All Stories

  1. Total syntheses of strained polycyclic terpenes
  2. Biohybrid microswimmers against bacterial infections
  3. Synthesis and biological evaluation of new cephalosporin derivatives containing cyclic disulfide moieties
  4. Thiol- and Disulfide-Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation
  5. Concise Total Synthesis of Peyssonnoside A
  6. Thiol and Disulfide Containing Vancomycin Derivatives Against Bacterial Resistance and Biofilm Formation
  7. Boron Trifluoride-Mediated Cycloaddition of 3-Bromotetrazine and Silyl Enol Ethers: Synthesis of 3-Bromo-pyridazines
  8. Cross-Coupling Reactions of Monosubstituted Tetrazines
  9. Cross-coupling Reactions of Monosubstituted Tetrazines
  10. Cross-coupling Reactions of Monosubstituted Tetrazines
  11. Novel fidaxomicin antibiotics through site-selective catalysis
  12. Biohybrid Microswimmers Against Bacterial Infections
  13. Development of a Cell Surface Display System in Chlamydomonas reinhardtii
  14. Nucleophilic Attack on Nitrogen in Tetrazines by Silyl-Enol Ethers
  15. Design, Synthesis, and Biological Evaluation of Light-Activated Antibiotics
  16. Design, Synthesis, and Biological Evaluation of Light-Activated Antibiotics
  17. Design, Synthesis, and Biological Evaluation of Light-Activated Antibiotics
  18. Green Algae as a Drug Delivery System for the Controlled Release of Antibiotics
  19. Nucleophilic Attack on Nitrogen in Tetrazines by Silyl-Enol Ethers
  20. Nucleophilic Attack on Nitrogen in Tetrazines by Silyl-Enol Ethers
  21. Semisynthetic Analogs of the Antibiotic Fidaxomicin—Design, Synthesis, and Biological Evaluation
  22. Synthesis and Biological Evaluation of Iodinated Fidaxomicin Antibiotics
  23. Synthesis of Colibactin Pyrrolidono[3,4-d]pyridones via Regioselective C(sp3)–H Activation
  24. Synthesis and Biological Evaluation of Iodinated Fidaxomicin Antibiotics
  25. Synthesis and Biological Evaluation of Iodinated Fidaxomicin Antibiotics
  26. Semisynthetic Analogs of the Antibiotic Fidaxomicin – Design, Synthesis, and Biological Evaluation
  27. Semisynthetic Analogs of the Antibiotic Fidaxomicin – Design, Synthesis, and Biological Evaluation
  28. Novel Fidaxomicin Antibiotics through Site-Selective Catalysis
  29. Novel Fidaxomicin Antibiotics through Site-Selective Catalysis
  30. Synthesis and Biological Evaluation of Iodinated Fidaxomicin Antibiotics
  31. Chemistry and Biology of the Clinically Used Macrolactone Antibiotic Fidaxomicin
  32. Biosynthesis and Structure–Activity Relationship Investigations of the Diazeniumdiolate Antifungal Agent Fragin
  33. Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach
  34. 3-Bromotetrazine: labelling of macromolecules via monosubstituted bifunctional s-tetrazines
  35. 3-Bromotetrazine: A Versatile Precursor for the Synthesis of 3-Monosubstituted s-Tetrazines and the Labelling of Macromolecules
  36. 3-Bromotetrazine: A Versatile Precursor for the Synthesis of 3-Monosubstituted s-Tetrazines and the Labelling of Macromolecules
  37. Total Synthesis and Structural Revision of Mangrolide D
  38. The Furan Shuffling Hypothesis: A Biogenetic Proposal for Eremophilane Sesquiterpenoids
  39. The Furan Shuffling Hypothesis: A Biogenetic Proposal for Eremophilane Sesquiterpenoids
  40. Preparation of Indolenines via Nucleophilic Aromatic Substitution
  41. Synthesis of Two Key Fragments of the Complex Polyhalogenated Marine Meroterpenoid Azamerone
  42. Synthesis and Biological Evaluation of the Novel Growth Inhibitor Streptol Glucoside, Isolated from an Obligate Plant Symbiont
  43. Pyrrolizidines for direct air capture and CO2 conversion
  44. Metal‐Free Regioselective Chloroazidation of Internal Alkynes
  45. On-cell catalysis by surface engineering of live cells with an artificial metalloenzyme
