All Stories

  1. Enhancement of β-Lactam-Mediated Killing of Gram-Negative Bacteria by Lysine Hydrochloride

    Article • Microbiology Spectrum, August 2023, ASM Journals

    Dr Xilin Zhao

  2. Interplays of mutations in waaA, cmk, and ail contribute to phage resistance in Yersinia pestis

    Article • Frontiers in Cellular and Infection Microbiology, May 2023, Frontiers

    Dr Xilin Zhao

  3. Bicyclomycin Activity against Multidrug-Resistant Gram-Negative Pathogens

    Article • Microbiology Spectrum, February 2023, ASM Journals

    Dr Xilin Zhao

  4. Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms

    Article • Frontiers in Cellular and Infection Microbiology, December 2022, Frontiers

    Dr Xilin Zhao

  5. Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement

    Article • Frontiers in Cellular and Infection Microbiology, September 2022, Frontiers

    Dr Xilin Zhao

  6. A broadly applicable, stress-mediated bacterial death pathway regulated by the phosphotransferase system (PTS) and the cAMP-Crp cascade

    Article • Proceedings of the National Academy of Sciences, June 2022, Proceedings of the National Academy of Sciences

    Dr Xilin Zhao

  7. MicroPET imaging of bacterial infection with nitroreductase-specific responsive 18F-labelled nitrogen mustard analogues

    Article • European Journal of Nuclear Medicine and Molecular Imaging, February 2022, Springer Science + Business Media

    Dr Xilin Zhao

  8. In Situ Live Imaging of Gut Microbiota

    Article • mSphere, October 2021, ASM Journals

    Dr Xilin Zhao

  9. Gain-of-Function Mutations in Acid Stress Response (evgS) Protect Escherichia coli from Killing by Gallium Nitrate, an Antimicrobial Candidate

    Article • Antimicrobial Agents and Chemotherapy, February 2021, ASM Journals

    Dr Xilin Zhao

  10. Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations

    Article • Cytokine, February 2021, Elsevier

    Dr Xilin Zhao

  11. Bacterial death from treatment with fluoroquinolones and other lethal stressors

    Article • Expert Review of Anti-infective Therapy, November 2020, Taylor & Francis

    Dr Xilin Zhao

  12. Rapid and dynamic detection of antimicrobial treatment response using spectral amplitude modulation in MZO nanostructure-modified quartz crystal microbalance

    Article • Journal of Microbiological Methods, November 2020, Elsevier

    Dr Xilin Zhao

  13. Early stage detection of Staphylococcus epidermidis biofilm formation using MgZnO dual-gate TFT biosensor

    Article • Biosensors and Bioelectronics, March 2020, Elsevier

    Dr Xilin Zhao

  14. Magnesium Zinc Oxide Nanostructure-Modified Multifunctional Sensors for Full-Scale Dynamic Monitoring of Pseudomonas aeruginosa Biofilm Formation

    Article • ECS Journal of Solid State Science and Technology, January 2020, The Electrochemical Society

    Dr Xilin Zhao

  15. Reactive oxygen species play a dominant role in all pathways of rapid quinolone-mediated killing

    Article • Journal of Antimicrobial Chemotherapy, December 2019, Oxford University Press (OUP)

    Dr Xilin Zhao

  16. Emergence of carbapenem resistance in Bacteroides fragilis in China

    Article • International Journal of Antimicrobial Agents, June 2019, Elsevier

    Dr Xilin Zhao

  17. Post-stress bacterial cell death mediated by reactive oxygen species

    Article • Proceedings of the National Academy of Sciences, April 2019, Proceedings of the National Academy of Sciences

    Dr Xilin Zhao

  18. Antimicrobial-Mediated Bacterial Suicide

    Article • January 2018, Springer Science + Business Media

    Dr Xilin Zhao

  19. Heteroresistance: A Harbinger of Future Resistance

    Article • January 2018, Springer Science + Business Media

    Dr Xilin Zhao

  20. Suppression of Reactive Oxygen Species Accumulation Accounts for Paradoxical Bacterial Survival at High Quinolone Concentration

    Article • Antimicrobial Agents and Chemotherapy, December 2017, ASM Journals

    Dr Xilin Zhao

  21. Contribution of reactive oxygen species to thymineless death in Escherichia coli

    Article • Nature Microbiology, October 2017, Nature

    Dr Xilin Zhao

  22. IFN-ε protects primary macrophages against HIV infection

    Article • JCI Insight, December 2016, American Society for Clinical Investigation

    Dr Xilin Zhao

  23. Spoligotyping of Mycobacterium tuberculosis Complex Isolates by Use of Ligation-Based Amplification and Melting Curve Analysis

