All Stories

  1. A transcriptomic analysis of the effects of macrophage polarization and endotoxin tolerance on the response to Salmonella

    Article • PLoS ONE, October 2022, PLOS

    Dr Robert E Hancock

  2. Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa

    Article • PLoS ONE, April 2021, PLOS

    Dr Daniel Pletzer, Dr Robert E Hancock

  3. Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media

    Article • Proceedings of the National Academy of Sciences, December 2020, Proceedings of the National Academy of Sciences

    Dr Robert E Hancock, Dr Daniel Pletzer

  4. Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58

    Article • PLoS Pathogens, March 2020, PLOS

    Dr Daniel Pletzer, Dr Robert E Hancock

  5. Surfing Motility: a Conserved yet Diverse Adaptation among Motile Bacteria

    Article • Journal of Bacteriology, September 2018, ASM Journals

    Dr Robert E Hancock

  6. Broad-Spectrum Adaptive Antibiotic Resistance Associated with Pseudomonas aeruginosa Mucin-Dependent Surfing Motility

    Article • Antimicrobial Agents and Chemotherapy, July 2018, ASM Journals

    Dr Robert E Hancock

  7. New Mouse Model for Chronic Infections by Gram-Negative Bacteria Enabling the Study of Anti-Infective Efficacy and Host-Microbe Interactions

    Article • mBio, February 2017, ASM Journals

    Dr Robert E Hancock, Dr Daniel Pletzer

  8. Antibiofilm Peptides: Potential as Broad-Spectrum Agents

    Article • Journal of Bacteriology, April 2016, ASM Journals

    Dr Robert E Hancock, Dr Daniel Pletzer

  9. Antibiofilm Peptides Increase the Susceptibility of Carbapenemase-Producing Klebsiella pneumoniae Clinical Isolates to β-Lactam Antibiotics

    Article • Antimicrobial Agents and Chemotherapy, April 2015, ASM Journals

    Octavio Franco, Dr Robert E Hancock

  10. Using anti-biofilm peptides to treat antibiotic-resistant bacterial infections

    Article • Postdoc Journal, February 2015, Postdoc Journal

    Dr Robert E Hancock

  11. D-Enantiomeric Peptides that Eradicate Wild-Type and Multidrug-Resistant Biofilms and Protect against Lethal Pseudomonas aeruginosa Infections

    Article • Chemistry & Biology, February 2015, Elsevier

    Dr Robert E Hancock

  12. Antibiotic Adjuvants: Diverse Strategies for Controlling Drug‐Resistant Pathogens

    Article • Chemical Biology & Drug Design, December 2014, Wiley

    Dr Robert E Hancock

  13. Antibiotic resistance in Pseudomonas aeruginosa biofilms: Towards the development of novel anti-biofilm therapies

    Article • Journal of Biotechnology, December 2014, Elsevier

    Dr Robert E Hancock

  14. An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation

    Article • EBioMedicine, November 2014, Elsevier

    Dr Robert E Hancock

  15. Antimicrobial Peptide Delivery from Trabecular Bone Grafts

    Article • Journal of Biomaterials and Tissue Engineering, November 2014, American Scientific Publishers

    Dr Robert E Hancock

  16. Peptide IDR-1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic-resistant bacterial infections

    Article • Journal of Peptide Science, October 2014, Wiley

    Dr Robert E Hancock

  17. Host defense peptides: front-line immunomodulators

    Article • Trends in Immunology, September 2014, Elsevier

    Dr Robert E Hancock

  18. Pseudomonas Aeruginosa Elastase Disrupts the Cortisol-Binding Activity of Corticosteroid-Binding Globulin

    Article • Endocrinology, August 2014, Endocrine Society

    Dr Robert E Hancock

  19. A Broad-Spectrum Antibiofilm Peptide Enhances Antibiotic Action against Bacterial Biofilms

    Article • Antimicrobial Agents and Chemotherapy, June 2014, ASM Journals

    Dr Robert E Hancock

  20. A Systems Biology Approach to the Analysis of Subset-Specific Responses to Lipopolysaccharide in Dendritic Cells

    Article • PLoS ONE, June 2014, PLOS

    Dr Robert E Hancock

  21. Identification of a Novel Inhibition Site in Translocase MraY Based upon the Site of Interaction with Lysis Protein E from Bacteriophage ϕX174

    Article • ChemBioChem, June 2014, Wiley

    Dr Robert E Hancock

  22. Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response

    Article • PLoS Pathogens, May 2014, PLOS

    Dr Robert E Hancock

  23. Barriers to the effective treatment of sepsis: antimicrobial agents, sepsis definitions, and host-directed therapies

    Article • Annals of the New York Academy of Sciences, May 2014, Wiley

    Dr Robert E Hancock

  24. Host Defense (Antimicrobial) Peptides and Proteins

    Article • April 2014, ASM Journals

    Dr Robert E Hancock

  25. Increased IL-8 production in human bronchial epithelial cells after exposure to azithromycin-pretreatedPseudomonas aeruginosa in vitro

    Article • FEMS Microbiology Letters, April 2014, Oxford University Press (OUP)

    Dr Robert E Hancock

  26. Skin Electroporation of a Plasmid Encoding hCAP-18/LL-37 Host Defense Peptide Promotes Wound Healing

    Article • April 2014, Elsevier

    Dr Robert E Hancock

  27. Collateral damage

    Article • Nature Biotechnology, January 2014, Springer Science + Business Media

    Dr Robert E Hancock

  28. Requirement of the Pseudomonas aeruginosa CbrA Sensor Kinase for Full Virulence in a Murine Acute Lung Infection Model

    Article • Infection and Immunity, December 2013, ASM Journals

    Dr Robert E Hancock

  29. Electrophoresis and Blotting of DNA

    Article • December 2013, Wiley

    Dr Robert E Hancock

  30. The Extra-Cytoplasmic Function Sigma Factor SigX Modulates Biofilm and Virulence-Related Properties in Pseudomonas aeruginosa

    Article • PLoS ONE, November 2013, PLOS

    Prof Eric Déziel, Dr Robert E Hancock

  31. Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

    Article • Nature Chemical Biology, November 2013, Springer Science + Business Media

    Dr Robert E Hancock

  32. Peptide design for antimicrobial and immunomodulatory applications

    Article • Biopolymers, November 2013, Wiley

    Dr Robert E Hancock

  33. Expression of an Engineered Heterologous Antimicrobial Peptide in Potato Alters Plant Development and Mitigates Normal Abiotic and Biotic Responses

    Article • PLoS ONE, October 2013, PLOS

    Dr Robert E Hancock

  34. New strategies and compounds for anti-infective treatment

    Article • Current Opinion in Microbiology, October 2013, Elsevier

    Dr Robert E Hancock

  35. Characterization of a Proteolytically Stable Multifunctional Host Defense Peptidomimetic

    Article • Chemistry & Biology, October 2013, Elsevier

    Dr Robert E Hancock

  36. Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies

    Article • Current Opinion in Microbiology, October 2013, Elsevier

    Dr Robert E Hancock

  37. Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections

    Article • Biomaterials, August 2013, Elsevier

    Dr Robert E Hancock

  38. Effect of Nitroxides on Swarming Motility and Biofilm Formation, Multicellular Behaviors in Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, July 2013, ASM Journals

    Dr Robert E Hancock

  39. Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies

    Article • Vaccine, June 2013, Elsevier

    Dr Robert E Hancock

  40. Host Defence (Antimicrobial) Peptides and Proteins

    Article • May 2013, Wiley

    Dr Robert E Hancock

  41. Identification of Genes Involved in Pseudomonas aeruginosa Biofilm-Specific Resistance to Antibiotics

    Article • PLoS ONE, April 2013, PLOS

    Dr Robert E Hancock

  42. Pseudomonas aeruginosa : new insights into pathogenesis and host defenses

    Article • Pathogens and Disease, March 2013, Oxford University Press (OUP)

    Dr Robert E Hancock

  43. Synthetic innate defense regulator peptides modulate various functions of human neutrophils

    Article • Journal of Dermatological Science, February 2013, Elsevier

    Dr Robert E Hancock

  44. Activity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6 and CP26 against Mycobacterium tuberculosis

    Article • International Journal of Antimicrobial Agents, February 2013, Elsevier

    Dr Robert E Hancock, Bruno Rivas-Santiago

  45. Genome-Wide Identification of Genes Conferring Energy Related Resistance to a Synthetic Antimicrobial Peptide (Bac8c)

