All Stories

  1. Exploiting species specificity to understand the tropism of a human-specific toxin
  2. Specific blood group antibodies inhibit Shigella flexneri interaction with human cells in the absence of spinoculation
  3. MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
  4. Lectin activity of Pseudomonas aeruginosa vaccine candidates PSE17-1, PSE41-5 and PSE54
  5. Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: a new strategy to generate antimicrobial peptides
  6. Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M
  7. Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel modA Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease
  8. The HMW2 adhesin of non-typeable Haemophilus influenzae is a human-adapted lectin that mediates high-affinity binding to 2–6 linked N -acetylneuraminic acid glycans
  9. Glycointeractions in bacterial pathogenesis
  10. Specificity and utility of SubB2M, a new N -glycolylneuraminic acid lectin
  11. Signal peptidase I processed secretory signal sequences: Selection for and against specific amino acids at the second position of mature protein
  12. A genetic screen reveals a periplasmic copper chaperone required for nitrite reductase activity in pathogenic Neisseria
  13. Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors
  14. The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity
  15. A random six-phase switch regulates pneumococcal virulence via global epigenetic changes
  16. ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media
  17. Phasevarions Mediate Epigenetic Regulation of Antimicrobial Susceptibility in Neisseria meningitidis
  18. A Role for Lactate Dehydrogenases in the Survival of Neisseria gonorrhoeae in Human Polymorphonuclear Leukocytes and Cervical Epithelial Cells
  19. A Drug Delivery Strategy: Binding Enkephalin to Asialoglycoprotein Receptor by Enzymatic Galactosylation
  20. F9 Fimbriae of Uropathogenic Escherichia coli Are Expressed at Low Temperature and Recognise Galβ1-3GlcNAc-Containing Glycans
  21. Selection against glycosylation sites in potential target proteins of the general HMWC N-glycosyltransferase in Haemophilus influenzae
  22. Selection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients
  23. Identification of a Crucial Residue Required for Staphylococcus aureus LukAB Cytotoxicity and Receptor Recognition
  24. α-1,4-Galactosyltransferase-catalyzed glycosylation of sugar and lipid modified Leu-enkephalins
  25. Role of Neisseria meningitidis PorA and PorB Expression in Antimicrobial Susceptibility
  26. Evaluation of Truncated NhhA Protein as a Candidate Meningococcal Vaccine Antigen
  27. Distinct physiological roles for the two l-asparaginase isozymes of Escherichia coli
  28. Liposomes for Improved Enzymatic Glycosylation of Lipid-Modified Lactose Enkephalin
  29. Staphylococcus aureusLukAB cytotoxin kills human neutrophils by targeting the CD11b subunit of the integrin Mac-1
  30. Analysis of Nontypeable Haemophilus influenzae Phase-Variable Genes During Experimental Human Nasopharyngeal Colonization
  31. Dual Pili Post-translational Modifications Synergize to Mediate Meningococcal Adherence to Platelet Activating Factor Receptor on Human Airway Cells
  32. Identification of Bacterial Protein O-Oligosaccharyltransferases and Their Glycoprotein Substrates
  33. Characterization of an ntrX Mutant of Neisseria gonorrhoeae Reveals a Response Regulator That Controls Expression of Respiratory Enzymes in Oxidase-Positive Proteobacteria
  34. A Glutathione-Dependent Detoxification System Is Required for Formaldehyde Resistance and Optimal Survival of Neisseria meningitidis in Biofilms
  35. Substrate recognition of a structure motif for phosphorylcholine post-translational modification in Neisseria meningitidis
  36. Recombinant truncated AniA of pathogenic Neisseria elicits a non-native immune response and functional blocking antibodies
  37. Interplay between Manganese and Iron in Pneumococcal Pathogenesis: Role of the Orphan Response Regulator RitR
  38. Origin of the Diversity in DNA Recognition Domains in Phasevarion Associated modA Genes of Pathogenic Neisseria and Haemophilus influenzae
  39. A glutathione-based system for defense against carbonyl stress in Haemophilus influenzae
  40. Phenotypic Characterization of acopAMutant of Neisseria gonorrhoeae Identifies a Link between Copper and Nitrosative Stress
  41. Phasevarion Mediated Epigenetic Gene Regulation in Helicobacter pylori
  42. Directed evolution of efficient secretion in the SRP-dependent export of TolB
  43. A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44
  44. Coupling between codon usage, translation and protein export in Escherichia coli
  45. Neisseria gonorrhoeae pilin glycan contributes to CR3 activation during challenge of primary cervical epithelial cells
