All Stories

  1. Chemical and Biological Evaluation of Thiosemicarbazone-Bearing Heterocyclic Metal Complexes

    Article • Current Topics in Medicinal Chemistry, January 2021, Bentham Science Publishers

    Dr ANA I MATESANZ, Dr ADORACION GOMEZ QUIROGA

  2. Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles

    Article • BioMetals, April 2016, Springer Science + Business Media

    Dr ADORACION GOMEZ QUIROGA

  3. Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(ii) complexes

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  4. cis-Pt I2(NH3)2: a reappraisal

    Article • Dalton Transactions, January 2015, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  5. Interactions between Anticancer trans-Platinum Compounds and Proteins: Crystal Structures and ESI-MS Spectra of Two Protein Adducts of trans-(Dimethylamino)(methylamino)dichloridoplatinum(II)

    Article • Inorganic Chemistry, July 2014, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  6. Peculiar Features in the Crystal Structure of the Adduct Formed between cis-PtI2(NH3)2 and Hen Egg White Lysozyme

    Article • Inorganic Chemistry, November 2013, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  7. The second generation of iodido complexes: trans-[PtI2(amine)(amine′)] bearing different aliphatic amines

    Article • Journal of Inorganic Biochemistry, October 2013, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  8. anticancer non traditional drugs

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  9. Novel clioquinol and its analogous platinum complexes: importance, role of the halogen substitution and the hydroxyl group of the ligand

    Article • Dalton Transactions, January 2013, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA, Dr. José M. Padrón

  10. Reactivity and Biological Properties of a Series of Cytotoxic PtI2(amine)2 Complexes, Either cis or trans Configured

    Article • Inorganic Chemistry, January 2012, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA, Dr. José M. Padrón, Dott Giuseppe Pieraccini

  11. Non-Classical Structures Among Current Platinum Complexes with Potential as Antitumor Drugs

    Article • Current Topics in Medicinal Chemistry, November 2011, Bentham Science Publishers

    Dr ADORACION GOMEZ QUIROGA

  12. The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicity

    Article • Dalton Transactions, January 2011, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  13. Photoactivation of trans diamine platinum complexes in aqueous solution and effect on reactivity towards nucleotides

    Article • Journal of Inorganic Biochemistry, September 2010, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  14. Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel “Rule-Breaker” Iodidoplatinum(II) Complex

    Article • ACS Medicinal Chemistry Letters, July 2010, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA, Dr. José M. Padrón

  15. Proteins as Possible Targets for Cytotoxic trans-Platinum(II) Complexes with Aliphatic Amine Ligands: Further Exceptions to the DNA Paradigm

    Article • ChemMedChem, June 2010, Wiley

    Dr ADORACION GOMEZ QUIROGA

  16. ChemInform Abstract: Synthesis, Cytotoxic Activities and Proposed Mode of Binding of a Series of Bis{[(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl}alkylamines.

    Article • ChemInform, May 2010, Wiley

    Dr ADORACION GOMEZ QUIROGA

  17. An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(ii) metallo-drug

    Article • Dalton Transactions, January 2010, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA, Professor Alison Rodger

  18. Conjugation of testosterone modifies the interaction of mono-functional cationic platinum(ii) complexes with DNA, causing significant alterations to the DNA helix

    Article • Dalton Transactions, January 2010, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA, Professor Alison Rodger

  19. New reactions of anticancer-platinum complexes and their intriguing behaviour under various experimental conditions

    Article • Dalton Transactions, January 2010, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  20. The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine

    Article • European Journal of Medicinal Chemistry, January 2010, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  21. Solution Behaviour and Biomolecular Interactions of Two Cytotoxictrans-Platinum(II) Complexes Bearing Aliphatic Amine Ligands

    Article • Chemistry - A European Journal, September 2009, Wiley

    Dr ADORACION GOMEZ QUIROGA

  22. [1H,15N] NMR studies of the aquation of cis-diamine platinum(II) complexes

    Article • Inorganica Chimica Acta, February 2009, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  23. Influence of amine ligands on the aquation and cytotoxicity of trans-diamine platinum(ii) anticancer complexes

    Article • Dalton Transactions, January 2009, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA

  24. Influence of (Hydroxymethyl)pyridine and Pyridine-carboxylic Acids, intrans-Position to the Isopropylamine and Ammine Ligands, on the Cytotoxicity of Platinum Complexes

    Article • Chemistry & Biodiversity, October 2008, Wiley

    Dr ADORACION GOMEZ QUIROGA

  25. Platinum(IV) Complexes of 3‐ and 4‐Picolinic Acids Containing Ammine or Isopropylamine Ligands – Synthesis, Characteri­zation, X‐ray Structures, and Evaluation of Their Cytotoxic Activity against Cancer Cell Lines