  46. Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A
  47. Total Synthesis and Biological Evaluation of the Glycosylated Macrocyclic Antibiotic Mangrolide A
  48. Total Synthesis of Tiacumicin A. Total Synthesis, Relay Synthesis, and Degradation Studies of Fidaxomicin (Tiacumicin B, Lipiarmycin A3)
  49. Biosynthesis of fragin is controlled by a novel quorum sensing signal
  50. Antibiotic Algae by Chemical Surface Engineering
  51. Total Synthesis of the Sesquiterpenoid Periconianone A Based on a Postulated Biogenesis
  52. Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis
  53. Securinega Alkaloids: Complex Structures, Potent Bioactivities, and Efficient Total Syntheses
  54. Total Synthesis and Structural Revision of Aeruginosin KT608A
  55. Investigating Biogenetic Hypotheses of the Securinega Alkaloids: Enantioselective Total Syntheses of Secu’amamine E/ent-Virosine A and Bubbialine
  56. Collective Syntheses of Icetexane Natural Products Based on Biogenetic Hypotheses
  57. Investigating the Toxicity of the Aeruginosin Chlorosulfopeptides by Chemical Synthesis
  58. Synthese von Aeruginosin-Chlorsulfopeptiden und Untersuchung ihrer Toxizität
  59. Synthetisch gewonnene Naturstofffragmente in der Wirkstoffentwicklung
  60. Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis
  61. The third orthogonal dynamic covalent bond
  62. Preparation of Antimalarial Endoperoxides by a Formal [2 + 2 + 2] Cycloaddition
  63. Total Synthesis of the Glycosylated Macrolide Antibiotic Fidaxomicin
  64. Direct Preparation of Pyrrolizidines Using Imines and Isonitriles
  65. Preparation of Fluorescent Microcystin Derivatives by Direct Arginine Labelling and Their Biological Evaluation
  66. Made for sharing: A small molecule from a bacteria/plant symbiosis. What is it good for?
  67. Isolation and Total Synthesis of Kirkamide, an Aminocyclitol from an Obligate Leaf Nodule Symbiont
  68. Copy, Edit, and Paste: Natural Product Approaches to Biomaterials and Neuroengineering
  69. Synthesis of maculalactone A and derivatives for environmental fate tracking studies
  70. Direct Arginine Modification in Native Peptides and Application to Chemical Probe Development
  71. Total Synthesis of the Protected Aglycon of Fidaxomicin (Tiacumicin B, Lipiarmycin A3)
  72. The toxicity and enzyme activity of a chlorine and sulfate containing aeruginosin isolated from a non-microcystin-producing Planktothrix strain
  73. Balgacyclamides, Antiplasmodial Heterocyclic Peptides from Microcystis aeruguinosa EAWAG 251
  74. Neuritogenic Surfaces using Natural Product Analogs
  75. Catalytic Enantioselective Total Synthesis of (–)-Pyridovericin
  76. Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on Their Mode of Action
  77. Fluorescent Labeling Agents for Quorum-Sensing Receptors (FLAQS) in Live Cells
  78. Bioinspired Surfaces Against Bacterial Infections
  79. Syntheses of Taiwaniaquinone F and Taiwaniaquinol A via an Unusual Remote C–H Functionalization
  80. Enantioselective Total Syntheses and Absolute Configuration of JBIR-02 and Mer-A2026B
  81. Telomerase Inhibitors from Cyanobacteria: Isolation and Synthesis of Sulfoquinovosyl Diacylglycerols fromMicrocystis aeruguinosaPCC 7806
  82. Strategies for the Asymmetric Total Synthesis of Natural Products: ‘‘Chiral Pool’’ versus Chiral Catalysts
  83. Total Synthesis of Gelsemiol
  84. Bioinspired, releasable quorum sensing modulators
  85. Enantioselective total synthesis of virosaine A and bubbialidine
  86. Truncated militarinone fragments identified by total chemical synthesis induce neurite outgrowth
  87. Caged retinoids as photoinducible activators: implications for cell differentiation and neurite outgrowth
  88. Withanolide A: synthesis and structural requirements for neurite outgrowth