    Article • PLoS ONE, January 2013, PLOS

    Dr Robert E Hancock

  46. The Liver X Receptor Agonist GW3965 Improves Recovery from Mild Repetitive Traumatic Brain Injury in Mice Partly through Apolipoprotein E

    Article • PLoS ONE, January 2013, PLOS

    Dr Robert E Hancock

  47. Synthetic Cationic Peptide IDR-1018 Modulates Human Macrophage Differentiation

    Article • PLoS ONE, January 2013, PLOS

    Dr Robert E Hancock

  48. Cathelicidins

    Article • January 2013, Elsevier

    Dr Robert E Hancock

  49. Armand-Frappier Outstanding Student Award — Role of ATP-dependent proteases in antibiotic resistance and virulence 1

    Article • Canadian Journal of Microbiology, January 2013, Canadian Science Publishing

    Dr Robert E Hancock

  50. Deciphering the Ion Selectivity of the Phosphate Specific Channel OprP from Pseudomonas Aeruginosa: A Free-Energy Molecular Dynamics Simulation Study

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Robert E Hancock

  51. Host Defense Peptides: Immune Modulation and Antimicrobial Activity In Vivo

    Article • December 2012, Springer Science + Business Media

    Dr Robert E Hancock

  52. Modeling the Ion Selectivity of the Phosphate Specific Channel OprP

    Article • The Journal of Physical Chemistry Letters, December 2012, American Chemical Society (ACS)

    Dr Robert E Hancock

  53. The Lon Protease Is Essential for Full Virulence in Pseudomonas aeruginosa

    Article • PLoS ONE, November 2012, PLOS

    Dr Robert E Hancock

  54. Impaired pulmonary defense againstPseudomonas aeruginosain VEGF gene inactivated mouse lung

    Article • Journal of Cellular Physiology, October 2012, Wiley

    Dr Robert E Hancock

  55. Characterization of the Polymyxin B Resistome of Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, October 2012, ASM Journals

    Dr Robert E Hancock

  56. Specific Association of Lectin LecB with the Surface of Pseudomonas aeruginosa: Role of Outer Membrane Protein OprF

    Article • PLoS ONE, October 2012, PLOS

    Dr Robert E Hancock

  57. The Two-Component System CprRS Senses Cationic Peptides and Triggers Adaptive Resistance in Pseudomonas aeruginosa Independently of ParRS

    Article • Antimicrobial Agents and Chemotherapy, September 2012, ASM Journals

    Dr Robert E Hancock

  58. Innate Defense Regulator Peptide 1018 in Wound Healing and Wound Infection

    Article • PLoS ONE, August 2012, PLOS

    Dr Robert E Hancock

  59. Phosphate Starvation Promotes Swarming Motility and Cytotoxicity of Pseudomonas aeruginosa

    Article • Applied and Environmental Microbiology, July 2012, ASM Journals

    Dr Robert E Hancock

  60. The Pseudomonas aeruginosa PhoP-PhoQ Two-Component Regulatory System Is Induced upon Interaction with Epithelial Cells and Controls Cytotoxicity and Inflammation

    Article • Infection and Immunity, June 2012, ASM Journals

    Dr Robert E Hancock

  61. Transcription of the oprF Gene of Pseudomonas aeruginosa Is Dependent Mainly on the SigX Sigma Factor and Is Sucrose Induced

    Article • Journal of Bacteriology, June 2012, ASM Journals

    Dr Robert E Hancock

  62. Drug release and bone growth studies of antimicrobial peptide-loaded calcium phosphate coating on titanium

    Article • Journal of Biomedical Materials Research Part B Applied Biomaterials, May 2012, Wiley

    Dr Robert E Hancock, Dr Bassam A Masri

  63. Mucin Promotes Rapid Surface Motility in Pseudomonas aeruginosa

    Article • mBio, May 2012, ASM Journals

    Dr Robert E Hancock

  64. Involvement of the Lon Protease in the SOS Response Triggered by Ciprofloxacin in Pseudomonas aeruginosa PAO1

    Article • Antimicrobial Agents and Chemotherapy, March 2012, ASM Journals

    Dr Robert E Hancock

  65. Modulating immunity as a therapy for bacterial infections

    Article • Nature Reviews Microbiology, March 2012, Springer Science + Business Media

    Dr Robert E Hancock

  66. Therapeutic Potential of Host Defense Peptides in Antibiotic-resistant Infections

    Article • Current Pharmaceutical Design, February 2012, Bentham Science Publishers

    Dr Robert E Hancock

  67. Biomembrane Interactions Reveal the Mechanism of Action of Surface-Immobilized Host Defense IDR-1010 Peptide

    Article • Chemistry & Biology, February 2012, Elsevier

    Dr Robert E Hancock

  68. Erratum: Designing antimicrobial peptides: form follows function

    Article • Nature Reviews Drug Discovery, January 2012, Springer Science + Business Media

    Dr Robert E Hancock

  69. Structure, Dynamics, and Antimicrobial and Immune Modulatory Activities of Human LL-23 and Its Single-Residue Variants Mutated on the Basis of Homologous Primate Cathelicidins

    Article • Biochemistry, January 2012, American Chemical Society (ACS)

    Dr Robert E Hancock

  70. Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection

    Article • Vaccine, January 2012, Elsevier

    Dr Robert E Hancock

  71. Synthetic Immunomodulatory Peptide IDR-1002 Enhances Monocyte Migration and Adhesion on Fibronectin

    Article • Journal of Innate Immunity, January 2012, Karger Publishers

    Dr Robert E Hancock

  72. Signaling Pathways Mediating Chemokine Induction in Keratinocytes by Cathelicidin LL-37 and Flagellin

    Article • Journal of Innate Immunity, January 2012, Karger Publishers

    Dr Robert E Hancock

  73. Immunomodulatory Cationic Peptide Therapeutics: A New Paradigm in Infection and Immunity

    Article • January 2012, American Chemical Society (ACS)

    Dr Robert E Hancock

  74. Complete Genome Sequences of Three Pseudomonas aeruginosa Isolates with Phenotypes of Polymyxin B Adaptation and Inducible Resistance

    Article • Journal of Bacteriology, December 2011, ASM Journals

    Dr Robert E Hancock

  75. Designing antimicrobial peptides: form follows function

    Article • Nature Reviews Drug Discovery, December 2011, Springer Science + Business Media

    Dr Robert E Hancock

  76. Peptide IDR-1018 attenuates the severity of DSS colitis by enhancing recruitment of non-inflammatory neutrophils with increased bacteriocidal activity

    Article • Inflammatory Bowel Diseases, December 2011, Wolters Kluwer Health

    Dr Robert E Hancock

  77. Role of Intracellular Proteases in the Antibiotic Resistance, Motility, and Biofilm Formation of Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, November 2011, ASM Journals

    Dr Robert E Hancock

  78. Pseudomonas aeruginosa: A Persistent Pathogen in Cystic Fibrosis and Hospital-Associated Infections

    Article • November 2011, Springer Science + Business Media

    Dr Robert E Hancock

  79. Local delivery of antimicrobial peptides using self-organized TiO2 nanotube arrays for peri-implant infections

    Article • Journal of Biomedical Materials Research Part A, November 2011, Wiley

    Dr Robert E Hancock

  80. Antibacterial Surfaces Based on Polymer Brushes: Investigation on the Influence of Brush Properties on Antimicrobial Peptide Immobilization and Antimicrobial Activity

    Article • Biomacromolecules, October 2011, American Chemical Society (ACS)

    Dr Robert E Hancock

  81. New insights into cathelicidin modulation of adaptive immunity

    Article • European Journal of Immunology, September 2011, Wiley

    Dr Robert E Hancock

  82. Pseudomonas aeruginosa: all roads lead to resistance

    Article • Trends in Microbiology, August 2011, Elsevier

    Dr Robert E Hancock

  83. Lipopolysaccharide Renders Transgenic Mice Expressing Human Serum Amyloid P Component Sensitive to Shiga Toxin 2

    Article • PLoS ONE, June 2011, PLOS

    Romney Humphries, Dr Robert E Hancock

  84. The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides

    Article • Biomaterials, June 2011, Elsevier

    Dr Robert E Hancock, Prof Kai Hilpert

  85. Effect of BMAP-28 Antimicrobial Peptides on Leishmania major Promastigote and Amastigote Growth: Role of Leishmanolysin in Parasite Survival

