All Stories

  1. Comparison of ROS1-rearrangement detection methods in a cohort of surgically resected non-small cell lung carcinomas
  2. Chinese never smokers with adenocarcinoma of the lung are younger and have fewer lymph node metastases than smokers
  3. Air exposure and cell differentiation are essential for investigation of SARS-CoV-2 entry genes in human primary airway epithelial cells in vitro
  4. Characterization of phospholipid-modified lung surfactant in vitro and in a neonatal ARDS model reveals anti-inflammatory potential and surfactant lipidome signatures
  5. Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes
  6. Editorial: Treatment for Non-Small Cell Lung Cancer in Distinct Patient Populations
  7. Treatment for Non Small Cell Lung Cancer in Distinct Patient Populations
  8. PD-L1 Dependent Immunogenic Landscape in Hot Lung Adenocarcinomas Identified by Transcriptome Analysis
  9. WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis
  10. Pathogen-free diagnosis of tuberculosis
  11. Immune-evasion of KRAS-mutant lung adenocarcinoma mediated by cAMP response element-binding protein
  12. Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma
  13. Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma
  14. Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas
  15. Haemophilus influenzae causes cellular trans-differentiation in human bronchial epithelia
  16. DNA methylation profiles of bronchoscopic biopsies for the diagnosis of lung cancer
  17. PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung
  18. Prediction of anti-tuberculosis treatment duration based on a 22-gene transcriptomic model
  19. Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer
  20. Molekularpathologie der Tuberkulose
  21. Mycobacterium szulgai als Posititivkontrolle zur Detektion von Kontaminationen beim Nachweis des Mycobacterium tuberculosis-Komplexes durch eine spezifische 16S-rDNA-PCR an FFPE-Material
  22. Gene Expression Signatures Identify Biologically and Clinically Distinct Tuberculosis Endotypes
  23. Exploration of the sputum methylome and omics deconvolution by quadratic programming in molecular profiling of asthma and COPD: the road to sputum omics 2.0
  24. A 22-gene transcriptomic model indicating individual therapy durations in multidrug-resistant tuberculosis
  25. The impact of heated tobacco products on arterial stiffness
  26. WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by M. tuberculosis
  27. Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes
  28. The Multi-Modal Effect of the Anti-fibrotic Drug Pirfenidone on NSCLC
  29. Role of the erythropoietin receptor in Lung Cancer cells: erythropoietin exhibits angiogenic potential
  30. Live and let die: epigenetic modifications of Survivin and Regucalcin in non-small cell lung cancer tissues contribute to malignancy
  31. Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma
  32. Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers
  33. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
  34. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5
  35. Human alveolar epithelial cells type II are capable of TGFβ-dependent epithelial-mesenchymal-transition and collagen-synthesis
  36. The epigenetic clock of Non Small cell lung Cancer ticks differently
  37. Identification of novel target genes in human lung tissue involved in chronic obstructive pulmonary disease
  38. ΙκΒ kinase α is required for development and progression of KRAS-mutant lung adenocarcinoma.
