All Stories

  1. Epidermal Growth Factor Receptor Transactivation Is Required for Mitogen-Activated Protein Kinase Activation by Muscarinic Acetylcholine Receptors in HaCaT Keratinocytes

    Article • International Journal of Molecular Sciences, November 2014, MDPI AG

    Professor Ritva Tikkanen

  2. Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

    Article • Basic Research in Cardiology, September 2014, Springer Science + Business Media

    Professor Ritva Tikkanen

  3. Endocytic Trafficking of Membrane-Bound Cargo: A Flotillin Point of View

    Article • Membranes, July 2014, MDPI AG

    Professor Ritva Tikkanen

  4. Role of dynamin and clathrin in the cellular trafficking of flotillins

    Article • FEBS Journal, May 2014, Wiley

    Professor Ritva Tikkanen

  5. Flotillins bind to the dileucine sorting motif of β‐site amyloid precursor protein‐cleaving enzyme 1 and influence its endosomal sorting

    Article • FEBS Journal, March 2014, Wiley

    Professor Ritva Tikkanen

  6. Flotillins in Receptor Tyrosine Kinase Signaling and Cancer

    Article • Cells, February 2014, MDPI AG

    Professor Ritva Tikkanen

  7. Increased activity of mitogen activated protein kinase pathway in flotillin-2 knockout mouse model

    Article • Cellular Signalling, February 2014, Elsevier

    Professor Ritva Tikkanen

  8. Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells

    Article • BMC Cancer, December 2013, Springer Science + Business Media

    Professor Ritva Tikkanen

  9. Non-Neuronal Functions of the M2 Muscarinic Acetylcholine Receptor

    Article • Genes, April 2013, MDPI AG

    Professor Ritva Tikkanen

  10. Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount

    Article • International Journal of Molecular Sciences, March 2013, MDPI AG

    Professor Ritva Tikkanen

  11. Transcriptional Regulation of Flotillins by the Extracellularly Regulated Kinases and Retinoid X Receptor Complexes

    Article • PLoS ONE, September 2012, PLOS

    Professor Ritva Tikkanen

  12. Flotillin-1/Reggie-2 Protein Plays Dual Role in Activation of Receptor-tyrosine Kinase/Mitogen-activated Protein Kinase Signaling

    Article • Journal of Biological Chemistry, January 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Ritva Tikkanen

  13. Molecular Networks in FGF Signaling: Flotillin-1 and Cbl-Associated Protein Compete for the Binding to Fibroblast Growth Factor Receptor Substrate 2

    Article • PLoS ONE, January 2012, PLOS

    Professor Ritva Tikkanen

  14. Functional Aspects of Membrane Association of Reggie/Flotillin Proteins

    Article • Current Protein and Peptide Science, December 2011, Bentham Science Publishers

    Professor Ritva Tikkanen

  15. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis

    Article • Cellular Signalling, August 2009, Elsevier

    Professor Ritva Tikkanen

  16. Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney

    Article • Kidney International, August 2008, Elsevier

    Professor Ritva Tikkanen

  17. AP-1 and AP-3 Mediate Sorting of Melanosomal and Lysosomal Membrane Proteins into Distinct Post-Golgi Trafficking Pathways

    Article • Traffic, July 2008, Wiley

    Professor Ritva Tikkanen

  18. Dissecting the molecular function of reggie/flotillin proteins

    Article • European Journal of Cell Biology, September 2007, Elsevier

    Professor Ritva Tikkanen

  19. Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton

    Article • Journal of Cell Science, January 2007, The Company of Biologists

    Professor Ritva Tikkanen

  20. Polarized Transport of Alzheimer Amyloid Precursor Protein Is Mediated by Adaptor Protein Complex AP1-1B

    Article • Traffic, December 2006, Wiley

    Professor Ritva Tikkanen

  21. A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia

    Article • Biochemical Journal, November 2005, Portland Press Ltd.

    Professor Ritva Tikkanen

  22. Flotillin

    Article • July 2004, Wiley

    Professor Ritva Tikkanen

  23. Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression

    Article • Biochemical Journal, March 2004, Portland Press Ltd.

    Professor Ritva Tikkanen

  24. The Receptor-Bound N-Terminal Ectodomain of the Amyloid Precursor Protein Is Associated with Membrane Rafts

    Article • Biological Chemistry, January 2002, De Gruyter

    Professor Ritva Tikkanen

  25. The biological role of the Alzheimer amyloid precursor protein in epithelial cells

    Article • Histochemistry and Cell Biology, November 2001, Springer Science + Business Media

    Professor Ritva Tikkanen

  26. The Dileucine Motif Within the Tail of MPR46 is Required for Sorting of the Receptor in Endosomes

    Article • Traffic, August 2000, Wiley

    Professor Ritva Tikkanen

  27. Activation and Oligomerization of Aspartylglucosaminidase

    Article • Journal of Biological Chemistry, September 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Ritva Tikkanen

  28. Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase

    Article • The EMBO Journal, November 1997, Wiley

    Professor Ritva Tikkanen

  29. Primary Folding of Aspartylglucosaminidase. SIGNIFICANCE OF DISULFIDE BRIDGES AND EVIDENCE OF EARLY MULTIMERIZATION

    Article • Journal of Biological Chemistry, August 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Ritva Tikkanen

  30. Ser72Pro active-site disease mutation in human lysosomal aspartylglucosaminidase: abnormal intracellular processing and evidence for extracellular activation

    Article • Human Molecular Genetics, June 1996, Oxford University Press (OUP)

    Professor Ritva Tikkanen

  31. Large-scale purification and preliminary X-ray diffraction studies of human aspartylglucosaminidase

    Article • Proteins Structure Function and Bioinformatics, February 1996, Wiley

    Professor Ritva Tikkanen

  32. Large‐scale purification and preliminary x‐ray diffraction studies of human aspartylglucosaminidase

    Article • Proteins Structure Function and Bioinformatics, February 1996, Wiley

    Professor Ritva Tikkanen

  33. Three-dimensional structure of human lysosomal aspartylglucosaminidase

    Article • Nature Structural & Molecular Biology, December 1995, Springer Science + Business Media

    Professor Ritva Tikkanen

  34. Intracellular Sorting of Aspartylglucosaminidase: The Role of N -Linked Oligosaccharides and Evidence of Man-6-P-Independent Lysosomal Targeting

    Article • DNA and Cell Biology, April 1995, Mary Ann Liebert Inc

    Professor Ritva Tikkanen

  35. Immediate Interaction between the Nascent Subunits and Two Conserved Amino Acids Trp34 and Thr206 Are Needed for the Catalytic Activity of Aspartylglucosaminidase

    Article • Journal of Biological Chemistry, March 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Ritva Tikkanen