All Stories

  1. The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1

    Article • The EMBO Journal, February 2019, EMBO

    Dr Joan Isern

  2. Dual cholinergic signals regulate daily migration of hematopoietic stem cells and leukocytes

    Article • Blood, October 2018, American Society of Hematology

    Dr Joan Isern

  3. Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

    Article • Nature Communications, October 2015, Nature

    Dr Joan Isern

  4. Estrogen Signaling Selectively Induces Apoptosis of Hematopoietic Progenitors and Myeloid Neoplasms without Harming Steady-State Hematopoiesis

    Article • Cell Stem Cell, December 2014, Elsevier

    Dr Joan Isern

  5. Low/Negative Expression of PDGFR-α Identifies the Candidate Primary Mesenchymal Stromal Cells in Adult Human Bone Marrow

    Article • Stem Cell Reports, December 2014, Elsevier

    Dr Joan Isern

  6. The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function

    Article • eLife, September 2014, eLife

    Dr Simon Mendez-Ferrer, Dr Daniel Martin-Perez, Dr Joan Isern

  7. Clonal analysis identifies hemogenic endothelium as the source of the blood-endothelial common lineage in the mouse embryo

    Article • Blood, August 2014, American Society of Hematology

    Dr Joan Isern

  8. Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms

    Article • Nature, June 2014, Springer Science + Business Media

    Dr Joan Isern

  9. Expression of Podocalyxin Separates the Hematopoietic and Vascular Potentials of Mouse Embryonic Stem Cell-Derived Mesoderm

    Article • Stem Cells, January 2014, Wiley

    Dr Joan Isern, Dr Stuart Fraser

  10. Analysis of primitive erythroid cell proliferation and enucleation using a cyan fluorescent reporter in transgenic mice

    Article • genesis, August 2013, Wiley

    Dr Joan Isern, Dr Stuart Fraser

  11. Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion

    Article • Cell Reports, May 2013, Elsevier

    Dr Joan Isern

  12. Isern J, He Z, Fraser ST, et al. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood. 2011;117(18):4924-4934.

    Article • Blood, December 2012, American Society of Hematology

    Dr Stuart Fraser, Dr Joan Isern

  13. The embryonic origins of erythropoiesis in mammals

    Article • Blood, February 2012, American Society of Hematology

    Dr Joan Isern, Dr Stuart Fraser

  14. BMP4 signaling directs primitive endoderm-derived XEN cells to an extraembryonic visceral endoderm identity

    Article • Developmental Biology, January 2012, Elsevier

    Dr Joan Isern

  15. Stem Cell Interactions in a Bone Marrow Niche

    Article • Current Osteoporosis Reports, September 2011, Springer Science + Business Media

    Dr Joan Isern

  16. Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo

    Article • Blood, January 2011, American Society of Hematology

    Dr Joan Isern, Dr Stuart Fraser

  17. Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf

    Article • Blood, August 2010, American Society of Hematology

    Dr Joan Isern, Dr Stuart Fraser

  18. Developmental niches for embryonic erythroid cells

    Article • Blood Cells Molecules and Diseases, April 2010, Elsevier

    Dr Joan Isern, Dr Stuart Fraser

  19. Use of Transgenic Fluorescent Reporter Mouse Lines to Monitor Hematopoietic and Erythroid Development During Embryogenesis

    Article • January 2010, Elsevier

    Dr Joan Isern, Dr Stuart Fraser

  20. The fetal liver is a niche for maturation of primitive erythroid cells

    Article • Proceedings of the National Academy of Sciences, May 2008, Proceedings of the National Academy of Sciences

    Dr Joan Isern, Dr Stuart Fraser

  21. Returning to the primitive: A new perspective on an overlooked hematopoietic lineage

    Article • Blood Cells Molecules and Diseases, March 2007, Elsevier

    Dr Joan Isern, Dr Stuart Fraser

  22. Maturation and enucleation of primitive erythroblasts during mouse embryogenesis is accompanied by changes in cell-surface antigen expression

    Article • Blood, January 2007, American Society of Hematology

    Dr Joan Isern, Dr Stuart Fraser

  23. Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development

    Article • Developmental Dynamics, January 2006, Wiley

    Dr Joan Isern, Dr Stuart Fraser

  24. Sex steroid regulation and identification of different transcription units of the SA gene in mouse kidney

    Article • October 2004, Bioscientifica

    Dr Joan Isern

  25. Hormonal regulation and characterisation of the mouse Cyp4b1 gene 5′-flanking region

    Article • Biochemical and Biophysical Research Communications, July 2003, Elsevier

    Dr Joan Isern

  26. Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney

    Article • Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, March 2001, Elsevier

    Dr Joan Isern, Bruno Stieger

  27. Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epithelium

    Article • Gut, September 2000, BMJ

    Dr Joan Isern