All Stories

  1. Tarantula Toxins use Common Surfaces for Interacting with Kv and ASIC Ion Channels

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Kenton Jon Swartz

  2. Ion Accumulation and Depletion in Patch Clamp Experiments

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Kenton Jon Swartz

  3. Unraveling Allosteric Coupling Mechanisms in the TRPV1 Channel

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Kenton Jon Swartz

  4. Rapid Activation of Distinct Conducting States in P2X Receptor Channels

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Kenton Jon Swartz

  5. Investigating the Function of a Novel Voltage-Sensing Protein

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Kenton Jon Swartz

  6. Surface Characterization and Membrane Interaction of Double-Knot Toxin, an Activator of TRPV1 Channels

    Article • Biophysical Journal, January 2015, Elsevier

    Dr Kenton Jon Swartz

  7. Structural interactions of a voltage sensor toxin with lipid membranes

    Article • Proceedings of the National Academy of Sciences, December 2014, Proceedings of the National Academy of Sciences

    Dr Kenton Jon Swartz

  8. Subtype-specific control of P2X receptor channel signaling by ATP and Mg 2 +

    Article • Proceedings of the National Academy of Sciences, August 2013, Proceedings of the National Academy of Sciences

    Dr Kenton Jon Swartz

  9. The scorpion toxin and the potassium channel

    Article • eLife, May 2013, eLife

    Dr Kenton Jon Swartz

  10. The design principle of paddle motifs in voltage sensors

    Article • Nature Structural & Molecular Biology, May 2013, Springer Science + Business Media

    Dr Kenton Jon Swartz

  11. Exploring structure-function relationships between TRP and Kv channels

    Article • Scientific Reports, March 2013, Springer Science + Business Media

    Dr Kenton Jon Swartz

  12. Common Principles of Voltage-Dependent Gating for Hv and Kv Channels

    Article • Neuron, January 2013, Elsevier

    Dr Kenton Jon Swartz

  13. Opening the Shaker Kv Channel with Hanatoxin

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Kenton Jon Swartz

  14. Defining the Interactive Surfaces of Tarantula Toxins for Voltage Sensors in Kv Channels

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Kenton Jon Swartz

  15. Engineering Metal Bridges to Constrain the Structure of the Open State of P2X Receptors

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Kenton Jon Swartz

  16. Molecular Dynamics Studies of Lipophilic Small Molecule TRPV1 Ligands in Lipid Bilayers

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Kenton Jon Swartz

  17. Functional Characterization of the Double Knot Toxin (DkTx) as an Activator of the TRPV1 Ion Channel

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Kenton Jon Swartz

  18. High Yield Production and Refolding of the Double-Knot Toxin, an Activator of TRPV1 Channels

    Article • PLoS ONE, December 2012, PLOS

    Dr Kenton Jon Swartz

  19. Structural Interactions between Lipids, Water and S1–S4 Voltage-Sensing Domains

    Article • Journal of Molecular Biology, November 2012, Elsevier

    Dr Kenton Jon Swartz

  20. Solution Structure of Kurtoxin: A Gating Modifier Selective for Cav3 Voltage-Gated Ca 2+ Channels

    Article • Biochemistry, March 2012, American Chemical Society (ACS)

    Dr Kenton Jon Swartz

  21. Protein- Lipid Interactions in Lipid Reconstituted Potassium Channel Voltage-Sensing Domains

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Kenton Jon Swartz

  22. Mechanism of Inhibition of Voltage-Gated Potassium Channels by Guanidine Compounds

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Kenton Jon Swartz

  23. Sodium Channel Voltage Sensor Movements Are Influenced by the Auxiliary β1 Subunit

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Kenton Jon Swartz

  24. Activation of TRPV1 by a Recombinant Double-Knot Toxin from a Chinese Bird Spider

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Kenton Jon Swartz

  25. Subtype Specific Activation of P2X Receptors by Free and Magnesium-Bound ATP

    Article • Biophysical Journal, January 2012, Elsevier

    Dr Kenton Jon Swartz

  26. Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels

    Article • Biochemical and Biophysical Research Communications, December 2011, Elsevier

