All Stories

  1. Optical Probes for Metabolic Signals

    Article • January 2015, Taylor & Francis

    Professor Gary Yellen

  2. Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

    Article • eLife, July 2014, eLife

    Professor Gary Yellen

  3. A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging

    Article • Frontiers in Pharmacology, April 2014, Frontiers

    Professor Gary Yellen

  4. Imaging Changes in the Cytosolic ATP-to-ADP Ratio

    Article • January 2014, Elsevier

    Professor Gary Yellen

  5. Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

    Article • Nature Communications, October 2013, Springer Science + Business Media

    Professor Gary Yellen

  6. Live-Cell Imaging of Cytosolic NADH–NAD+ Redox State Using a Genetically Encoded Fluorescent Biosensor

    Article • August 2013, Springer Science + Business Media

    Professor Gary Yellen

  7. The ketogenic diet: metabolic influences on brain excitability and epilepsy

    Article • Trends in Neurosciences, January 2013, Elsevier

    Professor Gary Yellen

  8. Structural changes during HCN channel gating defined by high affinity metal bridges

    Article • The Journal of General Physiology, August 2012, Rockefeller University Press

    Professor Gary Yellen

  9. BAD-Dependent Regulation of Fuel Metabolism and KATP Channel Activity Confers Resistance to Epileptic Seizures

    Article • Neuron, May 2012, Elsevier

    Professor Gary Yellen

  10. Optogenetic reporters

    Article • January 2012, Elsevier

    Professor Gary Yellen

  11. Imaging Cytosolic NADH-NAD+ Redox State with a Genetically Encoded Fluorescent Biosensor

    Article • Cell Metabolism, October 2011, Elsevier

    Professor Gary Yellen

  12. Imaging Intracellular pH in Live Cells with a Genetically Encoded Red Fluorescent Protein Sensor

    Article • Journal of the American Chemical Society, July 2011, American Chemical Society (ACS)

    Professor Gary Yellen

  13. Single KATP Channel Opening in Response to Action Potential Firing in Mouse Dentate Granule Neurons

    Article • Journal of Neuroscience, June 2011, Society for Neuroscience

    Professor Gary Yellen

  14. A genetically encoded fluorescent reporter of ATP:ADP ratio

    Article • Nature Methods, January 2009, Nature

    Professor Gary Yellen

  15. Ketone bodies, glycolysis, and KATPchannels in the mechanism of the ketogenic diet

    Article • Epilepsia, November 2008, Wiley

    Professor Gary Yellen

  16. Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges

    Article • April 2004, Nature

    Professor Gary Yellen

  17. Inactivation in HCN Channels Results from Reclosure of the Activation Gate

    Article • Neuron, March 2004, Elsevier

    Professor Gary Yellen

  18. The voltage-gated potassium channels and their relatives

    Article • Nature, September 2002, Springer Science + Business Media

    Professor Gary Yellen

  19. Tight Steric Closure at the Intracellular Activation Gate of a Voltage-Gated K+ Channel

    Article • Neuron, November 2001, Elsevier

    Professor Gary Yellen

  20. Dimers among friends: ion channel regulation by dimerization of tail domains

    Article • Trends in Pharmacological Sciences, September 2001, Elsevier

    Professor Gary Yellen

  21. The bacterial K+ channel structure and its implications for neuronal channels

    Article • Current Opinion in Neurobiology, June 1999, Elsevier

    Professor Gary Yellen

  22. The Activation Gate of a Voltage-Gated K+ Channel Can Be Trapped in the Open State by an Intersubunit Metal Bridge

    Article • Neuron, September 1998, Elsevier

    Professor Gary Yellen

  23. The moving parts of voltage-gated ion channels

    Article • Quarterly Reviews of Biophysics, August 1998, Cambridge University Press

    Professor Gary Yellen

  24. Premonitions of ion channel gating

    Article • Nature Structural Biology, June 1998, Springer Science + Business Media

    Professor Gary Yellen

  25. Single Channel Seeks Permeant Ion for Brief but Intimate Relationship

    Article • The Journal of General Physiology, August 1997, Rockefeller University Press