    Article • Journal of Clinical Microbiology, June 2016, ASM Journals

    Dr Xilin Zhao, qingge li

  24. Dimethyl Sulfoxide Protects Escherichia coli from Rapid Antimicrobial-Mediated Killing

    Article • Antimicrobial Agents and Chemotherapy, May 2016, ASM Journals

    Dr Xilin Zhao

  25. Resveratrol Antagonizes Antimicrobial Lethality and Stimulates Recovery of Bacterial Mutants

    Article • PLoS ONE, April 2016, PLOS

    Dr Xilin Zhao

  26. Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones

    Article • Nucleic Acids Research, March 2016, Oxford University Press (OUP)

    Dr Xilin Zhao

  27. Involvement of Holliday Junction Resolvase in Fluoroquinolone-Mediated Killing of Mycobacterium smegmatis

    Article • Antimicrobial Agents and Chemotherapy, December 2014, ASM Journals

    Dr Xilin Zhao

  28. Ribosomal Elongation Factor 4 Promotes Cell Death Associated with Lethal Stress

    Article • mBio, December 2014, ASM Journals

    Dr Xilin Zhao

  29. Moving forward with reactive oxygen species involvement in antimicrobial lethality

    Article • Journal of Antimicrobial Chemotherapy, November 2014, Oxford University Press (OUP)

    Dr Xilin Zhao

  30. Reactive oxygen species and the bacterial response to lethal stress

    Article • Current Opinion in Microbiology, October 2014, Elsevier

    Dr Xilin Zhao

  31. Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics

    Article • Journal of Antimicrobial Chemotherapy, July 2014, Oxford University Press (OUP)

    Dr Xilin Zhao

  32. Fluoroquinolone-Gyrase-DNA Complexes

    Article • Journal of Biological Chemistry, February 2014, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Xilin Zhao

  33. Quinolones☆

    Article • January 2014, Elsevier

    Dr Xilin Zhao

  34. Mycoplasma pneumoniae infection is associated with subacute cough

    Article • European Respiratory Journal, November 2013, European Respiratory Society (ERS)

    Dr Xilin Zhao

  35. Superoxide-Mediated Protection of Escherichia coli from Antimicrobials

    Article • Antimicrobial Agents and Chemotherapy, August 2013, ASM Journals

    Dr Liping li, Dr Xilin Zhao

  36. YihE Kinase Is a Central Regulator of Programmed Cell Death in Bacteria

    Article • Cell Reports, February 2013, Elsevier

    Dr Xilin Zhao

  37. Inhibitors of Reactive Oxygen Species Accumulation Delay and/or Reduce the Lethality of Several Antistaphylococcal Agents

    Article • Antimicrobial Agents and Chemotherapy, September 2012, ASM Journals

    Dr Liping li, Dr Xilin Zhao

  38. Induction of Mycobacterial Resistance to Quinolone Class Antimicrobials

    Article • Antimicrobial Agents and Chemotherapy, May 2012, ASM Journals

    Dr Xilin Zhao

  39. Fluoroquinolone Resistance: Mechanisms, Restrictive Dosing, and Anti-Mutant Screening Strategies for New Compounds

    Article • November 2011, Springer Science + Business Media

    Dr Xilin Zhao

  40. A Toxin-Antitoxin Module in Bacillus subtilis Can Both Mitigate and Amplify Effects of Lethal Stress

    Article • PLoS ONE, August 2011, PLOS

    Dr Xilin Zhao

  41. Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis

    Article • Antimicrobial Agents and Chemotherapy, March 2011, ASM Journals

    Dr Xilin Zhao

  42. Mutant Prevention Concentration-Based Pharmacokinetic/Pharmacodynamic Indices as Dosing Targets for Suppressing the Enrichment of Levofloxacin-Resistant Subpopulations of Staphylococcus aureus

    Article • Antimicrobial Agents and Chemotherapy, February 2011, ASM Journals

    Dr Xilin Zhao

  43. Multicolor Combinatorial Probe Coding for Real-Time PCR

    Article • PLoS ONE, January 2011, PLOS

    Dr Xilin Zhao

  44. Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death

    Article • Journal of Antimicrobial Chemotherapy, January 2010, Oxford University Press (OUP)

    Dr Xilin Zhao

  45. Escherichia coli genes that reduce the lethal effects of stress

    Article • BMC Microbiology, January 2010, Springer Science + Business Media

    Dr Xilin Zhao

  46. Quinolones: Action and Resistance Updated

    Article • Current Topics in Medicinal Chemistry, August 2009, Bentham Science Publishers