  46. A novel nickel responsive MerR-like regulator, NimR, from Haemophilus influenzae
  47. Novel Bacterial MerR-Like Regulators
  48. The Composition and Metabolic Phenotype of Neisseria gonorrhoeae Biofilms
  49. Identification, Characterization and Immunogenicity of an O-Antigen Capsular Polysaccharide of Francisella tularensis
  50. Central Role of Manganese in Regulation of Stress Responses, Physiology, and Metabolism in Streptococcus pneumoniae
  51. Signal sequence non-optimal codons are required for the correct folding of mature maltose binding protein
  52. The Multi-Copper-Ion Oxidase CueO of Salmonella enterica Serovar Typhimurium Is Required for Systemic Virulence
  53. Anaerobic Metabolism Occurs in the Substratum of Gonococcal Biofilms and May Be Sustained in Part by Nitric Oxide
  54. Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae
  55. The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes
  56. Phase variation of bacterial surface glycosylated molecules in immune evasion
  57. A Periplasmic Thioredoxin-Like Protein Plays a Role in Defense against Oxidative Stress in Neisseria gonorrhoeae
  58. Esterase D Is Essential for Protection of Neisseria gonorrhoeae against Nitrosative Stress and for Bacterial Growth during Interaction with Cervical Epithelial Cells
  59. Transcriptional Profiling Identifies the Metabolic Phenotype of Gonococcal Biofilms
  60. Phasevarions Mediate Random Switching of Gene Expression in Pathogenic Neisseria
  61. Biased codon usage in signal peptides: a role in protein export
  62. Development of Non-Antibiotic-Resistant, Chromosomally Based, Constitutive and Inducible Expression Systems for aroA-Attenuated Salmonella enterica Serovar Typhimurium
  63. Thioredoxin Reductase Is Essential for Protection of Neisseria gonorrhoeae against Killing by Nitric Oxide and for Bacterial Growth during Interaction with Cervical Epithelial Cells
  64. The pilin O-glycosylation pathway of pathogenic Neisseria is a general system that glycosylates AniA, an outer membrane nitrite reductase
  65. Receptor-mediated endocytosis of Neisseria gonorrhoeae into primary human urethral epithelial cells: the role of the asialoglycoprotein receptor
  66. Metal Binding Specificity of the MntABC Permease of Neisseria gonorrhoeae and Its Influence on Bacterial Growth and Interaction with Cervical Epithelial Cells
  67. Functional analysis of the multi-copper oxidase from Legionella pneumophila
  68. Secretory signal sequence non-optimal codons are required for expression and export of β-lactamase
  69. Discovery of virulence factors of pathogenic bacteria
  70. A Pneumococcal MerR‐Like Regulator and S ‐nitrosoglutathione Reductase Are Required for Systemic Virulence
  71. Duplicate Copies of lic1 Direct the Addition of Multiple Phosphocholine Residues in the Lipopolysaccharide of Haemophilus influenzae
  72. PrrC, a Sco homologue from Rhodobacter sphaeroides , possesses thiol-disulfide oxidoreductase activity
  73. Phase variable type III restriction-modification systems of host-adapted bacterial pathogens
  74. Selection for efficient translation initiation biases codon usage at second amino acid position in secretory proteins
  75. The multicopper oxidase (CueO) and cell aggregation in Escherichia coli
  76. Additive and Synergistic Bactericidal Activity of Antibodies Directed against Minor Outer Membrane Proteins of Neisseria meningitidis
  77. Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression
  78. Glutathione-Dependent Alcohol Dehydrogenase AdhC Is Required for Defense against Nitrosative Stress in Haemophilus influenzae
  79. Experimental confirmation of a key role for non-optimal codons in protein export
  80. The Phase-Variable Allele of the Pilus Glycosylation Gene pglA Is Not Strongly Associated with Strains of Neisseria gonorrhoeae Isolated from Patients with Disseminated Gonococcal Infection
  81. Rapid and efficient screening of a Representational Difference Analysis library using reverse Southern hybridisation: Identification of genetic differences between Haemophilus parasuis isolates
  82. Evidence for Distinctive Mechanisms of S-Nitrosoglutathione Metabolism by AdhC in Two Closely Related Species, Neisseria gonorrhoeae and Neisseria meningitidis
  83. Characterization of the OxyR regulon of Neisseria gonorrhoeae
  84. Pilin glycosylation in Neisseria meningitidis occurs by a similar pathway to wzy-dependent O-antigen biosynthesis in Escherichia coli
  85. Defenses against Oxidative Stress in Neisseria gonorrhoeae: a System Tailored for a Challenging Environment
  86. PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae
  87. Azurin of Pathogenic Neisseria spp. Is Involved in Defense against Hydrogen Peroxide and Survival within Cervical Epithelial Cells
