All Stories

  1. Enhancement of the affinity of 2′-O-Me-oligonucleotides for complementary RNA by incorporating a stereoregulated boranophosphate backbone

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    Professor Natsuhisa Oka, Takeshi Wada

  2. α-Selective Ribofuranosylation of Alcohols with Ribofuranosyl Iodides and Triphenylphosphine Oxide

    Article • The Journal of Organic Chemistry, August 2014, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  3. Solid-Phase Synthesis of P -Boronated Oligonucleotides by the H -Boranophosphonate Method

    Article • The Journal of Organic Chemistry, April 2014, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  4. Glycosylation of alcohols using glycosyl boranophosphates as glycosyl donors

    Article • Tetrahedron Letters, July 2013, Elsevier

    Professor Natsuhisa Oka

  5. Stereocontrolled synthesis of dinucleoside phosphorothioates using a fluorous tag

    Article • Journal of Fluorine Chemistry, June 2013, Elsevier

    Professor Natsuhisa Oka

  6. Purification and comparison of native and recombinant tRNA-guanine transglycosylases from Methanosarcina acetivorans

    Article • Protein Expression and Purification, March 2013, Elsevier

    Professor Natsuhisa Oka

  7. Synthesis of inosine 6-phosphate diesters via phosphitylation of the carbonyl oxygen

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Professor Natsuhisa Oka

  8. Stereocontrolled Solid-Phase Synthesis of Phosphorothioate Oligoribonucleotides Using 2′- O -(2-Cyanoethoxymethyl)-nucleoside 3′- O -Oxazaphospholidine Monomers

    Article • The Journal of Organic Chemistry, September 2012, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  9. Stereocontrolled synthesis of oligodeoxyribonucleoside boranophosphates by an oxazaphospholidine approach using acid-labile N-protecting groups

    Article • Tetrahedron Letters, August 2012, Elsevier

    Professor Natsuhisa Oka

  10. Synthesis of nucleoside 5′-boranophosphorothioate derivatives using an H-boranophosphonate monoester as a precursor

    Article • Bioorganic & Medicinal Chemistry Letters, July 2012, Elsevier

    Professor Natsuhisa Oka

  11. Synthesis of 2-Pyridylphosphinate and Thiophosphinate Derivatives by Nucleophilic Aromatic Substitution of N-Methoxypyridinium Tosylates

    Article • Chemistry Letters, January 2012, Chemical Society of Japan

    Professor Natsuhisa Oka

  12. Recent Progress in the Synthesis of Glycosyl Phosphate Derivatives

    Article • Trends in Glycoscience and Glycotechnology, January 2012, Forum: Carbohydrates Coming of Age

    Professor Natsuhisa Oka

  13. Trimethylsilyl Trifluoromethanesulfonate-promoted Reductive 2′-O-arylmethylation of Ribonucleoside Derivatives

    Article • Nucleosides Nucleotides & Nucleic Acids, June 2011, Taylor & Francis

    Professor Natsuhisa Oka

  14. Synthesis of Oligo(α- d -glycosyl phosphate) Derivatives by a Phosphoramidite Method via Boranophosphate Intermediates

    Article • The Journal of Organic Chemistry, April 2011, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  15. Stereocontrolled synthesis of oligonucleotide analogs containing chiral internucleotidic phosphorus atoms

    Article • Chemical Society Reviews, January 2011, Royal Society of Chemistry

    Professor Natsuhisa Oka

  16. Rapid glycosylations under extremely mild acidic conditions. Use of ammonium salts to activate glycosyl phosphites via P-protonation

    Article • Carbohydrate Research, June 2010, Elsevier

    Professor Natsuhisa Oka

  17. 1,2- Trans -Selective Synthesis of Glycosyl Boranophosphates and Their Utility as Building Blocks for the Synthesis of Phosphodiester-Linked Disaccharides

    Article • The Journal of Organic Chemistry, April 2010, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  18. Solid-Phase Synthesis of Oligodeoxyribonucleotides without Base Protection UtilizingO-Selective Reaction of Oxazaphospholidine Derivatives

    Article • Nucleosides Nucleotides & Nucleic Acids, February 2010, Taylor & Francis