    Article • PLoS Neglected Tropical Diseases, May 2011, PLOS

    Dr Robert E Hancock

  86. Multifunctional cationic host defence peptides and their clinical applications

    Article • Cellular and Molecular Life Sciences, May 2011, Springer Science + Business Media

    Dr Robert E Hancock

  87. The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility

    Article • FEMS Microbiology Letters, May 2011, Oxford University Press (OUP)

    Dr Robert E Hancock

  88. The Human Cathelicidin, LL-37, Induces Granzyme-mediated Apoptosis in Regulatory T Cells

    Article • Journal of Immunotherapy, April 2011, Wolters Kluwer Health

    Dr Robert E Hancock

  89. The intrinsic resistome ofPseudomonas aeruginosato β-lactams

    Article • Virulence, March 2011, Taylor & Francis

    Dr Robert E Hancock

  90. Involvement of an ATP-Dependent Protease, PA0779/AsrA, in Inducing Heat Shock in Response to Tobramycin in Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, February 2011, ASM Journals

    Dr Robert E Hancock

  91. The human cathelicidin, LL-37, induces granzyme-mediated apoptosis in cytotoxic T lymphocytes

    Article • Experimental Cell Research, February 2011, Elsevier

    Dr Robert E Hancock

  92. Antibody responses in adult and neonatal BALB/c mice to immunization with novel Bordetella pertussis vaccine formulations

    Article • Vaccine, February 2011, Elsevier

    Dr Robert E Hancock

  93. Creeping baselines and adaptive resistance to antibiotics

    Article • Drug Resistance Updates, February 2011, Elsevier

    Dr Robert E Hancock

  94. The Pseudomonas aeruginosa Autoinducer 3O-C12 Homoserine Lactone Provokes Hyperinflammatory Responses from Cystic Fibrosis Airway Epithelial Cells

    Article • PLoS ONE, January 2011, PLOS

    Dr Robert E Hancock

  95. The Sensor Kinase CbrA Is a Global Regulator That Modulates Metabolism, Virulence, and Antibiotic Resistance in Pseudomonas aeruginosa

    Article • Journal of Bacteriology, December 2010, ASM Journals

    Dr Robert E Hancock

  96. The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium

    Article • American Journal of Respiratory Cell and Molecular Biology, December 2010, American Thoracic Society

    Dr Robert E Hancock

  97. Antimicrobial peptides on calcium phosphate-coated titanium for the prevention of implant-associated infections

    Article • Biomaterials, December 2010, Elsevier

    Dr Robert E Hancock

  98. Importance of Residue 13 and the C-Terminus for the Structure and Activity of the Antimicrobial Peptide Aurein 2.2

    Article • Biophysical Journal, November 2010, Elsevier

    Dr Robert E Hancock

  99. A Synthetic Adjuvant to Enhance and Expand Immune Responses to Influenza Vaccines

    Article • PLoS ONE, October 2010, PLOS

    Dr Robert E Hancock, Dr Sylvie Bertholet

  100. Optimization of Antibacterial Peptides by Genetic Algorithms and Cheminformatics

    Article • Chemical Biology & Drug Design, October 2010, Wiley

    Dr Robert E Hancock

  101. Pseudomonas Genome Database: improved comparative analysis and population genomics capability for Pseudomonas genomes

    Article • Nucleic Acids Research, October 2010, Oxford University Press (OUP)

    Dr Robert E Hancock

  102. Immunomodulators as adjuvants for vaccines and antimicrobial therapy

    Article • Annals of the New York Academy of Sciences, October 2010, Wiley

    Dr Robert E Hancock

  103. Cathelicidin Peptide LL-37 Modulates TREM-1 Expression and Inflammatory Responses to Microbial Compounds

    Article • Inflammation, September 2010, Springer Science + Business Media

    Dr Robert E Hancock

  104. Structural Studies of a Peptide with Immune Modulating and Direct Antimicrobial Activity

    Article • Chemistry & Biology, September 2010, Elsevier

    Dr Robert E Hancock, Prof Kai Hilpert

  105. Curating the innate immunity interactome

    Article • BMC Systems Biology, August 2010, Springer Science + Business Media

    Dr Robert E Hancock

  106. Genetic Determinants Involved in the Susceptibility of Pseudomonas aeruginosa to β-Lactam Antibiotics

    Article • Antimicrobial Agents and Chemotherapy, August 2010, ASM Journals

    Dr Robert E Hancock

  107. Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory System ParR-ParS

    Article • Antimicrobial Agents and Chemotherapy, June 2010, ASM Journals

    Dr Robert E Hancock

  108. Contrasting Transcriptional Responses of a Virulent and an Attenuated Strain of Mycobacterium tuberculosis Infecting Macrophages

    Article • PLoS ONE, June 2010, PLOS

    Dr Robert E Hancock

  109. Cathelicidins Link the Endocrine and Immune Systems

    Article • Cell Host & Microbe, April 2010, Elsevier

    Dr Robert E Hancock

  110. Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity

    Article • Journal of Translational Medicine, January 2010, Springer Science + Business Media

    Dr Robert E Hancock

  111. Structural Studies of An Immune Modulating and Direct Antimicrobial Peptide

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Robert E Hancock

  112. Systems-Level Analyses of the Mammalian Innate Immune Response

    Article • January 2010, Springer Science + Business Media

    Dr Robert E Hancock

  113. G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9

    Article • Cellular Immunology, January 2010, Elsevier

    Dr Robert E Hancock, Dr Karsten Hokamp

  114. Understanding the Importance of Residue 13 and the C-terminus on the Structure and Activity of the Amphibian Antimicrobial Peptide, Aurein 2.2

    Article • Biophysical Journal, January 2010, Elsevier

    Dr Robert E Hancock

  115. Systems-Level Comparison of Host-Responses Elicited by Avian H5N1 and Seasonal H1N1 Influenza Viruses in Primary Human Macrophages

    Article • PLoS ONE, December 2009, PLOS

    Dr Robert E Hancock

  116. Potential of immunomodulatory host defense peptides as novel anti-infectives

    Article • Trends in Biotechnology, October 2009, Elsevier

    Dr Robert E Hancock

  117. Therapeutic Potential of HDPs as Immunomodulatory Agents

    Article • September 2009, Springer Science + Business Media

    Dr Robert E Hancock

  118. Low concentrations of LL-37 alter IL-8 production by keratinocytes and bronchial epithelial cells in response to proinflammatory stimuli

    Article • FEMS Immunology & Medical Microbiology, August 2009, Oxford University Press (OUP)

    Dr Robert E Hancock

  119. Involvement of pmrAB and phoPQ in Polymyxin B Adaptation and Inducible Resistance in Non-Cystic Fibrosis Clinical Isolates of Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, July 2009, ASM Journals

    Dr Robert E Hancock

  120. Swarming of Pseudomonas aeruginosa Is Controlled by a Broad Spectrum of Transcriptional Regulators, Including MetR

    Article • Journal of Bacteriology, July 2009, ASM Journals

    Dr Robert E Hancock

  121. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity

    Article • Vaccine, July 2009, Elsevier

    Dr Robert E Hancock

  122. The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically regulated, cation-selective channel

    Article • FEMS Microbiology Letters, July 2009, Oxford University Press (OUP)

    Dr Robert E Hancock

  123. Enabling a systems biology approach to immunology: focus on innate immunity

    Article • Trends in Immunology, June 2009, Elsevier

    Dr Robert E Hancock

  124. Identification of Novel Antibacterial Peptides by Chemoinformatics and Machine Learning †

    Article • Journal of Medicinal Chemistry, April 2009, American Chemical Society (ACS)

    Dr Robert E Hancock, Prof Kai Hilpert

  125. Regulation of virulence and antibiotic resistance by two-component regulatory systems inPseudomonas aeruginosa

    Article • FEMS Microbiology Reviews, March 2009, Oxford University Press (OUP)

    Dr Robert E Hancock

  126. Strategies to link innate and adaptive immunity when designing vaccine adjuvants

    Article • Veterinary Immunology and Immunopathology, March 2009, Elsevier

    Dr Robert E Hancock

  127. The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa

    Article • Microbiology, March 2009, Society for General Microbiology

    Dr Robert E Hancock

  128. Killing of Trypanosomatid Parasites by a Modified Bovine Host Defense Peptide, BMAP-18

    Article • PLoS Neglected Tropical Diseases, February 2009, PLOS

    Dr Robert E Hancock

  129. Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs

    Article • ACS Chemical Biology, January 2009, American Chemical Society (ACS)

