All Stories

  1. Staphylococcus aureus toxin LukSF dissociates from its membrane receptor target to enable renewed ligand sequestration

    Article • The FASEB Journal, December 2018, Federation of American Societies For Experimental Biology (FASEB)

    Professor Mark C Leake, Adam Wollman

  2. Superresolution imaging of single DNA molecules using stochastic photoblinking of minor groove and intercalating dyes

    Article • Methods, October 2015, Elsevier

    Professor Mark C Leake

  3. From Animaculum to single molecules: 300 years of the light microscope

    Article • Open Biology, April 2015, Royal Society Publishing

    Professor Mark C Leake

  4. Observing Signal Transduction Directly at the Single-Molecule Level in Live Eukaryotic Cells

    Article • Biophysical Journal, January 2015, Elsevier

    Professor Mark C Leake

  5. Combined Magneto-Optical Tweezers and Supperesolution Fluorescence Imaging for Probing Dynamic Single-Molecule Topology of DNA, and Protein Machines that Manipulate DNA Topology

    Article • Biophysical Journal, January 2015, Elsevier

    Professor Mark C Leake

  6. Single-Molecule Cellular Biophysics . By Mark C. Leake. Cambridge and New York: Cambridge University Press. $80.00. xiii + 275 p.; ill.; index. ISBN: 978-1-107-00583-9. 2013.

    Article • The Quarterly Review of Biology, December 2014, University of Chicago Press

    Professor Mark C Leake

  7. Localisation and interactions of theVipp1 protein in cyanobacteria

    Article • Molecular Microbiology, October 2014, Wiley

    Professor Mark C Leake, Luning Liu

  8. In vivo imaging of the supramolecular organization of Escherichia coli OxPhos complexes

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2014, Elsevier

    Professor Mark C Leake

  9. Delocalised electron transport and chemiosmosis in Escherichia coli

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, July 2014, Elsevier

    Professor Mark C Leake

  10. Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, June 2014, Elsevier

    Professor Mark C Leake, Luning Liu

  11. Independent mobility of proteins and lipids in the plasma membrane of E scherichia coli

    Article • Molecular Microbiology, April 2014, Wiley

    Professor Mark C Leake

  12. Positioning of chemosensory proteins and FtsZ through theRhodobacter sphaeroidescell cycle

    Article • Molecular Microbiology, September 2013, Wiley

    Professor Mark C Leake

  13. Single-Molecule Cellular Biophysics

    Article • January 2013, Cambridge University Press

    Professor Mark C Leake

  14. Inferring diffusion in single live cells at the single-molecule level

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, December 2012, Royal Society Publishing

    Professor Mark C Leake

  15. The physics of life: one molecule at a time

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, December 2012, Royal Society Publishing

    Professor Mark C Leake

  16. In Vivo Architecture and Action of Bacterial Structural Maintenance of Chromosome Proteins

    Article • Science, October 2012, American Association for the Advancement of Science

    Professor Mark C Leake

  17. Experimental approaches for addressing fundamental biological questions in living, functioning cells with single molecule precision

    Article • Open Biology, June 2012, Royal Society Publishing

    Professor Mark C Leake

  18. Sub-Millisecond Single Molecule Fluorescence Imaging Combined with Dual Optical Tweezers on DNA Tethers

    Article • Biophysical Journal, January 2012, Elsevier

    Professor Mark C Leake

  19. Single Molecule Live Cell Millisecond Fluorescence Imaging of Bacterial Condensins

    Article • Biophysical Journal, January 2012, Elsevier

    Professor Mark C Leake

  20. Functioning Nanomachines Seen in Real-Time in Living Bacteria Using Single-Molecule and Super-Resolution Fluorescence Imaging

    Article • International Journal of Molecular Sciences, April 2011, MDPI AG

    Professor Mark C Leake

  21. Shining the spotlight on functional molecular complexes

    Article • Communicative & Integrative Biology, September 2010, Taylor & Francis

    Professor Mark C Leake

  22. Signal-dependent turnover of the bacterial flagellar switch protein FliM

    Article • Proceedings of the National Academy of Sciences, May 2010, Proceedings of the National Academy of Sciences

    Professor Mark C Leake

  23. Stoichiometry and Architecture of Active DNA Replication Machinery in Escherichia coli

    Article • Science, April 2010, American Association for the Advancement of Science

    Professor Mark C Leake

  24. Discrete and Continuous Three Dimensional Simulations for Fluorescence Recovery In Bacteria

    Article • Biophysical Journal, January 2010, Elsevier

    Professor Mark C Leake

  25. Fast Millisecond Imaging of Single Fluorescent Protein Molecules Using a Simple “Slimfield” Optical Trick

    Article • Biophysical Journal, January 2010, Elsevier

    Professor Mark C Leake

  26. Stoichiometry of Active DNA Replication Machinery Within Living Escherichia Coli Cells

    Article • Biophysical Journal, January 2010, Elsevier

    Professor Mark C Leake

  27. Dynamics and Co-Localization of the Electron Transport Chain of Escherichia Coli: Investigations Through Fluorescence Microscopy

    Article • Biophysical Journal, January 2010, Elsevier

    Professor Mark C Leake

  28. Advanced Multidimensional Optics to Investigate Biological Complexity at the Single Molecule Level in Living, Functional Cells

    Article • Biophysical Journal, January 2010, Elsevier

    Professor Mark C Leake

  29. Proteins of Functioning Flagellar Rotor Turnover but only in the Presence of Signalling Proteins

    Article • Biophysical Journal, January 2010, Elsevier

    Professor Mark C Leake

  30. A general approach for segmenting elongated and stubby biological objects: Extending a chord length transform with the Radon transform

    Article • January 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Mark C Leake