  39. Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation
  40. Neutrophil extracellular trap formation is regulated by CXCR2 in COPD neutrophils
  41. Gene Network Analysis of Interstitial Macrophages After Treatment with Induced Pluripotent Stem Cells Secretome (iPSC-cm) in the Bleomycin Injured Rat Lung
  42. Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression
  43. Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells
  44. Signalling mechanisms in PAF-induced intestinal failure
  45. Lipidomes of lung cancer and tumour-free lung tissues reveal distinct molecular signatures for cancer differentiation, age, inflammation, and pulmonary emphysema
  46. P2Y6 Receptor Activation Promotes Inflammation and Tissue Remodeling in Pulmonary Fibrosis
  47. Meat allergy associated with galactosyl-α-(1,3)-galactose (α-Gal)-Closing diagnostic gaps by anti-α-Gal IgE immune profiling
  48. Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma
  49. Back into focus: tumour-associated macrophages and their role in immune checkpoint inhibition
  50. Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits
  51. Epigenetic modifications of the immune-checkpoint genes CTLA4 and PDCD1 in non-small cell lung cancer results in increased expression
  52. The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease
  53. PilY1 Promotes Legionella pneumophila Infection of Human Lung Tissue Explants and Contributes to Bacterial Adhesion, Host Cell Invasion, and Twitching Motility
  54. Functional Toll-Like Receptor 9 Expression and CXCR3 Ligand Release in Pulmonary Sarcoidosis
  55. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas
  56. Downregulation of the TGF  Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGF  Signaling and Invasion
  57. Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells
  58. Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: A large scale study of 1465 non-small cell lung cancer cases
  59. PD-L1 copy number gain in nonsmall-cell lung cancer defines a new subset of patients for anti PD-L1 therapy
  60. Budesonide Inhibits Intracellular Infection with Non-Typeable Haemophilus influenzae despite Its Anti-Inflammatory Effects in Respiratory Cells and Human Lung Tissue: A Role for p38 MAP Kinase
  61. Neutrophil extracellular trap formation and extracellular DNA in sputum of stable COPD patients
  62. Lipoproteins/peptides are sepsis-inducing toxins from bacteria that can be neutralized by synthetic anti-endotoxin peptides
  63. Placenta-derived conditioned medium with anti-tumor properties on human NSCLC
  64. Enhanced neutrophil extracellular trap (NET) formation in sputum of stable COPD patients
  65. Improved diagnostics targeting c-MET in non-small cell lung cancer: expression, amplification and activation?
  66. Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis
  67. Nontypeable Haemophilus influenzae (NTHi) reguliert die TGF-β-Signaltransduktion durch Induktion des TGF-β-Pseudorezeptors BAMBI im Lungengewebe und in respiratorischen Zellen
  68. Hydroxyethyl Starch (HES 130/0.4) Impairs Intestinal Barrier Integrity and Metabolic Function: Findings from a Mouse Model of the Isolated Perfused Small Intestine
  69. Quinidine, but Not Eicosanoid Antagonists or Dexamethasone, Protect the Gut from Platelet Activating Factor-Induced Vasoconstriction, Edema and Paralysis
  70. Multi-analyte profiling of inflammatory mediators in COPD sputum – The effects of processing
  71. Lipid Analysis of Airway Epithelial Cells for Studying Respiratory Diseases
  72. Correlation of EGFR expression, gene copy number and clinicopathological status in NSCLC
  73. Reduzierte Dosis von TKI führt nicht zu Wirkungsverlust bei Patienten mit aktivierender EGFR-Mutation
  74. Mechanisms of Cilia-Driven Transport in the Airways in the Absence of Mucus
  75. The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique
  76. HOPE-Fixation of Lung Tissue Allows Retrospective Proteome and Phosphoproteome Studies
  77. Transforming Growth Factor-Beta Signaling Leads to uPA/PAI-1 Activation and Metastasis: A Study on Human Breast Cancer Tissues
  78. Induktion des TGF-ß-Pseudorezeptors BAMBI durch Nontypeable Haemophilus influenzae (NTHi) und Auswirkungen auf TGF-ß vermittelte Effekte
  79. Reduzierte Dosis von TKI führt nicht zu Wirkungsverlust bei Patienten mit aktivierender EGFR Mutation