    Dr Robert E Hancock, Prof Kai Hilpert

  130. Gramicidin S is active against both gram-positive and gram-negative bacteria

    Article • International journal of peptide & protein research, January 2009, Wiley

    Dr Robert E Hancock

  131. Host Defense Peptides in Fish

    Article • January 2009, Taylor & Francis

    Dr Robert E Hancock

  132. Effects of net charge and the number of positively charged residues on the biological activity of amphipathic α-helical cationic antimicrobial peptides

    Article • January 2009, Springer Science + Business Media

    Michael Vasil, Dr Robert E Hancock

  133. Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells

    Article • Molecular BioSystems, January 2009, Royal Society of Chemistry

    Dr Robert E Hancock

  134. Antibiotic Resistance Due to Reduced Uptake

    Article • January 2009, Springer Science + Business Media

    Dr Robert E Hancock

  135. The roles of cathelicidin LL-37 in immune defences and novel clinical applications

    Article • Current Opinion in Hematology, January 2009, Wolters Kluwer Health

    Dr Robert E Hancock

  136. Effect of Membrane Composition on Antimicrobial Peptides Aurein 2.2 and 2.3 From Australian Southern Bell Frogs

    Article • Biophysical Journal, January 2009, Elsevier

    Dr Robert E Hancock

  137. Synthesis of Peptide Arrays Using SPOT-Technology and the CelluSpots-Method

    Article • January 2009, Springer Science + Business Media

    Dr Robert E Hancock, Prof Kai Hilpert

  138. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes

    Article • Nucleic Acids Research, January 2009, Oxford University Press (OUP)

    Dr Robert E Hancock

  139. Novel anti-infectives: is host defence the answer?

    Article • Current Opinion in Biotechnology, December 2008, Elsevier

    Dr Robert E Hancock

  140. Effects of Hydrophobicity on the Antifungal Activity of α‐Helical Antimicrobial Peptides

    Article • Chemical Biology & Drug Design, November 2008, Wiley

    Michael Vasil, Dr Robert E Hancock

  141. Host Defence Peptide LL-37 Induces IL-6 Expression in Human Bronchial Epithelial Cells by Activation of the NF-κB Signaling Pathway

    Article • Journal of Innate Immunity, November 2008, Karger Publishers

    Dr Robert E Hancock

  142. Complex Ciprofloxacin Resistome Revealed by Screening a Pseudomonas aeruginosa Mutant Library for Altered Susceptibility

    Article • Antimicrobial Agents and Chemotherapy, September 2008, ASM Journals

    Dr Robert E Hancock

  143. Novel Genetic Determinants of Low-Level Aminoglycoside Resistance in Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, September 2008, ASM Journals

    Dr Robert E Hancock

  144. Neutrophil Elastase Mediates Innate Host Protection against Pseudomonas aeruginosa

    Article • The Journal of Immunology, September 2008, The American Association of Immunologists

    Dr Robert E Hancock

  145. Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin

    Article • Antiviral Research, September 2008, Elsevier

    Dr Robert E Hancock

  146. Lipid-specific binding of the calcium-dependent antibiotic daptomycin leads to changes in lipid polymorphism of model membranes

    Article • Chemistry and Physics of Lipids, August 2008, Elsevier

    Dr Robert E Hancock

  147. Mutator Genes Giving Rise to Decreased Antibiotic Susceptibility in Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, July 2008, ASM Journals

    Dr Robert E Hancock

  148. Induction by Cationic Antimicrobial Peptides and Involvement in Intrinsic Polymyxin and Antimicrobial Peptide Resistance, Biofilm Formation, and Swarming Motility of PsrA in Pseudomonas aeruginosa

    Article • Journal of Bacteriology, June 2008, ASM Journals

    Dr Robert E Hancock

  149. Genome sequence of a cystic fibrosis epidemic strain of Pseudomonas aeruginosa

    Article • Journal of Cystic Fibrosis, June 2008, Elsevier

    Dr Robert E Hancock, Dr Catherine Paradis-Bleau

  150. Identification of novel host defense peptides and the absence of α-defensins in the bovine genome

    Article • Proteins Structure Function and Bioinformatics, April 2008, Wiley

    Dr Robert E Hancock, Prof Kai Hilpert

  151. Swarming of Pseudomonas aeruginosa Is a Complex Adaptation Leading to Increased Production of Virulence Factors and Antibiotic Resistance

    Article • Journal of Bacteriology, February 2008, ASM Journals

    Dr Robert E Hancock

  152. Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

    Article • Nature Protocols, January 2008, Springer Science + Business Media

    Dr Robert E Hancock, Prof Kai Hilpert

  153. Effects of net charge and the number of positively charged residues on the biological activity of amphipathic α‐helical cationic antimicrobial peptides

    Article • Biopolymers, January 2008, Wiley

    Michael Vasil, Dr Robert E Hancock

  154. Neutrophil-Derived Defensins as Modulators of Innate Immune Function

    Article • Critical Reviews™ in Immunology, January 2008, Begell House

    Dr Robert E Hancock

  155. X-ray spectromicroscopy study of competitive adsorption of protein and peptide onto polystyrene-poly(methyl methacrylate)

    Article • Biointerphases, January 2008, American Vacuum Society

    Dr Robert E Hancock, Prof Kai Hilpert

  156. Pseudomonas 2007

    Article • Journal of Bacteriology, December 2007, ASM Journals

    Dr Robert E Hancock

  157. Alternative mechanisms of action of cationic antimicrobial peptides on bacteria

    Article • Expert Review of Anti-infective Therapy, December 2007, Taylor & Francis

    Dr Robert E Hancock

  158. NMR structural studies of the antibiotic lipopeptide daptomycin in DHPC micelles

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, December 2007, Elsevier

    Dr Robert E Hancock

  159. The complexities of antibiotic action

    Article • Molecular Systems Biology, October 2007, EMBO

    Dr Robert E Hancock

  160. Role of Lon, an ATP-Dependent Protease Homolog, in Resistance of Pseudomonas aeruginosa to Ciprofloxacin

    Article • Antimicrobial Agents and Chemotherapy, September 2007, ASM Journals

    Dr Robert E Hancock

  161. Cathelicidins and functional analogues as antisepsis molecules

    Article • Expert Opinion on Therapeutic Targets, July 2007, Informa Healthcare

    Dr Robert E Hancock

  162. Antimicrobial, Host Defence Peptides and Proteins

    Article • July 2007, Wiley

    Dr Robert E Hancock

  163. Using Intrinsic X-ray Absorption Spectral Differences To Identify and Map Peptides and Proteins

    Article • The Journal of Physical Chemistry, July 2007, American Chemical Society (ACS)

    Dr Robert E Hancock, Prof Kai Hilpert

  164. Use of luminescent bacteria for rapid screening and characterization of short cationic antimicrobial peptides synthesized on cellulose using peptide array technology

    Article • Nature Protocols, June 2007, Springer Science + Business Media

    Dr Robert E Hancock, Prof Kai Hilpert

  165. Complexities of targeting innate immunity to treat infection

    Article • Trends in Immunology, June 2007, Elsevier

    Dr Robert E Hancock

  166. Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion

    Article • Nature Protocols, May 2007, Springer Science + Business Media

    Dr Robert E Hancock, Prof Kai Hilpert

  167. Characterization of the Structure and Membrane Interaction of the Antimicrobial Peptides Aurein 2.2 and 2.3 from Australian Southern Bell Frogs

    Article • Biophysical Journal, April 2007, Elsevier

    Dr Robert E Hancock

  168. Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-κB

    Article • European Journal of Immunology, April 2007, Wiley

    Dr Robert E Hancock

  169. An anti-infective peptide that selectively modulates the innate immune response

    Article • Nature Biotechnology, March 2007, Springer Science + Business Media

    Dr Robert E Hancock

  170. Antiviral indolicidin variant peptides: Evaluation for broad-spectrum disease resistance in transgenic Nicotiana tabacum

    Article • Plant Science, March 2007, Elsevier

    Dr Robert E Hancock

  171. The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility

    Article • Microbiology, February 2007, Society for General Microbiology

    Dr Robert E Hancock

  172. Fluorescent Probes Alter Miscibility Phase Boundaries in Ternary Vesicles

    Article • The Journal of Physical Chemistry, January 2007, American Chemical Society (ACS)

    Dr Robert E Hancock

  173. Cellulose-bound Peptide Arrays: Preparation and Applications

    Article • Biotechnology and Genetic Engineering Reviews, January 2007, Taylor & Francis

