All Stories

  1. A roadmap for interpreting 13C metabolite labeling patterns from cells

    Article • Current Opinion in Biotechnology, August 2015, Elsevier

    Dr Emmanuelle J Meuillet, Dr Daniel A Tennant, Prof. Markus Ralser

  2. Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis

    Article • Carcinogenesis, January 2015, Oxford University Press (OUP)

    Dr Emmanuelle J Meuillet

  3. Novel Inhibitors Induce Large Conformational Changes of GAB1 Pleckstrin Homology Domain and Kill Breast Cancer Cells

    Article • PLoS Computational Biology, January 2015, PLOS

    Dr Emmanuelle J Meuillet

  4. Targeted 13C-Labeled Tracer Fate Associations for Drug Efficacy Testing in Cancer

    Article • January 2015, Springer Science + Business Media

    Dr Emmanuelle J Meuillet

  5. Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer

    Article • International Journal of Nanomedicine, December 2014, Taylor & Francis

    Mr Justin Jeffery, Dr Emmanuelle J Meuillet

  6. Metformin and Pancreatic Cancer Metabolism

    Article • May 2014, IntechOpen

    Dr Emmanuelle J Meuillet

  7. Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells

    Article • Metabolomics, June 2013, Springer Science + Business Media

    Dr Emmanuelle J Meuillet

  8. Abstract 5563: Targeting the PH domain of TIAM1 to inhibit prostate cancer metastasis.

    Article • Cancer Research, April 2013, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  9. Metformin inhibits the TCA cycle and fatty acid synthesis in MIAPaCa-2 pancreatic cancer cells

    Article • Pancreatology, March 2013, Elsevier

    Dr Emmanuelle J Meuillet

  10. Targeting inflammation: multiple innovative ways to reduce prostaglandin E2

    Article • Pharmaceutical Patent Analyst, March 2013, Future Science

    Dr Emmanuelle J Meuillet

  11. Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells

    Article • Bioorganic & Medicinal Chemistry Letters, January 2013, Elsevier

    Dr Emmanuelle J Meuillet

  12. Monitoring the development of xenograft triple-negative breast cancer models using diffusion-weighted magnetic resonance imaging

    Article • Experimental Biology and Medicine, November 2012, SAGE Publications

    Dr Emmanuelle J Meuillet

  13. The matrix protein CCN1/CYR61 is required for αVβ5-mediated cancer cell migration

    Article • Cell Biochemistry and Function, June 2012, Wiley

    Dr Emmanuelle J Meuillet

  14. Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells

    Article • Bioorganic & Medicinal Chemistry Letters, May 2012, Elsevier

    Dr Emmanuelle J Meuillet

  15. Abstract 3694: Role of the inflammatory response in pancreatic cancer treatment

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  16. Abstract 3752: Nanoparticles delivery of a novel AKT/PDK1 inhibitor inhibits pancreatic cancer tumor growth

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  17. Abstract 2166: In silico identification and biological evaluation of potent small molecule inhibitors targeting GAB1 pleckstrin homology domain

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  18. Abstract 2834: Discovery of a novel class of prostaglandin e2 synthesis inhibitors with anti-tumor activity in colorectal cancer

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  19. Abstract 2835: Discovery of novel inhibitors for ECT2 as a novel therapeutic strategy for lung cancer

    Article • Cancer Research, April 2012, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  20. Abstract A242: A novel AKT inhibitor, PH427, prevents UVB-induced signaling in human squamous skin carcinomas.

    Article • Molecular Cancer Therapeutics, November 2011, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  21. Abstract A213: Topical PHT-427, a dual AKT/PDPK1 PH domain inhibitor, for treatment of primary and metastatic skin cancer.

    Article • Molecular Cancer Therapeutics, November 2011, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  22. Identification and development of mPGES-1 inhibitors: where we are at?