  80. Induktion des TGF-ß-Pseudorezeptors BAMBI durch Nontypeable Haemophilus influenzae (NTHi) und Auswirkungen auf TGF-ß vermittelte Effekte
  81. Roasting and lipid binding provide allergenic and proteolytic stability to the peanut allergen Ara h 8
  82. Human Lung Tissue Explants Reveal Novel Interactions during Legionella pneumophila Infections
  83. Optimized immunohistochemistry in combination with image analysis: A reliable alternative to quantitative ELISA determination of uPA and PAI-1 for routine risk group discrimination in breast cancer
  84. A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
  85. Comment on Nietner et al. [Virchows Arch (s2012) 461:259–269]
  86. Nontypeable Haemophilus Influenzae Infection Upregulates the NLRP3 Inflammasome and Leads to Caspase-1-Dependent Secretion of Interleukin-1β — A Possible Pathway of Exacerbations in COPD
  87. HOPE-preservation of paraffin-embedded sputum samples–A new way of bioprofiling in COPD
  88. Expression of the CTL2 transcript variants in human peripheral blood cells and human tissues
  89. Atypische Alterationen am EML-4 ALK Gen gehen nicht mit einem Ansprechen auf den ALKInhibitor Crizotinib einher
  90. Triggering receptor expressed on myeloid cells − 1 (Trem-1) on blood neutrophils is associated with cytokine inducibility in human E. coli sepsis
  91. Glioma infiltration of the corpus callosum: early signs detected by DTI
  92. Preclinical Investigations Reveal the Broad-Spectrum Neutralizing Activity of Peptide Pep19-2.5 on Bacterial Pathogenicity Factors
  93. The Effect of Dithiothreitol on the Transcriptome of Induced Sputum Cells
  94. Pulmonary haptoglobin (pHp) is part of the surfactant system in the human lung
  95. Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation
  96. Effects of Antimicrobial Peptides on Methanogenic Archaea
  97. Proteomics?
  98. Erratum to: effect of low tidal ventilation on lung function and inflammation in mice
  99. Pulmonary Haptoglobin and CD163 Are Functional Immunoregulatory Elements in the Human Lung
  100. Virtual slides in peer reviewed, open access medical publication
  101. Pathologie und Diagnose der Lungentuberkulose sowie nichttuberkulöser Mykobakterien
  102. Generation and evaluation of a monoclonal antibody, designated MAdL, as a new specific marker for adenocarcinomas of the lung
  103. To be at the right place at the right time
  104. Identification Of The CCL18 Receptor - Effects Of CCL18 On Human Lung Fibroblasts In Pulmonary Fibrosis Are Mediated Via CCR6
  105. COX2 Inhibition Attenuates Th2 Type Cytokine-Induced Mucus Expression In Human Airways
  106. A definition of time by relation of energy and mass
  107. Multiple Peptide Resistance Factor (MprF)-mediated Resistance ofStaphylococcus aureusagainst Antimicrobial Peptides Coincides with a Modulated Peptide Interaction with Artificial Membranes Comprising Lysyl-Phosphatidylglycerol
  108. Dexamethasone and N-acetyl-cysteine attenuate Pseudomonas aeruginosa-induced mucus expression in human airways
  109. HOPE-BAL
  110. Erreger-induzierte Modulation von Inflammation und Remodeling im humanen Lungengewebe durch Regulation des Transforming Growth Factor beta (TGF-β)-Pseudorezeptors BAMBI
  111. S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureusdetection
  112. Pulmonary haptoglobin: a new marker for adenocarcinomas of the lung?
  113. A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa
  114. Innate immunity in the human lung: pathogen recognition and lung disease
  115. I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development
  116. The TGF-beta-Pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae
  117. Lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide NK-2 againstEscherichia coliandProteus mirabilis
  118. Effect Of Dexamethasone And Acetyl-cysteine On Pseudomonas-induced Mucus Expression
  119. Effect of low tidal volume ventilation on lung function and inflammation in mice
  120. Comparison of the effect of lps and pam3 on ventilated lungs
  121. Facilities of a novel tissue fixation method: the HOPE-technology
  122. Improved molecular read-out options via adequate tissue fixation
  123. Molecular high throughput analyses and automated detection systems
  124. Light-dependent translocation of arrestin in rod photoreceptors is signaled through a phospholipase C cascade and requires ATP
