All Stories

  1. Evolution of Peptide-Based Prostate-Specific Membrane Antigen (PSMA) Inhibitors: An Approach to Novel Prostate Cancer Therapeutics

    Article • Current Medicinal Chemistry, June 2021, Bentham Science Publishers

    Professor Margaret A Brimble

  2. Using chemical synthesis to optimise antimicrobial peptides in the fight against antimicrobial resistance

    Article • Pure and Applied Chemistry, January 2019, De Gruyter

    Professor Margaret A Brimble

  3. Short Anabolic Peptides for Bone Growth

    Article • Medicinal Research Reviews, March 2016, Wiley

    Professor Margaret A Brimble

  4. Synthesis and bioactivity of antitubercular peptides and peptidomimetics: an update

    Article • Organic & Biomolecular Chemistry, January 2016, Royal Society of Chemistry

    Professor Margaret A Brimble

  5. Replacement of the CysA7–CysB7 disulfide bond with a 1,2,3-triazole linker causes unfolding in insulin glargine

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Professor Margaret A Brimble

  6. Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products

    Article • Natural Product Reports, January 2015, Royal Society of Chemistry

    Professor Margaret A Brimble

  7. On resin synthesis and cross-linking of collagen peptides containing the advanced glycation end-product pyrraline via Maillard condensation

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Margaret A Brimble

  8. Cell-targeted platinum nanoparticles and nanoparticle clusters

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Professor Margaret A Brimble

  9. Convergent chemo-enzymatic synthesis of mannosylated glycopeptides; targeting of putative vaccine candidates to antigen presenting cells

    Article • Chemical Science, January 2015, Royal Society of Chemistry

    Professor Margaret A Brimble, Antony Fairbanks, Dr Anna E.S Brooks

  10. An update on new methods to synthesize cyclotetrapeptides

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Professor Margaret A Brimble

  11. ChemInform Abstract: Total Synthesis of Virgatolide B (I).

    Article • ChemInform, January 2014, Wiley

    Professor Margaret A Brimble

  12. Total Synthesis of Heronapyrrole C

    Article • Organic Letters, January 2014, American Chemical Society (ACS)

    Professor Margaret A Brimble

  13. Synthesis of the 2-methylene analogue of the HRV 3C protease inhibitor thysanone (2-carbathysanone)

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Margaret A Brimble

  14. Site-specific cross-linking of collagen peptides by lysyl advanced glycation endproducts

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Professor Margaret A Brimble

  15. Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure–activity relationships for amylin receptor agonism

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Antony Fairbanks, Dr Debbie L Hay, Professor Margaret A Brimble

  16. Recent developments in transition metal-catalysed spiroketalisation

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Professor Margaret A Brimble

  17. ChemInform Abstract: N-Alkylsulfonylimines as Dipolarophiles in Cycloaddition Reactions

    Article • ChemInform, April 2013, Wiley

    Professor Margaret A Brimble

  18. Total Synthesis of Chaetoquadrins A–C

    Article • Organic Letters, February 2013, American Chemical Society (ACS)

    Professor Margaret A Brimble

  19. Synthesis of the IGF-II-like hormone vesiculin using regioselective formation of disulfide bonds

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Margaret A Brimble

  20. Chemical synthesis of a masked analogue of the fish antifreeze potentiating protein (AFPP)

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Margaret A Brimble

  21. Enantioselective access to benzannulated spiroketals using a chiral sulfoxide auxiliary

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Margaret A Brimble

  22. Novel preparation of chiral α-amino acids using the Mitsunobu–Tsunoda reaction

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Professor Margaret A Brimble

  23. A Review of Neuroprotective Agents

    Article • March 2012, Bentham Science Publishers

    Professor Margaret A Brimble

  24. Synthesis of the Antifungal Cyclic Peptides Tunicyclins C and D

    Article • Synlett, January 2012, Thieme Publishing Group

    Professor Margaret A Brimble

  25. Total Synthesis of Danshenspiroketallactone

    Article • Synlett, November 2011, Thieme Publishing Group

    Professor Margaret A Brimble

  26. ChemInform Abstract: Synthetic Studies Toward the Spiroimine Unit of the Spirolides

    Article • ChemInform, November 2011, Wiley

    Professor Margaret A Brimble

  27. ChemInform Abstract: A Flexible Approach to 6,5-Benzannulated Spiroketals.

    Article • ChemInform, November 2011, Wiley

    Professor Margaret A Brimble

  28. Synthesis of Benzannulated Spiroketals Using an Oxidative Radical Cyclization

    Article • Synthesis, April 2011, Thieme Publishing Group

    Professor Margaret A Brimble

  29. Natural products targeting telomere maintenance

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Professor Margaret A Brimble