  89. Nitrocatechols as Tractable Surface Release Systems
  90. The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
  91. Total Synthesis of Cyrneine A
  92. Reduce to the Maximum: Truncated Natural Products as Powerful Modulators of Biological Processes
  93. Chemical Interference of Biological Systems with Natural Products
  94. Controlling Protein Transport by Small Molecules
  95. Catalytic Enantioselective Total Synthesis of (+)-Torrubiellone C
  96. Synthesis of Withanolide A, Biological Evaluation of Its Neuritogenic Properties, and Studies on Secretase Inhibition
  97. Out in the Green: Biologically Active Metabolites Produced by Cyanobacteria
  98. A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity
  99. Synthesis and Catalysis
  100. Bioorganic and Bioinorganic Chemistry
  101. A Synthetic Entry into the Taiwaniaquinoids Based on a Biogenetic Hypothesis: Total Synthesis of (−)-Taiwaniaquinone H
  102. Connecting C19 Norditerpenoids to C20 Diterpenes: Total Syntheses of 6-Hydroxy-5,6-dehydrosugiol, 6-Hydroxysugiol, and Taiwaniaquinone H, and Formal Synthesis of Dichroanone
  103. Multiple Toxin Production in the Cyanobacterium Microcystis : Isolation of the Toxic Protease Inhibitor Cyanopeptolin 1020
  104. Spatial isolation favours the divergence in microcystin net production by Microcystis in Ugandan freshwater lakes
  105. The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport
  106. Poly(ethylene glycol) Adlayers Immobilized to Metal Oxide Substrates Through Catechol Derivatives: Influence of Assembly Conditions on Formation and Stability
  107. Total Synthesis of the Marine Alkaloid Palau’amine
  108. Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport
  109. Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation
  110. Surface Assembly of Catechol-Functionalized Poly( l -lysine)- graft -poly(ethylene glycol) Copolymer on Titanium Exploiting Combined Electrostatically Driven Self-Organization and Biomimetic Strong Adhesion
  111. 4-Hydroxy-2-pyridone alkaloids: Structures and synthetic approaches
  112. Dimers of Nostocarboline with Potent Antibacterial Activity
  113. Design of a high-throughput device for screening surface modification protocols
  114. Synthetic Studies on the Sporolides: Exploration of the Enediyne Route
  115. Enantioselective Synthesis of the Sporolide Quinone Acid Fragment
  116. Occurrence of microcystin-producing cyanobacteria in Ugandan freshwater habitats
  117. Total Synthesis and Neuritotrophic Activity of Farinosone C and Derivatives
  118. Antimalarial natural products of marine and freshwater origin
  119. Surface modifications based on the cyanobacterial siderophore anachelin: from structure to functional biomaterials design
  120. Directed Biosynthesis of Phytotoxic Alkaloids in the CyanobacteriumNostoc78-12A
  121. The First Meeting for Young Chemistry Faculty, Organized by the "Platform Chemistry" of the Swiss Academy of Sciences (SCNAT)
  122. Isolation and Structure Determination of Two Microcystins and Sequence Comparison of the McyABC Adenylation Domains in Planktothrix Species
  123. Isolation of Aerucyclamides C and D and Structure Revision of Microcyclamide 7806A: Heterocyclic Ribosomal Peptides from Microcystis aeruginosa PCC 7806 and Their Antiparasite Evaluation
  124. Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization
  125. Stable β Turns of Tripeptides in Water through Cation-π Interactions
  126. Antimicrobial Surfaces through Natural Product Hybrids
  127. Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers
  128. Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806
  129. The cyanobacterial alkaloid nostocarboline: an inhibitor of acetylcholinesterase and trypsin