    Dr Xilin Zhao

  47. Contribution of Oxidative Damage to Antimicrobial Lethality

    Article • Antimicrobial Agents and Chemotherapy, February 2009, ASM Journals

    Dr Xilin Zhao

  48. Quinolones

    Article • January 2009, Elsevier

    Dr Xilin Zhao

  49. Lateral Flow Immunoassay Using Europium Chelate-Loaded Silica Nanoparticles as Labels

    Article • Clinical Chemistry, January 2009, Oxford University Press (OUP)

    Dr Xilin Zhao

  50. Antimicrobial Studies with the Pseudomonas aeruginosa Two-Allele Library Require Caution

    Article • Antimicrobial Agents and Chemotherapy, August 2008, ASM Journals

    Dr Xilin Zhao

  51. A unified anti-mutant dosing strategy

    Article • Journal of Antimicrobial Chemotherapy, June 2008, Oxford University Press (OUP)

    Dr Xilin Zhao

  52. Minimising moxifloxacin resistance with tuberculosis

    Article • The Lancet Infectious Diseases, May 2008, Elsevier

    Dr Xilin Zhao

  53. Mutant Selection Window Hypothesis: A Framework for Anti-mutant Dosing of Antimicrobial Agents

    Article • January 2008, Springer Science + Business Media

    Dr Xilin Zhao

  54. Daptomycin inoculum effects and mutant prevention concentration with Staphylococcus aureus

    Article • Journal of Antimicrobial Chemotherapy, October 2007, Oxford University Press (OUP)

    Dr Xilin Zhao

  55. Quinolone-Mediated Bacterial Death

    Article • Antimicrobial Agents and Chemotherapy, August 2007, ASM Journals

    Dr Xilin Zhao

  56. Mutant Selection Window Hypothesis Updated

    Article • Clinical Infectious Diseases, March 2007, Oxford University Press (OUP)

    Dr Xilin Zhao

  57. The Mutant Selection Window in Rabbits Infected withStaphylococcus aureus

    Article • The Journal of Infectious Diseases, December 2006, Oxford University Press (OUP)

    Dr Xilin Zhao

  58. Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli

    Article • Journal of Antimicrobial Chemotherapy, October 2006, Oxford University Press (OUP)

    Dr Xilin Zhao

  59. Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones

    Article • Molecular Microbiology, August 2006, Wiley

    Dr Xilin Zhao

  60. Mutant prevention concentration for ciprofloxacin and levofloxacin with Pseudomonas aeruginosa

    Article • International Journal of Antimicrobial Agents, February 2006, Elsevier

    Dr Xilin Zhao

  61. Lethal Action of Quinolones against a Temperature-Sensitive dnaB Replication Mutant of Escherichia coli

    Article • Antimicrobial Agents and Chemotherapy, January 2006, ASM Journals

    Dr Xilin Zhao

  62. Low Correlation between MIC and Mutant Prevention Concentration

    Article • Antimicrobial Agents and Chemotherapy, January 2006, ASM Journals

    Dr Xilin Zhao

  63. Selection of rifampicin-resistant Staphylococcus aureus during tuberculosis therapy: concurrent bacterial eradication and acquisition of resistance

    Article • Journal of Antimicrobial Chemotherapy, October 2005, Oxford University Press (OUP)

    Dr Xilin Zhao

  64. Lethality of Quinolones against Mycobacterium smegmatis in the Presence or Absence of Chloramphenicol

    Article • Antimicrobial Agents and Chemotherapy, May 2005, ASM Journals

    Dr Xilin Zhao

  65. Are the new quinolones appropriate treatment for community-acquired methicillin-resistant Staphylococcus aureus?

    Article • International Journal of Antimicrobial Agents, July 2004, Elsevier

    Dr Xilin Zhao

  66. Is ‘dosing-to-cure’ appropriate in the face of antimicrobial resistance?

    Article • Reviews in Medical Microbiology, April 2004, Wolters Kluwer Health

    Dr Xilin Zhao

  67. Clarification of MPC and the mutant selection window concept

    Article • Journal of Antimicrobial Chemotherapy, September 2003, Oxford University Press (OUP)

    Dr Xilin Zhao

  68. Emergence of resistant Streptococcus pneumoniae in an in vitro dynamic model that simulates moxifloxacin concentrations inside and outside the mutant selection window: related changes in susceptibility, resistance frequency and bacterial killing

    Article • Journal of Antimicrobial Chemotherapy, September 2003, Oxford University Press (OUP)

    Dr Xilin Zhao

  69. Fluoroquinolone-resistant Streptococcus pneumoniae

    Article • Reviews in Medical Microbiology, July 2003, Wolters Kluwer Health

    Dr Xilin Zhao

  70. Mutant Prevention Concentration of Garenoxacin (BMS-284756) for Ciprofloxacin-Susceptible or -Resistant Staphylococcus aureus

