All Stories

  1. An update on the validation of whole slide imaging systems following FDA approval of a system for a routine pathology diagnostic service in the United States
  2. Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis
  3. Ignac Fogelman: 1948-2016
  4. Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation
  5. Chronic tenosynovitis of the hand caused by Mycobacterium heraklionense
  6. Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice
  7. Increased bone density in mice lacking the proton receptor OGR1
  8. Analysis of new bone, cartilage, and fibrosis tissue in healing murine allografts using whole slide imaging and a new automated histomorphometric algorithm
  9. TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression
  10. High-Fat Diet Causes Bone Loss in Young Mice by Promoting Osteoclastogenesis Through Alteration of the Bone Marrow Environment
  11. NF-κB-Mediated Regulation of Osteoclastogenesis
  12. NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB
  13. NF-κB RelB Negatively Regulates Osteoblast Differentiation and Bone Formation
  14. Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia
  15. Distribution and Alteration of Lymphatic Vessels in Knee Joints of Normal and Osteoarthritic Mice
  16. RANKL-Based Osteoclastogenic Assays from Murine Bone Marrow Cells
  17. The Murine Femoral Bone Graft Model and a Semiautomated Histomorphometric Analysis Tool
  18. Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism
  19. Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation
  20. Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migration
  21. Bone and Immune Cell Interactions
  22. Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts
  23. Biology of Bone and Cartilage
  24. List of Contributors
  25. The osteoclast, bone remodelling and treatment of metabolic bone disease
  26. Wnt5a non-canonical signaling through Ror2; a novel co-stimulatory mechanism to enhance RANKL-induced osteoclastogenesis
  27. The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis
  28. Noncanonical NF‐κB Signaling Regulates Hematopoietic Stem Cell Self‐Renewal and Microenvironment Interactions
  29. Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data
  30. Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice
  31. Optimizing the use and applications of special stains: clinical and experimental approaches
  32. Metabolic bone diseases
  33. The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis
  34. Contributors
  35. DominantTRPV4mutations in nonlethal and lethal metatropic dysplasia
  36. Functions of nuclear factor κB in bone
  37. Contrasting mechanisms of hypercalcemia in patients with early and advanced humoral hypercalcemia of malignancy
  38. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
  39. Use of an in vivo model to determine the effects of interleukin-1 on cells at different stages in the osteoclast lineage
  40. Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo
  41. NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
  42. Stomaching calcium for bone health
  43. Sphingosine-1 Phosphate: A New Player in Osteoimmunology
  44. Disruption of Rankl/Rank Signaling Reduces TNF-Induced Joint Inflammation In Vivo
  45. Reduced COX-2 Expression in Aged Mice Is Associated With Impaired Fracture Healing
  46. The Role of Bone Marrow Edema and Lymphangiogenesis in Inflammatory-Erosive Arthritis
  47. Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption
  48. Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast‐enhanced magnetic resonance imaging
  49. Functions of RANKL/RANK/OPG in bone modeling and remodeling
  50. Bruton and Tec: New Links in Osteoimmunology
  51. Dimorphic effects of Notch signaling in bone homeostasis
  52. SAR of Carbon-Linked, 2-Substituted Purines: Synthesis and Characterization of AP23451 as a novel Bone-Targeted Inhibitor of Src Tyrosine Kinase With In Vivo Anti-Resorptive Activity
  53. TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
  54. Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography
  55. Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2
  56. What Are the Most Common Errors in the Management of Renal Osteodystrophy?
  57. The RANKL/RANK/OPG pathway
  58. Pseudoaneurysm of a Genicular Branch of the Popliteal Artery and Deep Venous Thrombosis: An Unusual Presentation of an Osteochondroma
  59. Biology of RANK, RANKL, and osteoprotegerin
  60. Increased lymphangiogenesis in joints of mice with inflammatory arthritis
  61. Osteoclasts, no longer osteoblast slaves
  62. CRTAP Is Required for Prolyl 3- Hydroxylation and Mutations Cause Recessive Osteogenesis Imperfecta
  63. Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease
  64. Osteoclast precursors, RANKL/RANK, and immunology
  65. Osteoprotegerin, the bone protector, is a surprising target for β-catenin signaling
  66. Lead Exposure Inhibits Fracture Healing and Is Associated with Increased Chondrogenesis, Delay in Cartilage Mineralization, and a Decrease in Osteoprogenitor Frequency
  67. Regulation of apoptosis in osteoclasts and osteoblastic cells
  68. Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy
  69. Roles for NF-κB and c-Fos in osteoclasts
  70. TNF.ALPHA. and pathologic bone resorption
  71. Malignant Autosomal Recessive Osteopetrosis Caused by Spontaneous Mutation of Murine Rank
  72. Systemic tumor necrosis factor ? mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor ?-transgenic mice
  73. RANK Signaling Is Not Required for TNFα-Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα-Mediated Inflammatory Arthritis
  74. Regulation of bone remodeling and emerging breakthrough drugs for osteoporosis and osteolytic bone metastases
  75. NF-κB Specifically Activates BMP-2 Gene Expression in Growth Plate Chondrocytes in Vivo and in a Chondrocyte Cell Line in Vitro
  76. Bad bones, grey hair, one mutation
  77. Expression of Either NF-κB p50 or p52 in Osteoclast Precursors Is Required for IL-1-Induced Bone Resorption
  78. NF-κB p50 and p52 Expression Is Not Required for RANK-Expressing Osteoclast Progenitor Formation but Is Essential for RANK- and Cytokine-Mediated Osteoclastogenesis
  79. In Vivo RANK Signaling Blockade Using the Receptor Activator of NF-κB:Fc Effectively Prevents and Ameliorates Wear Debris-Induced Osteolysis via Osteoclast Depletion Without Inhibiting Osteogenesis
  80. Apoptosis in Bone Cells
  81. Src inhibitors: genomics to therapeutics
  82. Evidence for a Direct Role of Cyclo-Oxygenase 2 in Implant Wear Debris-Induced Osteolysis
  83. Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation
  84. Bone metastasis: an update on mechanisms of bone resorption and therapeutic strategies
  85. Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice
  86. Estrogen, Transforming Growth Factor-Beta, and the Regulation of Bone Metabolism in Health and Disease
  87. Bone Disease in Malignancy
  88. Mice Lacking 5-Lipoxygenase Have Increased Cortical Bone Thickness
  89. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β
  90. Increased bone formation in osteocalcin-deficient mice
  91. Histomorphometric and immunocytochemical studies of src-related osteopetrosis
  92. Pathology of Metabolic Bone and Joint Diseases
  93. Cellular and subcellular localization of aluminum
  94. Bone biopsy and histomorphometry in metabolic bone disease
  95. List of contributors
  96. Bolus Injections of Recombinant Human Interleukin-1 Cause Transient Hypocalcemia in Normal Mice*
  97. Effects of Interleukin-1 on Bone Turnover in Normal Mice*
  98. 2 Uses and limitations of bone biopsy in management of metabolic bone disease
  99. Animal models for the investigation of the action of factors on bone metabolism
  100. Methods for studying cell death in bone