    Dr Robert E Hancock

  174. An arginine ladder in OprP mediates phosphate-specific transfer across the outer membrane

    Article • Nature Structural & Molecular Biology, December 2006, Springer Science + Business Media

    Dr Robert E Hancock

  175. The end of an era?

    Article • Nature Reviews Drug Discovery, December 2006, Springer Science + Business Media

    Dr Robert E Hancock

  176. Identification of Genes Involved in Swarming Motility Using a Pseudomonas aeruginosa PAO1 Mini-Tn5-lux Mutant Library

    Article • Journal of Bacteriology, December 2006, ASM Journals

    Dr Robert E Hancock

  177. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

    Article • Nature Biotechnology, December 2006, Springer Science + Business Media

    Dr Robert E Hancock

  178. Characterization of OpdH, a Pseudomonas aeruginosa Porin Involved in the Uptake of Tricarboxylates

    Article • Journal of Bacteriology, November 2006, ASM Journals

    Dr Robert E Hancock

  179. Sequence Requirements and an Optimization Strategy for Short Antimicrobial Peptides

    Article • Chemistry & Biology, October 2006, Elsevier

    Dr Robert E Hancock, Prof Kai Hilpert

  180. Involvement of two related porins, OprD and OpdP, in the uptake of arginine by Pseudomonas aeruginosa

    Article • FEMS Microbiology Letters, July 2006, Oxford University Press (OUP)

    Dr Robert E Hancock

  181. Contribution of the PhoP-PhoQ and PmrA-PmrB Two-Component Regulatory Systems to Mg2+-Induced Gene Regulation in Pseudomonas aeruginosa

    Article • Journal of Bacteriology, June 2006, ASM Journals

    Dr Robert E Hancock

  182. Host defence peptides from invertebrates – emerging antimicrobial strategies

    Article • Immunobiology, June 2006, Elsevier

    Dr Robert E Hancock

  183. Apoptosis of Airway Epithelial Cells

    Article • American Journal of Respiratory Cell and Molecular Biology, April 2006, American Thoracic Society

    Dr Robert E Hancock

  184. Cationic host defense (antimicrobial) peptides

    Article • Current Opinion in Immunology, February 2006, Elsevier

    Dr Robert E Hancock

  185. Utilization of alkaline phosphatase fusions to identify secreted proteins, including potential efflux proteins and virulence factors from Helicobacter pylori

    Article • FEMS Microbiology Letters, January 2006, Oxford University Press (OUP)

    Dr Robert E Hancock

  186. Role of the Novel OprD Family of Porins in Nutrient Uptake in Pseudomonas aeruginosa

    Article • Journal of Bacteriology, January 2006, ASM Journals

    Dr Robert E Hancock

  187. Solution Structure and Interaction of the Antimicrobial Polyphemusins with Lipid Membranes † , ‡

    Article • Biochemistry, November 2005, American Chemical Society (ACS)

    Dr Robert E Hancock

  188. Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance

    Article • Drug Discovery Today, September 2005, Elsevier

    Dr Robert E Hancock

  189. Ciprofloxacin Induction of a Susceptibility Determinant in Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, August 2005, ASM Journals

    Dr Robert E Hancock

  190. Salmonella’s Sensor for Host Defense Molecules

    Article • Cell, August 2005, Elsevier

    Dr Robert E Hancock

  191. Anti-endotoxin properties of cationic host defence peptides and proteins

    Article • Journal of Endotoxin Research, August 2005, SAGE Publications

    Dr Robert E Hancock

  192. High-throughput generation of small antibacterial peptides with improved activity

    Article • Nature Biotechnology, July 2005, Springer Science + Business Media

    Dr Robert E Hancock, Prof Kai Hilpert

  193. Porins of the Outer Membrane of Pseudomonas aeruginosa

    Article • June 2005, Wiley

    Dr Robert E Hancock

  194. Design of Host Defence Peptides for Antimicrobial and Immunity Enhancing Activities

    Article • Combinatorial Chemistry & High Throughput Screening, May 2005, Bentham Science Publishers

    Dr Robert E Hancock

  195. Mechanisms of action of newer antibiotics for Gram-positive pathogens

    Article • The Lancet Infectious Diseases, April 2005, Elsevier

    Dr Robert E Hancock

  196. A Re-evaluation of the Role of Host Defence Peptides in Mammalian Immunity

    Article • Current Protein and Peptide Science, February 2005, Bentham Science Publishers

    Dr Robert E Hancock

  197. Function and therapeutic potential of host defence peptides

    Article • Journal of Peptide Science, January 2005, Wiley

    Dr Robert E Hancock

  198. Structural Transitions as Determinants of the Action of the Calcium-Dependent Antibiotic Daptomycin

    Article • Chemistry & Biology, July 2004, Elsevier

    Dr Robert E Hancock

  199. Can innate immunity be enhanced to treat microbial infections?

    Article • Nature Reviews Microbiology, June 2004, Springer Science + Business Media

    Dr Robert E Hancock

  200. Structure–activity relationships for the β-hairpin cationic antimicrobial peptide polyphemusin I

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, May 2004, Elsevier

    Dr Robert E Hancock

  201. Transgenic Potatoes Expressing a Novel Cationic Peptide are Resistant to Late Blight and Pink Rot

    Article • Transgenic Research, April 2004, Springer Science + Business Media

    Dr Robert E Hancock

  202. Electrophoresis and Blotting of DNA

    Article • March 2004, Wiley

    Dr Robert E Hancock

  203. The Outer Membranes of Pseudomonads

    Article • January 2004, Springer Science + Business Media

    Dr Robert E Hancock

  204. Delivery of liposomes in dry powder form: aerodynamic dispersion properties

    Article • European Journal of Pharmaceutical Sciences, December 2003, Elsevier

    Dr Robert E Hancock

  205. Structure-Based Design of an Indolicidin Peptide Analogue with Increased Protease Stability † , ‡

    Article • Biochemistry, December 2003, American Chemical Society (ACS)

    Dr Robert E Hancock

  206. Cationic Antimicrobial Peptide Killing of African Trypanosomes and Sodalis glossinidius , a Bacterial Symbiont of the Insect Vector of Sleeping Sickness

    Article • Vector-Borne and Zoonotic Diseases, December 2003, Mary Ann Liebert Inc

    Dr Robert E Hancock

  207. Robert E W Hancock–boosting innate immunity to combat infection

    Article • The Lancet Infectious Diseases, November 2003, Elsevier

    Dr Robert E Hancock

  208. The relationship between peptide structure and antibacterial activity

    Article • Peptides, November 2003, Elsevier

    Dr Robert E Hancock

  209. Membrane binding and permeation by indolicidin analogs studied by a biomimetic lipid/polydiacetylene vesicle assay

    Article • Peptides, November 2003, Elsevier

    Dr Robert E Hancock

  210. Role of Pseudomonas putida tol-oprL Gene Products in Uptake of Solutes through the Cytoplasmic Membrane

    Article • Journal of Bacteriology, August 2003, ASM Journals

    Dr Robert E Hancock

  211. Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa

    Article • Molecular Microbiology, August 2003, Wiley

    Dr Robert E Hancock

  212. Aminoglycoside Efflux in Pseudomonas aeruginosa: Involvement of Novel Outer Membrane Proteins

    Article • Antimicrobial Agents and Chemotherapy, March 2003, ASM Journals

    Dr Robert E Hancock

  213. Bacterial biofilms of importance to medicine and bioterrorism: proteomic techniques to identify novel vaccine components and drug targets

    Article • Expert Opinion on Biological Therapy, January 2003, Informa Healthcare

    Dr Robert E Hancock

  214. Function ofPseudomonasPorins in Uptake and Efflux

    Article • Annual Review of Microbiology, October 2002, Annual Reviews

    Dr Robert E Hancock

  215. Pseudomonas aeruginosa outer membrane protein F is an adhesin in bacterial binding to lung epithelial cells in culture

    Article • Microbial Pathogenesis, September 2002, Elsevier

    Dr Robert E Hancock

  216. Biotechnological approaches for l-ascorbic acid production

    Article • Trends in Biotechnology, July 2002, Elsevier

    Dr Robert E Hancock

  217. Multidrug Efflux Systems Play an Important Role in the Invasiveness of Pseudomonas aeruginosa

    Article • The Journal of Experimental Medicine, July 2002, Rockefeller University Press