  30. ChemInform Abstract: Synthesis of Bis-Spiroacetal Ring Systems

    Article • ChemInform, June 2010, Wiley

    Professor Margaret A Brimble

  31. ChemInform Abstract: Addition of a Grignard Reagent to Bis-spiroacetal Aldehydes: Appendage of a Tetrahydrofuran Ring.

    Article • ChemInform, June 2010, Wiley

    Professor Margaret A Brimble

  32. ChemInform Abstract: Deprotonation and Alkylation of 2-Methyl-4,5,6,7-tetrahydro-3H-azepine.

    Article • ChemInform, June 2010, Wiley

    Professor Margaret A Brimble

  33. ChemInform Abstract: Synthetic Studies Towards Natural Products Containing Bis-spiroacetals

    Article • ChemInform, June 2010, Wiley

    Professor Margaret A Brimble

  34. ChemInform Abstract: Reductive Thioalkylation of a Pyranonaphthoquinone.

    Article • ChemInform, June 2010, Wiley

    Professor Margaret A Brimble

  35. ChemInform Abstract: Polyether Antibiotic CP44,161.

    Article • ChemInform, May 2010, Wiley

    Professor Margaret A Brimble

  36. ChemInform Abstract: Synthetic Studies Toward Pyranonaphthoquinone Antibiotics

    Article • ChemInform, May 2010, Wiley

    Professor Margaret A Brimble

  37. ChemInform Abstract: Synthesis of the Bis-spiroacetal Moiety of the Polyether Antibiotic CP44,161.

    Article • ChemInform, May 2010, Wiley

    Professor Margaret A Brimble

  38. ChemInform Abstract: The Synthesis of Potential Chemotherapeutic Agents Based on Leads from Nature

    Article • ChemInform, May 2010, Wiley

    Professor Margaret A Brimble

  39. ChemInform Abstract: Synthesis of Natural Products Containing Spiroketals via Intramolecular Hydrogen Abstraction.

    Article • ChemInform, April 2010, Wiley

    Professor Margaret A Brimble

  40. ChemInform Abstract: Molecules Derived from the Extremes of Life

    Article • ChemInform, May 2009, Wiley

    Professor Margaret A Brimble

  41. Buchwald-Hartwig Mono-N-arylation with 2,6-Dihaloisonicotinic Acid Derivatives: A Convenient Desymmetrization Method

    Article • Synthesis, September 2008, Thieme Publishing Group

    Professor Margaret A Brimble

  42. ChemInform Abstract: Pyranonaphthoquinones-Isolation, Biological Activity and Synthesis

    Article • ChemInform, July 2008, Wiley

    Professor Margaret A Brimble

  43. A Facile Enantioselective Synthesis of the Dimeric Pyranonaphthoquinone Core of the Cardinalins

    Article • Synlett, April 2008, Thieme Publishing Group

    Professor Margaret A Brimble

  44. 2-Trimethylsilyloxyfuran

    Article • March 2008, Wiley

    Professor Margaret A Brimble

  45. Synthesis of Macrocyclic Shellfish Toxins Containing Spiroimine Moieties

    Article • ChemInform, November 2007, Wiley

    Professor Margaret A Brimble

  46. Synthesis of the FG Fragment of the Pectenotoxins

    Article • Synlett, September 2007, Thieme Publishing Group

    Professor Margaret A Brimble

  47. Enantioselective Synthesis of an Analogue of Nanaomycin A

    Article • Synthesis, September 2007, Thieme Publishing Group

    Professor Margaret A Brimble

  48. Synthesis of the Spiroacetal-Containing anti-Helicobacter pylori Agents CJ-12,954 and CJ-13,014.

    Article • ChemInform, March 2007, Wiley

    Professor Margaret A Brimble

  49. Synthetic Studies Towards the Pectenotoxins: A Review

    Article • ChemInform, February 2007, Wiley

    Professor Margaret A Brimble

  50. Synthesis of macrocyclic shellfish toxins containing spiroimine moieties

    Article • Natural Product Reports, January 2007, Royal Society of Chemistry

    Professor Margaret A Brimble

  51. Margaret Brimble Wins Major International Award