    Article • European Journal of Inorganic Chemistry, October 2008, Wiley

    Dr ADORACION GOMEZ QUIROGA

  26. Isolation of an Intermediate in the Platination of p ‐Nitroacetophenone 4‐Methylthiosemicarbazone: Potential Application as an Antitumor Drug

    Article • European Journal of Inorganic Chemistry, March 2008, Wiley

    Dr ADORACION GOMEZ QUIROGA

  27. Isolation of an Intermediate in the Platination ofp-Nitroacetophenone 4-Methylthiosemicarbazone: Potential Application as an Antitumor Drug (Eur. J. Inorg. Chem. 8/2008)

    Article • European Journal of Inorganic Chemistry, March 2008, Wiley

    Dr ADORACION GOMEZ QUIROGA

  28. New trans-Platinum Drugs with Phosphines and Amines as Carrier Ligands Induce Apoptosis in Tumor Cells Resistant to Cisplatin

    Article • Journal of Medicinal Chemistry, April 2007, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  29. Trans platinum complexes design: One novel water soluble oxime derivative that contains aliphatic amines in trans configuration

    Article • Journal of Inorganic Biochemistry, January 2007, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  30. Structural Characterization, DNA Interactions, and Cytotoxicity of New Transplatin Analogues Containing One Aliphatic and One Planar Heterocyclic Amine Ligand

    Article • Journal of Medicinal Chemistry, March 2006, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  31. Novel Transplatinum(II) Complexes with [N2O2] Donor Sets. Cellular Pharmacology and Apoptosis Induction in Pam 212-ras Cells

    Article • Journal of Medicinal Chemistry, December 2005, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  32. Pyridine-Carboxylate Complexes of Platinum. Effect of N,O-Chelate Formation on Model Bifunctional DNA−DNA and DNA−Protein Interactions

    Article • Inorganic Chemistry, June 2005, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA

  33. Contribution to the SAR field of metallated and coordination complexes

    Article • Coordination Chemistry Reviews, January 2004, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  34. Synthesis and Characterization of New Transplatinum Complexes Containing Phosphane Groups − Cytotoxic Studies in Cisplatin‐Resistant Cells

    Article • European Journal of Inorganic Chemistry, April 2003, Wiley

    Dr ADORACION GOMEZ QUIROGA

  35. Orientation‐ and Temperature‐Dependent Rotational Behavior of Imidazole Ligands (L) in β‐[Ru(azpy) 2 (L) 2 ](PF 6 ) 2 ...

    Article • European Journal of Inorganic Chemistry, February 2003, Wiley

    Dr ADORACION GOMEZ QUIROGA

  36. Determination of catalase activity in samples treated with [ZnCl2(isopropylamine)2]: a novel zinc complex that slows down the decay in activity of catalase extracts

    Article • Journal of the Chemical Society Dalton Transactions, April 2002, Royal Society of Chemistry

    Dr ADORACION GOMEZ QUIROGA, Jorge García-Cañadas

  37. Synthesis, cytotoxic activities and proposed mode of binding of a series of bis{[(9-oxo-9,10-dihydroacridine-4-carbonyl)amino]alkyl}alkylamines

    Article • European Journal of Medicinal Chemistry, April 2002, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  38. Cellular Uptake, DNA Binding and Apoptosis Induction of Cytotoxic Trans-[PtCl2(N,N-dimethylamine)(Isopropylamine...

    Article • Metal-Based Drugs, January 2001, Hindawi Publishing Corporation

    Dr ADORACION GOMEZ QUIROGA

  39. A cycloplatinated compound of p-isopropylbenzaldehyde thiosemicarbazone and its chloro-bridged derivative induce apoptosis in cis-DDP resistant cells which overexpress the H-ras oncogene

    Article • Journal of Inorganic Biochemistry, April 1999, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  40. DNA binding and in vitro antileukemic activity of dimeric and tetrameric platinated complexes derived from p‐isopropylbenzaldehyde thiosemicarbazone

    Article • Applied Organometallic Chemistry, December 1998, Wiley

    Dr ADORACION GOMEZ QUIROGA

  41. Palladated and platinated complexes derived from phenylacetaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cells. Formation of DNA interstrand cross-links by these complexes

    Article • Journal of Inorganic Biochemistry, May 1998, Elsevier

    Dr ADORACION GOMEZ QUIROGA

  42. Novel Tetranuclear Orthometalated Complexes of Pd(II) and Pt(II) Derived from p-Isopropylbenzaldehyde Thiosemicarbazone with Cytotoxic Activity in cis-DDP Resistant Tumor Cell Lines. Interaction of These Complexes with DNA

    Article • Journal of Medicinal Chemistry, March 1998, American Chemical Society (ACS)

    Dr ADORACION GOMEZ QUIROGA, Dr Pascual Roman

  43. Binuclear chloro-bridged palladated and platinated complexes derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxicity against cisplatin resistant tumor cell lines

    Article • Journal of Inorganic Biochemistry, March 1998, Elsevier

    Dr ADORACION GOMEZ QUIROGA