    Professor Gary Yellen

  26. Gated Access to the Pore of a Voltage-Dependent K+ Channel

    Article • Neuron, July 1997, Elsevier

    Professor Gary Yellen

  27. Alternative mechanism for pathogenesis of an inherited epilepsy by a nicotinic AChR mutation

    Article • Nature Genetics, August 1996, Springer Science + Business Media

    Professor Gary Yellen

  28. Dynamic Rearrangement of the Outer Mouth of a K+ Channel during Gating

    Article • Neuron, April 1996, Elsevier

    Professor Gary Yellen

  29. Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K+ Channel

    Article • Science, February 1996, American Association for the Advancement of Science

    Professor Gary Yellen

  30. The inward rectification mechanism of the HERG cardiac potassium channel

    Article • Nature, February 1996, Springer Science + Business Media

    Professor Gary Yellen

  31. On the Use of Thiol-modifying Agents to Determine Channel Topology

    Article • Neuropharmacology, January 1996, Elsevier

    Professor Gary Yellen

  32. Modulation of K+ current by frequency and external [K+]: A tale of two inactivation mechanisms

    Article • Neuron, October 1995, Elsevier

    Professor Gary Yellen

  33. GENERAL ANESTHETIC POTENCY IS UNALTERED BY MUTATIONS IN THE M2 (ION CHANNEL) DOMAINS OF THE NICOTINIC ACETYLCHOLINE RECEPTOR THAT MODULATE LOCAL ANESTHETIC POTENCY

    Article • Anesthesiology, September 1994, Wolters Kluwer Health

    Professor Gary Yellen

  34. An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding

    Article • Biophysical Journal, April 1994, Elsevier

    Professor Gary Yellen

  35. Cysteines in the Shaker K+ channel are not essential for channel activity or zinc modulation

    Article • Biophysical Journal, March 1994, Elsevier

    Professor Gary Yellen

  36. Structure and selectivity

    Article • Nature, November 1993, Springer Science + Business Media

    Professor Gary Yellen

  37. The internal quaternary ammonium receptor site of Shaker potassium channels

    Article • Neuron, March 1993, Elsevier

    Professor Gary Yellen

  38. A novel K+ channel with unique localizations in mammalian brain: Molecular cloning and characterization

    Article • Neuron, March 1992, Elsevier

    Professor Gary Yellen

  39. Ion effects on gating of the Ca(2+)-activated K+ channel correlate with occupancy of the pore

    Article • Biophysical Journal, March 1992, Elsevier

    Professor Gary Yellen

  40. The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker

    Article • Neuron, November 1991, Elsevier

    Professor Gary Yellen

  41. Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel

    Article • Science, February 1991, American Association for the Advancement of Science

    Professor Gary Yellen

  42. Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels

    Article • Science, October 1990, American Association for the Advancement of Science

    Professor Gary Yellen

  43. Expression of Torpedo nicotinic acetylcholine receptor subunits in yeast is enhanced by use of yeast signal sequences

    Article • Gene, February 1990, Elsevier

    Professor Gary Yellen

  44. Permeation in Potassium Channels: Implications for Channel Structure

    Article • Annual Review of Biophysics and Biophysical Chemistry, June 1987, Annual Reviews

    Professor Gary Yellen

  45. Permeation In Potassium Channels: Implications For Channel Structure

    Article • Annual Review of Biophysics and Biomolecular Structure, January 1987, Annual Reviews

    Professor Gary Yellen

  46. The K+ channel of sarcoplasmic reticulum. A new look at Cs+ block

    Article • Biophysical Journal, September 1985, Elsevier

    Professor Gary Yellen

  47. Channels from genes: The oocyte as an expression system

    Article • Trends in Neurosciences, December 1984, Elsevier

    Professor Gary Yellen

  48. The immune system uses ion channels, too

    Article • Trends in Neurosciences, June 1984, Elsevier

    Professor Gary Yellen

  49. Analysis of Nonstationary Channel Kinetics

    Article • January 1983, Springer Science + Business Media

    Professor Gary Yellen

  50. Single Ca2+-activated nonselective cation channels in neuroblastoma

    Article • Nature, March 1982, Springer Science + Business Media

    Professor Gary Yellen