All Stories

  1. Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases
  2. Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes
  3. Protease inhibitors targeting coronavirus and filovirus entry
  4. Simple Plate-Based, Parallel Synthesis of Disulfide Fragments using the CuAAC Click Reaction
  5. Efficient and Stereocontrolled Synthesis of 1,2,4-Trioxolanes Useful for Ferrous Iron-Dependent Drug Delivery
  6. Drug Delivery to the Malaria Parasite Using an Arterolane-Like Scaffold
  7. Successes and Challenges in Phenotype-Based Lead Discovery for Prion Diseases
  8. Broad-Spectrum Allosteric Inhibition of Herpesvirus Proteases
  9. UCSF Small Molecule Discovery Center: Innovation, Collaboration and Chemical Biology in the Bay Area
  10. Fragment-based inhibitor discovery against β-lactamase
  11. Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells
  12. Inside Cover: Tailoring Small Molecules for an Allosteric Site on Procaspase-6 (ChemMedChem 1/2014)
  13. Antimalarial Drug Discovery: From Quinine to the Dream of Eradication
  14. Modulating caspase activity: beyond the active site
  15. Antiprion compounds that reduce PrPSc levels in dividing and stationary-phase cells
  16. Tailoring Small Molecules for an Allosteric Site on Procaspase-6
  17. A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2PChannels
  18. Correction: Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei
  19. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei
  20. Genetic and Neural Mechanisms that Inhibit Drosophila from Mating with Other Species
  21. Pharmacological brake-release of mRNA translation enhances cognitive memory
  22. 2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease
  23. Pharmacokinetics and Metabolism of 2-Aminothiazoles with Antiprion Activity in Mice
  24. Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target
  25. Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
  26. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite
  27. Predicting and Improving the Membrane Permeability of Peptidic Small Molecules
  28. Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A β-Lactamase
  29. Investigating the Antimalarial Action of 1,2,4-Trioxolanes with Fluorescent Chemical Probes
  30. Drug discovery for neglected tropical diseases at the Sandler Center
  31. Predicting Binding to P-Glycoprotein by Flexible Receptor Docking
  32. Simple One-Pot Synthesis of Disulfide Fragments for Use in Disulfide-Exchange Screening
  33. Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads
  34. Inside Cover: A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite (ChemMedChem 3/2011)
  35. 2-Aminothiazoles as Therapeutic Leads for Prion Diseases
  36. Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System
  37. A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite
  38. ChemInform Abstract: Synthesis of Substituted Pyridines via Regiocontrolled [4 + 2] Cycloadditions of Oximinosulfonates.
  39. Antibacterial oxazolidinones: emerging structure–toxicity relationships
  40. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases
  41. Divergent Modes of Enzyme Inhibition in a Homologous Structure−Activity Series
  42. Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening
  43. Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes
  44. The Echinocandins: Total and Semisynthetic Approaches in Antifungal Drug Discovery
  45. A Practical Synthesis of Differentially Protected 2-(Hydroxymethyl)piperazines
  46. A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials
  47. The Echinocandins: Total and Semi-Synthetic Approaches in Antifungal Drug Discovery
  48. Drug discovery and development for neglected parasitic diseases
  49. Synthesis and Structure—Activity Studies of Antibacterial Oxazolidinones Containing Dihydrothiopyran or Dihydrothiazine C-Rings.
  50. Synthesis and structure–activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings
  51. Recent developments in the identification of novel oxazolidinone antibacterial agents
  52. Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones
  53. Synthesis of Aza-, Oxa-, and Thiabicyclo[3.1.0]hexane Heterocycles from a Common Synthetic Intermediate.
  54. Conformational Constraint in Oxazolidinone Antibacterials. Synthesis and Structure−Activity Studies of (Azabicyclo[3.1.0]hexylphenyl)oxazolidinones
  55. Synthesis of Aza-, Oxa-, and Thiabicyclo[3.1.0]hexane Heterocycles from a Common Synthetic Intermediate
  56. Intramolecular [4 + 2] Cycloadditions of Iminoacetonitriles: A New Class of Azadienophiles for Hetero Diels—Alder Reactions.
  57. Preparation of Substituted Pyridines Via Regiocontrolled [4 + 2] Cycloadditions of Oximinosulfonates: Methyl 5-Methylpyridine-2-Carboxylate
  58. Intramolecular [4 + 2] Cycloadditions of Iminoacetonitriles:  A New Class of Azadienophiles for Hetero Diels−Alder Reactions
  59. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion
  60. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion
  61. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion
  62. Molecular Recognition with Introverted Functionality
  63. Molecular Recognition with Introverted Functionality
  64. Supercritical Fluids as Solvent Replacements in Chemical Synthesis
  65. Synthesis and Assembly of Self-Complementary Cavitands
  66. Nanoscale Container Structures and Their Host - Guest Properties
  67. Nanoscale Container Structures and Their Host – Guest Properties
  68. Self-Complementary Cavitands
  69. Encapsulation of Ion−Molecule Complexes:  Second-Sphere Supramolecular Chemistry
  70. Synthesis of Substituted Pyridines via Regiocontrolled [4 + 2] Cycloadditions of Oximinosulfonates
  71. Concerning the Regiochemical Course of the Diels−Alder Reaction in Supercritical Carbon Dioxide
  72. Kinetic Correlation of Diels−Alder Reactions in Supercritical Carbon Dioxide