    Professor Natsuhisa Oka

  19. Stereocontrolled synthesis of tertiary silanes via optically pure 1,3,2-oxazasilolidine derivatives

    Article • Journal of Organometallic Chemistry, June 2009, Elsevier

    Professor Natsuhisa Oka

  20. Stereocontrolled Synthesis of Oligoribonucleoside Phosphorothioates by an Oxazaphospholidine Approach

    Article • Organic Letters, February 2009, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  21. Stereocontrolled Solid-Phase Synthesis of OligonucleosideH-Phosphonates by an Oxazaphospholidine Approach

    Article • Angewandte Chemie International Edition, January 2009, Wiley

    Professor Natsuhisa Oka

  22. Stereocontrolled Solid-Phase Synthesis of OligonucleosideH-Phosphonates by an Oxazaphospholidine Approach

    Article • Angewandte Chemie, January 2009, Wiley

    Professor Natsuhisa Oka

  23. Nucleoside H-boranophosphonates: a new class of boron-containing nucleotide analogues

    Article • Chemical Communications, January 2009, Royal Society of Chemistry

    Professor Natsuhisa Oka

  24. Solid-Phase Synthesis of Stereoregular Oligodeoxyribonucleoside Phosphorothioates Using Bicyclic Oxazaphospholidine Derivatives as Monomer Units

    Article • Journal of the American Chemical Society, November 2008, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  25. Stereoselective Synthesis of α-Glycosyl Phosphites and Phosphoramidites via O -Selective Glycosylation of H -Phosphonate Derivatives

    Article • Organic Letters, November 2008, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  26. Chemical synthesis of diastereomeric diadenosine boranophosphates (ApbA) from 2′-O-(2-cyanoethoxymethyl)adenosine by the boranophosphotriester method

    Article • Bioorganic & Medicinal Chemistry, October 2008, Elsevier

    Professor Natsuhisa Oka

  27. Synthesis of Glycosyl Boranophosphates and Their Applications as Precursors of Glycosyl Phosphate Analogues

    Article • Organic Letters, April 2008, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  28. Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase

    Article • Nature, September 2007, Springer Science + Business Media

    Professor Natsuhisa Oka

  29. Synthesis, DNA Polymerase Incorporation, and Enzymatic Phosphate Hydrolysis of Formamidopyrimidine Nucleoside Triphosphates

    Article • Journal of the American Chemical Society, November 2006, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  30. Stereoselective synthesis of dinucleoside boranophosphates by an oxazaphospholidine method

    Article • Bioorganic & Medicinal Chemistry Letters, June 2006, Elsevier

    Professor Natsuhisa Oka

  31. Highly chemo- and regioselective phosphitylation of unprotected 2′-deoxyribonucleosides

    Article • Tetrahedron Letters, April 2006, Elsevier

    Professor Natsuhisa Oka

  32. 1,3-Dimethyl-2-(3-nitro-1,2,4-triazol-1-yl)-2-pyrrolidin-1-yl-1,3,2-diazaphospholidinium hexafluorophosphate (MNTP): a powerful condensing reagent for phosphate and phosphonate esters

    Article • Tetrahedron, April 2006, Elsevier

    Professor Natsuhisa Oka

  33. A Novel Method for the Synthesis of Dinucleoside Boranophosphates by a Boranophosphotriester Method

    Article • The Journal of Organic Chemistry, August 2004, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  34. 3,3′-Oxybis(dimethoxytrityl chloride) (O-DMTCl): synthesis and applications of a novel bifunctional protecting group

    Article • Bioorganic & Medicinal Chemistry Letters, June 2004, Elsevier

    Professor Natsuhisa Oka

  35. 1,2-Ethylene-3,3-bis(4′,4′′-dimethoxytrityl Chloride) (E-DMT): Synthesis and Applications of a Novel Protecting Reagent

    Article • Synlett, January 2004, Thieme Publishing Group

    Professor Natsuhisa Oka

  36. An Oxazaphospholidine Approach for the Stereocontrolled Synthesis of Oligonucleoside Phosphorothioates

    Article • Journal of the American Chemical Society, July 2003, American Chemical Society (ACS)

    Professor Natsuhisa Oka

  37. A new boranophosphorylation reaction for the synthesis of deoxyribonucleoside boranophosphates

    Article • Tetrahedron Letters, June 2002, Elsevier

    Professor Natsuhisa Oka

  38. Diastereocontrolled Synthesis of Dinucleoside Phosphorothioates Using a Novel Class of Activators, Dialkyl(cyanomethyl)ammonium Tetrafluoroborates

    Article • Journal of the American Chemical Society, May 2002, American Chemical Society (ACS)

    Professor Natsuhisa Oka