  125. AI (artificial intelligence) in histopathology--from image analysis to automated diagnosis.
  126. Monoclonal antibody S60-4-14 reveals diagnostic potential in the identification of Pseudomonas aeruginosa in lung tissues of cystic fibrosis patients
  127. Measuring Immune Responses In Situ
  128. Proteomics Out of the Archive: Two-dimensional Electrophoresis and Mass Spectrometry Using HOPE-fixed, Paraffin-embedded Tissues
  129. Expression of the acute phase protein haptoglobin in human lung cancer and tumor-free lung tissues
  130. Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs
  131. Theory of sampling and its application in tissue based diagnosis
  132. The human placenta releases substances that drive lung cancer into apoptosis
  133. On the significance of Surfactant Protein-A within the human lungs
  134. Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes
  135. Structural Analysis of the Capsular Polysaccharide fromAcinetobacter lwoffiiF78
  136. Modulation of the Inflammatory Response toStreptococcus pneumoniaein a Model of Acute Lung Tissue Infection
  137. Effect of Steroids, Acetyl-cysteine and Calcium-Activated Chloride Channel Inhibitors on Allergic Mucin Expression in Sinus Mucosa
  138. Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties
  139. Structure and mode of action of the antimicrobial peptide arenicin
  140. CXCR7 transcription in human non-small cell lung cancer and tumor-free lung tissues; possible regulation upon chemotherapy
  141. TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens
  142. Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer
  143. LED-FISH: Fluorescence microscopy based on light emitting diodes for the molecular analysis of Her-2/neu oncogene amplification
  144. Image standards in Tissue-Based Diagnosis (Diagnostic Surgical Pathology)
  145. How to measure image quality in tissue-based diagnosis (diagnostic surgical pathology)
  146. Interaction of aeroallergens with the respiratory interphase
  147. Effect of Dexamethasone and ACC on Bacteria-Induced Mucin Expression in Human Airway Mucosa
  148. Pore-formation by a NK-lysin derived peptide antibiotic in artificial and bacterial membranes
  149. DNA methylation markers of surfactant proteins in lung cancer
  150. A novel human ex vivo model for the analysis of molecular events during lung cancer chemotherapy
  151. Disparate Innate Immune Responses to Persistent and AcuteChlamydia pneumoniaeInfection in Chronic Obstructive Pulmonary Disease
  152. LPS-induced mucin expression in human sinus mucosa can be attenuated by hCLCA inhibitors
  153. Rationale for the Design of Shortened Derivatives of the NK-lysin-derived Antimicrobial Peptide NK-2 with Improved Activity against Gram-negative Pathogens
  154. HMGA2 overexpression in non-small cell lung cancer
  155. Pulmonary Responses to Overventilation in Late Multiple Organ Failure
  156. Legionella pneumophila Induces IFNbeta in Lung Epithelial Cells via IPS-1 and IRF3, Which Also Control Bacterial Replication
  157. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
  158. Mycobacteria Induce IFN-  Production in Human Dendritic Cells via Triggering of TLR2
  159. A Vicious Circle of Alveolar Macrophages and Fibroblasts Perpetuates Pulmonary Fibrosis via CCL18
  160. High-throughput DNA methylation profiling using universal bead arrays
  161. Interleukin-18 expression by alveolar epithelial cells type II in tuberculosis and sarcoidosis
  162. Natural Killer Cell-Mediated Rejection of Experimental Human Lung Cancer by Genetic Overexpression of Major Histocompatibility Complex Class I Chain-Related Gene A
  163. Natural Killer Cell-Mediated Rejection of Experimental Human Lung Cancer by Genetic Overexpression of Major Histocompatibility Complex Class I Chain-Related Gene A
  164. Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material
  165. CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II
  166. Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients
  167. Inter-laboratory validation of PCR-based detection of Mycobacterium tuberculosis in formalin-fixed, paraffin-embedded tissues
  168. Pulmonale Infektionen im humanen Lungengewebsmodell