    Dr Robert E Hancock

  218. Cationic Peptides: Distribution and Mechanisms of Resistance

    Article • Current Pharmaceutical Design, April 2002, Bentham Science Publishers

    Dr Robert E Hancock

  219. Role of membranes in the activities of antimicrobial cationic peptides

    Article • FEMS Microbiology Letters, January 2002, Oxford University Press (OUP)

    Dr Robert E Hancock

  220. TheVibrio fischeri sapABCDF locus is required for normal growth, both in culture and in symbiosis

    Article • Archives of Microbiology, January 2002, Springer Science + Business Media

    Dr Robert E Hancock

  221. Insect Cationic Antimicrobial Peptides

    Article • December 2001, Taylor & Francis

    Dr Robert E Hancock

  222. Cationic peptides: effectors in innate immunity and novel antimicrobials

    Article • The Lancet Infectious Diseases, October 2001, Elsevier

    Dr Robert E Hancock

  223. In Vitro Aerosol Delivery and Regional Airway Surface Liquid Concentration of a Liposomal Cationic Peptide

    Article • Journal of Pharmaceutical Sciences, October 2001, Elsevier

    Dr Robert E Hancock

  224. Determination of Membrane Immersion Depth with O2: A High-Pressure 19F NMR Study

    Article • Biophysical Journal, March 2001, Elsevier

    Dr Robert E Hancock

  225. Disruption of the β-Sheet Structure of Cyclic Peptides by Single Amino Acid Substitution: Influence on Prokaryotic and Eukaryotic Cell Viability

    Article • January 2001, Springer Science + Business Media

    Michael Vasil, Dr Robert E Hancock

  226. Evaluation of a Structural Model ofPseudomonas aeruginosa Outer Membrane Protein OprM, an Efflux Component Involved in Intrinsic Antibiotic Resistance

    Article • Journal of Bacteriology, January 2001, ASM Journals

    Dr Robert E Hancock

  227. Interactions of Bacterial Cationic Peptide Antibiotics with Outer and Cytoplasmic Membranes of Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, December 2000, ASM Journals

    Dr Robert E Hancock

  228. The Amino Terminus of Pseudomonas aeruginosa Outer Membrane Protein OprF Forms Channels in Lipid Bilayer Membranes: Correlation with a Three-Dimensional Model

    Article • Journal of Bacteriology, December 2000, ASM Journals

    Dr Robert E Hancock

  229. Structure of the Bovine Antimicrobial Peptide Indolicidin Bound to Dodecylphosphocholine and Sodium Dodecyl Sulfate Micelles † , ‡

    Article • Biochemistry, December 2000, American Chemical Society (ACS)

    Dr Robert E Hancock

  230. Interaction of Polyphemusin I and Structural Analogs with Bacterial Membranes, Lipopolysaccharide, and Lipid Monolayers †

    Article • Biochemistry, November 2000, American Chemical Society (ACS)

    Dr Robert E Hancock

  231. The Amino Terminus of Pseudomonas aeruginosaOuter Membrane Protein OprF Forms Channels in Lipid Bilayer Membranes: Correlation with a Three-Dimensional Model

    Article • Journal of Bacteriology, September 2000, ASM Journals

    Dr Robert E Hancock

  232. The role of cationic antimicrobial peptides in innate host defences

    Article • Trends in Microbiology, September 2000, Elsevier

    Dr Robert E Hancock

  233. Action of lysozyme and nisin mixtures against lactic acid bacteria

    Article • International Journal of Food Microbiology, September 2000, Elsevier

    Dr Robert E Hancock

  234. Cationic antimicrobial peptides: towards clinical applications

    Article • Expert Opinion on Investigational Drugs, August 2000, Informa Healthcare

    Dr Robert E Hancock

  235. Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment

    Article • Drug Resistance Updates, August 2000, Elsevier

    Dr Robert E Hancock

  236. Role of Putative Loops 2 and 3 in Imipenem Passage through the Specific Porin OprD of Pseudomonas aeruginosa

    Article • Antimicrobial Agents and Chemotherapy, July 2000, ASM Journals

    Dr Robert E Hancock

  237. Insertion Mutagenesis and Membrane Topology Model of the Pseudomonas aeruginosa Outer Membrane Protein OprM

    Article • Journal of Bacteriology, May 2000, ASM Journals

    Dr Robert E Hancock

  238. Antibiotic Resistance and Survival in the Host

    Article • January 2000, ASM Journals

    Dr Robert E Hancock

  239. Cationic Antimicrobial Peptides and Their Multifunctional Role in the Immune System

    Article • Critical Reviews™ in Immunology, January 2000, Begell House

    Dr Robert E Hancock

  240. PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and polymyxin B resistance

    Article • Molecular Microbiology, October 1999, Wiley

    Dr Robert E Hancock

  241. Mechanism of Interaction of Different Classes of Cationic Antimicrobial Peptides with Planar Bilayers and with the Cytoplasmic Membrane of Escherichia coli †

    Article • Biochemistry, June 1999, American Chemical Society (ACS)

    Dr Robert E Hancock

  242. Influence of Proline Residues on the Antibacterial and Synergistic Activities of α-Helical Peptides †

    Article • Biochemistry, June 1999, American Chemical Society (ACS)

    Dr Robert E Hancock

  243. Identification of oprG, a gene encoding a major outer membrane protein of Pseudomonas aeruginosa

    Article • Journal of Antimicrobial Chemotherapy, April 1999, Oxford University Press (OUP)

    Dr Robert E Hancock

  244. Host Defence (Cationic) Peptides

    Article • Drugs, January 1999, Springer Science + Business Media

    Dr Robert E Hancock

  245. Are we approaching the end of the antibiotic era?

    Article • Current Opinion in Microbiology, October 1998, Elsevier

    Dr Robert E Hancock

  246. Resistance Mechanisms in Pseudomonas aeruginosa and Other Nonfermentative Gram‐Negative Bacteria

    Article • Clinical Infectious Diseases, August 1998, Oxford University Press (OUP)

    Dr Robert E Hancock

  247. Structural Variations in Nisin Associated with Different Membrane Mimicking and pH Environments

    Article • Biochemical and Biophysical Research Communications, June 1998, Elsevier

    Professor Gary A Dykes, Dr Robert E Hancock, Gary Dykes

  248. Helicobacter pylori: A surprisingly conserved bacterium

    Article • Nature Biotechnology, March 1998, Springer Science + Business Media

    Dr Robert E Hancock

  249. Cationic peptides: a new source of antibiotics

    Article • Trends in Biotechnology, February 1998, Elsevier

    Dr Robert E Hancock

  250. The therapeutic potential of cationic peptides

    Article • Expert Opinion on Investigational Drugs, February 1998, Informa Healthcare

    Dr Robert E Hancock

  251. Outer Membrane Proteins

    Article • January 1998, Springer Science + Business Media

    Dr Robert E Hancock

  252. Pseudomonas Aeruginosa: Infection and Immunity

    Article • January 1998, Elsevier

    Dr Robert E Hancock

  253. Cationic Peptides

    Article • July 1997, Taylor & Francis

    Dr Robert E Hancock

  254. Peptide antibiotics

    Article • The Lancet, February 1997, Elsevier

    Dr Robert E Hancock

  255. Role of gyrA mutation and loss of OprF in the multiple antibiotic resistance phenotype of Pseudomonas aeruginosa G49

    Article • FEMS Microbiology Letters, September 1996, Oxford University Press (OUP)

    Dr Robert E Hancock

  256. The Role of Specific Lysine Residues in the Passage of Anions through the Pseudomonas aeruginosa Porin OprP

    Article • Journal of Biological Chemistry, August 1996, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Robert E Hancock

  257. The effect of the length of a malarial epitope on its antigenicity and immunogenicity in an epitope presentation system using the Pseudomonas aeruginosa outer membrane protein OprF as the carrier

    Article • FEMS Microbiology Letters, July 1996, Oxford University Press (OUP)

    Dr Robert E Hancock

  258. Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome

    Article • Microbiology, January 1996, Society for General Microbiology

    Dr Robert E Hancock

  259. Cloning and characterization of the Pseudomonas aeruginosa pbpB gene encoding penicillin-binding protein 3

    Article • Antimicrobial Agents and Chemotherapy, August 1995, ASM Journals

    Dr Robert E Hancock

  260. Membrane topology and site-specific mutagenesis of Pseudomonas aeruginosa porin OprD

    Article • Molecular Microbiology, June 1995, Wiley

    Dr Robert E Hancock

  261. Development of multiple-antibiotic-resistant (Mar) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones

    Article • Antimicrobial Agents and Chemotherapy, February 1995, ASM Journals

    Dr Robert E Hancock

  262. Pseudomonas aeruginosa outer membrane protein OprF as an expression vector for foreign epitopes: the effects of positioning and length on the antigenicity of the epitope