    Article • Antimicrobial Agents and Chemotherapy, March 2003, ASM Journals

    Dr Xilin Zhao

  71. Resistance to Levofloxacin and Failure of Treatment of Pneumococcal Pneumonia

    Article • New England Journal of Medicine, July 2002, New England Journal of Medicine (NEJM/MMS)

    Dr Xilin Zhao

  72. Restricting the Selection of Antibiotic‐Resistant Mutant Bacteria: Measurement and Potential Use of the Mutant Selection Window

    Article • The Journal of Infectious Diseases, February 2002, Oxford University Press (OUP)

    Dr Xilin Zhao

  73. Selection of Streptococcus pneumoniae Mutants Having Reduced Susceptibility to Moxifloxacin and Levofloxacin

    Article • Antimicrobial Agents and Chemotherapy, February 2002, ASM Journals

    Dr Xilin Zhao

  74. Enhancement of Fluoroquinolone Activity by C-8 Halogen and Methoxy Moieties: Action against a Gyrase Resistance Mutant of Mycobacterium smegmatis and a Gyrase-Topoisomerase IV Double Mutant of Staphylococcus aureus

    Article • Antimicrobial Agents and Chemotherapy, October 2001, ASM Journals

    Dr Xilin Zhao

  75. Fluoroquinolones as pneumococcal therapy: closing the barn door before the horse escapes

    Article • The Lancet Infectious Diseases, October 2001, Elsevier

    Dr Xilin Zhao

  76. Restricting the Selection of Antibiotic‐Resistant Mutants: A General Strategy Derived from Fluoroquinolone Studies

    Article • Clinical Infectious Diseases, September 2001, Oxford University Press (OUP)

    Dr Xilin Zhao

  77. Fluoroquinolone‐ResistantStreptococcus pneumoniaeAssociated with Levofloxacin Therapy

    Article • The Journal of Infectious Diseases, September 2001, Oxford University Press (OUP)

    Dr Xilin Zhao

  78. gyrB-225, a mutation of DNA gyrase that compensates for topoisomerase I deficiency: investigation of its low activity and quinolone hypersensitivity

    Article • Journal of Molecular Biology, June 2001, Elsevier

    Dr Xilin Zhao

  79. Mutant Prevention Concentrations of Fluoroquinolones for Clinical Isolates of Streptococcus pneumoniae

    Article • Antimicrobial Agents and Chemotherapy, February 2001, ASM Journals

    Dr Xilin Zhao

  80. Mutant Prevention Concentration as a Measure of Fluoroquinolone Potency against Mycobacteria

    Article • Antimicrobial Agents and Chemotherapy, December 2000, ASM Journals

    Dr Xilin Zhao

  81. Mutant Prevention Concentration as a Measure of Antibiotic Potency: Studies with Clinical Isolates ofMycobacterium tuberculosis

    Article • Antimicrobial Agents and Chemotherapy, September 2000, ASM Journals

    Dr Xilin Zhao

  82. Selective Targeting of Topoisomerase IV and DNA Gyrase in Staphylococcus aureus: Different Patterns of Quinolone- Induced Inhibition of DNA Synthesis

    Article • Antimicrobial Agents and Chemotherapy, August 2000, ASM Journals

    Dr Xilin Zhao

  83. Selection of Antibiotic‐Resistant Bacterial Mutants: Allelic Diversity among Fluoroquinolone‐Resistant Mutations

    Article • The Journal of Infectious Diseases, August 2000, Oxford University Press (OUP)

    Dr Xilin Zhao

  84. Gatifloxacin Activity against Quinolone-Resistant Gyrase: Allele-Specific Enhancement of Bacteriostatic and Bactericidal Activities by the C-8-Methoxy Group

    Article • Antimicrobial Agents and Chemotherapy, December 1999, ASM Journals

    Dr Xilin Zhao

  85. Cytotoxic Hammerhead Ribozymes

    Article • Antisense and Nucleic Acid Drug Development, April 1999, Mary Ann Liebert Inc

    Dr Xilin Zhao

  86. DNA topoisomerase targets of the fluoroquinolones: A strategy for avoiding bacterial resistance

    Article • Proceedings of the National Academy of Sciences, December 1997, Proceedings of the National Academy of Sciences

    Dr Xilin Zhao

  87. The effect of methylation outside the recognition sequence of restriction endonuclease PvuII on its cleavage efficiency

    Article • Gene, April 1992, Elsevier

    Dr Xilin Zhao

  88. Controlling Antibiotic Resistance: Strategies Based on the Mutant Selection Window

    Article • Springer Science + Business Media

    Dr Xilin Zhao

  89. An Anti-mutant Approach for Antimicrobial Use

    Article • Springer Science + Business Media

    Dr Xilin Zhao