    Dr Kenton Jon Swartz

  27. Atp4- Activates P2x Receptors

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Kenton Jon Swartz

  28. Palmitoylation Affects the Interaction of Animal Toxins with Sodium Channels

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Kenton Jon Swartz

  29. Ion Access Pathway to the Transmembrane Pore in P2X Receptors

    Article • Biophysical Journal, February 2011, Elsevier

    Dr Kenton Jon Swartz

  30. Pore-opening mechanism in trimeric P2X receptor channels

    Article • Nature Communications, July 2010, Springer Science + Business Media

    Dr Kenton Jon Swartz

  31. Structure and Orientation of a Voltage-Sensor Toxin in Lipid Membranes

    Article • Biophysical Journal, July 2010, Elsevier

    Dr Kenton Jon Swartz

  32. Solution Structure of GxTX-1E, a High-Affinity Tarantula Toxin Interacting with Voltage Sensors in Kv2.1 Potassium Channels,

    Article • Biochemistry, June 2010, American Chemical Society (ACS)

    Dr Kenton Jon Swartz

  33. Targeting voltage sensors in sodium channels with spider toxins

    Article • Trends in Pharmacological Sciences, April 2010, Elsevier

    Dr Kenton Jon Swartz

  34. Interactions Between Lipids and Voltage Sensor Paddles Detected with Tarantula Toxins

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Kenton Jon Swartz

  35. Conformational Changes in Potassium Channel Voltage-Sensing Domains Reconstituted into Different Lipids

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Kenton Jon Swartz

  36. Exploring Structural Relationships between TRP and Kv Channels

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Kenton Jon Swartz

  37. Structure Rearrangement of the Pore in P2X Receptors During Gating

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Kenton Jon Swartz

  38. Defining the Voltage Sensor Properties and Pharmacology of Nav1.9

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Kenton Jon Swartz

  39. Identifying the Ion Access Pathway to the Transmembrane Pore in P2X Receptors

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Kenton Jon Swartz

  40. Structure and hydration of membranes embedded with voltage-sensing domains

    Article • Nature, November 2009, Springer Science + Business Media

    Dr Kenton Jon Swartz

  41. Interactions between lipids and voltage sensor paddles detected with tarantula toxins

    Article • Nature Structural & Molecular Biology, September 2009, Springer Science + Business Media

    Dr Kenton Jon Swartz

  42. Trimeric ion-channel design

    Article • Nature, July 2009, Springer Science + Business Media

    Dr Kenton Jon Swartz

  43. Accessibility of Ag+ in the Pore of P2X Receptor Channels

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Kenton Jon Swartz

  44. Voltage-sensor Pharmacology Of Voltage-activated Calcium Channels (cav)

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Kenton Jon Swartz

  45. Water-filled Cavities in the Voltage-Sensing Domain of a Potassium Channel Embedded in Lipid Bilayers

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Kenton Jon Swartz

  46. Using Potassium Channels As Reporters To Deconstruct The Function And Pharmacology Of Sodium Channel Voltage Sensors

    Article • Biophysical Journal, February 2009, Elsevier

    Dr Kenton Jon Swartz

  47. Sensing voltage across lipid membranes

    Article • Nature, December 2008, Springer Science + Business Media

    Dr Kenton Jon Swartz

  48. Deconstructing voltage sensor function and pharmacology in sodium channels

    Article • Nature, November 2008, Springer Science + Business Media

    Dr Kenton Jon Swartz

  49. Gating the pore of P2X receptor channels

    Article • Nature Neuroscience, June 2008, Springer Science + Business Media

    Dr Kenton Jon Swartz

  50. Portability of paddle motif function and pharmacology in voltage sensors

    Article • Nature, November 2007, Springer Science + Business Media

    Dr Kenton Jon Swartz

  51. Ivermectin Interaction with Transmembrane Helices Reveals Widespread Rearrangements during Opening of P2X Receptor Channels