  169. Improved detection of mycobacterial DNA by PCR in formalin-fixed, paraffin-embedded tissues using thin sections
  170. Lung carcinoma-associated atypical adenomatoid hyperplasia, squamous cell dysplasia, and chromosome alterations in non-neoplastic bronchial mucosa
  171. Human lung cancer cells express functionally active Toll-like receptor 9
  172. The HOPE-technique permits Northern blot and microarray analyses in paraffin-embedded tissues
  173. HOPE technique enables western blot analysis from paraffin-embedded tissues
  174. Alveolar epithelial cells type II are major target cells forC. pneumoniaein chronic but not in acute respiratory infection
  175. Transkriptionelle Aktivität der Surfactant-Apoproteine A1 und A2 in nicht kleinzelligen Bronchialkarzinomen und tumorfreien Lungengeweben
  176. Phosphoinositide 3-OH Kinase Inhibition Prevents Ventilation-induced Lung Cell Activation
  177. Stretch Activates Nitric Oxide Production in Pulmonary Vascular Endothelial CellsIn Situ
  178. What's Cooking? Detection of Important Biomarkers in HOPE-Fixed, Paraffin-Embedded Tissues Eliminates the Need for Antigen Retrieval
  179. Atypical adenomatous hyperplasia of lung: its incidence and analysis of clinical, glycohistochemical and structural features including newly defined growth regulators and vascularization
  180. Progrediente L�hmungen infolge eines strahleninduzierten zervikalen malignen peripheren Nervenscheidentumors
  181. HOPE Fixation of Cytospin Preparations of Human Cells for In Situ Hybridization and Immunocytochemistry
  182. Alveolar macrophages are the main source for tumour necrosis factor‐α in patients with sarcoidosis
  183. Differential Haemoglobin Gene Expression in the Crustacean Daphnia magna Exposed to Different Oxygen Partial Pressures
  184. Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung
  185. HOPE-Fixation Enables Improved PCR-Based Detection and Differentiation of Mycobacterium tuberculosis Complex in Paraffin-Embedded Tissues
  186. Direct and Indirect In Situ PCR
  187. Ventilation-induced activation of the mitogen-activated protein kinase pathway
  188. Detection ofChlamydia pneumoniaein unexplained pulmonary hypertension
  189. HOPE – ANew Fixing Technique Enables Preservation and Extraction of High Molecular Weight DNAand RNA of >20 kb from Paraffin-embedded Tissues
  190. Human alveolar epithelial cells induce nitric oxide synthase‐2 expression in alveolar macrophages
  191. Assessment of Transcriptional Gene Activity in situ by Application of HOPE-fixed, Paraffin-embedded Tissues
  192. Cost-effective gel documentation using a web-cam
  193. Redox states of type 1 ryanodine receptor alter Ca 2+ release channel response to modulators
  194. Localization of Ceramide and Glucosylceramide in Human Epidermis by Immunogold Electron Microscopy
  195. Pattern of NOS2 and NOS3 mRNA expression in human A549 cells and primary cultured AEC II
  196. EnVision+, a New Dextran Polymer-based Signal Enhancement Technique for In Situ Hybridization (ISH)
  197. Formation of Granulomas in the Lungs of Severe Combined Immunodeficient Mice after Infection with Bacillus Calmette-Guerin
  198. Diagnostic value of immunohistochemically detected surfactant—apoprotein-A in malignant tumors located in the lungs: Report of two cases
  199. The prognostic value of the expression of collagenase IV, cathepsin D and metallothionein in squamous cell carcinomas of the skin determined by immunohistochemistry
  200. HOPE Fixation: A Novel Fixing Method and Paraffin-embedding Technique for Human Soft Tissues
  201. DNA-printing: utilization of a standard inkjet printer for the transfer of nucleic acids to solid supports
  202. Epipodite and fat cells as sites of hemoglobin synthesis in the branchiopod crustacean Daphnia magna
  203. Epipodite and fat cells as sites of hemoglobin synthesis in the branchiopod crustacean
  204. The Expression of Proteolytic Enzymes at the Dermal Invading Front of Primary Cutaneous Melanoma Predicts Metastasis
  205. Prognostic Classification of Malignant Melanomas by Combining Clinical, Histological, and Immunohistochemical Parameters
  206. Direct and Indirect In Situ PCR