    Article • Chemistry International, January 2007, De Gruyter

    Professor Margaret A Brimble

  52. Synthetic studies toward shellfish toxins containing spiroacetal units

    Article • Pure and Applied Chemistry, January 2007, De Gruyter

    Professor Margaret A Brimble

  53. Synthesis of the spiroacetal-containing anti-Helicobacter pylori agents CJ-12,954 and CJ-13,014

    Article • Chemical Communications, January 2006, Royal Society of Chemistry

    Professor Margaret A Brimble

  54. Synthesis of Pharmaceuticals Using Molecular Chess and Automated Synthesis

    Article • ChemInform, December 2005, Wiley

    Professor Margaret A Brimble

  55. The First Enantioselective Total Synthesis of the anti-Helicobacter pylori Agent (+)-Spirolaxine Methyl Ether.

    Article • ChemInform, August 2005, Wiley

    Professor Margaret A Brimble

  56. A Tribute to Prof. Jim Coxon

    Article • ARKIVOC, June 2005, University of Michigan Library

    Professor Margaret A Brimble

  57. A Tribute to Don Cameron

    Article • ARKIVOC, June 2005, ARKAT USA, Inc.

    Professor Margaret A Brimble

  58. Radical Oxidative Cyclization of Spiroacetals to Bis-spiroacetals

    Article • ChemInform, June 2005, Wiley

    Professor Margaret A Brimble

  59. A Double Alkylation—Ring Closing Metathesis Approach to Spiroimines.

    Article • ChemInform, October 2004, Wiley

    Professor Margaret A Brimble

  60. Synthesis of Regioisomeric Analogues of Crisamicin A.

    Article • ChemInform, April 2004, Wiley

    Professor Margaret A Brimble

  61. Chemistry of Bis-spiroacetal Systems—Natural Products: Synthesis and Stereochemistry

    Article • ChemInform, March 2004, Wiley

    Professor Margaret A Brimble

  62. Synthesis of Spirocyclic Imines: Key Pharmacophores in the Shellfish Toxins Spirolides and Gymnodimine.

    Article • ChemInform, February 2004, Wiley

    Professor Margaret A Brimble

  63. Synthesis and evaluation of vasoconstrictor and vasorelaxant activity of norbormide isomers

    Article • ARKIVOC, February 2004, University of Michigan Library

    Professor Margaret A Brimble

  64. Polyether Antibiotics

    Article • November 2003, Wiley

    Professor Margaret A Brimble

  65. Synthesis of regioisomeric analogues of crisamicin A

    Article • Organic & Biomolecular Chemistry, January 2003, Royal Society of Chemistry

    Professor Margaret A Brimble

  66. Synthetic Studies Towards The Rubromycins

    Article • January 2003, Elsevier

    Professor Margaret A Brimble

  67. Synthetic Studies Towards Spirolaxine

    Article • January 2003, Elsevier

    Professor Margaret A Brimble

  68. Synthesis of Spirocyclic Imines: Key Pharmacophores in the Shellfish Toxins Spirolides and Gymnodimine

    Article • Synlett, January 2003, Thieme Publishing Group

    Professor Margaret A Brimble

  69. Di-(−)-(1R,2S)-2-phenyl-1-cyclohexyl Diazenedicarboxylate

    Article • April 2002, Wiley

    Professor Margaret A Brimble

  70. Enantioselective synthesis of a cyclopentannulated kalafungin analogue

    Article • ARKIVOC, December 2000, University of Michigan Library

    Professor Margaret A Brimble

  71. Synthesis of a C-glycosylpyranonaphthoquinone related to medermycin

    Article • Tetrahedron Letters, April 2000, Elsevier

    Professor Margaret A Brimble

  72. 3-[5-(tert-Butyldimethylsilyloxy)-3-p-nitrobenzoyl-1-oxo- 2-(phenylmethoxy)hexyl]-4-(phenylmethyl)-2-oxazolidinone

    Article • Molecules, February 2000, MDPI AG

    Professor Margaret A Brimble

  73. 3-[5-(tert-Butyldimethylsilyloxy)-3-(3,5-dinitrobenzoyl)-1-oxo- 2-(phenylmethoxy)hexyl]-4-(phenylmethyl)-2-oxazolidinone