    Article • Future Medicinal Chemistry, November 2011, Future Science

    Dr Emmanuelle J Meuillet

  23. Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers

    Article • Investigational New Drugs, September 2011, Springer Science + Business Media

    Dr Emmanuelle J Meuillet

  24. Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain

    Article • Current Medicinal Chemistry, June 2011, Bentham Science Publishers

    Dr Emmanuelle J Meuillet

  25. Development of sulfonamide AKT PH domain inhibitors

    Article • Bioorganic & Medicinal Chemistry, March 2011, Elsevier

    Dr Emmanuelle J Meuillet, Professor Eugene A Mash

  26. Recent Development of Anticancer Therapeutics Targeting Akt

    Article • Recent Patents on Anti-Cancer Drug Discovery, January 2011, Bentham Science Publishers

    Dr Emmanuelle J Meuillet, Professor Eugene A Mash

  27. mPGES-1 as a target for cancer suppression

    Article • Biochimie, June 2010, Elsevier

    Dr Emmanuelle J Meuillet

  28. Abstract 3565: Novel inhibitors of mPGES-1 exhibit anti-tumor activity in colorectal and lung cancers

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  29. Abstract 1559: Targeting the PH domain of Tiam-1 to inhibit breast cancer metastasis

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  30. Abstract 1975: PHuDock®, a computational discovery and development platform for novel PH domain-binding agents, identifies a novel antitumor AKT/PDPK1 inhibitor, PHT- 427

    Article • Cancer Research, April 2010, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  31. Molecular Pharmacology and Antitumor Activity of PHT-427, a Novel Akt/Phosphatidylinositide-Dependent Protein Kinase 1 Pleckstrin Homology Domain Inhibitor

    Article • Molecular Cancer Therapeutics, March 2010, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  32. Direct Inhibition of Hypoxia-Inducible Transcription Factor Complex with Designed Dimeric Epidithiodiketopiperazine

    Article • Journal of the American Chemical Society, December 2009, American Chemical Society (ACS)

    Dr Emmanuelle J Meuillet

  33. Abstract B139: Molecular pharmacology and antitumor activity of PHT-427 a novel AKT/PDPK1 pleckstrin homology domain inhibitor

    Article • Molecular Cancer Therapeutics, December 2009, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  34. Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain

    Article • Bioorganic & Medicinal Chemistry, October 2009, Elsevier

    Dr Emmanuelle J Meuillet, Professor Eugene A Mash

  35. In vitro and In vivo Activity of Novel Small-Molecule Inhibitors Targeting the Pleckstrin Homology Domain of Protein Kinase B/AKT

    Article • Cancer Research, June 2009, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  36. Sodium Selenite Increases the Activity of the Tumor Suppressor Protein, PTEN, in DU-145 Prostate Cancer Cells

    Article • Nutrition and Cancer, May 2009, Taylor & Francis

    Dr Emmanuelle J Meuillet

  37. NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

    Article • Molecular Cancer Therapeutics, May 2009, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  38. Superoxide dismutase is regulated by LAMMER kinase in Drosophila and human cells

    Article • Free Radical Biology and Medicine, March 2009, Elsevier

    Dr Emmanuelle J Meuillet

  39. Discovery of a novel class of AKT pleckstrin homology domain inhibitors

    Article • Molecular Cancer Therapeutics, September 2008, American Association for Cancer Research (AACR)

    Dr Emmanuelle J Meuillet

  40. The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells

    Article • Experimental Cell Research, August 2007, Elsevier

    Dr Emmanuelle J Meuillet

  41. Regulation of the activity of the tumor suppressor PTEN by thioredoxin in Drosophila melanogaster

    Article • Experimental Cell Research, April 2007, Elsevier

    Dr Emmanuelle J Meuillet

  42. Deoxycholic Acid Induces Intracellular Signaling through Membrane Perturbations

    Article • Journal of Biological Chemistry, March 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Emmanuelle J Meuillet

  43. Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity

    Article • Archives of Biochemistry and Biophysics, September 2004, Elsevier

    Dr Emmanuelle J Meuillet

  44. Chemoprevention of prostate cancer with selenium: An update on current clinical trials and preclinical findings

    Article • Journal of Cellular Biochemistry, January 2004, Wiley

    Dr Emmanuelle J Meuillet

  45. Time and dose-dependent radiosensitization of the glioblastoma multiforme U251 cells by the EGF receptor tyrosine kinase inhibitor ZD1839 (‘Iressa’)

    Article • Cancer Letters, December 2003, Elsevier

    Dr Emmanuelle J Meuillet

  46. ZD1839 (‘Iressa’) an EGFR tyrosine kinase inhibitor radiosensitizes glioblastoma multiforme by inhibition of a cell survival pathway

    Article • International Journal of Radiation Oncology*Biology*Physics, October 2002, Elsevier