  88. Investigation of ansB and sspA derived promoters for multi- and single-copy antigen expression in attenuated Salmonella enterica var. typhimurium
  89. Investigation of Oxidative Stress Defenses of Neisseria gonorrhoeae by Using a Human Polymorphonuclear Leukocyte Survival Assay
  90. Chemo-Enzymatic Synthesis of a Trisaccharide-Linked Peptide Aimed at Improved Drug-Delivery
  91. Plasmid-Encoded Tet B Tetracycline Resistance in Haemophilus parasuis
  92. Recombinant Probiotics for Treatment and Prevention of Enterotoxigenic Escherichia coli Diarrhea
  93. The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes
  94. Copper sensitivity of cueO mutants of Escherichia coli K-12 and the biochemical suppression of this phenotype
  95. Whole genome analysis reveals a high incidence of non-optimal codons in secretory signal sequences of Escherichia coli
  96. Defenses against Oxidative Stress in Neisseria gonorrhoeae and Neisseria meningitidis: Distinctive Systems for Different Lifestyles
  97. Molecular analysis of the psa permease complex of Streptococcus pneumoniae
  98. Survey of Ferroxidase Expression and Siderophore Production in Clinical Isolates of Pseudomonas aeruginosa
  99. Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis
  100. Genetic characterization of pilin glycosylation and phase variation in Neisseria meningitidis
  101. Identification and Characterization ofpptA: a Gene Involved in the Phase-Variable Expression ofPhosphorylcholine on Pili of Neisseriameningitidis
  102. Genetic analysis of a plasmid encoding haemocin production in Haemophilus paragallinarum
  103. Purification of post-translationally modified proteins from bacteria: homologous expression and purification of histidine-tagged pilin from Neisseria meningitidis
  104. A Sco homologue plays a role in defence against oxidative stress in pathogenicNeisseria
  105. OxyR Acts as a Repressor of Catalase Expression in Neisseria gonorrhoeae
  106. The genetics of glycosylation in Gram-negative bacteria
  107. Phase variation in meningococcal lipooligosaccharide biosynthesis genes
  108. The multicopper oxidase of Pseudomonas aeruginosa is a ferroxidase with a central role in iron acquisition
  109. Virulence of Streptococcus pneumoniae: PsaA Mutants Are Hypersensitive to Oxidative Stress
  110. Phase variable restriction–modification systems in Moraxella catarrhalis
  111. Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity
  112. Identification and characterisation of a novel conserved outer membrane protein from Neisseria meningitidis
  113. Gonococcal lipooligosaccharide is a ligand for the asialoglycoprotein receptor on human sperm
  114. Tetranucleotide repeats identify novel virulence determinant homologues inNeisseria meningitidis
  115. Identification of a novel gene involved in pilin glycosylation inNeisseria meningitidis
  116. Isolation and characterization of the Neisseria meningitidis lpxD-fabZ-lpxA gene cluster involved in lipid A biosynthesis
  117. DNA repeats identify novel virulence genes in Haemophilus influenzae.
  118. Tandem repeats of the tetramer 5'-CAAT-3'present in lic2A are required for phase variation but not lipopolysaccharide biosynthesis in Haemophilus influenzae
  119. Tetrameric repeat units associated with virulence factor phase variation in Haemophilus also occur in Netsseria spp. and Moraxella catarrhalis
  120. Phenotypic switching of Haemophilus influenzae
  121. Identification of a locus involved in meningococcal lipopolysaccharide biosynthesis by deletion mutagenesis
  122. Cloning and molecular analysis of theIsi1(rfaF) gene ofNeisseria meningitidiswhich encodes a heptosyl-2-transferase involved in LPS biosynthesis: evaluation of surface exposed carbohydrates in LPS mediated toxicity for human endothelial cells
  123. Opc- and pilus-dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides
  124. Molecular analysis of a locus for the biosynthesis and phase-variable expression of the lacto-N -neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis
  125. Meningococcal pilin: a glycoprotein substituted with digalactosyl 2,4-diacetamido-2,4,6-trideoxyhexose
  126. Cloning and molecular analysis of thegalEgene ofNeisseria meningitidlsand its role in lipopolysaccharide biosynthesis
  127. Regulation of the ansB gene of Salmonella enterica
  128. Co-dependent positive regulation of the ansBF promoter of Escherichia coli by CRP and the FNR protein: a molecular analysis
  129. Site-specific mutagenesis of Escherichia coli asparaginase II. None of the three histidine residues is required for catalysis
  130. Construction of expression systems for Escherichia cofi asparaginase II and two-step purification of the recombinant enzyme from periplasmic extracts
  131. Structure and expression in Escherichia coli K-12 of the L-asparaginase I-encoding ansA gene and its flanking regions