    Article • Neuron, April 2007, Elsevier

    Dr Kenton Jon Swartz

  52. Tarantula toxins interacting with voltage sensors in potassium channels

    Article • Toxicon, February 2007, Elsevier

    Dr Kenton Jon Swartz

  53. Functional Interactions at the Interface between Voltage-Sensing and Pore Domains in the Shaker Kv Channel

    Article • Neuron, November 2006, Elsevier

    Dr Kenton Jon Swartz

  54. Greasing the gears of potassium channels

    Article • Nature Chemical Biology, August 2006, Springer Science + Business Media

    Dr Kenton Jon Swartz

  55. An Inhibitor of TRPV1 Channels Isolated from Funnel Web Spider Venom †

    Article • Biochemistry, November 2005, American Chemical Society (ACS)

    Dr Kenton Jon Swartz

  56. Voltage-sensor activation with a tarantula toxin as cargo

    Article • August 2005, Nature

    Dr Kenton Jon Swartz

  57. Solution Structure and Lipid Membrane Partitioning of VSTx1, an Inhibitor of the KvAP Potassium Channel † , ‡

    Article • Biochemistry, April 2005, American Chemical Society (ACS)

    Dr Kenton Jon Swartz

  58. Towards a structural view of gating in potassium channels

    Article • Nature Reviews Neuroscience, December 2004, Springer Science + Business Media

    Dr Kenton Jon Swartz

  59. Opening the gate in potassium channels

    Article • Nature Structural & Molecular Biology, June 2004, Springer Science + Business Media

    Dr Kenton Jon Swartz

  60. Solution Structure and Functional Characterization of SGTx1, a Modifier of Kv2.1 Channel Gating † , ‡

    Article • Biochemistry, February 2004, American Chemical Society (ACS)

    Dr Kenton Jon Swartz

  61. Interaction between Extracellular Hanatoxin and the Resting Conformation of the Voltage-Sensor Paddle in Kv Channels

    Article • Neuron, October 2003, Elsevier

    Dr Kenton Jon Swartz

  62. Defining the Conductance of the Closed State in a Voltage-Gated K+ Channel

    Article • Neuron, April 2003, Elsevier

    Dr Kenton Jon Swartz

  63. Solution Structure of ω-Grammotoxin SIA, A Gating Modifier of P/Q and N-type Ca2+ Channel

    Article • Journal of Molecular Biology, August 2002, Elsevier

    Dr Kenton Jon Swartz

  64. Solution structure of hanatoxin1, a gating modifier of voltage-dependent K+ channels: common surface features of gating modifier toxins

    Article • Journal of Molecular Biology, March 2000, Elsevier

    Dr Kenton Jon Swartz

  65. A Localized Interaction Surface for Voltage-Sensing Domains on the Pore Domain of a K+ Channel

    Article • Neuron, February 2000, Elsevier

    Dr Kenton Jon Swartz

  66. Hanatoxin Modifies the Gating of a Voltage-Dependent K+ Channel through Multiple Binding Sites

    Article • Neuron, April 1997, Elsevier

    Dr Kenton Jon Swartz

  67. Mapping the Receptor Site for Hanatoxin, a Gating Modifier of Voltage-Dependent K+ Channels

    Article • Neuron, April 1997, Elsevier

    Dr Kenton Jon Swartz

  68. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula

    Article • Neuron, October 1995, Elsevier

    Dr Kenton Jon Swartz

  69. Modulation of Ca2+ channels by protein kinase C in rat central and peripheral neurons: Disruption of G protein-mediated inhibition

