All Stories

  1. Crotonases: Nature’s Exceedingly Convertible Catalysts

    Article • ACS Catalysis, August 2017, American Chemical Society (ACS)

    Dr Refaat B Hamed

  2. Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo

    Article • Nature Communications, August 2017, Nature

    Dr Refaat B Hamed

  3. Stereoselective Production of Dimethyl-Substituted Carbapenams via Engineered Carbapenem Biosynthesis Enzymes

    Article • ACS Catalysis, January 2017, American Chemical Society (ACS)

    Dr Refaat B Hamed

  4. Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity

    Article • ChemBioChem, February 2016, Wiley

    Dr Refaat B Hamed

  5. Stereoselective preparation of lipidated carboxymethyl-proline/pipecolic acid derivatives via coupling of engineered crotonases with an alkylmalonyl-CoA synthetase

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Refaat B Hamed, Christopher Schofield

  6. The enzymes of β-lactam biosynthesis

    Article • Natural Product Reports, January 2013, Royal Society of Chemistry

    Dr Refaat B Hamed

  7. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

    Article • Nature Chemical Biology, October 2012, Springer Science + Business Media

    Dr Refaat B Hamed

  8. Self-hydroxylation of the splicing factor lysyl hydroxylase, JMJD6

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Dr Refaat B Hamed

  9. Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams

    Article • Journal of the American Chemical Society, December 2011, American Chemical Society (ACS)

    Dr Refaat B Hamed, Prof. Dr. Jasmin Mecinovic

  10. Stereoselective C–C bond formation catalysed by engineered carboxymethylproline synthases

    Article • Nature Chemistry, April 2011, Springer Science + Business Media

    Dr Refaat B Hamed

  11. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

    Article • FEBS Journal, February 2011, Wiley

    Dr Refaat B Hamed

  12. The 2-Oxoglutarate-Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues

    Article • ChemBioChem, January 2011, Wiley

    Dr Refaat B Hamed

  13. Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions

    Article • Chemical Communications, January 2011, Royal Society of Chemistry

    Dr Refaat B Hamed

  14. Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

    Article • FEBS Journal, August 2010, Wiley

    Dr Refaat B Hamed

  15. Monitoring the Activity of 2-Oxoglutarate Dependent Histone Demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde

    Article • ChemBioChem, March 2010, Wiley

    Dr Refaat B Hamed, Dr Nathan R Rose

  16. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles

    Article • Chemical Communications, January 2010, Royal Society of Chemistry

    Dr Refaat B Hamed, Prof. Dr. Jasmin Mecinovic

  17. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water

    Article • Angewandte Chemie International Edition, March 2009, Wiley

    Dr Refaat B Hamed, Prof. Dr. Jasmin Mecinovic

  18. Iron-Mediated Cleavage of CC Bonds in Vicinal Tricarbonyl Compounds in Water

    Article • Angewandte Chemie, March 2009, Wiley

    Prof. Dr. Jasmin Mecinovic, Dr Refaat B Hamed

  19. Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline

    Article • ChemBioChem, January 2009, Wiley

    Dr Refaat B Hamed, Prof. Dr. Jasmin Mecinovic

  20. Cover Picture: Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline (ChemBioChem 2/2009)

    Article • ChemBioChem, January 2009, Wiley

    Dr Refaat B Hamed

  21. Synthesis of regio- and stereoselectively deuterium-labelled derivatives of l-glutamate semialdehyde for studies on carbapenem biosynthesis

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Dr Refaat B Hamed

  22. Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily

    Article • Angewandte Chemie International Edition, October 2008, Wiley

    Dr Refaat B Hamed

  23. Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily

    Article • Angewandte Chemie, October 2008, Wiley

    Dr Refaat B Hamed

  24. Mechanisms and structures of crotonase superfamily enzymes – How nature controls enolate and oxyanion reactivity

    Article • Cellular and Molecular Life Sciences, May 2008, Springer Science + Business Media

    Dr Refaat B Hamed