  130. Secondary Metabolites from Cyanobacteria: Complex Structures and Powerful Bioactivities
  131. Aza-Annulation Strategies in Alkaloid Total Synthesis
  132. Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C
  133. Biomimetic Total Synthesis and Antimicrobial Evaluation of Anachelin H
  134. Total Synthesis of Complex Cyanobacterial Alkaloids without Using Protecting Groups
  135. Cyanobacterial Natural Products for the Inhibition of Biofilm Formation and Biofouling
  136. Natural Product Hybrids
  137. Stereoselective Total Synthesis of (-)-Galantinic Acid
  138. Potent Algicides Based on the Cyanobacterial Alkaloid Nostocarboline
  139. Biomimetic Surface Modifications Based on the Cyanobacterial Iron Chelator Anachelin
  140. Nostocarboline:  Isolation and Synthesis of a New Cholinesterase Inhibitor from Nostoc 78-12A
  141. Synthesis and Evaluation of theBis-Nor-Anachelin Chromophore as Potential Cyanobacterial Ligand
  142. Mechanistic Studies on the Tyrosinase-Catalyzed Formation of the Anachelin Chromophore
  143. Total Synthesis of Anachelin H
  144. A Biomimetic Route to the Peptide Alkaloid Anachelin
  145. The Peptide Alkaloid Anachelin: NMR Spectroscopic Evidence for β-Turn Formation in Aqueous Solution
  146. The Fourth Helical Secondary Structure of β-Peptides: The (P)-28-Helix of a β-Hexapeptide Consisting of (2R,3S)-3-Amino-2-hydroxy Acid Residues
  147. Highly Enantioselective Inverse-Electron-Demand Hetero-Diels–Alder Reactions of α,β-Unsaturated Aldehydes This work was supported by the NIH (GM-59316), with additional support from the Schweizerischer Nationalfonds zur Förderung der wissenschaftl...
  148. Synthesis of Cyclo--tripeptides and Their Biological in vitro Evaluation as Antiproliferatives against the Growth of Human Cancer Cell Lines
  149. Synthesis of Cyclo-β-tripeptides and Their Biologicalin vitro Evaluation as Antiproliferatives against the Growth of Human Cancer Cell Lines
  150. Peptide Folding Induces High and Selective Affinity of a Linear and Small β-Peptide to the Human Somatostatin Receptor 4
  151. Τhe β-Peptide Hairpin in Solution:  Conformational Study of a β-Hexapeptide in Methanol by NMR Spectroscopy and MD Simulation
  152. Synthesis of β-Hexa- and β-Heptapeptides Containing Novel β2,3-Amino Acids with Two Serine or Two Cysteine Side Chains - CD- and NMR-Spectroscopic Evidence for 314-Helical Secondary Structures in Water
  153. The Cyclo-β-Tetrapeptide (β-HPhe-β-HThr-β-HLys-β-HTrp): Synthesis, NMR Structure in Methanol Solution, and Affinity for Human Somatostatin Receptors
  154. β-Thiopeptides: Synthesis, NMR Solution Structure, CD Spectra, and Photochemistry
  155. Preparation and NMR Structure of the Cyclo-β-tripeptide [β3-HGlu]3 in Aqueous Solution: A New Class of Enterobactin-TypeC3-Symmetrical Ligands?, Preliminary Communication
  156. Pleated Sheets and Turns ofβ-Peptides with Proteinogenic Side Chains
  157. Pleated Sheets and Turns of -Peptides with Proteinogenic Side Chains
  158. Synthesis and Biological Evaluation of a Cyclo--tetrapeptide as a Somatostatin Analogue
  159. Peptide Folding: When Simulation Meets Experiment
  160. Peptide Folding: When Simulation Meets Experiment
  161. Temperature-Dependent NMR and CD Spectra ofβ-Peptides: On the Thermal Stability ofβ-Peptide Helices - Is the Folding Process ofβ-Peptides Non-cooperative?
  162. Linear and cyclic β3-oligopeptides with functionalised side-chains (-CH2OBn, -CO2Bn, -CH2CH2CO2Bn) derived from serine and from aspartic and glutamic acid
  163. ?-Peptides Forming More Stable Secondary Structures than ?-Peptides: Synthesis and helical NMR-solution structure of the ?-hexapeptide analog of H-(Val-Ala-Leu)2-OH
  164. ‘Mixed’ β-peptides: A unique helical secondary structure in solution. Preliminary communication