    Article • Molecules, February 2000, MDPI AG

    Professor Margaret A Brimble

  74. Synthetic studies toward pyranonaphthoquinone antibiotics

    Article • Pure and Applied Chemistry, January 2000, De Gruyter

    Professor Margaret A Brimble

  75. Synthetic studies towards natural products containing bis-spiroacetals

    Article • Journal of Heterocyclic Chemistry, November 1999, Wiley

    Professor Margaret A Brimble

  76. Synthesis of bis-spiroacetal ring systems

    Article • Tetrahedron, June 1999, Elsevier

    Professor Margaret A Brimble

  77. Pyranonaphthoquinone antibiotics—isolation, structure and biological activity

    Article • Natural Product Reports, January 1999, Royal Society of Chemistry

    Professor Margaret A Brimble

  78. Reductive thioalkylation of a kalafungin analogue

    Article • Tetrahedron Letters, July 1998, Elsevier

    Professor Margaret A Brimble

  79. [4R*,5R*,6S*]-1,7-Dioxaspiro[5.5]undecane-4,5-diol

    Article • Molecules, June 1997, MDPI AG

    Professor Margaret A Brimble

  80. [3S*,5S*,6S*]-1,7-Dioxaspiro[5.5]undecane-3,5-diol

    Article • Molecules, June 1997, MDPI AG

    Professor Margaret A Brimble

  81. [2R*,5S*,6S*]-2-Methyl-1,7-dioxaspiro[5.5]undec-2-en-5-ol

    Article • Molecules, June 1997, MDPI AG

    Professor Margaret A Brimble

  82. [2R*,5S*,6S*]-2-Methyl-1,7-dioxaspiro[5.5]undec-3-en-5-ol§

    Article • Molecules, June 1997, MDPI AG

    Professor Margaret A Brimble

  83. [3R*,5S*,6S*]-5-Hydroxy-1,7-dioxaspiro[5.5]undec-3-yl 3,5-Dinitrobenzoate

    Article • Molecules, June 1997, MDPI AG

    Professor Margaret A Brimble

  84. [3R*,5S*,6S*]-1,7-Dioxaspiro[5.5]undecane-3,5-diyl Bis(3,5-dinitrobenzoate)

    Article • Molecules, June 1997, MDPI AG

    Professor Margaret A Brimble

  85. [4R*,5R*,6S*]-1,7-Dioxaspiro[5.5]undec-4,5-diyl Diacetate

    Article • Molecules, June 1997, MDPI AG

    Professor Margaret A Brimble

  86. [3S*,5S*,6S*]-1,7-Dioxaspiro[5.5]undecane-3,5-diyl Diacetate

    Article • Molecules, June 1997, MDPI AG

    Professor Margaret A Brimble

  87. Synthesis of a new spiroacetal based herbicide

    Article • Tetrahedron Letters, May 1997, Elsevier

    Professor Margaret A Brimble

  88. Synthesis of Spiroketals Related to Griseusin A

    Article • Molecules, March 1996, Springer Science + Business Media

    Professor Margaret A Brimble

  89. Book Review, Organic Synthesis Highlights II

    Article • Synthesis, February 1996, Thieme Publishing Group

    Professor Margaret A Brimble

  90. Synthesis of an actinorhodin monomer

    Article • Tetrahedron Letters, December 1995, Elsevier

    Professor Margaret A Brimble

  91. Asymmetric dihydroxylation of α- and β-farnesene

    Article • Tetrahedron Letters, December 1994, Elsevier

    Professor Margaret A Brimble

  92. Synthe1sis of 5-epi-arizonin B1 and 5-epi-arizonin C1

    Article • Tetrahedron Letters, September 1993, Elsevier

    Professor Margaret A Brimble

  93. The synthesis of 5′-deoxyjuglomycin A and 5′-methoxyjuglomycin A.

    Article • Tetrahedron Letters, October 1991, Elsevier

    Professor Margaret A Brimble

  94. Highly stereoselective syn-hydroxylation of spiroketals

    Article • Tetrahedron Letters, August 1991, Elsevier

    Professor Margaret A Brimble

  95. Synthesis of a functionalised bis-spiroacetal

    Article • Tetrahedron Letters, January 1990, Elsevier

    Professor Margaret A Brimble

  96. A facile synthesis of spiroketals

    Article • Tetrahedron Letters, January 1988, Elsevier

    Professor Margaret A Brimble