    Article • Neuron, August 1993, Elsevier

    Dr Kenton Jon Swartz

  70. Protein kinase C modulates glutamate receptor inhibition of Ca2+ channels and synaptic transmission

    Article • Nature, January 1993, Springer Science + Business Media

    Dr Kenton Jon Swartz

  71. Developmental changes in brain kynurenic acid concentrations

    Article • Developmental Brain Research, July 1992, Elsevier

    Dr Kenton Jon Swartz

  72. Aminooxyacetic Acid Results in Excitotoxin Lesions by a Novel Indirect Mechanism

    Article • Journal of Neurochemistry, September 1991, Wiley

    Dr Kenton Jon Swartz

  73. 2-Chloroadenosine attenuates NMDA, kainate, and quisqualate toxicity

    Article • Neuroscience Letters, May 1991, Elsevier

    Dr Kenton Jon Swartz

  74. Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease

    Article • Neuroscience Letters, January 1991, Elsevier

    Dr Kenton Jon Swartz

  75. Kynurenine Pathway Measurements in Huntington's Disease Striatum: Evidence for Reduced Formation of Kynurenic Acid

    Article • Journal of Neurochemistry, October 1990, Wiley

    Dr Kenton Jon Swartz

  76. Galanin immunoreactivity is increased in the nucleus basalis of meynert in Alzheimer's disease

    Article • Annals of Neurology, August 1990, Wiley

    Dr Kenton Jon Swartz

  77. Ion channel expression by white matter glia: The O-2A glial progenitor cell

    Article • Neuron, April 1990, Elsevier

    Dr Kenton Jon Swartz

  78. Measurement of kynurenic acid in mammalian brain extracts and cerebrospinal fluid by high-performance liquid chromatography with fluorometric and coulometric electrode array detection

    Article • Analytical Biochemistry, March 1990, Elsevier

    Dr Kenton Jon Swartz

  79. Homocysteic acid lesions in rat striatum spare somatostatin—;Neuropeptide Y (NADPH-diaphorase) neurons

    Article • Neuroscience Letters, January 1990, Elsevier

    Dr Kenton Jon Swartz

  80. Tryptophan Metabolites in Parkinson’s Brain

    Article • January 1990, Springer Science + Business Media

    Dr Kenton Jon Swartz

  81. Neuroactive metabolises of L-tryptophan, serotonin and quinolinic acid, in striatal extracellular fluid effect of tryptophan loading

    Article • FEBS Letters, April 1989, Wiley

    Dr Kenton Jon Swartz

  82. Differential sparing of somatostatin-neuropeptide y and cholinergic neurons following striatal excitotoxin lesions

    Article • Synapse, January 1989, Wiley

    Dr Kenton Jon Swartz

  83. Developmental changes of neuropeptides and amino acids in baboon cortex

    Article • Developmental Brain Research, November 1988, Elsevier

    Dr Kenton Jon Swartz

  84. Distribution of galanin-like immunoreactivity in baboon brain

    Article • Peptides, July 1988, Elsevier

    Dr Kenton Jon Swartz

  85. Amino acid and neuropeptide neurotransmitters in Huntington's disease cerebellum

    Article • Brain Research, June 1988, Elsevier

    Dr Kenton Jon Swartz

  86. Somatostatin and neuropeptide Y concentrations in pathologically graded cases of huntington's disease

    Article • Annals of Neurology, June 1988, Wiley

    Dr Kenton Jon Swartz

  87. Characterization of galanin-like immunoreactivity in the rat brain: Effects of neonatal glutamate treatment

    Article • Neuroscience Letters, April 1988, Elsevier

    Dr Kenton Jon Swartz

  88. A detailed examination of substance P in pathologically graded cases of Huntington's disease

    Article • Journal of the Neurological Sciences, March 1988, Elsevier

    Dr Kenton Jon Swartz

  89. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

    Article • Nature, May 1986, Springer Science + Business Media

    Dr Kenton Jon Swartz

  90. Hill's (and Dana's) Scholarship

    Article • Contemporary Psychology, January 1974, Portico

    Dr Kenton Jon Swartz