    Article • Gene, January 1995, Elsevier

    Dr Robert E Hancock

  263. The interaction of a recombinant cecropin/melittin hybrid peptide with the outer membrane ofPseudomonas aeruginosa

    Article • Molecular Microbiology, June 1994, Wiley

    Dr Robert E Hancock

  264. Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria

    Article • Gene, November 1993, Elsevier

    Dr Robert E Hancock

  265. Synthesis of bulky .beta.-lactams for inhibition of cell surface .beta.-lactamase activity

    Article • Bioconjugate Chemistry, November 1993, American Chemical Society (ACS)

    Dr Robert E Hancock, Professor Desiree Nedra Karunaratne

  266. Conservation of surface epitopes in Pseudomonas aeruginosa outer membrane porin protein OprF

    Article • FEMS Microbiology Letters, November 1993, Oxford University Press (OUP)

    Dr Robert E Hancock

  267. Linker-insertion mutagenesis ofPseudomonas aeruginosaouter membrane protein OprF

    Article • Molecular Microbiology, October 1993, Wiley

    Dr Robert E Hancock

  268. Anion transport through the phosphate-specific OprP-channel of the Pseudomonas aeruginosa outer membrane: effects of phosphate, di-and tribasic anions and of negatively-charged lipids

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 1993, Elsevier

    Dr Robert E Hancock

  269. Mechanism of uptake of deglucoteicoplanin amide derivatives across outer membranes of Escherichia coli and Pseudomonas aeruginosa.

    Article • Antimicrobial Agents and Chemotherapy, March 1993, ASM Journals

    Dr Robert E Hancock

  270. Susceptibility and Resistance of Pseudomonas aeruginosa to Antimicrobial Agents

    Article • January 1993, Springer Science + Business Media

    Dr Robert E Hancock

  271. Characterization of lipid A from Pseudomonas aeruginosa O-antigenic B band lipopolysaccharide by 1D and 2D NMR and mass spectral analysis

    Article • Archives of Biochemistry and Biophysics, December 1992, Elsevier

    Dr Robert E Hancock

  272. Fluoroquinolone supersusceptibility mediated by outer membrane protein OprH overexpression in Pseudomonas aeruginosa: evidence for involvement of a nonporin pathway.

    Article • Antimicrobial Agents and Chemotherapy, November 1992, ASM Journals

    Dr Robert E Hancock

  273. Role of Pseudomonas aeruginosa outer membrane protein OprH in polymyxin and gentamicin resistance: isolation of an OprH-deficient mutant by gene replacement techniques.

    Article • Antimicrobial Agents and Chemotherapy, November 1992, ASM Journals

    Dr Robert E Hancock

  274. Analysis of two gene regions involved in the expression of the imipenem-specific, outer membrane porin protein OprD of Pseudomonas aeruginosa

    Article • FEMS Microbiology Letters, October 1992, Oxford University Press (OUP)

    Dr Robert E Hancock

  275. Polyphosphate-selective porin OprO of Pseudomonas aeruginosa: expression, purification and sequence

    Article • Molecular Microbiology, August 1992, Wiley

    Dr Robert E Hancock

  276. A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa.

    Article • Antimicrobial Agents and Chemotherapy, May 1992, ASM Journals

    Dr Robert E Hancock

  277. Extracellular lipase from Pseudomonas aeruginosa is an amphiphilic protein

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, April 1992, Elsevier

    Dr Robert E Hancock

  278. Antibiotic uptake: unusual results for unusual molecules

    Article • Journal of Antimicrobial Chemotherapy, January 1992, Oxford University Press (OUP)

    Dr Robert E Hancock

  279. Influence of outer membrane mutations on susceptibility of Escherichia coli to the dibasic macrolide azithromycin

    Article • Journal of Antimicrobial Chemotherapy, January 1992, Oxford University Press (OUP)

    Dr Robert E Hancock

  280. Expression in Caulobacter crescentus of the phosphate-starvation-inducible porin OprP of Pseudomonas aeruginosa

    Article • FEMS Microbiology Letters, January 1991, Oxford University Press (OUP)

    Dr Robert E Hancock

  281. Outer membrane proteins of Pseudomonas

    Article • Molecular Microbiology, July 1990, Wiley

    Dr Robert E Hancock

  282. Sequence and relatedness in other bacteria of the Pseudomonas aeruginosa oprP gene coding for the phosphate-specific porin P

    Article • Molecular Microbiology, May 1990, Wiley

    Dr Robert E Hancock

  283. Determinants of the efficacy of tobramycin therapy against isogenic nonmucoid and mucoid derivatives of Pseudomonas aeruginosa PAO1 growing in peritoneal chambers in mice.

    Article • Antimicrobial Agents and Chemotherapy, August 1989, ASM Journals

    Dr Robert E Hancock

  284. Gene cloning and expression of the Pseudomonas aeruginosa periplasmic phosphate-binding protein

    Article • FEMS Microbiology Letters, August 1988, Oxford University Press (OUP)

    Dr Robert E Hancock

  285. Roles of Porin and  -Lactamase in  -Lactam Resistance of Pseudomonas aeruginosa

    Article • Clinical Infectious Diseases, July 1988, Oxford University Press (OUP)

    Dr Robert E Hancock

  286. Enhanced binding of polycationic antibiotics to lipopolysaccharide from an aminoglycoside-supersusceptible, tolA mutant strain of Pseudomonas aeruginosa.

    Article • Antimicrobial Agents and Chemotherapy, May 1988, ASM Journals

    Dr Robert E Hancock

  287. Regulation of components of the Pseudomonas aeruginosa phosphate-starvation-inducible regulon in Escherichia coli

    Article • Molecular Microbiology, May 1988, Wiley

    Dr Robert E Hancock

  288. Large-scale purification and biochemical characterization of crystallization-grade porin protein P from Pseudomonas aeruginosa

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, April 1988, Elsevier

    Dr Robert E Hancock

  289. The hydrophobic uptake pathway across the outer membrane of the antibiotic supersusceptible Pseudomonas aeruginosa mutant Z61

    Article • FEMS Microbiology Letters, December 1987, Oxford University Press (OUP)

    Dr Robert E Hancock

  290. An Immunohistological Evaluation of Pseudomonas aeruginosa Pulmonary Infection in Two Patients with Cystic Fibrosis

    Article • Pediatric Research, December 1987, Springer Science + Business Media

    Dr Robert E Hancock

  291. Mapping and Characterization of Two Mutations to Antibiotic Supersusceptibility in Pseudomonas aeruginosa

    Article • Microbiology, October 1987, Society for General Microbiology

    Dr Robert E Hancock

  292. Role of beta-lactamase in in vivo development of ceftazidime resistance in experimental Pseudomonas aeruginosa endocarditis.

    Article • Antimicrobial Agents and Chemotherapy, February 1987, ASM Journals

    Dr Robert E Hancock

  293. Role of porins in intrinsic antibiotic resistance of Pseudomonas cepacia.

    Article • Antimicrobial Agents and Chemotherapy, January 1987, ASM Journals

    Dr Robert E Hancock

  294. Phosphate-selective porins from the outer membranes of fluorescent Pseudomonas sp.

    Article • Canadian Journal of Microbiology, January 1987, Canadian Science Publishing

    Dr Robert E Hancock

  295. Involvement of outer membrane of Pseudomonas cepacia in aminoglycoside and polymyxin resistance.

    Article • Antimicrobial Agents and Chemotherapy, December 1986, ASM Journals

    Dr Robert E Hancock

  296. Demonstration and chemical modification of a specific phosphate binding site in the phosphate-starvation-inducible outer membrane porin protein P of Pseudomonas aeruginosa

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, September 1986, Elsevier

    Dr Robert E Hancock

  297. Role of lysines in ion selectivity of bacterial outer membrane porins

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 1986, Elsevier

    Dr Robert E Hancock

  298. Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl-polymyxin.