  31. Visualizing Single Molecular Complexes In Vivo Using Advanced Fluorescence Microscopy

    Article • Journal of Visualized Experiments, September 2009, MyJove Corporation

    Professor Mark C Leake

  32. A molecular brake, not a clutch, stops the Rhodobacter sphaeroides flagellar motor

    Article • Proceedings of the National Academy of Sciences, July 2009, Proceedings of the National Academy of Sciences

    Professor Mark C Leake

  33. A novel multiple particle tracking algorithm for noisy in vivo data by minimal path optimization within the spatio-temporal volume

    Article • June 2009, Institute of Electrical & Electronics Engineers (IEEE)

    Professor Mark C Leake

  34. A Discrete Generalized Model for Dynamic Turnover in Molecular Protein Complexes

    Article • Biophysical Journal, February 2009, Elsevier

    Professor Mark C Leake

  35. Developing Statistical Diagnostic Tools For Discriminating Between Different Diffusive Modes Of Fluorescently Tagged Protein Complexes In Living Cells For Short Duration Trajectories

    Article • Biophysical Journal, February 2009, Elsevier

    Professor Mark C Leake

  36. How Does The Bacterial Flagellar Motor Of Rhodobacter Sphaeroides Stop - Using A Clutch Or A Brake?

    Article • Biophysical Journal, February 2009, Elsevier

    Professor Mark C Leake

  37. Advanced Fluorescence Microscopy Of Single, Living Cells: Using Optical Proteomics To Study Native Biochemistry One Molecule At A Time

    Article • Biophysical Journal, February 2009, Elsevier

    Professor Mark C Leake

  38. Millisecond timescale slimfield imaging and automated quantification of single fluorescent protein molecules for use in probing complex biological processes

    Article • Integrative Biology, January 2009, Oxford University Press (OUP)

    Professor Mark C Leake

  39. Clustering and dynamics of cytochromebd-I complexes in theEscherichia coliplasma membranein vivo

    Article • Molecular Microbiology, December 2008, Wiley

    Professor Mark C Leake

  40. Variable stoichiometry of the TatA component of the twin-arginine protein transport system observed by in vivo single-molecule imaging

    Article • Proceedings of the National Academy of Sciences, October 2008, Proceedings of the National Academy of Sciences

    Professor Mark C Leake

  41. Are Escherichia coli OXPHOS complexes concentrated in specialized zones within the plasma membrane? : Figure 1

    Article • Biochemical Society Transactions, October 2008, Portland Press Ltd.

    Professor Mark C Leake

  42. Nonequivalence of Membrane Voltage and Ion-Gradient as Driving Forces for the Bacterial Flagellar Motor at Low Load

    Article • Biophysical Journal, July 2007, Elsevier

    Professor Mark C Leake

  43. Stoichiometry and turnover in single, functioning membrane protein complexes

    Article • Nature, September 2006, Springer Science + Business Media

    Professor Mark C Leake

  44. Mechanical properties of cardiac titin’s N2B-region by single-molecule atomic force spectroscopy

    Article • Journal of Structural Biology, August 2006, Elsevier

    Professor Mark C Leake

  45. The maximum number of torque-generating units in the flagellar motor of Escherichia coli is at least 11

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Professor Mark C Leake

  46. Fluorescence Measurement of Intracellular Sodium Concentration in Single Escherichia coli Cells

    Article • Biophysical Journal, January 2006, Elsevier

    Professor Mark C Leake

  47. Direct observation of steps in rotation of the bacterial flagellar motor

    Article • October 2005, Nature

    Professor Mark C Leake

  48. The Elasticity of Single Titin Molecules Using a Two-Bead Optical Tweezers Assay

    Article • Biophysical Journal, August 2004, Elsevier

    Professor Mark C Leake

  49. Multiple sources of passive stress relaxation in muscle fibres

    Article • Physics in Medicine and Biology, July 2004, Institute of Physics Publishing

    Professor Mark C Leake

  50. Rapid rotation of micron and submicron dielectric particles measured using optical tweezers

    Article • Journal of Modern Optics, July 2003, Taylor & Francis

    Professor Mark C Leake

  51. Rapid rotation of micron and submicron dielectric particles measured using optical tweezers

    Article • Journal of Modern Optics, January 2003, Taylor & Francis

    Professor Mark C Leake

  52. The elasticity of single kettin molecules using a two-bead laser-tweezers assay

    Article • FEBS Letters, December 2002, Wiley

    Professor Mark C Leake

  53. Preface

    Article • Cambridge University Press

    Professor Mark C Leake

  54. Measuring forces and manipulating single molecules

    Article • Cambridge University Press

    Professor Mark C Leake

  55. Molecules from beyond the cell

    Article • Cambridge University Press

    Professor Mark C Leake

  56. Into the membrane

    Article • Cambridge University Press

    Professor Mark C Leake

  57. Inside cells

    Article • Cambridge University Press

    Professor Mark C Leake

  58. Once upon a (length and) time (scale). . .

    Article • Cambridge University Press

    Professor Mark C Leake

  59. The molecules of life – an idiot’s guide

    Article • Cambridge University Press

    Professor Mark C Leake

  60. Making the invisible visible: part 2 – without visible light

    Article • Cambridge University Press

    Professor Mark C Leake

  61. Making the invisible visible: part 1 – methods that use visible light

    Article • Cambridge University Press

    Professor Mark C Leake

  62. Single-molecule biophysics: the case studies that piece together the hidden machinery of the cell

    Article • Cambridge University Press

    Professor Mark C Leake

  63. Single-molecule biophysics beyond single cells and beyond the single molecule

    Article • Cambridge University Press

    Professor Mark C Leake

  64. Some Functions of Proteins from the Drosophila sallimus (sls) Gene

    Article • Springer Science + Business Media

    Professor Mark C Leake