All Stories

  1. RASSF1A Tumour Suppressor: Target the Network for Effective Cancer Therapy

    Article • Cancers, January 2020, MDPI AG

    Dr David Matallanas

  2. Protein and lipid homeostasis altered in rat macrophages after exposure to metallic oxide nanoparticles

    Article • Cell Biology and Toxicology, July 2019, Springer Science + Business Media

    Dr David Matallanas

  3. All over the place: deciphering HRAS signaling from different subcellular compartments

    Article • Molecular & Cellular Oncology, May 2019, Taylor & Francis

    Dr David Matallanas

  4. Characterisation of hras local signal transduction networks using engineered site-specific exchange factors

    Article • Small GTPases, November 2017, Taylor & Francis

    Dr David Matallanas

  5. The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair

    Article • Genes, June 2016, MDPI AG

    Dr David Matallanas

  6. Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device

    Article • Cell Cycle, January 2015, Taylor & Francis

    Professor Boris N. Kholodenko, Dr David Matallanas

  7. One Hippo and many masters: differential regulation of the Hippo pathway in cancer: Figure 1

    Article • Biochemical Society Transactions, August 2014, Portland Press Ltd.

    Dr David Matallanas

  8. Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

    Article • Nature Cell Biology, June 2014, Springer Science + Business Media

    Dr David Matallanas, Professor Boris N. Kholodenko

  9. HGF Induces Epithelial-to-Mesenchymal Transition by Modulating the Mammalian Hippo/MST2 and ISG15 Pathways

    Article • Journal of Proteome Research, June 2014, American Chemical Society (ACS)

    Dr David Matallanas

  10. The Differential Effects of Wild-Type and Mutated K-Ras on MST2 Signaling Are Determined by K-Ras Activation Kinetics

    Article • Molecular and Cellular Biology, March 2013, ASM Journals

    Dr David Matallanas

  11. Signalling by protein phosphatases and drug development: a systems-centred view

    Article • FEBS Journal, March 2012, Wiley

    Dr David Matallanas, Professor Boris N. Kholodenko

  12. Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia

    Article • Leukemia, March 2012, Springer Science + Business Media

    Dr David Matallanas

  13. Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras

    Article • Molecular Cell, December 2011, Elsevier

    Dr David Matallanas

  14. Raf Family Kinases: Old Dogs Have Learned New Tricks

    Article • Genes & Cancer, March 2011, SAGE Publications

    Marc Birtwistle, Dr David Matallanas

  15. The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

    Article • Oncogene, May 2010, Springer Science + Business Media

    Dr David Matallanas

  16. Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt

    Article • Cancer Research, January 2010, American Association for Cancer Research (AACR)

    Dr David Matallanas

  17. RAN GTPase Is a RASSF1A Effector Involved in Controlling Microtubule Organization

    Article • Current Biology, July 2009, Elsevier

    Dr David Matallanas

  18. RASSF2 associates with and stabilizes the proapoptotic kinase MST2

    Article • Oncogene, June 2009, Springer Science + Business Media

    Dr David Matallanas

  19. Proteomics and phosphoproteomics for the mapping of cellular signalling networks

    Article • PROTEOMICS, November 2008, Wiley

    Dr David Matallanas

  20. RASSF1A Elicits Apoptosis through an MST2 Pathway Directing Proapoptotic Transcription by the p73 Tumor Suppressor Protein

    Article • Molecular Cell, September 2007, Elsevier

    Professor Manuela Baccarini, Dr David Matallanas

  21. Distinct Utilization of Effectors and Biological Outcomes Resulting from Site-Specific Ras Activation: Ras Functions in Lipid Rafts and Golgi Complex Are Dispensable for Proliferation and Transformation

    Article • Molecular and Cellular Biology, January 2006, ASM Journals

    Dr David Matallanas

  22. Mammalian Sterile 20-Like Kinases in Tumor Suppression: An Emerging Pathway

    Article • Cancer Research, July 2005, American Association for Cancer Research (AACR)

    Dr David Matallanas

  23. Myc Antagonizes Ras-mediated Growth Arrest in Leukemia Cells through the Inhibition of the Ras-ERK-p21Cip1Pathway

    Article • Journal of Biological Chemistry, November 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas

  24. Subcellular Localization Determines the Protective Effects of Activated ERK2 against Distinct Apoptogenic Stimuli in Myeloid Leukemia Cells

    Article • Journal of Biological Chemistry, June 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas

  25. Activation of H-Ras in the Endoplasmic Reticulum by the RasGRF Family Guanine Nucleotide Exchange Factors

    Article • Molecular and Cellular Biology, February 2004, ASM Journals

    Dr David Matallanas

  26. Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

    Article • The EMBO Journal, July 2003, Wiley

    Dr David Matallanas

  27. Differences on the Inhibitory Specificities of H-Ras, K-Ras, and N-Ras (N17) Dominant Negative Mutants Are Related to Their Membrane Microlocalization

    Article • Journal of Biological Chemistry, November 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas

  28. Maintenance of Cdc42 GDP-bound State by Rho-GDI Inhibits MAP Kinase Activation by the Exchange Factor Ras-GRF

    Article • Journal of Biological Chemistry, April 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas

  29. The Rho Family GTPase Cdc42 Regulates the Activation of Ras/MAP Kinase by the Exchange Factor Ras-GRF

    Article • Journal of Biological Chemistry, June 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr David Matallanas