    Article • Antimicrobial Agents and Chemotherapy, March 1986, ASM Journals

    Dr Robert E Hancock

  299. Isolation of a Tn501 insertion mutant lacking porin protein P of Pseudomonas aeruginosa

    Article • MGG Molecular & General Genetics, March 1986, Springer Science + Business Media

    Dr Robert E Hancock

  300. Outer Membrane Permeability of Pseudomonas aeruginosa

    Article • January 1986, Elsevier

    Dr Robert E Hancock

  301. Intrinsic antibiotic resistance of Pseudomonas aeruginosa

    Article • Journal of Antimicrobial Chemotherapy, January 1986, Oxford University Press (OUP)

    Dr Robert E Hancock

  302. Monoclonal Antibody for an Outer Membrane Lipoprotein of the Pseudomonas fluorescens Group of the Family Pseudomonadaceae

    Article • International Journal of Systematic Bacteriology, October 1985, Society for General Microbiology

    Dr Robert E Hancock

  303. Characterization of two surface-localized antigenic sites on porin protein F of Pseudomonas aeruginosa

    Article • Canadian Journal of Microbiology, April 1985, Canadian Science Publishing

    Dr Robert E Hancock

  304. Application of Monoclonal Antibodies to the Study of the Surface Antigens in Pseudomonas aeruginosa

    Article • January 1985, Elsevier

    Dr Robert E Hancock

  305. Use of Monoclonal Antibodies in the Study of Common Antigens of Gram-Negative Bacteria

    Article • January 1985, Elsevier

    Dr Robert E Hancock

  306. Monoclonal Antibodies Against Bacterial Outer Membrane Antigens

    Article • January 1985, Springer Science + Business Media

    Dr Robert E Hancock

  307. Monoclonal Antibody Protection Against Pseudomonas aeruginosa

    Article • January 1985, Springer Science + Business Media

    Dr Robert E Hancock

  308. The Role of the Cell Surface Components of Pseudomonas aeruginosa in Virulence

    Article • January 1985, Springer Science + Business Media

    Dr Robert E Hancock

  309. Phosphate transport in Pseudomonas aeruginosa. Involvement of a periplasmic phosphate-binding protein

    Article • European Journal of Biochemistry, November 1984, Wiley

    Dr Robert E Hancock

  310. Use of the fluorescent probe 1-N-phenylnaphthylamine to study the interactions of aminoglycoside antibiotics with the outer membrane of Pseudomonas aeruginosa.

    Article • Antimicrobial Agents and Chemotherapy, October 1984, ASM Journals

    Dr Robert E Hancock

  311. Evidence for two distinct mechanisms of resistance to polymyxin B in Pseudomonas aeruginosa.

    Article • Antimicrobial Agents and Chemotherapy, October 1984, ASM Journals

    Dr Robert E Hancock

  312. Compounds which increase the permeability of the Pseudomonas aeruginosa outer membrane.

    Article • Antimicrobial Agents and Chemotherapy, July 1984, ASM Journals

    Dr Robert E Hancock

  313. Chemical modification of the anion selectivity of the PhoE porin from the Escherichia coli outer membrane

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 1984, Elsevier

    Dr Robert E Hancock

  314. Outer-membrane protein PhoE from Escherichia coli forms anion-selective pores in lipid-bilayer membranes

    Article • European Journal of Biochemistry, April 1984, Wiley

    Dr Robert E Hancock

  315. Quantitation and Identification of Antibodies to Outer-Membrane Proteins of Pseudomonas aeruginosa in Sera of Patients with Cystic Fibrosis

    Article • The Journal of Infectious Diseases, February 1984, Oxford University Press (OUP)

    Dr Robert E Hancock

  316. Characterization and Chemical Modification of Small Anion Specific Channels formed in Lipid Bilayer Membranes by Outer Membrane Protein P or Pseudomonas aeruginosa

    Article • Biophysical Journal, January 1984, Elsevier

    Dr Robert E Hancock

  317. Modification of the conductance, selectivity and concentration-dependent saturation of Pseudomonas aeruginosa protein P channels by chemical acetylation

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, October 1983, Elsevier

    Dr Robert E Hancock

  318. An anion-selective channel from the Pseudomonas aeruginosa outer membrane

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, May 1983, Elsevier

    Dr Robert E Hancock

  319. Alteration Of Susceptibility To Edta, Polymyxin B And Gentamicin In Pseudomonas Aeruginosa By Divalent Cation Regulation Of Outer Membrane Protein H1

    Article • Microbiology, February 1983, Society for General Microbiology

    Dr Robert E Hancock

  320. Secretion of alkaline phosphatase and phsopholipase C in Pseudomonas aeruginosa is specific and does not involve an increase in outer membrane permeability

    Article • FEMS Microbiology Letters, January 1983, Oxford University Press (OUP)

    Dr Robert E Hancock

  321. Comparison of Fatty Acid, Protein, and Serological Properties Distinguishing Outer Membranes of Pseudomonas anguilliseptica Strains from Those of Fish Pathogens and Other Pseudomonads

    Article • International Journal of Systematic Bacteriology, January 1983, Society for General Microbiology

    Dr Robert E Hancock

  322. Outer Membrane Proteins of Pseudomonas aeruginosa Serotype Strains

    Article • The Journal of Infectious Diseases, December 1982, Oxford University Press (OUP)

    Dr Robert E Hancock

  323. Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant.

    Article • Antimicrobial Agents and Chemotherapy, February 1982, ASM Journals

    Dr Robert E Hancock

  324. Chemical and chromatographic analysis of lipopolysaccharide from an antibiotic-supersusceptible mutant of Pseudomonas aeruginosa.

    Article • Antimicrobial Agents and Chemotherapy, February 1982, ASM Journals

    Dr Robert E Hancock

  325. Properties of the large ion-permeable pores formed from protein F of Pseudomonas aeruginosa in lipid bilayer membranes

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, August 1981, Elsevier

    Dr Robert E Hancock

  326. Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa.

    Article • Antimicrobial Agents and Chemotherapy, May 1981, ASM Journals

    Dr Robert E Hancock

  327. Aminoglycoside uptake and mode of action—with special reference to streptomycin and gentamicin

    Article • Journal of Antimicrobial Chemotherapy, January 1981, Oxford University Press (OUP)

    Dr Robert E Hancock

  328. Aminoglycoside uptake and mode of action—with special reference to streptomycin and gentamicin

    Article • Journal of Antimicrobial Chemotherapy, January 1981, Oxford University Press (OUP)

    Dr Robert E Hancock

  329. Protein D1 — A glucose-inducible, pore-forming protein from the outer membrane of Pseudomonas aeruginosa

    Article • FEMS Microbiology Letters, June 1980, Oxford University Press (OUP)

    Dr Robert E Hancock

  330. Protein D1 — A glucose-inducible, pore-forming protein from the outer membrane of Pseudomonas aeruginosa

    Article • FEMS Microbiology Letters, June 1980, Oxford University Press (OUP)

    Dr Robert E Hancock

  331. Identification of the protein producing transmembrane diffusion pores in the outer membrane of Pseudomonas aeruginosa PA01

    Article • Biochimica et Biophysica Acta (BBA) - Biomembranes, July 1979, Elsevier

    Dr Robert E Hancock

  332. Iron transport in Escherichia coli K-12

    Article • Archives of Microbiology, January 1977, Springer Science + Business Media

    Dr Robert E Hancock

  333. The colicin I receptor of Escherichia coli K-12 has a role in enterochelin-mediated iron transport

    Article • FEBS Letters, June 1976, Wiley

    Dr Robert E Hancock

  334. Fuctional organization of the outer membrane of escherichia coli: Phage and colicin receptors as components of iron uptake systems

    Article • Journal of Supramolecular Structure, January 1976, Wiley

    Dr Robert E Hancock

  335. Characterisation of the hydroxy acids of Pseudomonas aeruginosa 8602

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, March 1970, Elsevier

    Dr Robert E Hancock

  336. The extractable lipids of Pseudomonas aeruginosa

    Article • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, October 1969, Elsevier

    Dr Robert E Hancock

  337. Isolation and Characterization of Porins from H. pylori

    Article • Springer Science + Business Media

    Dr Robert E Hancock

  338. Interaction of Cationic Peptides with Bacterial Membranes

    Article • Springer Science + Business Media

    Dr Robert E Hancock

  339. Structure-activity relationships in cyclic ß-sheet antibacterial peptides

    Article • Springer Science + Business Media

    Dr Robert E Hancock

  340. Modulation of specificity in cyclic antimicrobial peptides by amphipathicity

    Article • Springer Science + Business Media

    Dr Robert E Hancock