All Stories

  1. Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

    Article • Journal of Thrombosis and Haemostasis, September 2019, Wiley

    Professor Robert L Medcalf

  2. Tranexamic Acid Influences the Immune Response, but not Bacterial Clearance in a Model of Post-Traumatic Brain Injury Pneumonia

    Article • Journal of Neurotrauma, August 2019, Mary Ann Liebert Inc

    Professor Robert L Medcalf

  3. Tranexamic acid modulates the immune response and reduces postsurgical infection rates

    Article • Blood Advances, May 2019, American Society of Hematology

    Professor Robert L Medcalf

  4. t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke

    Article • Frontiers in Immunology, March 2019, Frontiers

    Professor Robert L Medcalf

  5. What concentration of tranexamic acid is needed to inhibit fibrinolysis? A systematic review of pharmacodynamics studies

    Article • Blood Coagulation & Fibrinolysis, January 2019, Wolters Kluwer Health

    Professor Robert L Medcalf

  6. A flowcytometric analysis to efficiently quantify multiple innate immune cells and T Cell subsets in human blood

    Article • Cytometry Part A, March 2017, Wiley

    Professor Robert L Medcalf

  7. Protein aggregation or liberation during cell necrosis

    Article • Open Biology, November 2016, Royal Society Publishing

    Dr Andre L Samson, Professor Robert L Medcalf

  8. Plasminogen and stroke: more is better

    Article • Journal of Thrombosis and Haemostasis, August 2016, Wiley

    Professor Robert L Medcalf

  9. The Influence of Differentially Expressed Tissue-Type Plasminogen Activator in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis

    Article • PLoS ONE, July 2016, PLOS

    Professor Robert L Medcalf

  10. The Fibrinolytic System—More Than Fibrinolysis?

    Article • Transfusion Medicine Reviews, April 2015, Elsevier

    Professor Robert L Medcalf

  11. Is plasminogen activator inhibitor type 2 really a plasminogen activator inhibitor after all?

    Article • Journal of Thrombosis and Haemostasis, October 2014, Elsevier

    Professor Robert L Medcalf

  12. Plasmin-Dependent Modulation of the Blood–Brain Barrier: A Major Consideration during tPA-Induced Thrombolysis?

    Article • Journal of Cerebral Blood Flow & Metabolism, June 2014, SAGE Publications

    Professor Robert L Medcalf

  13. Species-Specific Regulation of t-PA and PAI-1 Gene Expression in Human and Rat Astrocytes

    Article • Gene Regulation and Systems Biology, May 2014, Libertas Academica, Ltd.

    Professor Robert L Medcalf

  14. Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier

    Article • Journal of Visualized Experiments, November 2013, MyJove Corporation

    Professor Robert L Medcalf

  15. Plasminogen Activation and Thrombolysis for Ischemic Stroke

    Article • International Journal of Stroke, March 2012, SAGE Publications

    Professor Robert L Medcalf

  16. Desmoteplase: discovery, insights and opportunities for ischaemic stroke

    Article • British Journal of Pharmacology, December 2011, Wiley

    Professor Robert L Medcalf

  17. Plasminogen Activation-Based Thrombolysis for Ischaemic Stroke: The Diversity of Targets may Demand New Approaches

    Article • Current Drug Targets, November 2011, Bentham Science Publishers

    Professor Robert L Medcalf

  18. Plasminogen Activator Inhibitor Type 2

    Article • January 2011, Elsevier

    Professor Robert L Medcalf

  19. Desmoteplase-mediated plasminogen activation and clot lysis are inhibited by the lysine analogue tranexamic acid

    Article • Blood Coagulation & Fibrinolysis, June 2008, Wolters Kluwer Health

    Professor Robert L Medcalf

  20. Tissue-Type Plasminogen Activator: A Multifaceted Modulator of Neurotransmission and Synaptic Plasticity

    Article • Neuron, June 2006, Elsevier

    Professor Robert L Medcalf, Dr Andre L Samson

  21. Meet the serpins

    Article • FEBS Journal, September 2005, Wiley

    Professor Robert L Medcalf

  22. The undecided serpin

    Article • FEBS Journal, September 2005, Wiley

    Professor Robert L Medcalf

  23. Transcriptional and posttranscriptional regulation of the plasminogen activator system

    Article • Thrombosis and Haemostasis, March 2005, Schattauer GmbH

    Professor Robert L Medcalf

  24. The urokinase-type-plasminogen-activator receptor (CD87) is a pleiotropic molecule

    Article • European Journal of Biochemistry, March 1998, Wiley

    Professor Robert L Medcalf

  25. 8 Destabilising properties of the uuauuuauu element in the 3' UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA

    Article • October 1997, Elsevier

    Professor Robert L Medcalf

  26. 14 Identification of endothelial nuclear factors which recognise the cre-like element in the human t-PA gene promoter

    Article • October 1997, Elsevier

    Professor Robert L Medcalf

  27. 19 Urokinase mediated induction of an interferon (IFN) responsive gene promoter may utilise IFN α-stimulated gene response elements (ISRE)

    Article • October 1997, Elsevier

    Professor Robert L Medcalf

  28. Identification of two repressor regions within the plasminogen activator inhibitor 2 (PAI-2) gene promoter

    Article • Fibrinolysis and Proteolysis, January 1994, Elsevier

    Professor Robert L Medcalf

  29. Regulation of Human Tissue-Type Plasminogen Activator Gene Transcription by Epidermal Growth Factor and 3′,5′-Cyclic Adenosine Monophosphate

    Article • Molecular Endocrinology, December 1991, Endocrine Society

    Professor Robert L Medcalf

  30. Thrombin increases proliferation and decreases fibrinolytic activity of kidney glomerular epithelial cells

    Article • Journal of Cellular Physiology, January 1991, Wiley

    Professor Robert L Medcalf

  31. Signal Transduction Chains Involved in the Control of the Fibrinolytic Enzyme Cascade

    Article • January 1990, Springer Science + Business Media

    Professor Robert L Medcalf

  32. Urokinase synthesis and binding by glomerular epithelial cells in culture

    Article • Kidney International, October 1989, Elsevier

    Professor Robert L Medcalf

  33. Deletion mutagenesis, DNAse 1 protection, and band shift analysis of human tissue-type plasminogen activator gene promoter reveals two functionally active protein binding domains

    Article • Fibrinolysis and Proteolysis, January 1989, Elsevier

    Professor Robert L Medcalf

  34. Human synovial fibroblasts produce urokinase-type plasminogen activator

    Article • Arthritis & Rheumatism, November 1986, Wiley

    Professor Robert L Medcalf

  35. Prejunctional β-adrenoceptors in human digital arteries

    Article • European Journal of Pharmacology, September 1982, Elsevier

    Professor Robert L Medcalf