    Dr Emmanuelle J Meuillet

  47. Synthesis and biological activity of 3-hydroxy(phosphono)methyl-bearing phosphatidylinositol ether lipid analogues

    Article • Tetrahedron Letters, April 2002, Elsevier

    Dr Emmanuelle J Meuillet

  48. Interaction of the Extracellular Domain of the Epidermal Growth Factor Receptor with Gangliosides

    Article • Journal of Biological Chemistry, January 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Emmanuelle J Meuillet

  49. Molecular Modeling Studies of the Akt PH Domain and Its Interaction with Phosphoinositides

    Article • Journal of Medicinal Chemistry, March 2001, American Chemical Society (ACS)

    Dr Emmanuelle J Meuillet

  50. Ganglioside Modulates Ligand Binding to the Epidermal Growth Factor Receptor

    Article • Journal of Investigative Dermatology, January 2001, Elsevier

    Dr Emmanuelle J Meuillet

  51. 3-Deoxy-3-substituted-d-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

    Article • Bioorganic & Medicinal Chemistry Letters, January 2001, Elsevier

    Dr Emmanuelle J Meuillet

  52. ChemInform Abstract: Synthesis and Akt Inhibitory Properties of a 1D-3,4-Dideoxyphosphatidylinositol Ether Lipid.

    Article • ChemInform, December 2000, Wiley

    Dr Emmanuelle J Meuillet

  53. Synthesis and Akt inhibitory properties of a 1d-3,4-dideoxyphosphatidylinositol ether lipid

    Article • Tetrahedron Letters, September 2000, Elsevier

    Dr Emmanuelle J Meuillet

  54. 3-(Hydroxymethyl)-Bearing Phosphatidylinositol Ether Lipid Analogues and Carbonate Surrogates Block PI3-K, Akt, and Cancer Cell Growth

    Article • Journal of Medicinal Chemistry, August 2000, American Chemical Society (ACS)

    Dr Emmanuelle J Meuillet

  55. Modulation of EGF Receptor Activity by Changes in the GM3 Content in a Human Epidermoid Carcinoma Cell Line, A431

    Article • Experimental Cell Research, April 2000, Elsevier

    Dr Emmanuelle J Meuillet

  56. Metformin modulates insulin receptor signaling in normal and cholesterol-treated human hepatoma cells (HepG2)

    Article • European Journal of Pharmacology, July 1999, Elsevier

    Dr Emmanuelle J Meuillet

  57. Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, May 1999, Elsevier

    Dr Emmanuelle J Meuillet

  58. Gangliosides and Neurotrophic Growth Factors in the Retina: Molecular Interactions and Applications as Neuroprotective Agentsa

    Article • Annals of the New York Academy of Sciences, June 1998, Wiley

    Dr Emmanuelle J Meuillet

  59. Sialidase gene transfection modulates keratinocyte behavior on a fibronectin matrix

    Article • Journal of Dermatological Science, March 1998, Elsevier

    Dr Emmanuelle J Meuillet

  60. Growth Factor Receptors as Targets for Therapy in Pediatric Brain Tumors

    Article • Pediatric Neurosurgery, January 1998, Karger Publishers

    Dr Emmanuelle J Meuillet

  61. Biguanide Effects on Insulin Signaling

    Article • Annals of the New York Academy of Sciences, September 1997, Wiley

    Dr Emmanuelle J Meuillet

  62. Ganglioside effects on basic fibroblast and epidermal growth factor receptors in retinal glial cells

    Article • Journal of Lipid Mediators and Cell Signalling, September 1996, Elsevier

    Dr Emmanuelle J Meuillet

  63. Differential modulation of basic fibroblast and epidermal growth factor receptor activation by ganglioside GM3 in cultured retinal M�ller glia

    Article • Glia, July 1996, Wiley

    Dr Emmanuelle J Meuillet

  64. P-33: Substitution of the glycophorin A transmembrane domain modifies the structure of the insulin receptor and inhibits the action of insulin

    Article • Experimental and Clinical Endocrinology & Diabetes, January 1996, Thieme Publishing Group

    Dr Emmanuelle J Meuillet

  65. Lipid Modulation of Insulin Receptor Tyrosine Kinase Activity in Cultured Cells, Animals, and Reconstituted Systems

    Article • Annals of the New York Academy of Sciences, June 1993, Wiley

    Dr Emmanuelle J Meuillet