All Stories

  1. Exogenous melatonin supplementation prevents oxidative stress-evoked DNA damage in human spermatozoa

    Article • Journal of Pineal Research, September 2014, Wiley

    Dr Javier Espino

  2. Melatonin’s Beneficial Effects in Metabolic Syndrome with Therapeutic Applications

    Article • September 2014, Taylor & Francis

    Dr Javier Espino

  3. FMLP-, thapsigargin-, and H2O2-evoked changes in intracellular free calcium concentration in lymphocytes and neutrophils of type 2 diabetic patients

    Article • Molecular and Cellular Biochemistry, November 2013, Springer Science + Business Media

    Dr Javier Espino

  4. The inhibition of TNF-α-induced leucocyte apoptosis by melatonin involves membrane receptor MT1/MT2 interaction

    Article • Journal of Pineal Research, February 2013, Wiley

    Dr Javier Espino

  5. Tempranillo-derived grape seed extract induces apoptotic cell death and cell growth arrest in human promyelocytic leukemia HL-60 cells

    Article • Food & Function, January 2013, Royal Society of Chemistry

    Dr Javier Espino

  6. Metabolic Syndrome, its Pathophysiology and the Role of Melatonin

    Article • Recent Patents on Endocrine Metabolic & Immune Drug Discovery, January 2013, Bentham Science Publishers

    Dr Javier Espino

  7. Metabolic Syndrome, its Pathophysiology and the Role of Melatonin

    Article • Recent Patents on Endocrine Metabolic & Immune Drug Discovery, December 2012, Bentham Science Publishers

    Dr Javier Espino

  8. Metabolic Syndrome, its Pathophysiology and the Role of Melatonin

    Article • Recent Patents on Endocrine Metabolic & Immune Drug Discovery, December 2012, Bentham Science Publishers

    Dr Javier Espino, Rahimah Zakaria

  9. The consumption of a Jerte Valley cherry product in humans enhances mood, and increases 5-hydroxyindoleacetic acid but reduces cortisol levels in urine

    Article • Experimental Gerontology, August 2012, Elsevier

    Dr Javier Espino

  10. Systemic Inflammatory Load in Young and Old Ringdoves Is Modulated by Consumption of a Jerte Valley Cherry-Based Product

    Article • Journal of Medicinal Food, August 2012, Mary Ann Liebert Inc

    Dr Javier Espino

  11. Apoptosis, ROS and Calcium Signaling in Human Spermatozoa: Relationship to Infertility

    Article • April 2012, IntechOpen

    Dr Javier Espino

  12. A Jerte Valley Cherry-Based Product as a Supply of Tryptophan

    Article • International Journal of Tryptophan Research, April 2012, Libertas Academica, Ltd.

    Dr Javier Espino

  13. Melatonin potentiates chemotherapy-induced cytotoxicity and apoptosis in rat pancreatic tumor cells

    Article • Journal of Pineal Research, January 2012, Wiley

    Dr Javier Espino

  14. Oxidative Stress and Immunosenescence: Therapeutic Effects of Melatonin

    Article • Oxidative Medicine and Cellular Longevity, January 2012, Hindawi Publishing Corporation

    Dr Javier Espino

  15. Jerte Valley cherry-based product modulates serum inflammatory markers in rats and ringdoves

    Article • Journal of Applied Biomedicine, January 2012, Elsevier

    Dr Javier Espino

  16. Melatonin protects human spermatozoa from apoptosis via melatonin receptor– and extracellular signal–regulated kinase-mediated pathways

    Article • Fertility and Sterility, June 2011, Elsevier

    Dr Javier Espino

  17. Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions

    Article • Journal of Pineal Research, April 2011, Wiley

    Dr Javier Espino

  18. Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells

    Article • Molecular and Cellular Biochemistry, March 2011, Springer Science + Business Media

    Dr Javier Espino

  19. Role of melatonin on diabetes-related metabolic disorders

    Article • World Journal of Diabetes, January 2011, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Dr Javier Espino

  20. Pro-Oxidant Effect of Melatonin in Tumour Leucocytes: Relation with its Cytotoxic and Pro-Apoptotic Effects

    Article • Basic & Clinical Pharmacology & Toxicology, December 2010, Wiley

    Dr Javier Espino

  21. Melatonin is able to delay endoplasmic reticulum stress-induced apoptosis in leukocytes from elderly humans

    Article • AGE, November 2010, Springer Science + Business Media

    Dr Javier Espino

  22. Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa

    Article • Fertility and Sterility, October 2010, Elsevier

    Dr Javier Espino

  23. Melatonin Counteracts Alterations in Oxidative Metabolism and Cell Viability Induced by Intracellular Calcium Overload in Human Leucocytes: Changes with Age

    Article • Basic & Clinical Pharmacology & Toxicology, February 2010, Wiley

    Dr Javier Espino

  24. Melatonin Reduces Apoptosis Induced by Calcium Signaling in Human Leukocytes: Evidence for the Involvement of Mitochondria and Bax Activation

    Article • The Journal of Membrane Biology, February 2010, Springer Science + Business Media

    Dr Javier Espino

  25. The correlation between urinary 5-hydroxyindoleacetic acid and sperm quality in infertile men and rotating shift workers

    Article • Reproductive Biology and Endocrinology, January 2010, Springer Science + Business Media

    Dr Javier Espino

  26. A nutraceutical product based on Jerte Valley cherries improves sleep and augments the antioxidant status in humans

    Article • e-SPEN the European e-Journal of Clinical Nutrition and Metabolism, December 2009, Elsevier

    Dr Javier Espino

  27. Selenium Modulates Oxidative Stress-Induced Cell Apoptosis in Human Myeloid HL-60 Cells Through Regulation of Calcium Release and Caspase-3 and -9 Activities

    Article • The Journal of Membrane Biology, November 2009, Springer Science + Business Media

    Dr Javier Espino

  28. Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells

    Article • Journal of Pineal Research, May 2009, Wiley

    Dr Javier Espino

  29. Reduced levels of intracellular calcium releasing in spermatozoa from asthenozoospermic patients

    Article • Reproductive Biology and Endocrinology, February 2009, Springer Science + Business Media

    Dr Javier Espino

  30. Relationship between Caspase Activity and Apoptotic Markers in Human Sperm in Response to Hydrogen Peroxide and Progesterone

    Article • Journal of Reproduction and Development, January 2009, Japanese Society of Animal Reproduction

    Dr Javier Espino