity or Parasite Persistence?
  107. Molecular cloning of the gene encoding the 83 kDa amastigote surface protein and its identification as a member of the Trypanosoma cruzi sialidase superfamily1Note: Nucleotide sequence data reported in this paper is available in the GenBank™ database u...
  108. Proteins with Glycosylphosphatidylinositol (GPI) Signal Sequences Have Divergent Fates during a GPI Deficiency
  109. The identification and molecular characterization of Trypanosoma cruzi amastigote surface protein-1, a member of the trans-sialidase gene super-family1Note: Nucleotide sequence data reported in this paper is available in the GenBank data base under the...
  110. Persistent Production of Inflammatory and Anti-inflammatory Cytokines and Associated MHC and Adhesion Molecule Expression at the Site of Infection and Disease in ExperimentalTrypanosoma cruziInfections
  111. Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: Lack of association between susceptibility and type 2 cytokine production
  112. Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease
  113. Construction and use of a multi-competitor gene for quantitative RT-PCR using existing primer sets
  114. The role of T cells in Trypanosoma cruzi infections
  115. In vitro Culture of Cardiac Mast Cells from Mice Experimentally Infected with <i>Trypanosoma cruzi</i>
  116. Interleukin 1 activity in haemolymph from strains of the snail biomphalaria glabrata varying in susceptibility to the human blood fluke, Schistosoma mansoni: presence, differential expression, and biological function
  117. Trypanosoma cruzi infection suppresses nuclear factors that bind to specific sites on the interleukin
  118. Trypanosomes and Microfilariae in Feral Owl and Squirrel Monkeys Maintained in Research Colonies
  119. Differentiation of trypanosomatid species by hybridization to selected rRNA probes
  120. Predominance of CD8+ T Lymphocytes in the Inflammatory Lesions of Mice with Acute Trypanosoma cruzi Infection
  121. Susceptibility of β2-microglobulin-deficient mice to Trypanosoma cruzi infection
  122. Regulation of immunity in Trypanosoma cruzi infection
  123. Differential control of IFN-gamma and IL-2 production during Trypanosoma cruzi infection.
  124. Trypanosoma cruzi: Cytokine effects on macrophage trypanocidal activity
  125. Discussion
  126. The role of T-cell subpopulations in experimental Chagas' disease
  127. Depletion of CD8+ T cells increases susceptibility and reverses vaccine-induced immunity in mice infected with Trypanosoma cruzi.
  128. Trypanosoma cruzi-induced suppression of IL-2 production. I. Evidence for the presence of IL-2-producing cells.
  129. Interleukin 2 production in patients with Chagas' disease: correlation with anti-parasite antibody responses
  130. A Monoclonal Antibody to Alpha Tubulin Recognizes Host Cell and Trypanosoma cruzi Tubulins1
  131. Initial induction of immunity, followed by suppression of responses to parasite antigens during Trypanosoma cruzi infection of mice
  132. Biology of tegument associated IgG-Fc and C3 receptors inSchistosoma mansoni
  133. Measurement of parasite‐specific immune responses in vitro: evidence for suppression of the antibody response to Trypanosoma cruzi
  134. Loss of Suppressor Activity in the Serum of Mice Infected with Trypanosoma cruzi
  135. Diagnosis of Chagas' Disease in Humans Using a Biotin-3H-Avidin Radioimmunoassay *
  136. Changes in cell populations and immunoglobulin-producing cells in the spleens of mice infected with Trypanosoma cruzi: Correlations with parasite-specific antibody response
  137. Measurement of parasite-specific antibody responses using a tritiated avidin-solid phase radioimmunoassay
  138. Trypanosoma cruzi: Effect on B-cell-responsive and -responding clones